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Document ID (ISN)100355
CIS number 02-1354
ISSN - Serial title 0019-8366 - Industrial Health
Year 2001
Convention or series no.
Author(s) Yokota K., Johyama Y., Miyaue H., Matsumoto N., Yamaguchi K.
Title Occupational contact urticaria caused by airborne methyhexahydrophthalic anhydride
Bibliographic information Oct. 2001, Vol.39, No.4, p.347-352. Illus. 20 ref.
Abstract Three subjects with occupational exposure to methyl hexahydrophthalic anhydride (MHHPA) and hexahydrophthalic anhydride (HHPA) from an epoxy resin system were studied to evaluate the nature of their reported skin and nose complaints. Specific IgE antibody was detected in serum from one of the three workers. One unsensitized worker displayed nasal pain and rhinorrhoea only when loading liquid epoxy resins into the pouring machine, probably as a result of an irritant reaction. Two workers had work-related symptoms at relatively low levels of exposure; one complained of only rhinitis, and the other was sensitized against HHPA and displayed both rhinitis and contact urticaria (in the face and neck). The worker's skin symptoms were evidently due to airborne contact, since she had not had any skin contact with liquid epoxy resin or mixtures of MHHPA and HHPA. These urticaria symptoms were confirmed by a 20-min closed patch test for MHHPA, but not by that for HHPA. The causative agent was considered to be MHHPA, although the specific IgE determination to MHHPA was not performed.
Descriptors (primary) irritants; urticaria; methyl hexahydrophthalic anhydride; epoxy resins
Descriptors (secondary) subjective assessment; immunoglobulins; rhinitis; case study; sensitization; exposure evaluation; skin tests; determination in blood; serological reactions; grotan
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases