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CISDOC database
| Document ID (ISN) | 100340 |
| CIS number |
02-1339 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2000 |
| Convention or series no. |
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| Author(s) |
Başaran N., Ündeğer Ü. |
| Title |
Effects of lead on immune parameters in occupationally exposed workers |
| Bibliographic information |
Sep. 2000, Vol.38, No.3, p.349-354. 36 ref. |
| Abstract |
To assess the immune competence of workers occupationally exposed to lead, several subsets of peripheral lymphocytes, i.e., T, TCD4+, TCD8+, B, NK cells, serum immunoglobulin and complement protein concentrations, chemotaxis, and intracellular killing activity of neutrophils of 25 male storage battery workers were analysed and compared with those of 25 healthy males with no history of lead exposure. The results indicated that industrial exposure to lead resulting in group mean blood lead concentrations of 75±18µg/dL are associated with a significant depression of: T helper lymphocytes, IgG, IgM and C3, C4 complement levels, chemotaxis, and random migration of neutrophils. No correlation was found between the duration of exposure and the altered immune parameters. In conclusion, the immune system can be a target for lead toxicity and elimination of lead hazard in working places is necessary. |
| Descriptors (primary) |
lead; exposure tests; immunobiological changes |
| Descriptors (secondary) |
lymphocytes; immunology; neutrophil changes |
| Document type |
D - Periodical articles |
| Country / State or Province | Turkey |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Inorganic substances
Biological monitoring
Lead and compounds
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