|Document ID (ISN)||100300|
|Convention or series no.
||INRS ED 5010
||HervÚ-Bazin B., Laudet-Hesbert A., Mahieu C., Dornier G.
||Les phtalates [in French]|
||Institut national de recherche et de sÚcuritÚ, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 2001. 4p. Illus. 4 ref.
||Approximately 3m tons of phthalates are produced worldwide each year. They are mainly used as plasticizers for flexible PVC products such as coated textiles, waterproofing membranes, adhesives, lubricants, electrical cable sheathing, medical products (in particular tubes and pouches for dialysis, transfusion and infusion), toys and floor-covering. Studies carried out during the last ten years have highlighted antifertility and carcinogenic effects of certain phthalates on rodents. This information sheet summarizes the current state of knowledge with respect to risks to human health from phthalates. Contents: toxicology (low oral toxicity, non irritant, long-term animal studies showing risks of hepatic tumours and antifertility effects, low risk from inhalation due to the low vapour pressures); European regulations concerning classification and labelling; protective measures; threshold limit values; substitution by higher molecular-weight products.
||France; health hazards; phthalates
||embryotoxic effects; benzyl butyl phthalate; antifertility effects; carcinogens; hepatotoxic effects; bis(ethylhexyl) phthalate; diisodecyl phthalate; dibutyl phthalate; toxicology; labelling; warning notices; substitution; animal experiments; teratogenic effects; classification; data sheet; threshold limit values
||F - Information notes, codes of practice, standards
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures
Esters and salts