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CISDOC database

Document ID (ISN)100182
CIS number 02-1326
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2000
Convention or series no.
Author(s) Meredith S.K., Bugler J., Clark R.L.
Title Isocyanate exposure and occupational asthma: A case-referent study
Bibliographic information Dec. 2000, Vol.57, No.12, p.830-836. 25 ref.
Abstract Case study of 34 workers from two British manufacturing companies. In one plant occupational asthma was mainly attributed to tolylene diisocyanate exposure, while in the other one to 4,4'-diphenylmethane diisocyanate. No difference in peak exposures between cases and referents was found in either plant. However, time weighted average (TWA) exposures at the time of onset of asthma were higher for cases. The findings were that asthma can occur at low concentrations of isocyanates, but even then the higher the exposure, the greater the risk. Smoking and atopy seemed to increase the odds of this occupational asthma due to isocyanates.
Descriptors (primary) diphenylmethane diisocyanate; asthma; tolylene diisocyanate; isocyanates
Descriptors (secondary) United Kingdom; smoking; individual susceptibility; case-control study; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds