| Document ID (ISN) | 100145 |
| CIS number |
02-1226 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2001 |
| Convention or series no. |
|
| Author(s) |
Yucesoy B., Vallyathan V., Landsittel D.P., Sharp D.S., Matheson J., Burleson F., Luster M.I. |
| Title |
Polymorphisms of the IL-1 gene complex in coal miners with silicosis |
| Bibliographic information |
Mar. 2001, Vol.39, No.3, p.286-291. 28 ref. |
| Abstract |
Pro-inflammatory cytokines, such as interleukin-1 (IL-1), play a role in the development of silicosis. The study compared 318 histopathologically confirmed pulmonary silicosis patients with controls. Genotyping was carried out through the polymerase chain reaction technique. The proportion of the IL-1 receptor antagonist (allele 2 genotype) was higher in miners with silicosis than in controls. This is the first report suggesting that such a genetic polymorphism may confer an increased risk for the development of the disease. |
| Descriptors (primary) |
silicosis; coal mining; cytological effects |
| Descriptors (secondary) |
genetic screening |
| Document type |
D - Periodical articles |
| Country / State or Province | Turkey; USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Pneumoconioses
Mining and quarrying
|
