ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)100019
CIS number 02-1352
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Zheng T., Zahm S.H., Cantor K.P., Weisenburger D.D., Zhang Y., Blair A.
Title Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma
Bibliographic information July 2001, Vol.43, No.7, p.641-649. 33 ref.
Abstract To explore the possible relationship between non-Hodgkin lymphoma (NHL) and carbamate insecticide use among farmers, a pooled analysis of three population-based case-control studies conducted in four mid-western states in the United States was conducted involving 985 white male subjects and 2895 matched controls. Compared with non-farmers, farmers who had ever used carbamate pesticides had a 30% to 50% increased risk of NHL, whereas farmers without carbamate pesticide use showed no increased risk. Analyses for individual carbamate pesticides found a more consistent association with Sevin but not carbofuran, butylate, or S-ethyl dipropylthiocarbamate plus protectant. Among farmers using Sevin, the risk of NHL was limited to those who personally handled the product, those who first used the product for >20 years before their disease diagnosis, and those who used the product for a longer period. These associations persisted after adjusting for other major classes of pesticides. These results suggest an increased risk of NHL associated with carbamate pesticide use, particularly Sevin. Further investigation of the association is warranted.
Descriptors (primary) carbamates; lymphoma; agriculture; long-term exposure; pesticides
Descriptors (secondary) USA; carbofuran; butylate; EPTC; carbaryl; exposure evaluation; case-control study; job-exposure relation; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Amides
Agriculture
Agricultural chemicals