ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)100002
CIS number 02-1366
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Viaene M.K., Pauwels W., Veulemans H., Roels H.A., Masschelein R.
Title Neurobehavioural changes and persistence of complaints in workers exposed to styrene in a polyester boat building plant: Influence of exposure characteristics and microsomal epoxide hydrolase phenotype
Bibliographic information Feb. 2001, Vol.58, No.2, p.103-112. Illus. 34 ref.
Abstract To investigate neurobehavioural effects in workers exposed to styrene and microsomal epoxide hydrolase (mEH) activity, a cross sectional study was performed among former workers of a polyester boat plant. A structured neurological anamnesis into former and present complaints, the NSC-60 questionnaire, and computer assisted neurobehavioural tests were administered. It was observed that most subjective symptoms were reversible, while dysfunction of visual-motor performance and perceptual speed seemed to persist. Duration of exposure at lamination tasks and duration of exposure multiplied by exposure concentration were found to be the best predictors of worsening visual-motor and perceptual speed performances. Activity of the mEH phenotype may play a modulating part in styrene neurotoxicity. The results suggest that less than 10 years of exposure to styrene at an average concentration of 155mg/m3 may result in persistent neurotoxic effects.
Descriptors (primary) neurotoxic effects; epoxide hydrolase; shipyards; enzyme activity; styrene
Descriptors (secondary) nervous function tests; sensorimotor activities; cross-sectional study; questionnaire survey
Document type D - Periodical articles
Country / State or ProvinceBelgium
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Aromatic hydrocarbons
Shipbuliding and ship repair
Diseases of the nervous system