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Document ID (ISN)100001
CIS number 02-1365
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2001
Convention or series no.
Author(s) Brodkin C.A., Moon J.M., Camp J., Echeverria D., Redlich C.A., Willson R.A., Checkoway H.
Title Serum hepatic biochemical activity in two populations of workers exposed to styrene
Bibliographic information Feb. 2001, Vol.58, No.2, p.95-102. Illus. 41 ref.
Abstract Two independent cross sectional studies were performed in the state of Washington (USA) comparing serum hepatic transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), cholestatic enzymes (alkaline phosphatase (AP) and γ glutamyl transpeptidase (GGT)), and bilirubin in 47 workers of glass-fibre reinforced plastics who were exposed to styrene, as well as to 21 boat and tank fabricators, with separate referent groups of unexposed workers. Exposure to styrene was assessed in air by dosimetry, and in venous blood by headspace gas chromatography. A significant relationship between direct bilirubin and direct to total bilirubin ratio, and exposure to styrene was observed, by both air and blood monitoring, providing evidence for diminished hepatic clearance of conjugated bilirubin with associated cholestasis in workers exposed to styrene. Also, a significant linear association between the hepatic transaminases ALT and AST and exposure to styrene was found in regression analyses, consistent with mild hepatic injury and associated metabolic dysfunction.
Descriptors (primary) hepatotoxic effects; fibrous glass industry; enzyme activity; styrene
Descriptors (secondary) USA; alkaline phosphatases; transaminases; gamma-glutamyl transpeptidase; Washington; determination in air; determination in blood; gas chromatography; cross-sectional study
Document type D - Periodical articles
Country / State or ProvinceKorea, Republic of; USA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Aromatic hydrocarbons
Glass, pottery and related materials