There is already a huge amount of literature about HIV and AIDS. Do we need one more toolkit? There is growing recognition that the world of work is a vital entry point for the achievement of universal access. The ILO has a unique role to play - because of its rights-based approach, the expertise gained over more than ninety years, and its structure, bringing together governments, employers and workers. The purpose of this toolkit is to support trade unions in the particular contribution they can make towards preventing HIV and reducing the impact of AIDS. We hope it will also be useful to other individuals and organizations with a stake in the world of work, especially employers– with whom unions work closely in many countries - and labour ministries.