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Vol. 1 - Pages 2.1-2.18 (Printed Version) - Tabl* 2.9

Cancer

OCCUPATIONAL CARCINOGENS

Drugs evaluated in IARC Monographs, Volumes 1-63 (1972-1995)

Drug1

Target organ2

IARC GROUP 1—Carcinogenic to humans

Analgesic mixtures containing phenacetin

Kidney, bladder

Azathioprine (446-86-6)

Lymphoma, hepatobiliary system, skin

N,N-Bis(2-chloroethyl)- b-naphthylamine (Chlornaphazine) (494-03-1)

Bladder

1,4-Butanediol dimethanesulphonate (Myleran)
(55-98-1)

Leukaemia

Chlorambucil (305-03-3)

Leukaemia

1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) (13909-09-6)

Leukaemia

Cyclosporin (79217-60-0)

Lymphoma, skin

Cyclophosphamide (50-18-0) (6055-19-2)

Leukaemia, bladder

Diethylstilboestrol (56-53-1)

Cervix, vagina, breast

Melphalan (148-82-3)

Leukaemia

8-Methoxypsoralen (Methoxsalen) (298-81-7) plus ultraviolet A radiation

Skin

MOPP and other combined chemotherapy including alkylating agents

Leukaemia

Oestrogen replacement therapy

Uterus

Oestrogens, nonsteroidal

Cervix, vagina, breast

Oestrogens, steroidal

Uterus

Oral contraceptives, combined

Liver

Oral contraceptives, sequential

Uterus

Thiotepa (52-24-4)

Leukaemia

Treosulfan (299-75-2)

Leukaemia

IARC GROUP 2A—Probably carcinogenic to humans

Adriamycin (23214-92-8)

–

Androgenic (anabolic) steroids

(Liver)

Azacitidine (320-67-2)

–

Bischloroethyl nitrosourea (BCNU) (154-93-8)

(Leukaemia)

Chloramphenicol (56-75-7)

(Leukaemia)

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (13010-47-4)

–

Chlorozotocine (54749-90-5)

–

Cisplatin (15663-27-1)

–

5-Methoxypsoralen (484-20-8)

–

Nitrogen mustard (51-75-2)

(Skin)

Phenacetin (62-44-2)

(Kidney, bladder)

Procarbazine hydrochloride (366-70-1)

–

1 CAS Registry Nos. appear between parentheses.
2 Suspected target organs are given in parentheses.

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Updated by AS. Approved by JT. Last modification: 1 July 2002.