ICSC 1435 - ISOFLURANE

[List of Chemicals] [Risk Notes] [Risk Phrases] [Safety Phrases] [Danger Symbols]

ISOFLURANE

ICSC: 1435
_{March 2002}

Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane

CAS No: 26675-46-7
RTECS No: KN6799000

C₃H₂ClF₅O
Molecular mass: 184.5

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: use appropriate extinguishing media.
EXPLOSION

EXPOSURE
Inhalation	Cough. Sore throat. Dizziness. Drowsiness. Headache. Unconsciousness. See Notes.	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	Redness. Dry skin.	Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness. Pain.	Safety spectacles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	(See Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention.

SPILLAGE DISPOSAL	PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Ventilation. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: self-contained breathing apparatus.

EMERGENCY RESPONSE	SAFE STORAGE
	Ventilation along the floor.

IMPORTANT DATA

Physical State; Appearance
COLOURLESS LIQUID

Physical dangers
The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.

Chemical dangers
On contact with hot surfaces or flames this substance decomposes forming corrosive fumes such as phosgene hydrogen chloride and hydrogen fluoride.

Occupational exposure limits
TLV not established.
MAK: IIb (not established but data is available) (DFG 2005).

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

Effects of short-term exposure
The substance is irritating to the eyes and the skin. The vapour is irritating to the respiratory tract. The substance may cause effects on the central nervous system and cardiovascular system. Exposure at high levels may result in unconsciousness.

PHYSICAL PROPERTIES	ENVIRONMENTAL DATA
Boiling point: 48.5°C Relative density (water = 1): 1.5 Solubility in water: poor Vapour pressure, kPa at 20°C: 32 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.2 Octanol/water partition coefficient as log Pow: 2.1

NOTES

Check oxygen content before entering area.
High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death.
Forane is a trade name.
Card has been partly updated in April 2005. See sections Physical properties, Occupational Exposure Limits.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004

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