ICSC 0611 - ACETONE CYANOHYDRIN

[List of Chemicals] [Risk Notes] [Risk Phrases] [Safety Phrases] [Danger Symbols]

ACETONE CYANOHYDRIN

ICSC: 0611
_{March 1998}

2-Hydroxy-2-methyl propionitrile
2-Methyl-lactonitrile
2-Cyanopropan-2-ol
p-Hydroxyisobutyronitrile

CAS No: 75-86-5
RTECS No: OD9275000
UN No: 1541
EC No: 608-004-00-X

(CH₃)₂C(OH)CN / C₄H₇NO
Molecular mass: 85.1

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Powder, AFFF, foam, carbon dioxide.
EXPLOSION	Above 74°C explosive vapour/air mixtures may be formed.	Above 74°C use a closed system, ventilation.	In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water. Combat fire from a sheltered position.

EXPOSURE		AVOID ALL CONTACT!	IN ALL CASES CONSULT A DOCTOR!
Inhalation	Convulsions. Cough. Dizziness. Headache. Laboured breathing. Nausea. Shortness of breath. Unconsciousness. Vomiting. Irregular heartbeat, tightness in the chest.	Closed system and ventilation.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! Redness. Pain. (See Inhalation).	Protective gloves. Protective clothing.	Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes	Redness. Pain.	Face shield, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	Abdominal cramps. Burning sensation. Convulsions. Unconsciousness. (See Notes, (see Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention.

SPILLAGE DISPOSAL	PACKAGING & LABELLING
Sweep spilled substance into containers. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.	T+ Symbol N Symbol R: 26/27/28-50/53 S: (1/2-)7/9-27-45-60-61 UN Hazard Class: 6.1 UN Pack Group: I	Airtight. Do not transport with food and feedstuffs. Marine pollutant.

EMERGENCY RESPONSE	SAFE STORAGE
Transport Emergency Card: TEC (R)-61S1541 NFPA Code: H4; F1; R2	Provision to contain effluent from fire extinguishing. Separated from strong bases, acids, water, food and feedstuffs. Well closed. Keep in a well-ventilated room.

IMPORTANT DATA

Physical State; Appearance
COLOURLESS LIQUID, WITH CHARACTERISTIC ODOUR.

Physical dangers
The vapour is heavier than air.

Chemical dangers
The substance decomposes rapidly on heating or on contact with bases or water producing highly toxic and flammable hydrogen cyanide (see ICSC 0492), and acetone (see ICSC 0087). Reacts violently with acids and oxidants causing fire and explosion hazard.

Occupational exposure limits
TLV: (as CN) 5 mg/m³ (Ceiling value); (skin); (ACGIH 2004).

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of short-term exposure
The substance is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the cardiovascular system and central nervous system, resulting in asphyxia, cardiac disorders, convulsions, cyanosis and respiratory failure. Exposure may result in death. Medical observation is indicated. See Notes.

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system and thyroid, resulting in impaired functions.

PHYSICAL PROPERTIES	ENVIRONMENTAL DATA
Boiling point: 95°C Melting point: -19°C Relative density (water = 1): 0.93 Solubility in water: freely soluble, but decomposes in water Vapour pressure, kPa at 20°C: 3.0 Relative vapour density (air = 1): 2.93 Flash point: 74°C c.c. Explosive limits, vol% in air: 2.2-12	The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use.

NOTES

The occupational exposure limit value should not be exceeded during any part of the working exposure.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Hazard and toxicity of this substance is due to its major metabolite - hydrogen cyanide (see ICSC 0492).
Card has been partly updated in October 2004 and 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004

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