ICSC 0405 - CAFFEINE

[List of Chemicals] [Risk Notes] [Risk Phrases] [Safety Phrases] [Danger Symbols]

CAFFEINE

ICSC: 0405
_{March 1998}

1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Methyltheobromine
Methyltheophylline

CAS No: 58-08-2
RTECS No: EV6475000
UN No: 1544
EC No: 613-086-00-5

C₈H₁₀N₄O₂
Molecular mass: 194.19

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Water spray, powder.
EXPLOSION

EXPOSURE		PREVENT DISPERSION OF DUST!
Inhalation	(See Ingestion).	Local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin		Protective gloves.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes		Safety spectacles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	Headache. Dizziness. Abdominal cramps. Nausea. Vomiting. Convulsions. Tremors.	Do not eat, drink, or smoke during work.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

SPILLAGE DISPOSAL	PACKAGING & LABELLING
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P2 filter respirator for harmful particles.	Xn Symbol R: 22 S: 2 UN Hazard Class: 6.1	Do not transport with food and feedstuffs.

EMERGENCY RESPONSE	SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III	Separated from food and feedstuffs. Well closed.

IMPORTANT DATA

Physical State; Appearance
ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER.

Chemical dangers
The substance decomposes on burning producing toxic fumes including nitrogen oxides.

Occupational exposure limits
TLV not established.

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on dust forming.

Effects of short-term exposure
The substance may cause effects on the central nervous system and cardiovascular system, resulting in insomnia, excitement, tachycardia, polyuria.

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction.

PHYSICAL PROPERTIES	ENVIRONMENTAL DATA
Sublimation point: 178°C Melting point: 238°C Density: 1.23 g/cm³ Solubility in water, g/100 ml: 2.17 Octanol/water partition coefficient as log Pow: -0.07

NOTES

Card has been partly updated in October 2005. See section Emergency Response.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004

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