ICSC 0006 - PARATHION

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PARATHION

ICSC: 0006
_{April 2004}

O,O-Diethyl-O-(4-nitrophenyl)phosphorothioate
Phosphorothioic acid O,O-diethyl O-(4-nitrophenyl) ester
Ethyl parathion

CAS No: 56-38-2
RTECS No: TF4550000
UN No: 3018
EC No: 015-034-00-1

(C₂H₅O)₂PSOC₆H₄NO₂
Molecular mass: 291.3

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRE FIGHTING
FIRE	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Liquid formulations containing organic solvents may be flammable.	NO open flames.	Water spray, dry powder, carbon dioxide.
EXPLOSION			In case of fire: keep drums, etc., cool by spraying with water.

EXPOSURE		PREVENT GENERATION OF MISTS! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!	IN ALL CASES CONSULT A DOCTOR!
Inhalation	Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Vomiting. Dizziness. Headache. Convulsions. Diarrhoea. Weakness. Laboured breathing. Wheezing. Unconsciousness.	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! (Further see Inhalation).	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes	MAY BE ABSORBED! Redness. Pain. Blurred vision.	Face shield, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	Abdominal cramps. Diarrhoea. Vomiting. (Further see Inhalation).	Do not eat, drink, or smoke during work. Wash hands before eating.	Give a slurry of activated charcoal in water to drink. Refer for medical attention. See Notes.

SPILLAGE DISPOSAL	PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable containers as far as possible. Treat remaining liquid with an alkaline substance. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus.	T+ Symbol N Symbol R: 24-26/28-48/25-50/53 S: (1/2-)28-36/37-45-60-61 UN Hazard Class: 6.1 UN Pack Group: I	Do not transport with food and feedstuffs. Severe marine pollutant.

EMERGENCY RESPONSE	STORAGE
Transport Emergency Card: TEC (R)-61GT6-I	Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs. Well closed. Keep in a well-ventilated room.

IMPORTANT DATA

Physical State; Appearance
PALE YELLOW TO BROWN (TECHNICAL PRODUCT) LIQUID, WITH CHARACTERISTIC ODOUR.

Chemical dangers
The substance decomposes on heating above 200°C, producing toxic gases including carbon monoxide, nitrogen oxides, phosphorous oxides and sulfur oxides. Reacts with strong oxidants. Attacks some forms of plastics, rubber and coatings.

Occupational exposure limits
TLV: (I,V) 0.05 mg/m³; A4; BEI issued; (skin); (ACGIH 2004).
MAK: (I) 0.1 mg/m³; H; Peak limitation category: II (8); Pregnancy risk group: D; (DFG 2003).

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin, by ingestion and through the eyes.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.

Effects of short-term exposure
The substance may cause effects on the nervous system, resulting in convulsions, respiratory failure, muscle weakness. Cholinesterase inhibition. Exposure may result in death. The effects may be delayed. Medical observation is indicated.

Effects of long-term or repeated exposure
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL PROPERTIES	ENVIRONMENTAL DATA
Boiling point: 375°C Melting point: 6°C Relative density (water = 1): 1.26 Solubility in water, g/100 ml at 25°C: 0.002 Flash point: 120°C Octanol/water partition coefficient as log Pow: 3.8	The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.

NOTES

Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004

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Updated by AS. Approved by EC. Last update: 05.07.2004