Taalaikul Isakunova was born on 14 July 1967. She is a graduate of Frunze Polytechnic Institute and holds a law degree from the Kyrgyz-Russian Slavic University.

As part of her career, she has worked with the Presidential Administration of Kyrgyzstan and has served over the years as expert and project manager in a number of non-governmental and international organizations, including the Centre for Research of Democratic Processes, which she led between 2006 and 2015.

Since December 2015, Taalaikul Isakunova has been a member of the Kyrgyz Parliament, where she has served on the Parliamentary Committee for Constitutional Legislation, State Structure, Judicial and Legal Issues and Rules of Procedure.