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ICSC 0944 - ROTENONE
ROTENONE
ICSC: 0944
Peer-Review Status: 13.04.2000 Validated
Tubotoxine
Derris powde 
CAS #: 83-79-4 RTECS #: DJ2800000
UN #: 2588
EC #: 650-005-00-2
EINECS #: 201-501-9
 		    Formula: C23H22O6
Molecular mass: 394.45

TYPES OF HAZARD
/ EXPOSURE 		ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Confusion. Cough. Headache. Tremor. Laboured breathing. Nausea. Sore throat. Unconciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. 
Skin Redness.  Protective gloves.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Rinse and then wash skin with water and soap. 
Eyes Redness.  Wear safety goggles or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Convulsions. Diarrhoea. Vomiting. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
 		PACKAGING & LABELLING
Sweep spilled substance into covered air-tight containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P3 filter respirator for toxic particles. Do NOT let this chemical enter the environment.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T, N; R: 25-36/37/38-50/53; S: (1/2)-22-24/25-36-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT7-III.  Separated from food and feedstuffs. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces irritating fumes. 

Occupational exposure limits
TLV: 5mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory depression. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the kidneys and liver. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes
Melting point: 165-166°C
Density: 1.27 g/cm³
Solubility in water: none
Octanol/water partition coefficient as log Pow: 4.10   		The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. The substance may cause long-term effects in the aquatic environment. 

NOTES
The substance is combustible but no flash point is available in literature.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Depending on the degree of exposure, periodic medical examination is suggested.
Card has been partly updated in April 2005.
See sections Emergency response, Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety 		WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.