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ICSC 0513 - N-METHYL-2-PYRROLIDONE
N-METHYL-2-PYRROLIDONE
ICSC: 0513
Peer-Review Status: 04.08.1997 Validated
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone 
CAS #: 872-50-4 RTECS #: UY5790000
EC #: 606-021-00-7
EINECS #: 212-828-1
    Formula: C5H9NO
Molecular mass: 99.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 96°C explosive vapour/air mixtures may be formed.  Above 96°C use a closed system and ventilation.   
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Headache.  Use ventilation.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Dry skin. Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain. Blurred vision.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: Xi; R: 36/38; S: (2)-41 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F1; R0.  Separated from oxidants, rubber, plastics, aluminium and light metals. Dry. Ventilation along the floor. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. TURNS YELLOW ON EXPOSURE TO HEAT. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides and carbon monoxide. Attacks aluminium, light metals, rubber and plastics. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: 20 ppm, 82 mg/m³; Peak limitation category: II(2); Pregnancy risk group: C; Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance is irritating to the eyes and skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 202°C
Melting point: -24°C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 25°C: 66
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 96°C o.c.
Auto-ignition temperature: 270°C
Explosive limits, vol% in air: 0.99-3.9 
 

NOTES
N-Methyl-2-pyrrolidone enhances the skin permeability for other substances.
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Card has been partly updated in October 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.