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ICSC 0513 - N-METHYL-2-PYRROLIDONE
N-METHYL-2-PYRROLIDONE
ICSC: 0513
Peer-Review Status: 11.04.2914 Validated
1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone
CAS #: 872-50-4 RTECS #: UY5790000
EC #: 606-021-00-7
EINECS #: 212-828-1
    Formula: C5H9NO
Molecular mass: 99.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 86°C explosive vapour/air mixtures may be formed.  Above 86°C use a closed system and ventilation.   
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Headache.  Use local exhaust or ventilation.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain.  Protective gloves. Protective clothing.  Rinse skin with plenty of water or shower. 
Eyes Redness. Pain. Blurred vision.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Burning sensation in the throat and chest.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Store and dispose of according to local regulations. Wash away remainder with plenty of water.   
EC Classification
R: 61-36/37/38; S: 53-45 
UN Classification
 
GHS Classification
Signal: Warning
Combustible liquid
May be harmful if swallowed
Causes serious eye irritation
May cause respiratory irritation
Suspected of damaging fertility or the unborn child 
excl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F2; R0.  Dry. Ventilation along the floor. Separated from strong oxidants, strong acids, strong bases, copper and plastics. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. It reacts violently with strong acids and strong bases. Attacks copper and its alloys. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: 20 ppm, 82 mg/m³; Peak limitation category: II(2); Pregnancy risk group: C; Skin absorption (H); (DFG 2013). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 202°C
Melting point: -24.4°C
Relative density (water = 1): 1.03
Solubility in water: miscible
Vapour pressure, Pa at 25°C: 39
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 86°C c.c.
Auto-ignition temperature: 245°C
Explosive limits, vol% in air: 1.3-9.5
Octanol/water partition coefficient as log Pow: -0.38
Viscosity: 1.62 mm²/s at 25°C 
 

NOTES
N-Methyl-2-pyrrolidone enhances the skin permeability for other substances. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
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