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CIS 79-251 Health and Safety (Genetic Manipulation) Regulations 1978.
These regulations dated 22 May 1978 (effective 1 Aug. 1978) provide that no person (self-employed or other) shall work on genetic manipulation without giving prior notification to the Health and Safety Executive (HSE) and that such work shall be covered by the terms of the Health and Safety at Work Act 1974. The regulations define genetic manipulation as: "the formation of new combinations of heritable material by the insertion of nucleic acid molecules, produced by whatever means outside the cell, into any virus, bacterial plasmid, or other vector system so as to allow their incorporation into a host organism in which they do not naturally occur but in which they are capable of continued propagation". They cover the following activities which could present a health hazard to laboratory workers: introduction of plant or animal virus nucleic acid into a prokaryote or a primitive eukaryote; introduction of prokaryote viral or plasmid nucleic acid into an eukaryote cell; or co-infection with potential vector nucleic acid and prepared DNA. HSE has issued a booklet in its Health and Safety at work series: "Genetic manipulation" (ISBN 0-11-883202-6; 14p., price £0.70) also available from H.M. Stationery Office, reproducing the text of these regulations, with guidance notes and comments, sources of further information, etc.
Statutory Instruments, No.752/1978, H.M. Stationery Office, P.O. Box 569, London SE1 9NH, United Kingdom. 3p. Price: £0.20.