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IARC Monographs - 57 entries found

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  • IARC Monographs

2010

CIS 11-0082 Cogliano V.J., Baan R., Straif K.
Updating IARC's carcinogenicity assessment of benzene
This article consists of the response of members of the IARC staff to criticisms concerning the evaluation of the carcinogenicity of benzene (see ISN 111361).
American Journal of Industrial Medicine, 2011, Vol. 54, p.165-167. 10 ref.

CIS 11-0081 Infante P.F.
The IARC October 2009 evaluation of benzene carcinogenicity was incomplete and needs to be reconsidered
This article consists of a critical appraisal of IARC's 2009 evaluation of benzene carcinogenicity, which it considers incomplete and inconsistent. It argues that IARC's conclusion that there is sufficient evidence for benzene to cause acute non-lymphocytic leukemia only was based on an incomplete review, and that IARC should schedule another monographs' meeting dedicated to a complete and full review and discussion of all potential cancers related to exposure to benzene and to benzene-containing mixtures. The IARC working group responds to these criticisms in a following article of the journal (see ISN 111362).
American Journal of Industrial Medicine, 2011, Vol. 54, p.157-164. 74 ref.

CIS 10-0251 Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures
This volume reviews the potential carcinogenicity of 60 polycyclic aromatic hydrocarbons (PAHs) and several occupational exposures involving coal-derived PAHs. These are formed during the incomplete combustion of organic material. Environmental sources of polycyclic aromatic hydrocarbons include industrial air pollution, urban air pollution, tobacco smoke and diet (which is commonly the main source of exposure in non-smokers who are not exposed to such hydrocarbons through their occupations). High occupational exposure can arise during the conversion of coal to coke and coal tar, and during the processing and use of products derived from coal tar. In this volume, benzo[a]pyrene, other PAHs and related occupational exposures were evaluated by an IARC Monographs Working Group, reviewing epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to their carcinogenic hazard to humans.
World Health Organization, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2010. viii, 853p. Illus. Bibl.ref. Index. Price: CHF 55.00; USD 55.00; CHF 38.50 in developing countries; downloadable version free of charge.
http://monographs.iarc.fr/ENG/Monographs/vol92/mono92.pdf [in English]

2008

CIS 09-659
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans. 1,3-Butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide)
This volume re-evaluates the available evidence on the carcinogenic potential of 1,3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). Ethylene oxide is widely used as a sterilizing agent for hospital equipment. The largest single use for 1,3-butadiene is in the production of styrene-butadiene rubber for tyres, while vinyl chloride is primarily used in the manufacture of polyvinyl chloride. Summary of final evaluations: ethylene oxide, 1,3-butadiene and vinyl chloride are classified in Group 1 (carcinogenic to humans); vinyl bromide is classified in Group 2A (probably carcinogenic to humans), while there is inadequate evidence for the carcinogenicity of vinyl fluoride in humans.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2008. ix, 510p. Illus. Bibl.ref. Index.
http://monographs.iarc.fr/ENG/Monographs/vol97/mono97.pdf [in English]

2007

CIS 08-762
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Smokeless tobacco and some tobacco-specific N-nitrosamines
This monograph considers the carcinogenic risks associated with the use of smokeless tobacco, including chewing tobacco and snuff. Some studies had suggested that smokeless tobacco may be used for smoking cessation, reducing exposure to carcinogens and risk for cancer. However, these claims are not supported by the available evidence. Occupational exposure to unburnt tobacco may occur during tobacco manufacture, particularly in bidi factories in India, which are often very small-scale industries that have poor working conditions. The workers, mainly women, are exposed to tobacco by dermal contact and to airborne tobacco dust and volatile substances by inhalation. Cancer of the oral cavity is one of the leading malignancies in India and many other countries in South-East Asia, and ranks first in incidence among men and third among women. Tobacco-specific N-nitroso compounds have been detected at high concentrations in snuff and chewing tobacco.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2007. ix, 626p. Illus. Bibl.ref. Index. Price: CHF 55.00 (CHF 38.50 in developing countries). Downloadable version free of charge
http://monographs.iarc.fr/ENG/Monographs/vol89/mono89.pdf [in English]

CIS 08-761
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Combined estrogen-progestogen contraceptives and combined estrogen-progestogen menopausal therapy
Combined estrogen-progestogens used in oral contraceptives and hormonal therapy have many similarities. Consequently, there is a possibility that women who use both during their lifetime may experience risks that are greater than women who use either contraceptives or hormonal therapy but not both. The conclusion that the increased risk for breast cancer returns to background levels 10 years after cessation of use of contraceptives may therefore not apply to women who have begun to use hormonal therapy. Further epidemiological studies of women who have used both contraceptives and hormonal therapy are necessary. Oral contraceptives can increase the risk for cervical cancer in women who have a human papillomavirus infection. Women who use this form of contraception over long periods of time should be encouraged to participate in cervical cancer screening programmes.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2007. ix, 528p. Illus. Bibl.ref. Index. Price: CHF 55.00 (CHF 38.50 in developing countries). Downloadable version free of charge.
http://monographs.iarc.fr/ENG/Monographs/vol91/mono91.pdf [in English]

CIS 08-962
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Human papillomaviruses
Human papillomaviruses (HPVs) are common sexually-transmitted infectious agents. Although most infections are asymptomatic and are cleared within a period of two years, genital HPV infection can lead to clinical disease, including anogenital warts, cervical neoplasia, cervical cancer and other anogenital cancers. Of the many types of HPVs, some are classified as carcinogenic to humans (Group 1), others as probably carcinogenic to humans (Group 2A) and yet other as possibly carcinogenic to humans (Group 2B). Recent data includes strong evidence of carcinogenicity at sites other than the cervix. Vaccination can reduce the incidence of HPV-related genital diseases. However, such prophylactic treatments require that such vaccines be provided women for whom access to cervical cancer screening services is problematic. Therefore, the development of vaccines that are cheaper and easier to deliver remains highly desirable. Update of the IARC Monograph No.64 on the same subject (see CIS 96-1096).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2007. viii, 670p. Illus. Bibl.ref. Index. Price: CHF 55.00 (CHF 38.50 in developing countries). Downloadable version free of charge.
http://monographs.iarc.fr/ENG/Monographs/vol90/mono90.pdf [in English]

2006

CIS 07-1141
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Formaldehyde, 2-butoxyethanol, and 1-tert-butoxypropan-2-ol
This volume re-evaluates the available evidence on the carcinogenic potential of formaldehyde, a substance that is widely used in binders for wood, paper; glass wool and rock wool, in plastics and coatings, textile finishing and chemical synthesis, and as a disinfectant and preservative. Also evaluated are two glycol ethers, 2-butoxyethanol and 1-tert-butoxypropan-2-ol, which are widely used as solvents in paints and paint thinners, coatings, glass and surface cleaners, inks, adhesives, personal-care products, and as chemical intermediates. Summary of final evaluations: formaldehyde is classified in Group 1 (carcinogenic to humans); 2-butoxyetahnol and 1-tert-butoxypropan-2-ol are classified in Group 3 (cannot be classified as to carcinogenicity to humans).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2006. v, 478p. Illus. Bibl.ref. Index. Price: USD 40.00.

CIS 07-667
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Inorganic and organic lead compounds
This volume of the IARC Monographs contains evaluations of inorganic and organic lead compounds. Contents: exposure data (production processes for lead and lead products, uses, environmental occurrence, exposure of the general population and of workers in specific occupations, methods of sampling and analysis in biological matter, exposure limits); studies of cancer in humans and experimental animals; studies of other toxic effects (effects on haeme-containing systems, nephrotoxicity, neurological and neurotoxic effects, cardiovascular toxicity, immunological, reproductive and genetic effects). Overall evaluation: inorganic lead compounds are probably carcinogenic to humans (Group 2A), organic lead compounds are not classifiable as to their carcinogenicity to humans (Group 3).
WHO Press, World Health Organization, 20 Avenue Appia, 1211 Genève 27, Switzerland; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2006. xiii, 506p. Approx. 1600 ref.

CIS 07-503
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide
Most of the compounds whose carcinogenicity is evaluated in this volume are poorly soluble solid materials. They are deposited in particulate form in the lung where they may be retained for a long period of time while exerting their toxic properties. Workers in the hard-metal industry may be exposed to cobalt in hard metals (with or without tungsten carbide); gallium arsenide and indium phosphide are used in the semi-conductor industry and vanadium pentoxide is mainly used in the production of metal alloys. Conclusions of this monograph: cobalt metal without tungsten carbide, cobalt sulfate and other soluble cobalt(II) salts are possibly carcinogenic to humans (Group 2B); gallium arsenide is carcinogenic to humans (Group 1); indium phosphide is probably carcinogenic to humans (Group 2A); vanadium pentoxide is possibly carcinogenic to humans (Group 2B).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2006. xiv, 330p. Illus. Bibl.ref. Index. Price: USD 40.00.

2004

CIS 04-420
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Volume 83: Tobacco smoke and involuntary smoking
In a previous IARC Monograph on Tobacco Smoking (Vol.38, see CIS 89-350), a certain number of cancers were identified as caused by cigarette smoking. In the present report, the studies reviewed by the Working Group show sufficient evidence for a additional association between cigarette smoking and cancers of the nasal cavities, nasal sinuses, oesophagus, stomach, liver, kidney and uterine cervix, as well as myeloid leukaemia. There is evidence of synergy between smoking and several occupational causes of lung cancer (arsenic, asbestos and radon). Secondhand tobacco smoke includes the same carcinogens and toxic substances produced by active smoking. Non-smoking spouses of smokers, as well as non-smoking workers exposed to secondhand tobacco smoke at the workplace are at a statistically-significant increased risk of lung cancer. Overall, the Working Group concludes that exposure to secondhand tobacco smoke is carcinogenic in humans (Group 1).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2004. xiv, 1452 pages. Illus. Bibl.ref. Index. Price: USD 40.00

2002

CIS 03-340
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Some traditional herbal medicines, some mycotoxins, naphthalene and styrene
The following substances are evaluated in this publication with respect to their carcinogenicity in humans: some herbal medicines (aristolochia species and aristolochic acids; rubia tinctorum, morinda officinalis and anthraquinones; senecio species and riddelliine); some mycotoxins (aflatoxins and fumonisin B1); naphthalene; styrene. Herbal remedies containing plant species of the genus aristolochia and naturally occurring mixtures of aflatoxins are classified in group 1 (carcinogenic in humans); naturally-occurring mixtures of aristolochic acids are classified in group 2A (probably carcinogenic in humans); laxatives containing anthraquinone derivatives, riddelliine, naturally-occurring mixtures of fumonisin B1, naphthalene and styrene are classified in group 2B (possibly carcinogenic in humans); madder root (rubia tinctorum) is classified in group 3 (cannot be classified as to its carcinogenicity in humans).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2002. vi, 590p. Illus. Bibl.ref. Index. Price: USD 40.00.

CIS 02-1834
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Man-made vitreous fibres
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 9-16 October 2001 on the evaluation of carcinogenic risks to humans of man-made vitreous fibres. Special-purpose glass fibres such as E-glass and 475-glass, as well as refractory ceramic fibres were rated 2B (possibly carcinogenic in humans); insulation glass wool, continuous glass filaments, rock wool and slag wool were rated 3 (not classifiable as to their carcinogenicity in humans).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2002. vii, 418p. Illus. Approx. 500 ref. Index.

CIS 02-1433
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Non-ionizing radiation, part 1: Static and extremely low-frequency (ELF) electric and magnetic fields
Report of an IARC working group on the evaluation of carcinogenic risks to humans from exposure to static and extremely low-frequency (ELF) electric and magnetic fields held in Lyon, France, 19-26 June 2001. Contents: general introduction and definitions; ELF sources, exposure and exposure assessment; studies of cancer in humans; studies of carcinogenicity in experimental animals; other data relevant to the evaluation of carcinogenicity and its mechanisms; summary and evaluation of reported data. It is concluded that ELF magnetic fields are possibly carcinogenic in humans (group 2B), and that static and ELF electric fields are not classifiable as to their carcinogenicity in humans (group 3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 2002. ix, 429p. Illus. Bibl.ref. Index.

2001

CIS 01-1778
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Volume 79: Some thyrotropic agents
This document presents the views and expert opinions of an IARC working group which met in Lyon, France, 10-17 October 2000. It contains 19 monographs on thyrotropic agents (methimazole, methylthiouracil, propylthiouracil, thiouracil, doxylamine succinate, phenobarbital and its sodium salt, griseofulvin, spironolactone, sulfomethazine and its sodium salt, sulfamethoxazole, amitrole, chlordane and heptachlor, hexachlorobenzene, toxaphene, kojic acid, 2,4-diaminoanisole and its salts, N,N'-diethylthiourea, ethylenethiourea and thiourea). Contents of each monograph: exposure data; studies of cancers in humans; studies of cancers in experimental animals; other data relevant to an evaluation of carcinogenicity; summary of data reported and evaluation.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2001. iv, 763p. Illus. Bibl.ref. Index.

CIS 01-1513
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Ionizing radiation, Part 2: Some internally deposited radionuclides
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 14-21 June 2000 on the cancer risks from internal radiations sources which result from ingestion, inhalation, dermal absorption or injection of radionuclides. Among the 34 radionuclides evaluated, 10 were classified in group 1 (carcinogenic to humans). The following aspects are covered: exposure data; studies of cancer in humans; studies of cancer in experimental animals; other data relevant to an evaluation of carcinogenicity and its mechanisms; summary of reported data and evaluation.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2001. xv, 595p. Illus. Bibl.ref. Index.

2000

CIS 02-335
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Some industrial chemicals
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 15-22 February 2000. 16 industrial organic chemicals were reviewed: three were rated 2A (probably carcinogenic to humans), five were rated 2B (possibly carcinogenic to humans) and eight were classified 3 (not classifiable as to its carcinogenicity to humans). For each chemical, the following aspects are covered: exposure data; studies of cancer in humans; studies of cancer in experimental animals; other data relevant to an evaluation of carcinogenicity and its mechanisms; summary of reported data and evaluation.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2000. iv, 563p. Illus. Bibl.ref. Index.

CIS 01-1512
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Ionizing radiation, Part 1: X- and gamma (γ)-radiation, and neutrons
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 26 May-2 June 1999 on cancer risks from X-radiation, γ-radiation and neutrons. All three are classified in group 1 (carcinogenic to humans). For each form of radiation, the following aspects are covered: exposure data; studies of cancer in humans; studies of cancer in experimental animals; other data relevant to an evaluation of carcinogenicity and its mechanisms; summary of reported data and evaluation.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 2000. x, 491p. Illus. Bibl.ref. Index.

1999

CIS 01-1492
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 13-20 October 1998. 21 chemicals or classes of chemicals were reviewed: eight were rated 2B (possibly carcinogenic to humans) and 13 were classified 3 (not classifiable as to its carcinogenicity to humans). For each chemical, the following aspects are covered: exposure data; studies of cancer in humans; studies of cancer in experimental animals; other data relevant to an evaluation of carcinogenicity and its mechanisms; summary of reported data and evaluation. The chemicals are: allyl isothiocyanate; ortho-anisidine; atrazine; butyl benzyl phthalate; chloroform; chlorothalonil (= 2,4,5,6-tetrachloroisophthalonitrile); cyclamates; dichlorobenzenes; hexachlorobutadiene; hexachloroethane; d-limonene; melamine; methyl tert-butyl ether; nitrilotriacetic acid and its salts; paracetamol (= acetaminophen); ortho-phenylphenol and its sodium salt; potassium bromate; quercetin; saccharin and its salts; simazine.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1999. iv, 674p. Illus. Bibl.ref. Index.

CIS 00-810
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Volume 71: Re-evaluation of some organic chemical, hydrazine and hydrogen peroxide (three parts)
Topics: animal experiments; biological hazards; carcinogenic effects; carcinogens; hydrazine; hydrogen peroxide; criteria document; epidemiologic study; exposure evaluation; hazard evaluation; IARC; literature survey; mutagenic effects; organic compounds; toxic effects; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1999. vi, 1,586p. (3 vols.). Bibl.ref. Index.

1997

CIS 98-972
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8
Topics: cancer; carcinogens; criteria document; determination in biological matter; epidemiologic study; Hodgkin's disease; IARC; immunology; infectious diseases; Kaposi's sarcoma; literature survey; lymphoma; nasal cancer; pharyngeal cancer; viruses; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1997. xiii, 524p. Illus. Bibl.ref. Price: CHF 80.00.

CIS 97-1639
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 4-11 February 1997. Overall evaluation: dibenzo-para-dioxin, polychlorinated dibenzo-para-dioxins (other than 2,3,7,8-tetrachlorodibenzo-para-dioxin) and polychlorinated dibenzofurans are not classifiable as to their carcinogenicity to humans; 2,3,7,8-tetrachlorodibenzo-para-dioxin is carcinogenic to humans.
IARC Press, 150 cours Albert Thomas, 69732 Lyon Cedex 08, France, Vol.69, 1997. ix, 666p. Bibl.ref. Index. Price: CHF 80.00.

CIS 97-1262
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Silica, some silicates, coal dust and para-aramid fibrils
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France, 15-22 October 1996. Overall evaluation: crystalline silica inhaled in the form of quartz or cristobalite from occupational sources is carcinogenic in humans; long palygorskite (attapulgite) fibres (>5µm) are possibly carcinogenic in humans; amorphous silica, para-aramid fibrils, coal dust, short palygorskite (attapulgite) fibres (<5µm), sepiolite, wollastonite, clinoptilote, phillipsite, mordenite, non-fibrous Japanese zeolite, and synthetic zeolites are not classifiable as to their carcinogenicity in humans.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1997. iv, 506p. Illus. Bibl.ref. Index.

1996

CIS 03-1809
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Some pharmaceutical drugs
This criteria document evaluates the following pharmaceutical compounds with respect to their carcinogenicity in humans: benzodiazepines and related compounds and phenytoin (diazepam, doxefazepam, estazolam, oxazepam, prazepam, ripazepam, temazepam, phenytoin); anti-oestrogenic compounds (droloxifene, tamoxifene, toremifene); hypolipidaemic drugs (clofibrate, gemfibrozil). Tamoxifene is classified in group 1 (carcinogenic in humans). Oxazepam and phenytoin are classified in group 2B (possibly carcinogenic in humans). All others fall under group 3 (not classifiable as to their carcinogenicity in humans).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France 1996. iv, 514p. Illus. Bibl.ref. Index. Price: CHF 80.00.

CIS 99-658
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Human immunodeficiency viruses and human T-cell lymphotropic viruses
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France 11-18 June 1996. Overall evaluation: infection with human immunodeficiency virus 1 (HIV-1) or human T-cell lymphotropic virus I (HTLV-I) is carcinogenic to humans; infection with HIV-2 is possibly carcinogenic to humans; infection with HTLV-II is not classifiable as to its carcinogenicity to humans. Topics: animal experiments; antibodies; carcinogenic effects; criteria document; Hodgkin's disease; human experiments; IARC; immunobiological changes; immunodeficiency syndrome; Kaposi's sarcoma; leukaemia; literature survey; lymphatic diseases; lymphoma; viruses; WHO.
IARC Press, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1996. xii, 424p. Illus. Bibl.ref.

CIS 96-925
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Printing processes and printing inks, carbon black and some nitro compounds
This monograph presents the views and expert opinions of an IARC Working Group which met in Lyon, France, 10-17 October 1995. Overall evaluation: occupational exposures in printing processes, carbon black, 3,7-dinitrofluoranthene, 3,9-dinitrofluoranthene, 2,4-dinitrotoluene, 2,6-dinitrotoluene, 2-nitroanisole, nitrobenzene and tetranitromethane are possibly carcinogenic in humans (Group 2B); printing inks, chloronitrobenzenes, 3,5-dinitrotoluene, musk ambrette, musk xylene, nitrotoluenes and 2,4,6-trinitrotoluene are not classifiable as to their carcinogenicity in humans (Group 3).
IARC Press, 150 cours Albert Thomas, 69732 Lyon Cedex 08, France, 1996. v, 578p. Bibl.ref. Index. Price: CHF 90.00.

1995

CIS 99-1989
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Dry cleaning, some chlorinated solvents and other industrial chemicals
Topics: carcinogenic effects; acrolein; vinyl acetate; tetrachloroethylene; benzofuran; chloral hydrate; crotonaldehyde; fluoroethylene; chloral; trichloroacetic acid; trichloroethylene; dichloroacetic acid; 1,2,3-trichloropropane; furfural; furan; chlorinated hydrocarbons; chloropropenes; criteria document; dry cleaning; epidemiologic study; genetic effects; IARC; literature survey; solvents; WHO.
IARC Press, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France, 1995. iv, 551p. Illus. Bibl.ref. Index. Price: CHF 90.00.

CIS 96-1096
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Human papillomaviruses
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France, 6-13 June 1995. The nature of human papillomavirus (HPV) infection is described (molecular biology of HPVs, serological response, detection of HPV infections, epidemiology, pathology, therapy and vaccination), along with studies of cancer in animals and humans, and molecular mechanisms of carcinogenesis. There is compelling evidence that some HPV types are human carcinogens. Overall evaluation: HPV types 16 and 18 are carcinogenic in humans (Group 1); HPV types 31 and 33 are probably carcinogenic in humans (Group 2A); some other HPV types are possibly carcinogenic in humans (Group 2B).
IARC Press, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1995. viii, 409p. Illus. Bibl.ref. Index. Price: CHF 80.00.

CIS 95-1446
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Wood dust and formaldehyde
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France, 11-18 October 1994. Epidemiological studies have shown increased risks of cancer of the nasal cavities and paranasal sinuses associated with exposure to wood dust; these findings are supported by numerous case reports. Adenocarcinoma of the nasal cavities and paranasal sinuses is clearly associated with exposure to hardwood dust. Epidemiological studies suggest a causal relationship between exposure to formaldehyde and nasopharyngeal cancer and cancer of the nasal cavities and paranasal sinuses. IARC final classifications: wood dust is carcinogenic in humans (Group 1); formaldehyde is probably carcinogenic in humans (Group 2A).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1995. viii, 405p. Illus. Bibl.ref. Index. Price: CHF 80.00.

1994

CIS 01-1535
World Health Organization (WHO)
IARC monographs on the evaluation of carcinogenic risks to humans - Schistosomes, liver flukes and Helicobacter pylori
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France, 7-14 June 1994, concerning the cancer risks of helminths (parasitic worms), schistosoma and Heliobacter pylori. Of the seven agents reviewed, three were rated 1 (carcinogenic to humans), one was rated 2A (probably carcinogenic to humans), one was rated 2B (possibly carcinogenic to humans) and two were classified 3 (not classifiable as to its carcinogenicity to humans). For each agent, the following aspects are covered: exposure data; studies of cancer in humans; studies of cancer in experimental animals; other data relevant to an evaluation of carcinogenicity and its mechanisms; summary of reported data and evaluation.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1994. 270p. Illus. Bibl.ref. Index. Price: CHF 70.00.

CIS 99-657
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Hepatitis viruses
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France 8-15 June 1993. Overall evaluation: chronic infection with hepatitis B or hepatitis C virus is carcinogenic to humans; infection with hepatitis D virus is not classifiable as to its carcinogenicity to humans. Topics: animal experiments; carcinogenic effects; contagion; criteria document; human experiments; IARC; infectious hepatitis; literature survey; liver cancer; race-linked differences; viruses; WHO.
IARC Press, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1994. 286p. Illus. Bibl.ref. Price: CHF 65.00.

CIS 95-252
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Some industrial chemicals
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France, 15-22 February 1994. IARC final classifications: ethylene oxide is carcinogenic in humans (Group 1); styrene-7,8-oxide and acrylamide are probably carcinogenic in humans (Group 2A); propylene oxide, isoprene, styrene, 4-vinylcyclohexene and 4-vinylcyclohexene diepoxide are possibly carcinogenic in humans (Group 2B); ethylene, propylene, vinyl toluene, N-methylolacrylamide, methyl methacrylate and 2-ethylhexyl acrylate are not classifiable as to their carcinogenicity in humans (Group 3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 560p. Illus. Bibl.ref. Index. Price: CHF 90.00.

1993

CIS 94-1331
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Beryllium, cadmium, mercury and exposures in the glass manufacturing industry
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France, 9-16 February 1993. IARC final classifications: beryllium and beryllium compounds and cadmium and cadmium compounds are carcinogenic to humans (Group 1); methylmercury compounds are possibly carcinogenic to humans (Group 2B); metallic mercury and inorganic mercury compounds are not classifiable as to their carcinogenicity to humans (Group 3). In the glass manufacturing industry, the manufacture of art glass, glass containers and pressed ware entails exposures that are probably carcinogenic to humans (Group 2A) while occupational exposures in flat-glass and special glass manufacture are not classifiable as to their carcinogenicity to humans (Group 3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 444p. Bibl.ref. Index. Price: CHF 75.00.

CIS 94-328
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of the carcinogenic risks to humans - Occupational exposures of hairdressers and barbers and personal use of hair colourants; some hair dyes, cosmetic colourants, industrial dyestuffs and aromatic amines
This monograph represents the views and expert opinions of an IARC Working Group which met in Lyon, France 6-13 October 1992. IARC final classifications: the manufacture of magenta entails exposures that are carcinogenic (Group 1); occupation as a hairdresser or barber entails exposures that are probably carcinogenic (Group 2A); 4,4'-methylenebis(2-chloroaniline) (MOCA) is probably carcinogenic in humans (Group 2A); para-chloroaniline, CI Acid Red 114, CI Direct Blue 15, 2,6-dimethylaniline (2,6 xylidine), HC Blue No.1, CI Basic Red 9 and magenta containing CI basic red 9 are possibly carcinogenic in humans (Group 2B); 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, CI Acid Orange 3, CI Pigment Red 3, D&C Red No.9, 1,4-diamino-2-nitrobenzene (2-nitro-para-phenylenediamine), N-N-dimethylaniline, HC Blue No.2, HC Red No.3, HC Yellow No.4 and personal use of hair colorants are not classifiable as to their carcinogenicity in humans (Group 3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 427p. Index. Bibl.ref. Price: CHF 75.00.

CIS 93-1976
International Agency for Research on Cancer
IARC monographs on the evaluation of carcinogenic risks to humans - Some naturally occurring substances - food items and constituents, heterocyclic aromatic amines and mycotoxins
This publication represents the views and expert opinions on an IARC Working Group (Lyon, France, 9-16 June 1992). IARC final classification: Chinese-style salted fish and naturally occurring aflatoxins are carcinogenic in humans (Group 1); IQ (2-amino-3-methylimidazo[4,5-f]quinoline) is probably carcinogenic in humans (Group 2A); pickled vegetables (traditional Asian), caffeic acid, MeIQ (2-amino-3,4-dimethylimidazo[4,5-f]quinoline), MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine), aflatoxin M1, fumonisins B1 and B2, fusarin C and ochratoxin A are possibly carcinogenic in humans (Group 2B); other salted fish, d-Limonene, zearlenone, deoxynivalenol, nivalenol, fusarenone X and T-2 toxin are not classifiable as to their carninogenicity in humans (Group 3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 608p. Index. Bibl.ref. Price: CHF 95.00.

1992

CIS 93-652
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Solar and ultraviolet radiation
This publication contains data reviewed and evaluated by an international group of experts (Lyon, 11-18 Feb. 1992). IARC overall evaluation: solar radiation is carcinogenic in humans (Group 1); ultraviolet A, B and C radiations are probably carcinogenic in humans (Group 2A); use of sunlamps and sunbeds entails exposures that are probably carcinogenic in humans (Group 2A); exposure to fluorescent lighting is not classifiable as to its carcinogenicity in humans (Group 3). Glossary.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1992. 316p. Illus. ca. 900 ref. Price: CHF 65.00.

CIS 93-269
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Occupational exposures to mists and vapours from strong inorganic acids and other industrial chemicals
These monographs consist of data reviewed and evaluated by an international group of experts (Lyon, 15-22 Oct. 1991). IARC final classification: occupational exposure to strong-inorganic-acid mists containing sulfuric acid is carcinogenic in humans (Group 1); diethyl sulfate and 1,3-butadiene are probably carcinogenic in humans (2A); diisopropyl sulfate is possibly carcinogenic in humans (2B); sulfur dioxide, sulfites, metabisulfites and hydrochloric acid are not classifiable as to their carcinogenicity in humans (3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1992. 336p. Bibl.ref. Index. Price: CHF 65.00.

1991

CIS 99-595
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Chlorinated drinking-water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds
This monograph presents the views and expert opinions of an IARC working group which met in Lyon, France 12-19 June 1990. Overall evaluation: bromodichloromethane and cobalt and cobalt compounds are possibly carcinogenic to humans; other substances studied here are not classifiable as to their carcinogenicity to humans. Topics: carcinogenic effects; carcinogens; chlorodibromomethane; ethyl bromide; cobalt; ethyl chloride; tribromomethane; bromodichloromethane; sodium chlorite; 1,1,2-trichloroethane; chlorination; chlorine and compounds; cobalt and compounds; criteria document; drinking water; halogenated organic compounds; hypochlorites; IARC; literature survey; mutagenic effects; toxic effects; toxicology; WHO.
IARC Press, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1991. 544p. Bibl.ref. Price: CHF 80.00.

CIS 92-580
International Agency for Research on Cancer
IARC monographs on the evaluation of carcinogenic risks to humans - Occupational exposures to insecticide application, and some pesticides
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (16-23 October 1990, Lyon, France). The report concludes that spraying and application of nonarsenical insecticides entail exposures that are probably carcinogenic in humans (Group 2A). Chlordane, heptachlor, DDT, dichlorvos, pentachlorophenol, atrazine are possibly carcinogenic in humans (2B) and captafol is probably carcinogenic in humans (2A). Aldicarb, deltamethrin, fenvalerate, permethrin, thiram, ziram, monuron, picloram, simazine and trifluralin are not classifiable as to their carcinogenicity in humans (3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1991. 612p. Bibl.ref. Price: CHF 95.00.

CIS 91-938
International Agency for Research on Cancer (IARC)
IARC monographs on the evaluation of carcinogenic risks to humans - Coffee, tea, mate, methylxanthines and methylglyoxal
Monographs evaluate the carcinogenic risks to humans of coffee, tea, mate, caffeine, theophylline, theobromine and methylglyoxal. IARC final classification: coffee is possibly carcinogenic to the human urinary bladder (Group 2B); hot mate drinking is probably carcinogenic to humans (2A); the other compounds are not classifiable as to their carcinogenicity in humans (3). The monographs are the result of the meeting of an IARC Working Group, held in Lyon (France), 27 Feb.-6 Mar. 1990.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1991. 513p. Illus. Bibl.ref. Index. Price: CHF 80.00.

1990

CIS 91-572
International Agency for Research on Cancer (IARC)
IARC Monographs on the evaluation of carcinogenic risks to humans - Pharmaceutical drugs
These monographs survey the available literature on 5 antineoplastic agents, 4 antimicrobial agents, 2 diuretics, ciclosporin (an immunosuppressant), cimetidine (used in the treatment of gastric and duodenal ulcers), paracetamol (a popular analgesic and antipyretic drug) and dantron (a laxative). Data include: chemical and physical properties; production, occurrence and analysis; biological data relevant to the evaluation of carcinogenic risk to humans; carcinogenic evaluation. Appendices provide a summary table and activity profiles for genetic and related effects. Of the drugs studies, ciclosporin and thiotepa are classified as carcinogenic to humans.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1990. 415p. Bibl.ref. Price: CHF 65.00; USD 52.00.

CIS 91-214
International Agency for Research on Cancer (IARC)
IARC Monographs on the evaluation of carcinogenic risks to humans - Chromium, nickel and welding
Monographs providing chemical and physical data for chromium and nickel and their compounds, details of production, use, occurrence and analysis, and a review of biological data relevant to the evaluation of carcinogenic risk to humans. It is concluded that chromium (VI) compounds are carcinogenic to humans, while metallic chromium (III) compounds are not classifiable as to their carcinogenicity. Nickel sulfate and combinations of nickel sulfides and oxides are considered to be carcinogenic, while metallic nickel is possibly carcinogenic. The major welding processes are described along with the composition of welding fumes, operational exposures of welders and relevant biological data. Welding fumes are evaluated as being possibly carcinogenic in humans.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1990. 677p. Bibl. ref. Price: CHF 95.00; USD 76.00.

CIS 90-1979
International Agency for Research on Cancer (IARC)
IARC Monographs on the evaluation of carcinogenic risks to humans - Some flame retardants and textile chemicals, and exposures in the textile manufacturing industry
The flame retardants chlorendic acid and chlorinated paraffins, and textile dye Disperse Blue I are possible carcinogens, as is nitrilotriacetic acid. Textile dye para-chloro-ortho-toluidine is a probable carcinogen. Processes and chemicals used in the textile manufacturing industry are described. Exposure data are provided for organic dusts, dyes, finishing agents and other compounds. Findings of bladder and nasal cancer among textile workers show that work in the textile manufacturing industry entails exposures that are possibly carcinogenic.
World Health Organization, Distribution and Sales, 1211 Genève 27, Switzerland, 1990. 345p. Bibl. Index. Price: CHF 65.00.

1989

CIS 90-1725 IARC monographs on the evaluation of carcinogenic risks to humans - Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting
Topics covered include organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. Monographs on individual chemicals or complex mixtures contain data on chemical and physical properties and on production, use, occurrence and analysis. Sections covering biological data relevant to the evaluation of carcinogenic risk to humans contain reports of animal studies and human epidemiological studies where available. The monograph on occupational exposure in the painting trades covers a description of paint products, a history of their manufacture, applications in various industries, and current production processes. Studies of workplace exposures are reviewed and biological data on the human carcinogenic risk are presented. Appendices provide a summary table and activity profiles of genetic and related effects.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1989. 535p. Illus. Bibl. Index. Price: CHF 65.00.

CIS 90-252
International Agency for Research on Cancer
IARC Monographs on the evaluation of carcinogenic risks to humans - Diesel and gasoline engine exhausts and some nitroarenes
IARC final classification: Diesel engine exhaust is probably carcinogenic in humans (2A); gasoline engine exhaust is possibly carcinogenic in humans (2B). In the 15 aromatic nitro compounds present in exhaust fumes and evaluated separately, 6 are possibly carcinogenic in humans (2B) and the others are not classifiable as to their carcinogenicity (3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1989. 458p. Bibl. Price: CHF 65.00.

CIS 89-1998 IARC monographs on the evaluation of carcinogenic risks to humans - Occupational exposures in petroleum refining; crude oil and major petroleum fuels
The classes of chemicals evaluated are: crude oil, gasoline, jet fuel, diesel fuels and fuel oils (heating fuels). Occupational exposures in petroleum refining have been classified as probably carcinogenic to humans (2A). The degree of evidence for carcinogenicity of gasoline diesel fuels and fuel oils is inadequate or limited (2B), and that of crude oil, jet fuels and light fuel oils is inadequate (3).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1989, Vol.45, 322p. Bibl. Price: CHF 65.00.

1988

CIS 89-1310 IARC monographs on the evaluation of carcinogenic risks to humans - Man-made mineral fibres and radon
Conclusions of an IARC Working Group which met in Lyon, France, 16-23 June 1987. Overall evaluation indicates that: glasswool, rockwool, slagwool and ceramic fibres are possibly carcinogenic to humans (IARC Classification Group 2B). Glass filaments are not classifiable as to their carcinogenicity to humans (Group 3); radon and its decay products are carcinogenic to humans (Group 1).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1988. Vol.43. 300p. Bibl. Price: CHF 65.00.

CIS 89-1050 IARC monographs on the evaluation of carcinogenic risks to humans - Alcohol drinking
On the basis of its evaluation of the related available toxicological data, IARC states that: (1) there is sufficient evidence for the carcinogenicity of acetaldehyde (the major metabolite of ethanol) in experimental animals; (2) there is inadequate evidence for the carcinogenicity of ethanol and of alcoholic beverages in animals; (3) there is sufficient evidence for the carcinogenicity of alcoholic beverages in humans: the occurrence of malignant tumours of the oral cavity, pharynx, larynx, ¿sophagus and liver is causally related to the consumption of alcoholic beverages; (4) alcoholic beverages are carcinogenic in humans (Group 1).
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1988. Vol.44. 416p. Bibl. Price: CHF 65.00.

1987

CIS 89-216
International Agency for Research on Cancer
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans - Silica and some silicates
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (10-17 June, 1986, Lyon, France). Minerals considered were: silica, wollastonite, sepiolite, talc, erionite. Information covered for each mineral: synonyms and trade names, structure, mechanisms of biological activity, chemical and physical properties, occupational and nonoccupational exposures, occupational exposure limits, biological data relevant to the evaluation of the carcinogenic risk to humans, carcinogenicity studies in animals, toxic effects, mutagenicity and other short-term tests, long-term toxicity, effects on reproduction and prenatal toxicity, epidemiological studies, extensive bibliography.
Distribution and Sales Service, World Health Organization, 1211 Genève 27, Switzerland, 1987. 289p. Illus. Bibl. Glossary. Price: CHF 65.00.

CIS 89-173 IARC Monographs on the evaluation of carcinogenic risks to humans - Genetic and related effects: An updating of selected IARC Monographs from Volumes 1 to 42
Presentation of the results of a recent appraisal of the findings from tests for genetic and related effects in experimental systems and from studies of DNA damage, chromosomal effects and mutation in humans for all agents (chemicals, groups of chemicals, industrial processes, occupational exposures and cultural habits totalling 209 items) that had been evaluated in Volumes 1-42 of the Monographs.
International Research Agency for Research on Cancer, IARC, 150 Cours Albert-Thomas, 69372 Lyon Cedex 2, France, 1987. 729p. Bibl.

CIS 88-1547 Evaluation of carcinogenic risks to humans - Overall evaluation of carcinogenicity: An updating of IARC Monographs Volumes 1 to 42
This supplement updates supplement 4 and presents conclusions and relevant data from supplement 6 concerning genetic effects and DNA and chromosome damage of the agents evaluated in vols. 1-42 and for which some data on human carcinogenicity were available. It summarises as well the data on carcinogenicity in humans and animals for all 189 agents evaluated in these volumes for which some data on human carcinogenicity were available, and it makes overall evaluations of human carcinogenicity for all 628 agents evaluated in the volumes.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1987. 440p. Bibl. Price: CHF 65.00.

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