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2011

CIS 11-0370 Richardson D.B., Wing S.
Evidence of confounding by smoking of associations between radiation and lung cancer mortality among workers at the Savannah River Site
This study investigates confounding by cigarette smoking in the associations between occupational exposure to ionizing radiation and lung cancer mortality among workers at the Savannah River Site (SRS), a facility in the United States involved in the production of basic materials used in the fabrication of nuclear weapons, primarily tritium and plutonium-239. Thirteen thousand two hundred sixty-five white males hired at SRS between 1950 and 1986 were followed through 2002 to ascertain causes of death. Estimates of radiation doses from external sources and internal tritium uptakes were derived from dosimetry records. Logistic regression methods were used to derive discrete-time estimates of rate ratios. Prior to adjustment for smoking, there was minimal evidence of association between lung cancer mortality and cumulative radiation dose under a 10-year lag assumption. Subsequent to indirect adjustment for smoking, the association between lung cancer mortality and cumulative radiation dose under a 10-year lag was positive.
American Journal of Industrial Medicine, 2011, Vol.54, p.421-427. 25 ref.