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Morfeld P., McCunney R.J.
Bayesian bias adjustments of the lung cancer SMR in a cohort of German carbon black production workers
A German cohort study on 1,528 carbon black production workers estimated an elevated lung cancer SMR ranging from 1.8-2.2 depending on the reference population. No positive trends with carbon black exposures were noted in the analyses. A nested case control study, however, identified smoking and previous exposures to known carcinogens, such as crystalline silica, received prior to work in the carbon black industry as important risk factors. This study used a Bayesian procedure to adjust the SMR, based on seven independent parameter distributions describing smoking behaviour and crystalline silica dust exposure (as indicator of a group of correlated carcinogen exposures received previously) in the cohort and population as well as the strength of the relationship of these factors with lung cancer mortality. The Markov Chain Monte Carlo Methods (MCMC) was implemented. When putting a flat prior to the SMR a Markov chain of length 1,000,000 returned a median posterior SMR estimate (that is, the adjusted SMR) in the range between 1.32 and 1.00 depending on the method of assessing previous exposures. It is concluded that Bayesian bias adjustment is an excellent tool to effectively combine data about confounders from different sources. Quantitative bias adjustment should become a regular tool in occupational epidemiology.
Journal of Occupational Medicine and Toxicology, 2010, 5:23, 14p. Illus. 66 ref.
Bayesian_bias_adjustments.pdf [in English]
Benoit J, Ponce F., Falcy M., Keck G.
Anti-cancer drugs in veterinary medicine. Risks related to their use and preventive measures
Anti-cancéreux en médecine vétérinaire. Risques liés à leur utilisation et prévention [in French]
Based on a doctoral thesis, this article presents the current state of knowledge with respect to the risks arising from the use of cytotoxic drugs in veterinary practice. Indeed, veterinarians do not adequately protect themselves from these substances, whose toxicity is currently established. It compares the basic precautions required for handling these products (preparation, administration and waste disposal) and the findings of a survey among 134 veterinarians in France to conclude that there is a dire need for communicating better awareness of the risks by means of a training programme, currently non-existent.
Documents pour le médecin du travail, 3rd quarter 2008, No.115, p.373-377. Illus. 5 ref.
TF_173.pdf [in French]
Nordling Nilson L., Barregård L., Sällsten G., Hagberg S.
Self-reported symptoms and their effects on cognitive functioning in workers with past exposure to solvent-based glues: an 18-year follow-up
The objective of this study was to examine to what extent exposure to organic solvents during the working life affects general well-being in the long term, and to explore the relationship between self-reported symptoms and cognitive functioning in previously solvent-exposed floor layers. The study included 41 solvent-exposed floor layers and 40 unexposed referents participating in a longitudinal follow-up study 18 years after the baseline assessment. Data were collected by means of general health examinations and self-administered questionnaires on symptoms, exposures and non-occupational activities. Findings confirm that prolonged high occupational exposure to solvents may negatively interact with the normal ageing process.
International Archives of Occupational and Environmental Health, Oct. 2007, Vol.81, No.1, p.69-79. Illus. 40 ref.