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Organosulfur compounds - 93 entries found

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  • Organosulfur compounds

2007

CIS 08-162 Bergendorff O., Persson C., Lüdtke A, Hansson C.
Chemical changes in rubber allergens during vulcanization
Vulcanization accelerators such as thiurams, dithiocarbamates and mercaptobenzothiazoles are among the rubber additives often responsible for allergic reactions recognized by dermatologists. The chemistry of the vulcanization process is complicated; as it occurs at an elevated temperature with a mixture of reactive chemicals. This study investigated the changes in composition of common allergens during vulcanization at different stages of the process. Major changes were found in which added chemicals were consumed and new ones produced. An important observation is that thiuram disulfides rarely appear in the final rubber even when used as additives. Instead, thiurams are often converted to dithiocarbamates or to products formed by addition to mercaptobenzothiazoles, if these have been used together with thiurams as accelerators. In conclusion, an assessment of exposure to allergens should not be based solely on knowledge concerning the additives used, but also on the chemical analysis of products formed during the vulcanization reaction.
Contact Dermatitis, Sep. 2007, Vol.57, No.3, p.152-157. Illus. 13 ref.

CIS 07-1254
Advisory Committee on Existing Chemicals (BUA)
Pyrazolic acid 3
Conclusions of this criteria document which reflects the state of knowledge of July 2006: in rabbits, pyrazolic acid 3 is not irritating to the skin and weakly irritating to the eye. In rats, the oral LD5l0 is more than 2000mg/kg body weight. In mutagenicity tests, the product is non-mutagenic up to the cytotoxic range. No data are available for an evaluation of the sensitization potential, genotoxicity, carcinogenicity and reproductive toxicity.
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. xiii, 22p. 37 ref. Price: EUR 00.00. Downloadable version free of charge.
http://www.dav-buchhandlung.de/ [in English]

2003

CIS 03-1536
Agency for Toxic Substances and Disease Registry (ATSDR)
Toxicological profile for sulfur mustard (Update)
This profile was prepared in accordance with guidelines set by the US Agency for Toxic Substances and Disease Registry and the EPA. The key literature related to the toxic effects of sulfur mustard (mustard gas) is identified and reviewed. Contents: public health statement; health effects; chemical and physical information; production, importation, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: irritation of eyes and the respiratory tract; skin burns (blisters); cough; bronchitis; long-term respiratory diseases; antifertility effects; cancer (respiratory airways, lung, skin).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Sep. 2003. xix, 217p. Illus. Approx. 650 ref.
http://www.atsdr.cdc.gov/toxprofiles/tp49.pdf [in English]

2002

CIS 02-856 Bilans de connaissances B-062, Bégin D., Lavoué J., Gérin M.
Substitution of solvents by dimethyl sulfoxide
La substitution des solvants par le diméthylsulfoxyde [in French]
Because of its strong solvating power, dimethyl sulfoxide (DMSO) is used in many areas as a substitute for more harmful solvents, particularly in stripping. It is characterized by its ease and rapidity of skin penetration, diffusion to all biological compartments, partial oxidation by hepatic microsomes to dimethyl sulfone which is primarily excreted in urine along with unchanged DMSO, and a partial reduction to dimethyl sulfane with a garlic smell found in exhaled air. It has low acute toxicity. In humans, skin exposure to concentrated DMSO can give rise to localized irritation with desquaming, erythema and puritis. Hepatic, kidney, haemolitic and neurotoxic effects are observed in animals or humans only at high concentrations. DMSO may be mildly mutagenic. Available data do not appear to indicate carcinogenic effects, but remain inconclusive. Animal experiments indicate that DMSO has little embryo- or reproductive toxicity and is not teratogenic at concentrations that are non toxic to the mother. In occupational settings, preventive measures should focus primarily on skin protection. In Switzerland, Germany and Sweden, and eight-hour TWA exposure limit has been set at 50ppm.
Institut de recherche Robert-Sauvé en santé et en sécurité du travail du Québec (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, Mar. 2002. vi, 71p. 160 ref. Price: CAD 25.00.

1998

CIS 98-1152 Benzenethiol
Topics: thiophenol; chemical burns; data sheet; elimination of spills; fire fighting; fire hazards; first aid; health hazards; hepatic damage; irritation; limitation of exposure; lung diseases; medical examinations; New Jersey; paresis; personal protective equipment; renal damage; respirators; skin absorption; storage; threshold limit values; USA; waste disposal.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

1997

CIS 98-44 Perchloromethyl mercaptan
Mercaptán perclorometílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: data sheet; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; hepatic damage; irritation; limitation of exposure; medical supervision; personal protective equipment; pulmonary oedema; renal damage; respirators; respiratory diseases; skin absorption; trichloromethanethiol; USA; waste disposal.
Noticias de seguridad, Aug. 1997, Vol.59, No.8. 4p. Insert.

1996

CIS 97-1109 Dodecylbenzene sulfonic acid
Data sheet. May enter the body when breathed in. May irritate and burn the eyes, skin and respiratory tract.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996, rev. 2003. 6p.
http://www.state.nj.us/health/eoh/rtkweb/0822.pdf [in English]

CIS 97-1092 Butyl mercaptan
Data sheet. Synonym: butanethiol. May enter the body when breathed in. May irritate the eyes, skin and respiratory tract. May cause dizziness, nausea, confusion and fainting. It is a flammable liquid.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-171 Bangha E., Hinnen U., Elsner P.
Irritancy testing in occupational dermatology: Comparison between two quick tests and the acute irritation induced by sodium lauryl sulphate
This study is a comparison between two quick, non-invasive irritancy tests (using dimethyl sulfoxide and sodium hydroxide) with the time-consuming patch testing relying on sodium lauryl sulfate (SLS). No correlation between the "quick tests" and SLS tests was observed as a result of skin testing in 181 metal worker trainees. It is proposed to use a spectrum of different tests in occupational dermatology for predicting the individual's risk of developing irritant contact dermatitis.
Acta dermato-venereologica, Nov. 1996, Vol.76, No.6, p.450-452. 10 ref.

CIS 96-901
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Existing chemicals of environmental relevance III - Priority setting and classified existing chemicals of the third priority list
This document, translation of a report finalized in June 1992, describes the German Chemical Society's procedure for the classification and priority setting of existing chemicals requiring toxicity evaluation and presents summary toxicity data for some 130 substances in the third priority list. The substances are arranged in four chemical groups: sulfonic acid compounds, phosphoric acid esters, acrylic acid and acrylic acid esters (acrylates), and methacrylic acid and methacrylic acid esters (methacrylates). Data relate to acute toxicity, irritation, sensitization, repeated dose toxicity, genotoxicity, carcinogenicity and reproductive toxicity.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. 119p. Price: DEM 72.00.

1995

CIS 95-1826 Nölle P.
Adding odorants to oxygen
Odorierung von Sauerstoff [in German]
Oxygen is used in the metal-working industry for gas welding and cutting. An increase of oxygen in the atmosphere on the workplace, for example through a leak in the oxygen supply line, enhances the flammability of substances and the rate of fire spread. For olfactory signalling of an oxygen leak, dimethyl sulfide is added to oxygen in a concentration of at least 3.6mL/m3 but not more than 10.8ppm. A new injection system is presented for the safe addition of the appropriate concentration of dimethyl sulfide to oxygen. It consists of the gas cylinder holding the toxic and easily inflammable dimethyl sulfide in a carrier gas, the injector and the unit controlling pressure, flow and temperature during the injection process.
Sicherheitsingenieur, Mar. 1995, Vol.26, No.3, p.16-19. Illus. 5 ref.

1994

CIS 97-243 Cézard C.
Hydrogen sulfide and mercaptans
Hydrogène sulfuré et mercaptans [in French]
Data sheet on the effects, the determination and the sampling of hydrogen sulfide (H2S) and of mercaptans in the atmosphere and biological matter. Even today H2S is one of the gases that cause the greatest number of fatal occupational accidents following acute exposure. The acute effects of mercaptans are on the whole less drastic. Main points covered: metabolic fate; toxicity; exposure monitoring; treatment after acute exposure; exposure limits: H2S (ceiling: 10ppm, TWA: 5ppm); methylmercaptan (TWA: 0.5ppm); ethylmercaptan (TWA: 0.5ppm); butylmercaptan (synonym butanethiol, TWA: 0.5ppm); phenylmercaptan (synonym thiophenol, TWA: 0.5ppm).
Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle, 2nd Quarter 1994, No.103, 8p. 148 ref.

CIS 95-2169 Ihara Y.
Follow-up study of chronic obstructive pulmonary disease among workers poisoned by gas at Okunojima
Ōkunojima doku gasu shōgaisha ni okeru mansei heisokusei haishikkan no keikai [in Japanese]
From 1927 to 1945, a factory in Ōkunojima, Japan, produced yperite (dichlorodiethyl sulfide) and lewisite (β-chlorovinyldichloroarsine). Observation of 72 surviving workers from 1981 to 1991, with analysis of chest x-rays, sputa and respiratory function tests, was followed up by computerized tomography. Whereas previous reports on chronic bronchitis among these workers stated it to be mainly inflammatory and to have a variable clinical course, the present results indicate long-term progression of obstructive ventilatory disorder due to emphysematous changes in the respiratory tract.
Japanese Journal of Thoracic Diseases, 25 Mar. 1994, Vol.32, No.3, p.216-224. Illus. 21 ref.

CIS 95-851 Dimethylsulfoxide
Diméthylsulfoxyde [in French]
Chemical safety information sheet. Acute toxicity: skin irritation and erythema on contact. Chronic toxicity: neurotoxic effects (central nervous system); gastrointestinal diseases; haematotoxic effects; dermatitis.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1994. 4p. 24 ref.

1993

CIS 96-1572 Dimethyl sulfide
International Chemical Safety Card. Highly flammable. Short-term exposure effects: unconsciousness.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 96-431 p-Toluenesulfonic acid
International chemical safety card. Short-term exposure effects: corrosive effect on the eyes, skin and respiratory tract; pulmonary oedema (may be delayed).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-1849 Sulfanilic acid
International chemical safety card. Short term exposure effects: irritation of the eyes, skin and respiratory tract; methaemoglobinaemia. Long term exposure effects: skin sensitization; may affect the lungs.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 94-1012
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
p-Toluene sulphonic acid
No data are available on the effects of p-toluene sulfonic acid in humans. Animal studies indicate that the substance causes skin irritation and burns; the principal effect following acute oral exposure is injury to the gastro-intestinal tract. No genotoxic effects have been observed.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1993. xv, 80p. 115 ref. Price: DEM 48.00.

CIS 94-455 Ethanethiol
International chemical safety card. Short-term exposure effects: irritation of eyes, skin and respiratory tract; neurotoxic effects (central nervous system). Occupational exposure limits: TLV: 0.5ppm; 1.3mg/m3 (ACGIH 1989-1990). PDK: 1mg/m3 (USSR 1988).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-41 Dimethyl sulphoxide
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes, skin and respiratory tract; visual function disorders. Long-term exposure effects: dermatitis; skin sensitization; hepatic damage.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-25 Benzenethiol
International chemical safety card. Synonym: thiophenol. Short term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; neurotoxic effects. Long term exposure effects: dermatitis. Occupational exposure limits: TLV: 0.5ppm; 2.3mg/m3 (TWA) (ACGIH 1991-1992).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

1992

CIS 02-61 Methanethiol; Ethanethiol; 1-Butanethiol
Méthanethiol; éthanethiol; 1-butanethiol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 83-1937. Synonyms: methylmercaptan, ethylmercaptan, n-butylmercaptan. Acute toxicity: pulmonary irritation; nausea; diarrhoea; unconsciousness; respiratory impairment; methaemoglobinaemia or sulfhaemoglobinaemia; pulmonary oedema; transient renal damage. Chronic toxicity: irritation of the skin and of ocular and respiratory mucous membranes. Exposure limits (France): TWA = 1mg/m3 (0.5ppm) for methanethiol and ethanethiol; 1.5mg/m3 (0.5ppm) for all butanethiol isomers. EEC numbers and mandatory labelling codes: No.016-021-00-3 (methanethiol), No.016-022-00-9 (ethanethiol); F, Xn, R13, R20, S16, S25. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, 2001. 4p. Illus. 27 ref.

CIS 94-81 1-Dodecanethiol
Dodécane-1 thiol [in French]
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis; skin sensitization. United Nations number and hazard class: UN 1228 (3; 6.1-109 & 167: II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p. Illus.

CIS 94-74 1-Decanethiol
Décane-1 thiol [in French]
International chemical safety card. Short-term exposure effects: skin absorption; irritates skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: dermatitis. United Nations number and hazard class: UN 1228 (3; 6.1; II; 109/167).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p.

CIS 94-71 Cyclohexanethiol
Cyclohexanethiol [in French]
International chemical safety card. Short-term exposure effects: skin absorption; irritates skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: dermatitis. United Nations number and hazard class: UN 3054 (3; III).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p.

CIS 94-64 1-Hexadecanethiol
Hexadécane-1 thiol [in French]
International chemical safety card. Short term exposure effects: irritation of eyes, skin and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis. United Nations number and hazard class: UN 1228 (3; 6.1; 109/167; II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p. Illus.

CIS 94-58 2-Methyl-2-propanethiol
Méthyle-2-propane-2 thiol [in French]
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p. Illus.

CIS 94-57 1-Butanethiol
Butane-1 thiol [in French]
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis. United Nations number and hazard class: UN 2347 (3; II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1992. 2p. Illus.

CIS 93-2007 Lundberg P.
Scientific basis for Swedish occupational standards - XIII
Vetenskapligt underlag för hygienska gränsvärden. 13 [in Swedish]
Consensus reports of the Criteria Group of the Swedish National Institute of Occupational Health on diethanolamine, ethanolamine, catechol, resorcinol, acetamide, dimethyl sulfoxide, ethyl chloride, dioxane, chloromethane, methylhydrazine, hydrazine, cadmium and pyridine. An appendix lists consensus reports appearing in previous volumes of Arbete och Hälsa.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1992. 85p. (Eng.); 152p. (Swe.). 496 ref.

CIS 93-1097 Allyl propyl disulfide
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Effects of short-term exposure: irritation of the eyes, nose, throat and mucous membranes.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1992. 5p. 15 ref.

CIS 93-766 Ethyl mercaptan
Etil mercaptán [in Spanish]
Chemical safety data sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Synonym: ethanethiol. Health hazards: irritation of the mucous membranes; neurotoxic effects (central nervous system); may affect the liver, cardiovascular system and haematopoietic system.
Noticias de seguridad, June 1992, Vol.54, No.6. 5p. Insert.

1991

CIS 98-1574 1-Hexadecanethiol
Hexadecano-1-tiol [in Spanish]
Spanish version of IPCS ICSC 0025. International Chemical Safety Card. Topics: hexadecanethiol; chemical hazards; data sheet; dermatitis; elimination of spills; eye irritation; fire fighting; fire hazards; first aid; functional respiratory disorders; health hazards; IPCS; irritants; labelling; skin absorption; Spain; storage; translation; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 98-1122 Dodecanethiol
Dodecano-1-tiol [in Spanish]
Spanish version of IPCS ICSC 0042 (CIS 91-382). International Chemical Safety Card. Topics: asthma; dodecanethiol; central nervous system; chemical hazards; data sheet; delayed effects; dermatitis; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; IPCS; irritation; labelling; neurotoxic effects; respiratory insufficiency; sensitization; Spain; storage; translation; unconsciousness; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 97-1457 Dimethyl sulfide
Sulfuro de dimetilo [in Spanish]
Spanish version of IPCS ICSC 10-0878. International Chemical Safety Card. Highly flammable. Short-term exposure effects: unconsciousness.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 96-2006 Ethanethiol
Etanotiol [in Spanish]
Spanish version of IPCS ICSC 7-0470. International chemical safety card. Short-term exposure effects: irritation of the eyes, skin and respiratory tract; neurotoxic effects (central nervous system); convulsions; respiratory insufficiency. Occupational exposure limits: TLV: 0.5ppm, 1.3mg/m3 (ACGIH 1990-1991); PDK: 1mg/m3 (USSR 1988).
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 94-1823 Dimethyl sulfoxide
Dimetil sulfóxido [in Spanish]
Spanish version of IPCS ICSC 6-0459. International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes, skin and respiratory tract; visual function disorders. Long-term exposure effects: dermatitis; skin sensitization; hepatic damage.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 93-53 Perchloromethyl mercaptan
International chemical safety card. Short term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; pulmonary oedema. Long term exposure effects: dermatitis; may affect the lungs.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1821 Methyl mercaptan
International chemical safety card. Short term exposure effects: irritant; pulmonary oedema; neurotoxic effects; methaemoglobinaemia.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1654 Knudsen L.E.
Nordic Expert Group for Documentation of Occupational Exposure Limits - 97. Dimethyl sulfoxide
Nordiska expertgruppen för gränsvärdesdokumentation - 97. Dimethylsulfoxid [in Danish]
The literature on dimethyl sulfoxide was reviewed and evaluated. DMSO has a very low acute toxicity, and chronic effects are seen only at high exposure levels. The critical toxicological effects are irritation (skin and mucous membranes), central nervous system effects (dizziness and nausea) and disturbance of normal cellular functions, which contribute to development of cancer and teratogenic effects. Occupational exposure is most likely to occur by skin contact; DMSO also greatly enhances the permeability of the skin to other substances. Further studies on the genotoxic, teratogenic and carcinogenic effects of DMSO are necessary before these hazards can be properly evaluated.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1991. 36p. 113 ref.

CIS 92-946 Deneauve-Lockhart C.
Acute yperite poisoning - An occupational accident
Intoxication aiguë par l'ypérite. A propos d'un accident du travail [in French]
Dissertation for a Diploma in Special Studies in occupational medicine. A case of yperite poisoning during ground clearing operations is described and the use of the gas in chemical warfare is reviewed. A study of its toxic mechanisms shows that this gas is an alkylating agent responsible for DNA modifications. Survey of some other cases of occupational poisoning, as well as of clinical effects, diagnosis, and treatment. Evidence of long term risk, including experimental mutagenic and carcinogenic data, and human genotoxic and epidemiological data, serves to classify yperite as a human carcinogen. Advice is given on the action to take in the case of occupational poisoning.
Université Pierre et Marie Curie, UER Broussais Hôtel-Dieu, 15 rue de l'Ecole de Médecine, 75006 Paris, France, 1991. 25p. 19 ref.

CIS 92-550 Cowell J.E., Lottman C.M., Manning M.J.
Assessment of lawn care worker exposure to dithiopyr
Eighteen lawn care specialists were monitored by both passive dosimetry and biological monitoring techniques for exposure to the herbicide dithiopyr (trade name Dimension) in the normal course of their duties. The mean body dose estimate from urinalysis of the specimens collected over a 72-hour period was 4.60 x 10-5mg/kg/lb applied. The passive dosimetry body dose estimates using dermal deposition measurements corrected for skin penetration and simulated inhalation measurements were calculated for the 2 clothing scenarios observed in the worker tests. The mean body dose estimate for a fully clothed worker wearing a long-sleeved shirt was 8.09 x 10-5mg/kg/lb while for a specialist wearing a short-sleeved shirt the estimate was 3.62 x 10-4mg/kg/lb. The lower leg regions, which were protected by long trousers and boots, had the highest exposure by passive dosimetry data.
Archives of Environmental Contamination and Toxicology, Aug. 1991, Vol.21, No.2, p.195-201. Illus. 13 ref.

CIS 92-59 Methyl mercaptan
Metil mercaptano [in Spanish]
Chemical safety sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. It is an adaptation into Spanish of the corresponding data sheet from the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards" (DHHS (NIOSH) Publication No.89-104).
Noticias de seguridad, Aug. 1991, Vol.53, No.8, 5p. Insert.

CIS 91-373 N-Butyl mercaptan
Mercaptán de n-butilo [in Spanish]
Chemical safety data sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA, and adaptation into Spanish of the corresponding data sheet from the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards" (DHHS (NIOSH) Publication No. 89-104).
Noticias de seguridad, Mar. 1991, Vol.53, No.3, 5p. Insert.

1990

CIS 91-382 1-Dodecanethiol
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis; skin sensitisation. United Nations number and hazard class: UN 1228 (3; 6.1-109 & 167: II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 91-39 1-Decanethiol
International chemical safety card. Short-term exposure effects: skin absorption; irritates skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: dermatitis. United Nations number and hazard class: UN 1228 (3; 6.1; II; 109/167).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p.

CIS 91-37 Cyclohexanethiol
International chemical safety card. Short-term exposure effects: skin absorption; irritates skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: dermatitis. United Nations number and hazard class: UN 3054 (3; III).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p.

CIS 90-1467 1-Hexadecanethiol
International chemical safety card. Short term exposure effects: irritation of eyes, skin and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis. United Nations number and hazard class: UN 1228 (3; 6.1; 109/167; II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 90-1135 2-Methyl-2-propanethiol
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 90-1112 1-Butanethiol
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects (central nervous system). Long term exposure effects: dermatitis. United Nations number and hazard class: UN 2347 (3; II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

1988

CIS 90-1477 Methyl mercaptan
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Exposure limits: OSHA PEL (ceiling) = 20mg/m3; NIOSH REL (ceiling 15min) = 1mg/m3; ACGIH TLV (8h-TWA) = 1mg/m3. Odour threshold = 1ppb. Toxicity: irritation of eyes and respiratory tract; methaemoglobinaemia; dermatitis.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226, USA, 1988. 6p. Bibl.

CIS 90-110 Easton D.F., Peto J., Doll R.
Cancers of the respiratory tract in mustard gas workers
In a study of a cohort of 2498 men and 1032 women employed in the manufacture of mustard gas in Cheshire (England) during the Second World War, 3354 (95%) individuals were successfully traced for mortality to the end of 1984. Highly significant excesses were observed as compared with national death rates for deaths from cancer of the larynx, pharynx and all other buccal cavity and upper respiratory sites combined. For lung cancer, a highly significant but more moderate excess was observed. Significant excesses were also observed for deaths from acute and chronic non-malignant respiratory disease. The risks for cancers of the pharynx and lung were significantly related to duration of employment. The results provide strong evidence that exposure to mustard gas can cause cancers of the upper respiratory tract and some evidence that it can cause lung cancer and non-malignant respiratory disease.
British Journal of Industrial Medicine, Oct. 1988, Vol.45, No.10, p.652-659. 14 ref.

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