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Glycols - 55 entries found

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2008

CIS 08-1143 Mégarbane B., Baud F.J.
Poisoning from alcohols (other than ethanol) and glycols
Intoxication par les alcools (autres que l'éthanol) et les glycols [in French]
Poisonings from toxic alcohols or glycols are rare but potentially serious. The main clinical outcome is the occurrence of a metabolic acidosis, giving rise to Küssmaul's dyspnoea. Other more specific complications can also arise during more severe poisonings; ethylene glycol can cause acute renal insufficiency, while methanol can cause vision disorders leading to irreversible blindness. Treatment is based on the administration of an antidote such as fomepizol for blocking the metabolic transformation of alcohol into toxic products by alcohol dehydrogenase, along with symptomatic resuscitation measures and intravenous perfusions of sodium bicarbonate. In the most serious cases, haemodialysis should be systematically performed together with the antidote treatment.
Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle, 2nd Quarter 2008, No.159, 9p. Illus. 81 ref.

2005

CIS 06-384 Teschke K., Chow Y., van Netten C., Varughese S., Kennedy S.M., Brauer M.
Exposures to atmospheric effects in the entertainment industry
Theatrical fogs are commonly used in the entertainment industry to create special atmospheric effects during filming and live productions. This study examined exposures to mineral oil and glycol-based theatrical fogs to determine what fluids were commonly used, to measure the size distributions of the aerosols and to identify factors associated with personal exposure levels to these substances. Airborne concentrations of inhalable aerosol, aldehydes and polycyclic aromatic hydrocarbons were measured in a range of production types (television, film, live theatre and concerts), and observations about the sites and tasks performed were collected. Findings are discussed. It is important to consider these exposures in light of any health effects observed, since existing occupational exposure limits were developed in other industries where the aerosol composition differs from that of theatrical fogs.
Journal of Occupational and Environmental Hygiene, May 2005, Vol.2, No.5, p.277-284. 9 ref.

2002

CIS 03-538 Gomes R., Liteplo R., Meek M.E.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Ethylene glycol: Human health aspects
Conclusions of this criteria document: data available from acute poisoning indicate that the kidney is a critical organ for the toxicity of ethylene glycol; neurological and neurobehavioural disorders have been reported but available data are inadequate to assess potential neurological and immunological effects associated with ethylene glycol. Data from animal studies indicate that ethylene glycol has nephrotoxic and teratogenic effects; there is evidence of reproductive toxicity in mice (at very high doses) but not in rats.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2002. iv, 38p. Illus. 134 ref.
http://www.who.int/ipcs/publications/cicad/en/cicad45.pdf [in English]

CIS 02-1560 Screening information data set SIDS for high production volume chemicals - Volume 8, Parts 1 and 2
Ecotoxicological and toxicological (acute toxicity, chronic toxicity, effects on reproduction, genetic effects) data for the risk assessment of 7 chemicals: 1,4-butanediol, p-tert-butylphenol, diacetone alcohol, 4-5-dihydroxy-1,3-bis(hydroxymethyl) imidazolidin-2-one (synonym: dimethylol dihydroxyethylene urea), glycidyl methacrylate, 4,4'- methylenedianiline and 1,1,2-trichloroethane.
United Nations Environment Programme, 11-13 chemin des Anémones, 1219 Châtelaine, Genève, Switzerland, Nov. 2002. viii, 264p. Bibl.ref. (Part 1); viii, 302p. Bibl.ref. (Part 2).

2000

CIS 01-1361
International Programme on Chemical Safety (IPCS)
Screening information data set SIDS for high production volume chemicals - Volume 6, Part 1
Ecotoxicological and toxicological (acute toxicity, chronic toxicity, effects on reproduction, genetic effects) data for the risk assessment of acetone, 2,2'-azobis(2-methylpropionitrile) or azobisisobutyronitrile, hexamethylene glycol (1,6-hexanediol), 4-hydroxybenzoic acid (p-hydroxybenzoic acid) and isocyanuric acid.
United Nations Environment Programme, Case postale 356, 1219 Châtelaine, Genève, Switzerland, June 2000. viii, 319p. Bibl.ref.
http://www.chem.unep.ch/irptc/sids/volume6/part1/COVOL61.PDF [in English]

CIS 00-1260 Dobson S.
International Programme on Chemical Safety (IPCS)
Ethylene glycol: Environmental aspects
Two-thirds of the word production of ethylene glycol is used as a chemical intermediate and one-fourth as an antifreeze in engine coolants. It is also used as a runway de-icer in airports; in this case the local release is important. Tests show that ethylene glycol is readily biodegradable. Pure ethylene glycol has generally low toxicity in organisms; ethylene glycol-based de-icers however show greater toxicity. Studies in the vicinity of an airport have reported toxic signs in aquatic organisms, fish kills and reduced biodiversity, but these effects cannot be attributed with certainty to ethylene glycol. Terrestrial organisms are less exposed and show low sensitivity. The appropriate International Chemical Safety Card (ICSC) is given. Summaries in French and in Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 2000. iii, 24p. Illus. 88 ref. Price: CHF 13.00 (CHF 9.10 in developing countries).
http://www.who.int/ipcs/publications/cicad/en/cicad22.pdf [in English]

1999

CIS 00-454 Pendergrass S.M.
Determination of glycols in air: Development of sampling and analytical methodology and application to theatrical smokes
Glycol-based fluids are used in the production of theatrical smokes in theatres, concerts and other stage productions. The fluids are heated and dispersed in aerosol form to create the effect of a smoke, mist or fog. There have been reports of adverse health effects such as respiratory irritation, chest tightness, shortness of breath, asthma and skin rashes. In order to assess workplace exposures, an Occupational Safety and Health Administration versatile sampler tube was selected for the collection of various glycol aerosols. Limits of detection of the glycol analytes ranged from 7 to 16µg/sample. Desorption efficiencies for all glycol compounds were determined over the range of study and averaged greater than 90%. Storage stability results were acceptable after 28 days for all analytes except ethylene glycol, which was stable at ambient temperature for 14 days. Based on the results of this study, the new glycol method was published in the NIOSH Manual of Analytical Methods.
American Industrial Hygiene Association Journal, July-Aug. 1999, Vol.60, No.4, p.452-457. Illus. 23 ref.

1998

CIS 99-951
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
p-Hydroxybenzoic acid. Hexabromocyclododecane. Propylene glycol
Topics: animal experiments; hexabromocyclododecane; propylene glycol; p-hydroxybenzoic acid; criteria document; ecotoxicology; Germany; legislation; literature survey; skin allergies; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O.Box 10 10 61, 70009 Stuttgart, Germany, 1998. 250p. Bibl.ref. Price: DEM 112.00.

1997

CIS 01-687 Ethylene glycol
Ethylène-glycol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-411. Acute toxicity: depressive effect on the central nervous system after several hours' delay; pulmonary oedema; hyperglycaemia. Chronic toxicity: irritation of the eye and of the respiratory tract mucous membranes; signs of central nervous system depression. Exposure limits: ceiling value = France: 125mg/m3 (50ppm); USA: 100mg/m3 (ACGIH 1996). EEC number and mandatory labelling codes: No.603-027-00-1; Xn, R22, 203-473-3. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 18 ref.

CIS 99-1620
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for ethylene glycol and propylene glycol
Topics: ethylene glycol; propylene glycol; criteria document; exposure evaluation; functional heart disorders; functional respiratory disorders; glossary; health hazards; irritation; limitation of exposure; literature survey; nephrotoxic effects; neurological effects; skin absorption; toxic effects; toxicity evaluation; toxicology; USA.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Sep. 1997. xvii, 249p. Illus. approx. 500 ref.

1996

CIS 97-388 Ethylene glycol
Data sheet. May enter the body when breathed in and through the skin. It is a teratogen and should be handled with extreme caution. Irritates the eyes and respiratory tract. May cause neurotoxic effects and damage the kidneys and the brain.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

1995

CIS 95-2184
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Melamine. Diisopropanolamine. 1,6-Hexanediol. Tri/Dibutyl phosphate
Conclusions of these criteria documents, translation of reports finalized in June-Dec. 1992: no data are available on the acute or chronic effects of melamine in man; tests for irritating or sensitizing properties proved negative. Animal studies indicate that diisopropanolamine (1,1'-iminodi-2-propanol) is of low acute toxicity; tests on humans reveal that it does not induce allergic or photoallergic reactions. No data are available on the effects of 1,6-hexanediol in man; animal studies indicate a slight acute toxicity. Tributyl phosphate is strongly irritating to the skin and mucous membranes in man; exposure by inhalation leads to nausea and headache. The toxicological action of dibutyl phosphate is assumed to be comparable to that of tributyl phosphate.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. xxvii, 197p. Bibl.ref. Price: DEM 96.00.

1994

CIS 97-939 Lundberg P.
Criteria Group for Occupational Standards
Scientific basis for Swedish occupational standards XV
Vetenskapligt underlag för hygieniska gränsvärden. 15 - Criteria Group for Occupational Standards XV [in Swedish]
Critical evaluation of those scientific data which are relevant as background for discussion of Swedish occupational exposure limits. This volume consists of the consensus reports submitted by the Criteria Group at the Swedish National Institute of Occupational Health between July 1993 and June 1994. They cover: ethylene glycol monopropylether (propoxyethanol) and its acetate (2-propoxyethanol acetate), hexachloroethane, some metal stearates, some stearates, hexylene glycol, barium and barium compounds, strontium and strontium compounds, dicyclopentadiene, N,N-dimethylacetamide, indium and inorganic indium compounds, o-chlorobenzylidene malononitrile and thioglycolic (mercaptoacetic) acid.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1994. 72p. (Eng.); 79p. (Swe.). 298 ref.

CIS 95-1012 Skogstad M., Levy F.
Occupational irritant contact dermatitis and fungal infection in construction workers
A study was made of six construction workers who developed chronic skin diseases on their hands over a period of 15 years. Four developed Trichophyton rubrum infection, and the other two an irritant contact dermatitis. All of them carried out jobs which caused traumatization of the skin due to the presence of ethylene glycol and mineral oils during operation of pneumatic hammers in winter. Construction workers may be at risk of developing an occupational skin disease involving fungal infection.
Contact Dermatitis, July 1994. Vol.31, No.1, p.28-30. 6 ref.

CIS 95-857 Propylene glycol
Propylèneglycol [in French]
Chemical safety information sheet. Acute toxicity: mild irritation of the skin. Chronic toxicity: metabolic disturbances; renal insufficiency; neurotoxic effects; irritation of the skin (dermatitis).
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1994. 4p. 20 ref.

CIS 95-1033
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Ethylene glycol
There are numerous reports of ethylene glycol poisoning in humans in which the kidneys proved to be the target organ; neurotoxic and cardiopulmonary effects have also been observed following poisoning. The substance has a strong irritative effect. Animal studies indicate that ethylene glycol has a low acute toxicity; general symptoms are depression of the central nervous system and kidney damage; no mutagenic or carcinogenic effects have been observed; embryotoxic and teratogenic effects have been demonstrated at very high doses.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1994. xvii, 139p. Bibl.ref. Price: DEM 88.00.

1993

CIS 95-1233 Hexylene glycol
International chemical safety card. Short-term exposure effects: irritation of the eyes and skin. Long-term exposure effects: dermatitis; may affect the kidneys. Occupational exposure limits: TLV: 25ppm, 121mg/m3 (ceiling) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 94-466 1,6-Hexanediol
International chemical safety card. Short term exposure effects: irritation of eyes and respiratory tract.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-295 Lin C.K., Chen R.Y.
Survey of glycol ether use in Taiwan, 1991
Recently, E-series glycol ethers have been found to show reproductive and teratogenic toxicity, and throughout much of the world they are being replaced by the so-called P-series glycol ethers. In responding to the impact of the worldwide transition from E- to P-series glycol ethers, the current status of glycol ether use in Taiwan was studied. This study found that large quantities of E-series glycol ethers were imported and used in Taiwan. The best estimates are: 2-ME, 2,500 tons; 2-EE, 1,200 tons; 2-EEA, 5,000-8,000 tons; 2-BE, 8,000 tons annually in 1991. For P-series glycol ethers, only about 2,500 tons are being used. Lack of knowledge about the potential toxic effects of the E-series glycol ethers is very common among users, regulatory agencies, academic institutes, and the general public. It is hoped that the results of this study, along with educational efforts, government regulations, and provision of technical services, will help prevent Taiwan becoming a dumping site for these toxic chemicals.
American Journal of Industrial Medicine, July 1993, Vol.24, No.1, p.101-108. 9 ref.

CIS 93-1783 1,2-Butanediol
International chemical safety card. Short-term exposure effects: eye irritation. Long-term exposure effects: may affect the kidneys.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1463 Propylene glycol
International chemical safety card. Short-term exposure effects: irritation of the eyes.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

1992

CIS 93-229 Cicolella A.
Glycol ethers - State of the art and research prospects
Les éthers de glycol - Etat actuel des connaissances - Perspective de recherche [in French]
Glycol ethers are a family of products, the use of which, as solvents, has increased sharply during the last few years: paints, inks, varnishes, cosmetics, cleaning products, etc. Two million people are thought to be exposed at work and many more at home. Experimental data are consistent as far as testicular and developmental effects are concerned, but rather scarce for the haematological ones and non-existent for carcinogenicity. No chronic toxicity study has been published. Human data are scarce: a few cases of malformations and haematological effects as well as some epidemiological studies on morbidity (with poor exposure evaluation), and no mortality or case-control studies. The INRS has therefore launched a research programme consisting of epidemiological, clinical, toxicological and monitoring studies on exposure to glycol ethers.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 3rd Quarter 1992, No.148, Note No.1890-148-92, p.359-378. Illus. 132 ref.

1991

CIS 98-1127 Ethanediol
Etano-1,2-diol [in Spanish]
Spanish version of IPCS ICSC 0270 (CIS 92-1792). International Chemical Safety Card. Topics: brain tissue damage; central nervous system; chemical hazards; data sheet; elimination of spills; ethylene glycol; fire fighting; fire hazards; first aid; health hazards; IPCS; irritation; labelling; neurotoxic effects; renal damage; skin absorption; Spain; storage; threshold limit values; translation; unconsciousness; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 96-2029 1,6-Hexanediol
Hexano-1,6-diol [in Spanish]
Spanish version of IPCS ICSC 7-0491. International chemical safety card. Short-term exposure effects: irritation of the eyes and respiratory tract; unconsciousness. Data are insufficiently available on the health hazards of this substance.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 95-1229 Propylene glycol
Propano-1,2-diol [in Spanish]
Spanish version of IPCS ICSC 6-0321. International chemical safety card. Short-term exposure effects: irritation of the eyes.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 94-1148 1,2-Butanediol
Butano-1,2-diol [in Spanish]
Spanish version of IPCS ICSC 6-0395. International chemical safety card. Short-term exposure effects: eye irritation. Long-term exposure effects: may affect the kidneys.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 93-382 Ethylene glycol
Fire safety data sheet prepared by the Loss Prevention Association of India, Warden House, Sir P.M. Road, Bombay 400 001, India. Health hazards: injury to kidneys, liver and brain; mild irritation of skin and eyes.
Loss Prevention News, Oct.-Dec. 1991, Vol.13, No.4, p.21-22.

CIS 93-47 Neopentyl glycol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1802 2,5-Hexanediol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract. Long-term exposure effects: dermatitis; may affect nervous system resulting in polyneuropathy and changes in the electromyogramme.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1792 Ethylene glycol
International chemical safety card. Short term exposure effects: irritation of eyes, skin and respiratory tract; possible effects on kidneys and central nervous system resulting in brain damage. Long term exposure effects: risk of dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

1990

CIS 90-1807 Ethylene glycol
Ethylène glycol [in French]
Chemical safety information sheet. Toxicity: skin absorption; at high levels, vapours irritate the eyes and the respiratory tract; lethal dose by ingestion is 1.6g/kg; severe prolonged exposure may cause softening of the skin.
Canadian Centre for Occupational Health and Safety, 250 Main St. E., Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

CIS 90-1463 Ethylene glycol
Ethylène glycol [in French]
Chemical safety information sheet. Toxicity: irritation of respiratory tract and eyes (from mist and vapours); skin absorption; human lethal dose is 1.6g/kg; teratogen.
Canadian Centre for Occupational Health and Safety, 250 Main St. E., Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

1988

CIS 02-45 2-Methyl-2,4-pentanediol
2-Méthyl-2,4-pentanediol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-842. Synonyms: hexylene glycol; 2,4-dihydroxy-2-methyl pentane. Toxicity: irritation of the eyes, nose, pharynx and larynx and respiratory discomfort. Exposure limits (France): TWA = 125mg/m3 or 25ppm. EEC number and mandatory labelling codes: No.603-053-00-3; Xi, R36/38. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, 2000. 4p. Illus. 12 ref.

CIS 88-1454 Ethylene glycol
Etileno-glicol [in Portuguese]
Chemical safety information sheet. Based on Fiche toxicologique No.25-1987 published by the Institut national de recherches en sécurité (see CIS 87-411).
Prevenção no trabalho, Apr. 1988, No.116, p.16.

1987

CIS 87-842 2-Methyl-2,4-pentanediol
2-Méthyl-2,4-pentanediol [in French]
Chemical safety information sheet. Synonym: hexylene glycol. Moderately flammable liquid. Is absorbed through the skin. Irritates the eyes and mucous membranes at concentrations above 1,000ppm. Exposure limit: ACGIH (USA, 1986) Ceiling limit = 125mg/m3.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75690 Paris Cedex 14, France, 1987. 4p. 12 ref.

CIS 87-411 Ethyleneglycol
Ethylène-glycol [in French]
Chemical safety information sheet. Vapours may form explosive mixtures with air. Health hazards: depression of the central nervous system; irritation of eyes and upper respiratory tract. Exposure limit: ACGIH (USA, ceiling limit, 1986) = 125mg/m3.
Institut national de recheche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1987. 4p. 19 ref.

1986

CIS 89-76 Ethylene glycol
Chemical safety information sheet. Exposure limit: ACGIH TLV (ceiling value, vapour) = 125mg/m3. Toxicity: pulmonary oedema; depression of the central nervous system; kidney damage.
Indian Chemical Manufacturers Association, India Exchange, India Exchange Place, Calcutta 700 001, India, 1986. 1p.

1985

CIS 87-430 Propylene glycol
This Workplace Environmental Exposure Level Guide (WEEL) presents the available toxicological data and recommends appropriate exposure limits for industrial chemicals for which no standards have been developed. Synonym: 1,2-propanediol. Has a low level of toxicity by all routes of exposure. Skin irritation or sensitisation may occur from prolonged or repeated contact. Recommended exposure limits: 8h TWA limit =125mg/m3 for total vapour and aerosol; 8h TWA limit=10mg/m3 for aerosol alone.
American Industrial Hygiene Association, 475 Wolf Ledges Parkway, Akron, OH 44311, USA, 1985, 5p. 34 ref.

CIS 86-1912 Ethylene glycol
Contents of this data sheet: properties; occupational exposure limits (8-h TWA: 100ppm, 10-min short-term TWA: 125ppm, both as recommended for the United Kingdom for vapours; no limits for particulates); industrial uses; fire hazards and extinguishants to be used; hazardous reactions; toxicity and biological hazards (minor if absorbed orally or affecting the eye, but can be absorbed through the skin in toxic amounts); carcinogenicity (none); handling and storage; safety precautions; first aid.
Safety Practitioner, Nov. 1985, Vol.3, No.11, p.32-33. 9 ref.

CIS 86-1646 Koga M., Hori H., Tanaka I., Akiyama T., Inoue N.
Quantitative analysis of urinary ethylene glycol in rats
Ethylene glycol in urine was separated by azeotropic distillation and esterified with n-butylboronic acid. The derivatised ethylene glycol was separated by gaz chromatography at 70° on a 2m by 3mm glass column of 2% OV-225 on 60-80 mesh Uniport HPS. A flame ionisation detector was used. Known amounts of z-methylcyclohexanone were included in the samples as internal standards. A linear calibration curve was obtained up to 500µg/mL of ethylene glycol. The detection limit was 10µg/mL and the relative standard deviation was 3.5% for 100µg/mL of ethylene glycol. This method was used to determine the urinary excretion of ethylene glycol in rats exposed to ethylene oxide at various concentrations (50-500ppm). The amounts of ethylene glycol excreted were sigmoidally dependent on the concentration of ethylene oxide to which the rats had been exposed.
Journal of UOEH, Mar. 1985, Vol.7, No.1, p.45-49. Illus. 7 ref.

1983

CIS 84-1298 Swensson Å.
Propylene glycol
Propylenglykol [in Swedish]
Literature survey to serve as a basis for determination of exposure limits: metabolism, toxicity, organ effects, other effects. Propylene glycol has low toxicity; high doses have been given to animals in long-term experiments without negative effects. No studies that can be used to determine a hygienic standard are available. There is no evidence that inhalation of air saturated with propylene glycol has any deleterious effects.
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1983. 38p. 113 ref. Bibl.

1982

CIS 84-395 Filatova V.S., Smirnova E.S., Gronsberg E.Š., Russkih A.A., Klimova Ė.I., Kaštanova I.M., Gorjačeva L.A., Ždanova I.V.
Data for the establishment of a MAC for ethylene glycol in workplace air
Materialy k gigieničeskomu normirovaniju ėtilenglikolja v vozduhe rabočej zony [in Russian]
Exposure of rats and mice to ethylene glycol at a concentration of 198mg/m3 produced morphological and functional alterations in the kidney and liver and morphological alterations in the heart, thyroid, adrenals and blood. Ethylene glycol concentrations of 19mg/m3 produced no effect. Because clinical studies of workers in ethylene glycol and antifreeze production showed no adverse response to prolonged exposure to 0.1-5.0mg/m3, 5mg/m3 appears to be a reasonable MAC.
Gigiena truda i professional'nye zabolevanija, June 1982, No.6, p.28-30. 7 ref.

CIS 82-1977 Guillon F., Raphael J.C., Girard-Wallon C., Goulon M.
Toxicity of ethylene glycol. Case study of fatal ingestion
Toxicité de l'éthylène glycol. A propos d'un cas d'ingestion mortelle [in French]
Clinical and anatomo-pathological case study of death due to ethylene glycol (EG) ingestion. Review of toxicological data, clinical and biological factors in EG poisoning, problems involved and importance of rapid diagnosis. Description of symptoms and disorders observed at different stages of EG metabolism.
Archives des maladies professionnelles, 1982, Vol.43, No.3, p.163-168. Illus. 39 ref.

CIS 82-1321 Morel C., Gendre M., Cavigneaux A., Protois J.C.
Hexylene glycol
Hexylène-glycol [in French]
Synonyms, uses, physical and chemical properties, methods of detection and determination in air, fire hazards (flash-point: 93°C, closed-cup method), pathology and toxicology (skin and eye irritant, narcotic effect at high concentrations, USA (ACGIH) TLV: 25ppm or 125mg/m3). Reference to French OSH regulations, and to French and international regulations on transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 2nd quarter 1982, No.107, p.313-316. 11 ref.

1980

CIS 81-425
American Industrial Hygiene Association
Workplace environmental exposure level guide - Polypropylene glycols.
Information given: chemical and physical properties; toxicological and use experience; recommended workplace environmental exposure level (WEEL) guide. Polypropylene glycols present no significant hazard to health in the workplace environment, and a WEEL of 10mg/m3 is recommended.
American Industrial Hygiene Association Journal, Oct. 1980, Vol.41, No.10, p.A-53 to A-55. 8 ref.

CIS 81-420 Nordic Group of Experts for TLV Documentation - 14. Ethylene glycol
Nordiska expertgruppen för gränsvärdesdokumentation - 14. Etylenglykol [in Swedish]
Literature survey on the toxicity of this antifreeze and solvent: metabolic model (inhalation, ingestion, skin absorption, distribution, metabolism and elimination; biological half-life; factors influencing metabolism); toxic mechanisms; effects on skin and mucosae, liver, kidneys, stomach, heart, central nervous system, eyes; genetic and carcinogenic effects; exposure indices; dose-response relations; evaluation of data. Appended: TLVs adopted in 11 countries; sampling and analysis methods.
Arbetarskyddsverket, 17184 Solna, Sweden, 1980. 36p. 116 ref.

CIS 81-120 Brenner Ė.S.
Separate determination of ethylene glycol and methacrylic acid in air by thin-layer chromatography
Razdel'noe opredelenie ėtilenglikolja i metakrilovoj kisloty v vozduhe metodom tonkoslojnoj hromatografii [in Russian]
Studies with different solvents led to the use of a CHCl3-ethanol system (4:1) for separation of the substances sampled together, which is optimal for the mobile phase and can be used again. It is recommended to activate the plates at 105-110°C for 1h in advance and to protect them from humidity. Sensitivity of the assay is 1µg for each substance.
Gigiena truda i professional'nye zabolevanija, Feb. 1980, No.2, p.54-55. 5 ref.

CIS 81-112
American Industrial Hygiene Association
Workplace environmental exposure level guide - Polyethylene glycols.
Workplace environment exposure levels (WEELS) are provided for chemicals, stresses, or agents in the workplace for which there are no current authoritative guidelines. Information given: chemical and physical properties; toxicological and use experience; recommended WEEL guide. Polyethylene glycols present no significant hazard to health, and a WEEL of 10mg/m3 is recommended.
American Industrial Hygiene Association Journal, Sep. 1980, Vol.41, No.9, p.A-55 to A-57. 8 ref.

1978

CIS 78-1373 Koleva M.
Changes in urinary excretion of γ-glutamyl transpeptidase, leucine aminopeptidase and alkaline phosphatase on combined exposure to ethylene glycol and high temperature
Promeni v ekskrecijata na gama-glutamiltranspeptidazata, levcinaminopeptidazata i alkalnata fosfataza v urinata pri kombinirano dejstvie na etilenglikol i visoka temperatura [in Bulgarian]
Results of experiments with rats to determine these changes 2, 8, 15, 30 and 90 days after exposure, separately or simultaneously, to ethylene glycol (EG) (1/8 LD50) and 35°C ambient temperature. The effect of ambient heat alone caused an increase in enzyme excretion at the early stage of exposure, whereas exposure to EG alone caused a reduction in γ-glutamyl transpeptidase (GTR) and leucine-aminopeptidase, and an increase in alkaline phosphatase excretion. The temperature factor attenuated the toxic effect of EG on these enzymes towards the end of the observation period. Changes in GTR excretion are the earliest and most sensitive sign of tubular lesions.
Problemi na higienata, 1977, Vol.3, p.35-46. 26 ref.

1976

CIS 77-1227 Ethylene glycol.
Details are given of uses of ethylene glycol, hazards, fire precautions, source of further information, fire fighting, physical and chemical properties.
H 47, Information sheets on hazardous materials, Fire Protection Association, Aldermary House, Queen Street, London EC4N 1TJ, United Kingdom, June 1976. 2p.

1974

CIS 75-1368 Wills J.H., Coulston F., Harris E.S., McChesney E.W., Russell J.C., Serrone D.M.
Inhalation of aerosolized ethylene glycol by man.
After a brief review of the literature and a description of the signs and symptoms observed after experimental ethylene glycol ingestion, the authors present their own experiments in humans, in which 19 male volunteers were exposed to aerosolized ethylene glycol in mean daily concentrations of 3-67mg/m3 almost continually for 4 weeks. Blood and urine examinations gave no evidence of the absorption of important quantities of ethylene glycol. There were no serious signs of toxicity but some complaints of irritation of the upper respiratory tract. Irritation became common with an ethylene glycol concentration of 140mg/m3, and more than 200mg/m3 was intolerable. It was concluded that an individual with normal sensory apparatus could not absorb a harmful quantity of ethylene glycol through the respiratory tract. Detailed results of laboratory and psychometric tests are given in tables.
Clinical Toxicology, Oct. 1974, Vol.7, No.5, p.463-476. Illus. 27 ref.

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