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Aromatic amines - 303 entries found

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  • Aromatic amines

2007

CIS 08-760
Advisory Committee on Existing Chemicals (BUA)
Supplementary Reports XV (Nos. 96, 113, 126, 207, 208)
Ergänzungsberichte XV [in German]
This document includes translations of supplementary reports, finalized between August 1992 and December 1996, relating to five substances (N,N'-diphenylguanidine, N-phenyl-1-naphthylamine, 2,2'-dithio-bis-benzothiazole, N-isopropyl-N'-phenyl-1,4-phenylene diamine (IPPD) and N-(1,3-dimethylbutyl)-N` phenyl-1,4 phenylendiamine (6PPD)) evaluated in earlier BUA reports. The new data relate mainly to ecotoxicological aspects and the results of animal studies carried out following recommendations in the original reports. Sensitizing effects in humans are reported for N,N'-diphenylguanidine, N-phenyl-1-naphthylamine, N-isopropyl-N'-phenyl-1,4-phenylene diamine (IPPD) and N-(1,3-dimethylbutyl)-N' phenyl-1,4 phenylendiamine (6PPD).
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2007. 85p. Bibl.ref. Price: EUR 47.00.

2006

CIS 08-396 Rømyhr O., Nyfors A., Leira H.L., Smedbold H.T.
Allergic contact dermatitis caused by epoxy resin systems in industrial painters
A group of 2236 industrial painters employed in six companies of the Norwegian oil industry was followed between 1997 and 2001 to assess the incidence of allergic contact dermatitis (ACD) caused by exposure to epoxy resin systems. Commercially-available patch test series were supplemented with a series based on known or suspected sensitizers present at the workplaces. Of 57 patch-tested workers, 23 with ACD caused by epoxy resin systems were found, indicating an incidence rate of 4.5/1000 person years. Positive patch tests to 2,4,6-tris-(dimethylaminomethyl)phenol (tris-DMP) and m-xylene-α,α'-diamine (XAD) were seen in seven and eight workers, respectively, indicating that both chemicals are important sensitizers in industrial painters. They are, however, not classified as skin sensitizers according to the European regulations on the classification and labelling of dangerous chemicals.
Contact Dermatitis, Sep. 2006, Vol.55, No.3, p.167-172. 22 ref.

2005

CIS 06-1014
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals (BUA)
C. I. Acid Blue 9
Conclusions of this criteria document (status September 2002): C. I. Acid Blue 9 (E133) is a cosmetic dye, permitted for dyeing certain foods; data on sensitization in humans are difficult to assess; animal experiments indicate low acute toxicity after oral administration.
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2005. xiv, 147p. 115 ref. Price: EUR 54.50.

CIS 06-898 Gołofit-Szymczak M.
4,4'-Methylenedianiline: Documentation of maximum admissible values for occupational exposure
4,4'-Metylenodianilina: Dokumentacja proponowanych wartości dopuszczalnych wielkości narażenia zawodowego [in Polish]
4,4'-Methylenodianiline (MDA) exists as colourless to pale yellow crystalline flakes. Occupational exposure to MDA occurs by dermal, oral and inhalation routes. MDA is a hepatotoxic agent. Acute human exposure to MDA results in liver damage, cholangitis and centrilobular cholestasis. Chronic exposure also causes liver damage. The Expert Group has recommended a TLV of 0.8 mg/m3 for 4,4' -methylenodianiline. A skin notation and a carcinogen notation (probably carcinogenic to humans) are also assigned.
Podstawy i Metody Oceny Środowiska Pracy, 2005, Vol.44, No.2, p.131-161. 78 ref.

CIS 06-125 Wróblewska-Jakubowska K.
4,4'-Methylenodianiline - determination method
4,4'-Metylenodianilina - metoda oznaczania [in Polish]
A method for the determination of 4,4'-methylenodianiline in air is described. Air samples are collected by drawing a known volume of air through polypropylene filters. The filters are transferred into vials and the substance is extracted with 2 ml of a chloroform-methanol (4:1) mixture. The obtained extracts are analysed by high performance liquid chromatography with ultraviolet detection. The working range of the analytical method is 0.2 ÷ 2.4 µg/ml (0.02 ÷ 0.24 mg/m3 for 20 l of air sample).
Podstawy i Metody Oceny Środowiska Pracy, 2005, Vol.43, No.1, p.27-32.

2004

CIS 05-380 Rosenman K.D., Reilly M.J.
Cancer mortality and incidence among a cohort of benzidine and dichlorobenzidine dye manufacturing workers
538 workers potentially exposed to benzidine and/or dichlorobenzidine at a chemical manufacturing facility were followed. Vital status through 2001 and cancer incidence through 2002 were determined for all employees who worked at the facility from 1960 to 1977. 22 bladder cancer cases were identified. For three individuals, bladder cancer was the underlying cause of death. Increased standardized mortality ratios (SMRs) were 1.54 for all cancers, 8.34 for bladder cancer and 2.84 for lymphohaematopoietic cancer. The standardized incidence ratio (SIR) for bladder cancer was 6.85. Among the workers who were exposed to dichlorobenzidine only, there was a single case of bladder cancer, but an increased risk for lymphohaematopoietic cancer (SMR 6.62). This study confirms the high risk of bladder cancer among benzidine exposed workers even years after exposure has ceased, and raises suggestive evidence of increased risk of lymphohaematopoietic cancer from exposure to benzidine or dichlorobenzidine.
American Journal of Industrial Medicine, Nov. 2004, Vol.46, No.5, p.505-512. 32 ref.

CIS 05-7 Villa A.F., Conso F.
Aromatic amines
Amines aromatiques [in French]
While aromatic amines form part of one family of chemical compounds, their toxicity varies from one substance to another. They are used in a wide variety of industries. Contamination can occur through the skin, by inhalation or by ingestion. Acute toxic effects include methaemoglobinaemia (aniline), haemolytic anaemia and hepatitis (MDA), rhabdomyolysis with renal insufficiency, cardiomyopathy or eye disorders. Chronic effects can include irritation, and skin or respiratory sensitization (paraphenylene diamine). Several of these componds (benzidine, 2-naphtylamine) are known human carcinogens. Occupational bladder cancer is the most frequent cancer caused by exposure to aromatic amines. Regulations include a ban on the use of carcinogenic amines in occupational settings and the surveillance of previously-exposed workers.
Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle, 4th Quarter 2004, No.145, 11p. Illus. 91 ref.

CIS 04-629 Tchicaya A.F., Bonny J.S., Yeboue-Kouame Y.B., Wognin S.B., Kouassi M.Y.
Study of exposure to aromatic amines in the chemical industries in Abidjan
Etude de l'exposition aux amines aromatiques dans les industries chimiques à Abidjan [in French]
Aromatic amines are carcinogens. Prolonged exposure leads to bladder cancer. To assess the extent of this exposure, a prospective cross-sectional study was conducted among chemical industries in Abidjan. Interviews with workers were followed by job observations. Participants consisted of 362 workers (all male) of average age 34 years working in 12 companies where aromatic amines were used. Natural ventilation was the only form of ventilation in 75% of the cases. Monitoring of the working atmosphere was carried out in only 44% of the cases. Heavy nicotine addiction and urinary bilharziosis were found in 2% and 10.5% of the workers respectively. Personal protective equipment was insufficient and inadequate. Hygiene and working conditions safety committees were unknown or non operational and medical supervision was restricted to annual chest radiographs. These findings indicate the presence of bladder cancer risk and a poor enforcement of regulatory protection measures.
Archives des maladies professionnelles et de médecine du travail, Mar. 2004, Vol.65, No.1, p.36-40. 17 ref.

CIS 04-254
Advisory Committee on Existing Chemicals (BUA)
Pentachlorophenol (No. 3). 3-Trifluoromethylaniline (No. 44). Chlorotoluidines (No. 55). 2-Mercaptobenzothiazole (No. 74). Chlorinated paraffins (No. 93). 4-Chloro-2-methylphenol (No. 134). Dimethyldicykan (No. 143). Isodecanol (No. 149). Propargyl Alcohol (No 213)
This document comprises supplementary reports, finalized between December 1999 and June 2002, relating to nine substances evaluated in earlier BUA reports: pentachlorophenol (CIS 94-995), 3-trifluoromethylaniline (CIS 92-565), chlorotoluidines, benzothiazolethiol (CIS 97-1265), chlorinated paraffins (CIS 96-286), 4-chloro-o-cresol (CIS 95-2188), 4,4'-diamino-3,3'-dimethyldicyclohexylmethane, isodecyl alcohol (CIS 97-1269) and propargyl alcohol (CIS 02-572). The new data relate mainly to the results of ecotoxicity and animal studies carried out following recommendations made in the original reports. No new effects on humans are reported. Protective measures are recommended when handling some of these substances.
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2004. 152p. Bibl.ref. Price: EUR 54.50.

CIS 03-1772 Markowitz S.B., Levin K.
Continued epidemic of bladder cancer in workers exposed to ortho-toluidine in a chemical factory
Ortho-toluidine (o-toluidine), an aromatic amine, is classified by the International Agency for Research on Cancer as a probable human carcinogen. A cohort study published in 1991 reported a 6.5-fold excess incidence of bladder cancer in a US chemical plant that used o-toluidine. This article reports 19 additional cases of bladder cancer among workers in this cohort, yielding a total of 34 cases of bladder cancer in the cohort to date. The number of bladder cancers diagnosed in the recent period has increased. The timing of onset of exposure to o-toluidine of numerous cases of bladder cancer after 1968, and especially 1975, suggests that occupational exposures other than o-toluidine were probably not responsible for the observed excess bladder cancer. This study further supports the bladder carcinogenicity of o-toluidine.
Journal of Occupational and Environmental Medicine, Feb. 2004, Vol.46, No.2, p.154-160. Illus. 15 ref.

2003

CIS 05-165 Cassidy L.D., Youk A.O., Marsh G.M.
The Drake Health Registry Study: Cause-specific mortality experience of workers potentially exposed to beta-naphthylamine
The objective of this study was to examine the cause-specific mortality experience of a cohort with past exposure to beta-naphthylamine (BNA). Subjects were 374 male and 26 female workers employed at a chemical plant that produced or used BNA between 1940 and 1981. Vital status through 1998 was determined for 97.5% of the cohort and cause of death for 100% of 79 deaths. Industrial hygiene data and reports from former employees were used to categorize workers as high, medium, or low risk for BNA exposure. Standardized mortality ratios (SMRs) were calculated on the basis of mortality data of the local population. Statistically-significantly elevated SMRs were observed for all causes (SMR=1.98), all malignant neoplasms (28 deaths, SMR=3.08), respiratory system cancer (12 deaths, SMR=3.91) and bladder cancer (four deaths, SMR=16.83). Mortality risks were also elevated for most other malignant and non-malignant diseases examined.
American Journal of Industrial Medicine, Sep. 2003, Vol.44, No.3, p.282-290. 36 ref.

CIS 04-165 Fahrig R., Görlitz B.D., Preiß A.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Genotoxic effects of 3,3'-dihydroxybenzidine including stability investigations
Prüfung der genotoxischen Wirkung von 3,3'-Dihydroxybenzidin einschließlich Untersuchungen zur Stabilität [in German]
In this study, the mutagenic activity of 3,3'-dihydroxybenzidine in various biological systems was examined. 3,3'-dihydroxybenzidine induced isolated mutations in bacteria as well as genetic mutations and chromosomal aberrations in cell cultures (V79). In a UDS test (non-programmed DNA synthesis) on rat hepatocytes, toxic effects were observed on the hepatocytes, but there was no increase in DNA synthesis. There was no evidence of 3,3'-dihydroxybenzidine toxicity in a micronucleus test on mice. The stability of 3,3'-dihydroxybenzidine in acetonitrile and in aqueous and organic solvent mixtures was also examined. In the latter case, degradation was observed in both buffered and unbuffered mixtures.
Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2003. 196p. Illus. 7 ref. Price: EUR 17.00.

2002

CIS 05-519 Starek A.
N,N-Dimethylaniline
N,N-Dimetyloanilina [in Polish]
N,N-Dimethylaniline (DMA) is used as a solvent and chemical intermediate for organic synthesis. Exposure to this compound in industry is poorly documented. Experimental exposure to DMA in both humans and laboratory animals resulted in the following haematotoxic effects: symptoms of cyanosis; spleen enlargement; methaemoglobinaemia; extra marrow haematopoesis. DMA is clastogenic. However, carcinogenic, embryotoxic and teratogenic effects have not been confirmed. Based on the haematotoxic effects observed on rats administered DMA intragastrically, a LOAEL value of 31.25mg/m3 was determined, from which a threshold limit value (time-weighted average) of 12mg/m3 was derived, and a short-term exposure limit value of 40mg/m3 was proposed. Furthermore, a methaemoglobin concentration of 2% in peripheral blood was proposed as a biological exposure index value.
Podstawy i Metody Oceny Środowiska Pracy, 2002, Vol.33, No.3, p.103-116. 30 ref.

CIS 05-503 Starek A.
4-Aminobiphenyl
Bifenylo-4-amina [in Polish]
4-Aminobiphenyl is used in the rubber industry as an antioxidant and in the synthesis of azo dyes. It has a relatively low toxicity but is highly genotoxic and carcinogenic. The oral LD50 values for this compound in rodents range from 205 to 500mg/kg. 4-Aminobiphenyl and its metabolite N-hydroxy-4-aminobiphenyl demonstrate the ability to induce gene mutations in bacterial tests. This and other metabolites produce adducts with the DNA and RNA of bladder epithelial cells. The carcinogenic potential of 4-aminobiphenyl has been evidenced in some animal species and in humans. The substance induces bladder tumours. A threshold limit value (time-weighted average) of 0.001mg/m3 is proposed.
Podstawy i Metody Oceny Środowiska Pracy, 2002, Vol.31, No.1, p.5-23. Illus. 78 ref.

CIS 03-1056 m-Anisidine
m-Anisidine [in French]
International Chemical Safety Card published in 2002. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: methaemoglobinaemia; medical observation is indicated; effects may be delayed. Threshold limit value not established. Synonyms: 3-aminoanisole; 3-methoxyaniline; 3-aminophenol methyl ether; 3-methoxybenzeneamine.
Internet documents, 2002. 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc03/icsc0375.pdf [in English]
http://www.cdc.gov/Niosh/ipcsnfrn/nfrn0375.html [in French]

CIS 02-1560 Screening information data set SIDS for high production volume chemicals - Volume 8, Parts 1 and 2
Ecotoxicological and toxicological (acute toxicity, chronic toxicity, effects on reproduction, genetic effects) data for the risk assessment of 7 chemicals: 1,4-butanediol, p-tert-butylphenol, diacetone alcohol, 4-5-dihydroxy-1,3-bis(hydroxymethyl) imidazolidin-2-one (synonym: dimethylol dihydroxyethylene urea), glycidyl methacrylate, 4,4'- methylenedianiline and 1,1,2-trichloroethane.
United Nations Environment Programme, 11-13 chemin des Anémones, 1219 Châtelaine, Genève, Switzerland, Nov. 2002. viii, 264p. Bibl.ref. (Part 1); viii, 302p. Bibl.ref. (Part 2).

2001

CIS 04-675 Tomás García P., Obiols Quinto J.
Aniline exposure assessment: Environmental and biological monitoring
Evaluación de la exposición a anilina: control ambiental y biológico [in Spanish]
This information note on the evaluation of exposure to aniline covers biological and environmental monitoring. Contents: characteristics of aniline; metabolism and toxicokinetics; effects on health (methaemoglobinaemia, damage to the central nervous system, bladder cancer); classification (harmful by inhalation, ingestion and skin contact, and highly toxic to aquatic organisms); threshold limit values (daily TLV 2ppm); sampling and analysis methods for aniline in workplace air; biological monitoring (determination of p-aminophenol in urine and methaemoglobin in blood).
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 2001. 6p. Illus. 9 ref.
http://internet.mtas.es/Insht/ntp/ntp_584.htm [in Spanish]

CIS 03-66
Agency for Toxic Substances and Disease Registry (ATSDR)
Toxicological profile for benzidine (Update)
This profile was prepared in accordance with guidelines set by the US Agency for Toxic Substances and Disease Registry and the EPA. The key literature related to the toxic effects of benzidine is identified and reviewed. Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: carcinogenic effects (primarily bladder cancer and other sites); immunological effects (T-lymphocyte reduction); allergic eczematous dermatitis and sensitization. (Update of CIS 97-227).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Sep. 2001. xix, 201p. Illus. Approx. 720 ref.
http://www.atsdr.cdc.gov/toxprofiles/tp62.html [in English]

2000

CIS 02-1137 4,4'-Diaminodiphenylmethane
4,4'-Diaminodiphénylméthane [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-108. Synonyms: 4,4'-methylenedianiline; p,p'-diaminophenylmethane; MDA; DDM; DADP; DADPM. Acute toxicity: liver damage; myocardiopathy. Chronic toxicity: allergic skin diseases; photosensitization; yellow staining of integuments. Exposure limits (USA ACGIH 2000): TWA = 0.8mg/m3 (0.1ppm). EEC number and mandatory labelling codes: No.612-051-00-1; T, N, R45, R39/23/24/25, R48/20/21/22, R43, R51/53, S53, S45, S61, 202-974-4. Complete datasheet collection on CD-ROM analysed under CIS 02-1407.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, 2002. 4p. Illus. 24 ref.

CIS 02-1134
German Chemical Society - GDCh-Advisory Committee on Existing Chemicals (BUA)
Diphenylamine (No.15); Bis(2-chloroethyl)ether (No.21); Naphthalene (No.39); Tetrachloromethane (No.45); Biphenyl (No.50); N,N-Dimethylaniline (No.91); Trichloroethene (No.95); Hexachlorobenzene (No.119); Bisphenol A (no.203)
These short reports concern 9 substances suspected of having a hazardous potential, but for which available data are insufficient. The purpose of these reports is to establish a basis for assessment, identify gaps in knowledge and recommend areas for further investigation.
S. Hirzel Wissenschaftliche Verlagsgesellschaft mbH, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2000. 136p. Bibl.ref.

CIS 02-169 Alguacil J., Kauppinen T., Porta M., Partanen T., Malats N., Kogevinas M., Benavides F.G., Obiols J., Bernal F., Rifa J., Carrato A.
Risk of pancreatic cancer and occupational exposures in Spain
Cases of pancreatic cancer and controls among hospital patients free of pancreatic cancer were identified during their stay in hospital. Occupational history was obtained by direct interviews with the patients. Occupational exposures to 22 suspected carcinogens associated with pancreatic cancer in previous studies were evaluated. Increased odds ratios (OR) were apparent in all pesticide groups, highest for arsenical pesticides (OR = 3.4) and "other pesticides" (OR = 3.17). ORs were also higher for high-intensity exposure to aniline derivatives, dyes and organic pigments. ORs above 3 were observed for pesticides, benzo(a)pyrene, lead, volatile sulfur compounds, and sedentary work. Results lend support to the hypothesis of an association between exposure to some pesticides and pancreatic cancer. Suggestive increases in risk from aniline derivatives, dyes and organic pigments, and benzo(a)pyrene also deserve further study.
Annals of Occupational Hygiene, Aug. 2000, Vol.44, No.5, p.391-403. 72 ref.

CIS 01-1316 N-Isopropyl-N'-phenyl-p-phenylenediamine
N-Isopropyl-N'-phényl-p-phénylènediamine [in French]
N-isopropiel-N'-fenil-p-fenilendiamina [in Spanish]
International Chemical Safety Card. Exposure route: inhalation. Short-term exposure effects: irritation of the skin and eyes. Long-term exposure effects: prolonged or repeated contact may induce skin sensitization. No TLV has been established.
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 00-1557 p-Phenylenediamine
Diamina de p-fenileno [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit: 0.1 mg/m3 8h-TWA (OSHA). Toxicity: irritation of the throat; allergic asthma; sensitization; skin rash; contact dermatitis.
Noticias de seguridad, June 2000, Vol.62, No.6. 4p. Insert.

1999

CIS 03-1060 1,4-Benzenediamine dihydrochloride
Dichlorhydrate de benzène-1,4-diamine [in French]
International Chemical Safety Card. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: irritation of skin, eyes and respiratory tract; methaemoglobinaemia; kidney impairment; effects may be delayed. Long-term exposure effects: prolonged or repeated contact may induce skin sensitization and asthma. Threshold limit value (as 1,4-benzenbediamine): 0.1mg/m3 (ACGIH 1999). Synonyms: 1,4-phenylenediamine dihydrochloride, 1,4-diaminobenzene dihydrochloride; 4-aminoaniline dihydrochloride; p-phenylenediamine dihydrochloride.
Internet documents, 1999. 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc03/icsc0386.pdf [in English]
http://www.cdc.gov/Niosh/ipcsnfrn/nfrn0386.html [in French]

CIS 01-1746 Blome H., Lichtenstein N., Kredel P., Goergens U.
2-Naphthylamine - Material samples, environmental concentrations, biological monitoring
2-Naphthylamin - Materialproben, Luftkonzentrationen, Biomonitoring [in German]
2-Naphthylamine is a human carcinogen to which exposure is prohibited in Germany. Although this substance is no longer produced, it exists in certain other products as an impurity. Concentrations of 2-naphthylamine were determined in samples of a number of products including those formed by pyrolysis (coal tar products, chimney soot, cigarette smoke) and products based on mineral oil. Concentrations in the air of an old coking plant and a primary aluminium plant were also determined, as well as in the air breathed by chimney sweeps. For the latter, concentrations were below detection levels. During biological monitoring of workers exposed to an adhesive based on coal tar, no 2-naphthylamine was detectable in the urine.
Gefahrstoffe Reinhaltung der Luft, Nov.-Dec. 1999, Vol.59, No.11-12, p.445-446. 11 ref.

CIS 00-1667 Armstrong D.K.B., Jones A.B., Smith H.R., Ross J.S., White I.R., Rycroft R.J.G, McFadden J.P.
Occupational sensitisation to p-phenylenediamine: A 17-year review
The substance p-phenylenediamine (PPD) is a potent contact allergen commonly found in hairdye. Between 1982 and 1998, 26,706 patients with suspected contact dermatitis were patch tested. 667 (2.5%) were positive. The commonest sites of dermatitis were the hands (35%) and the face and neck (27%). Of occupational groups, hairdressers had the highest rate of PPD allergy (19%), the great majority with hand dermatitis, followed by rubber workers (6%).
Contact Dermatitis, Dec. 1999, Vol.41, No.6, p.348-349. 12 ref.

CIS 00-32 Ortho-toluidine
Orto-toluidina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 22mg/m3. Health hazards: skin absorption; irritation of the eyes; methaemoglobinaemia; hypoxia; cyanosis; haematuria.
Noticias de seguridad, Aug. 1999, Vol.61, No.8, 4p. Insert.

CIS 99-1800 beta-Naphthylamine
Beta-naftilamina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: 2-naphthylamine; bladder tumour; carcinogens; data sheet; determination in air; dyspnoea; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; irritants; limitation of exposure; liver cancer; medical supervision; neurological effects; personal protective equipment; respirators; USA; waste disposal.
Noticias de seguridad, July 1999, Vol.61, No.7, 5p. Insert.

CIS 99-1450 alpha-Naphthylamine
Alfa-naftilamina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: 1-naphthylamine; bladder tumour; data sheet; delayed effects; determination in air; dyspnoea; eczema; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; irritants; irritation; labelling; limitation of exposure; medical supervision; methaemoglobinaemia; neurological effects; personal protective equipment; respirators; skin absorption; skin allergies; storage; USA; waste disposal.
Noticias de seguridad, Feb. 1999, Vol.61, No.2. 5p. Insert.

CIS 99-1448 4-Aminobiphenyl
4-Aminodifenilo [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: 4-aminobiphenyl; bladder diseases; bladder tumour; carcinogens; data sheet; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; irritants; labelling; limitation of exposure; medical supervision; methaemoglobinaemia; personal protective equipment; self-contained breathing apparatus; skin absorption; storage; USA; waste disposal.
Noticias de seguridad, Jan. 1999, Vol.61, No.1. 5p. Insert.

1998

CIS 00-1326 Vitry-Henry L., Deschamps F., Léone J., Germain M.L., Richard G., Pennaforte J.L.
Lupus induced by aromatic amines in a hairdresser
Lupus induit par les amines aromatiques chez une coiffeuse [in French]
Aromatic amine-induced toxic lupus is uncommon. A case in a hairdresser is reported. Laboratory findings showed a pattern of toxic lupus. Aromatic amines were found in hair dyes and permanent lotions. The patient was not taking any drugs. A cause-effect relationship was established between the aromatic amines and lupus. Based on the Pharmacovigilance Centre's methodology for unexpected or toxic drug reactions, intrinsic toxicity is likely.
Archives des maladies professionnelles et de médecine du travail, Dec. 1998, Vol.59, No.8, p.548-551. 13 ref.

CIS 00-60
Agency for Toxic Substances and Disease Registry (ATSDR)
Toxicological profile for methylenedianiline
Topics: methylenedianiline; criteria document; exposure evaluation; glossary; health hazards; hepatotoxic effects; limitation of exposure; literature survey; sensitization dermatitis; skin absorption; skin eruption; toxic effects; toxicity evaluation; toxicology; USA.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1998. xvii, 158p. Illus. approx. 220 ref.

CIS 99-1437 Trifluralin
Topics: anaemia; trifluralin; data sheet; delayed effects; elimination of spills; fire hazards; first aid; glossary; health hazards; hepatotoxic effects; irritants; limitation of exposure; medical examinations; nephrotoxic effects; New Jersey; personal protective equipment; photosensitization dermatitis; respiratory diseases; skin absorption; skin diseases; storage; toxic gases; USA.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 99-1236 Brouwer D.H., Hoogendoorn L., Bos P.M.J, Boogaard P.J., van Hemmen J.J.
Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 2. Feasibility study for application in an exposure scenario for MDA by two different dermal exposure sampling methods
Six workers were monitored for exposure to 4,4'-methylene dianiline (MDA) in a factory that made glass fibre reinforced resin pipes. Dermal exposure of the hands and forearms was assessed during week 1 by a surrogate skin technique (cotton monitoring gloves) and during week 2 by a removal technique (hand wash). Urinary excretion of MDA over 24 hours was also measured during week 2. Surface contamination of the workplace and equipment was monitored qualitatively by colorimetric wipe samples. Significant differences between the mean daily exposure of the hands (for both weeks and sampling methods) were found for all workers. The results of the colorimetric wipe samples indicated a general contamination of the workplace and equipment. Cumulative hand wash and MDA excretion results over a week showed a high correlation. It is concluded that both dermal exposure monitoring methods were applicable and showed a compatible performance in the present exposure scenario, where the exposure relevant to dermal absorption is considered mainly restricted to hands. For Part 1, see CIS 99-1235. Topics: methylenedianiline; colorimetry; description of technique; evaluation of technique; exposure evaluation; exposure tests; limitation of exposure; sampling methods; skin absorption; urinary excretion.
Occupational and Environmental Medicine, Dec. 1998, Vol.55, No.12, p.805-811. Illus. 51 ref.

CIS 99-1235 Bos P.M.J., Brouwer D.H., Stevenson H., Boogaard P.J., de Kort W.L.A.M., van Hemmen J.J.
Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 1. Development of a concept to derive a quantitative dermal occupational exposure limit
An attempt was made to develop a quantitative dermal occupational exposure limit (DOEL) complementary to respiratory occupational exposure limits (OELs). The DOEL refers to the total dose deposited on the skin during a working shift. Based on available data and experience a theoretical procedure for the assessment of a DOEL was developed. A DOEL was derived for cyclophosphamide and 4,4'-methylene dianiline (MDA) according to this procedure. The DOEL for MDA was tested for applicability in an occupational exposure scenario. The proposed concept for a DOEL is relevant and can be made applicable for health surveillance in occupational situations where dermal exposure contributes notably to systematic exposure. For Part 2, see CIS 99-1236. Topics: methylenedianiline; description of technique; determination of exposure limits; exposure tests; limitation of exposure; skin absorption; threshold limit values.
Occupational and Environmental Medicine, July-Dec. 1998, Vol.55, No.12, p.795-804. Illus. 48 ref.

CIS 99-1110 2-Naphthylamine
Topics: 2-naphthylamine; bladder tumour; carcinogens; combustible substances; data sheet; dyspnoea; elimination of spills; explosion hazards; fire hazards; first aid; glossary; health hazards; irritation; limitation of exposure; medical examinations; methaemoglobinaemia; New Jersey; personal protective equipment; skin absorption; storage; USA.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 99-1107 5-Nitro-o-anisidine
Topics: 5-nitro-o-anisidine; carcinogenic effects; combustible substances; data sheet; dyspnoea; elimination of spills; fire hazards; first aid; glossary; health hazards; limitation of exposure; medical examinations; methaemoglobinaemia; New Jersey; personal protective equipment; skin absorption; storage; USA.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 99-957 Koennecker G., Mangelsdorf I., Wibbertmann A.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
N-Phenyl-1-naphthylamine
Summaries in French and in Spanish. Topics: carcinogenic effects; N-phenyl-1-naphthylamine; criteria document; ecotoxicology; first aid; IPCS; literature survey; toxic effects; toxicology.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 25p. 71 ref. Price: CHF 13.00 (CHF 9.10 in developing countries).
http://www.who.int/ipcs/publications/cicad/en/cicad09.pdf [in English]

CIS 99-954
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Chloroform (No.1). 1,1,2,2-Tetrachloroethane (No.29). 1,1-Dichloroethene (No.33). Chloroethane (No.60). 1,2,4,5-Tetrachlorobenzene (No.86). N,N'-Diphenylguanidine (No.96). Phenylenediamines (No.97). Aminofen (No.118)
Supplementary reports to CIS 94-994, CIS 92-570, CIS 94-1009, CIS 94-1679, CIS 95-1797 and CIS 96-287. Topics: 1,1,2,2-tetrachloroethane; 1,2,4,5-tetrachlorobenzene; 4-(2,4-dichlorophenoxy)aniline; animal experiments; diphenylguanidine; p-phenylenediamine; phenylenediamine; chloroform; ethyl chloride; vinylidene chloride; o-phenylenediamine; criteria document; ecotoxicology; Germany; legislation; literature survey; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O.Box 10 10 61, 70009 Stuttgart, Germany, 1998. 120p. Bibl. Price: DEM 80.00.

CIS 99-952
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
N-Isopropyl-N'-phenyl-1,4-phenylene diamine (IPPD). N-(1,3-Dimethylbutyl)-N'-phenyl-1,4-phenylene diamine (6PPD)
Topics: animal experiments; isopropylphenylphenylenediamine; dimethylbutylphenylphenylenediamine; criteria document; ecotoxicology; Germany; irritation; legislation; literature survey; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O.Box 10 10 61, 70009 Stuttgart, Germany, 1998. xvii, 70p. and xii, 72p. Bibl.ref. Price: DEM 97.00.

CIS 99-948
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
4-Chloro-o-toluidine - Evaluation of the carcinogenicity and genotoxicity
Summary in Dutch. Topics: 4-chloro-o-toluidine; carcinogenic effects; criteria document; mutagenic effects; Netherlands; toxicity evaluation; toxicology.
Gezondheidsraad, Postbus 1236, 2280 CE Rijswijk, Netherlands, 1998. 35p. 9 ref.

CIS 99-946
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
o-Phenylenediamine - Evaluation of the carcinogenicity and genotoxicity
Summary in Dutch. Topics: carcinogenic effects; o-phenylenediamine; criteria document; mutagenic effects; Netherlands; toxicity evaluation; toxicology.
Gezondheidsraad, Postbus 1236, 2280 CE Rijswijk, Netherlands, 1998. 33p. 18 ref.

CIS 99-535 Je@z8ewska A.
Aniline
Anilina [in Polish]
Topics: aniline; description of technique; determination in air; gas chromatography; sampling and analysis.
Podstawy i Metody Oceny Środowiska Pracy, 1998, Vol.19, p.17-20. 1 ref.

CIS 99-567 Axtell C.D., Ward E.M., McCabe G.P., Schulte P.A., Stern F.B., Glickman L.T.
Underlying and multiple cause mortality in a cohort of workers exposed to aromatic amines
In a follow-up study at a synthetic dye plant that manufactured beta-naphthylamine from 1940 to 1979, underlying and nonunderlying causes of death were analyzed to end 1992 using data from the National Death Index. There were three bladder cancer deaths listed as underlying cause (standardized mortality ratio (SMR) 2.4) and a total of eight bladder cancers listed anywhere on the death certificates (SMR 5.6). Mortality from all causes was significantly higher than expected. The elevated bladder cancer risk in this cohort was detected by the multiple cause, but not the underlying cause, analysis. Elevated mortality from other causes of death, especially among short-term workers, may be related to regional and lifestyle factors. Topics: aromatic amines; bladder tumour; cohort study; dyestuff industry; long-term study; mortality.
American Journal of Industrial Medicine, Nov. 1998, Vol.34, No.5, p.506-511. 20 ref.

CIS 98-1157 4-Chloro-o-toluidine hydrochloride
Topics: bladder diseases; bladder tumour; carcinogens; p-chloro-o-toluidine hydrochloride; data sheet; elimination of spills; fire fighting; fire hazards; first aid; health hazards; irritation; limitation of exposure; medical examinations; methaemoglobinaemia; New Jersey; personal protective equipment; renal damage; respirators; skin absorption; storage; USA; waste disposal.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 98-839 Gregg N., Dobson S., Cary R.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
o-Toluidine
Topics: carcinogens; o-toluidine; criteria document; first aid; ILO; IPCS; literature survey; sampling and analysis; skin absorption; threshold limit values; toxic effects; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. iv, 18p. 60 ref. Price: CHF 13.00 (CHF 9.10 in developing countries).
http://www.who.int/ipcs/publications/cicad/en/cicad07.pdf [in English]

CIS 98-816
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
2,4-Toluylenediamine (1,3-diamino-4-methylbenzene) and 2,6-toluylenediamine (1,3-diamino-2-methylbenzene)
This report is a translation of a report finalized in German in August 1995. Topics: 2,4-diaminotoluene; 2,6-diaminotoluene; carcinogenic effects; criteria document; ecotoxicology; Germany; hepatic damage; legislation; literature survey; poisoning; skin absorption; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1998. xviii, 159p. 303 ref.

CIS 98-414 Dimethylaniline
Dimetilanilina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: N,N-dimethylaniline; cyanogenic effects; data sheet; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; hypoxia; irritation; limitation of exposure; medical supervision; methaemoglobinaemia; neurotoxic effects; personal protective equipment; respirators; skin absorption; USA; waste disposal.
Noticias de seguridad, Jan. 1998, Vol.60, No.1. 4p. Insert.

1997

CIS 01-681 Aniline
Aniline [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 89-1113. Acute toxicity: methaemoglobinaemia; cyanosis; anaemia; eye irritation; skin absorption. Chronic toxicity: headache, vertigo, asthenia and cyanosis; haemolytic anaemia; eczematous dermatosis. Exposure limits (France): TWA = 10mg/m3 (2ppm). EEC number and mandatory labelling codes: No.612-008-00-7; T, N, R20/21/22, R40, R48/23/24/25, R50, S28, S36/37, S45, S61, 200-539-3. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 5p. Illus. 30 ref.

CIS 00-1052 Robert A., Ducos P., Francin J.M.
Assessment of occupational exposure to 4,4'-methylenedianiline (MDA) in France
Evaluación de la exposición profesional a la 4,4-metilendianilina (MDA) en Francia [in Spanish]
Translation of an article originally published in the French journal Cahiers de notes documentaires - Hygiène et sécurité du travail, 4th Quarter 1996, No.165, Note No.2032-165-96 (see CIS 97-173). Contents: Methylenedianiline (MDA), a suspected human carcinogen in the European carcinogen classification system, is used in a number of industrial sectors in conjunction with resins and composite materials. Exposure to MDA was assessed in workers in 10 French firms by measuring urinary MDA excretion levels. Analysis of 368 post-shift urine samples collected from 133 workers reveals that urinary excretion of MDA is much higher in workers handling flaked MDA than in those handling MDA in solution (44% and 8% of values, respectively, in excess of 50µg/L). The mean rates were 140µg/L for the factories using flaked MDA and 13µg/L for the 6 factories using liquid formulations, with values ranging from 58 to 197µg/L and from <2 to 33µg/L respectively. Simple modifications of working practices can greatly reduce the urinary excretion levels, especially in workers handling flaked MDA. The usefulness of biological monitoring for following up exposed workers and assessing preventive measures is stressed. In the light of the current technical and analytical possibilities in France, it is recommended to reduce the present biological guide value used by industrial hygienists from 100µg/L down to 50µg/L.
Medicina y seguridad del trabajo, 1997, Vol.XLIV, No.173, p.1-11. 35 ref.

CIS 98-840
Health and Safety Executive
Aniline - Risk assessment document
Topics: aniline; carcinogenic effects; criteria document; exposure evaluation; exposure tests; hypoxia; irritants; methaemoglobinaemia; mutagenic effects; sampling and analysis; sensitization; skin absorption; toxic effects; toxicology; United Kingdom.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1997. iv, 79p. Bibl.ref. Price: GBP 10.00.

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