Aliphatic amines - 169 entries found

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2004

CIS 04-254
Advisory Committee on Existing Chemicals (BUA)
Pentachlorophenol (No. 3). 3-Trifluoromethylaniline (No. 44). Chlorotoluidines (No. 55). 2-Mercaptobenzothiazole (No. 74). Chlorinated paraffins (No. 93). 4-Chloro-2-methylphenol (No. 134). Dimethyldicykan (No. 143). Isodecanol (No. 149). Propargyl Alcohol (No 213)
This document comprises supplementary reports, finalized between December 1999 and June 2002, relating to nine substances evaluated in earlier BUA reports: pentachlorophenol (CIS 94-995), 3-trifluoromethylaniline (CIS 92-565), chlorotoluidines, benzothiazolethiol (CIS 97-1265), chlorinated paraffins (CIS 96-286), 4-chloro-o-cresol (CIS 95-2188), 4,4'-diamino-3,3'-dimethyldicyclohexylmethane, isodecyl alcohol (CIS 97-1269) and propargyl alcohol (CIS 02-572). The new data relate mainly to the results of ecotoxicity and animal studies carried out following recommendations made in the original reports. No new effects on humans are reported. Protective measures are recommended when handling some of these substances.
S. Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2004. 152p. Bibl.ref. Price: EUR 54.50.

2003

CIS 03-754 Page E.H., Cook C.K., Hater M.A., Mueller C.A., Grote A.A., Mortimer V.D.
Visual and ocular changes associated with exposure to two tertiary amines
To determine if exposure to dimethylisopropanolamine (DMIPA) and dimethylaminoethanol (DMAE) in a label-printing plant was associated with visual disturbances or ocular changes, questionnaire surveys, eye examinations (visual acuity, contrast sensitivity, slit lamp biomicroscopy and pachymetry) and measurements of workplace airborne concentrations of DMIPA and DMAE were performed over a two-week period. 89% of line (high-speed printing) workers reported having experienced blurry vision while at work in the past 12 months, compared to 12.5% of prime (lower-speed printing) workers. The mean time weighted average concentrations of DMIPA, DMAE and total amines were significantly higher in the line division than in the prime division. Higher levels of total amines were associated with increased risk of reporting blurry vision, halo vision, and blue-gray vision. The prevalence of corneal opacity increased with increasing duration of exposure to total amines and with increasing concentration of total amines. There was a statistically significant relation between total amine concentration and increased risk of reduced bilateral visual acuity and 2.5% contrast sensitivity.
Occupational and Environmental Medicine, Jan. 2003, Vol.60, No.1, p.69-75. Illus. 11 ref.

2002

CIS 05-512 Kupczewska-Dobecka M., Czerczak S.
Trimethylamine
Trimetyloamina [in Polish]
Trimethylamine is used in pest control, as an olfactory warning agent against natural gas leaks, as a flotation agent and as an intermediate in chemical synthesis. It is a skin and eye irritant. Concentrated aqueous solutions applied to human skin have caused severe burning and hyperaemia. Long-term exposure to trimethylamine vapours at a concentration of 48.5mg/m³ caused nasal, eye and skin irritation, while exposure at concentrations of 0.24-19.5mg/m³ produced no observable irritation. Based on these human data, the Polish Expert Group for Chemical Agents established a threshold limit value (8-hour time-weighted average) of 12mg/m³ and a short-term exposure limit value of 24mg/m³.
Podstawy i Metody Oceny Środowiska Pracy, 2002, Vol.31, No.1, p.137-154. 30 ref.

CIS 05-504 Sapota A., Ligocka D.
Ethylenediamine
Etylenodiamina [in Polish]
Ethylenediamine is used as a chemical intermediate in the synthesis of chelating compounds, fungicides, synthetic waxes, polyamide resins and anticorrosive agents and as an emulsifier and rubber stabilizer. In humans, ethylenediamine demonstrates moderate to strong irritation of the nasal mucosa. Ethylenediamine vapours are irritating to the eyes, mucosa and respiratory tract of experimental animals. No harmful effects were observed at a concentration of 147.5mg/m³, which is assumed to be the no observed adverse effect level (NOAEL). In animal experiments, no carcinogenic, teratogenic or embryotoxic activity was found nor any effects on reproduction. The suggested threshold limit value (time-weighted average) is 20mg/m³. Because of the strong the irritating action of ethylenediamine, it is suggested that the short-term exposure limit value be set at 50mg/m³. Since the LD₅₀ value through skin exposure is lower than 1000mg/kg, it is suggested that the skin absorption symbol "Sk" be added.
Podstawy i Metody Oceny Środowiska Pracy, 2002, Vol.31, No.1, p.25-35. 20 ref.

2001

CIS 02-821 Dibo M., Brasch J.
Occupational allergic contact dermatitis from N,N-bis(3-aminopropyl)dodecylamine and dimethyldidecylammonium chloride in 2 hospital staff
A case study of 2 nurses developing eczema on their hands and arms after contact with a new disinfectant containing quaternary ammonium compounds. After changing their workplace, the nurses recovered.
Contact Dermatitis, July 2001, Vol.45, No.1, p.40. 3 ref.

2000

CIS 02-556 Diisopropylamine
Diisopropilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit: 20mg/m³ or 5ppm (OSHA). Exposure routes: inhalation, ingestion and skin absorption. Toxicity: irritation of the skin, eyes and respiratory tract, headache; vision disorders; nausea.
Noticias de seguridad, Nov. 2000, Vol.62, No.11, 4p. Insert.

1999

CIS 02-854 Buschmann J., Dasenbrock C., Pohlmann G., Bartsch W., Creutzenberg O., Ernst H., Schneider B.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
90-day inhalation toxicity study of di-n-butylamine in Wistar (WU) rats
90-Tage Inhalationstoxizitätsprüfung von Di-n-butylamin an Wistar (WU)-Ratten [in German]
Dibutylamine is a known skin and eye irritant. The objective of this study was to investigate whether the irritant nature of dibutylamine also applies to the respiratory tract and gives rise to inhalation toxicity. Rats were exposed to dibutylamine concentrations of 0, 50, 150 and 450mg/m³ over 90 days. Pathological examinations were carried out on randomly-selected rats after 3, 28 and 91 days. Irritating effects could only be shown in the nasal cavities. Effects were noted in the high dose group after 3 and 28 days. Slight adaptive effects in the form of mucous cell hyperplasia were also seen in the low dose group after 91 days. Only marginal effects were observed in the lungs.
Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 1999. 218p. Illus. 1 ref. Price: EUR 18.00.

CIS 01-1350 Isopropylamine
Isopropylamine [in French]
Isopropilamina [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: corrosive for the skin, eyes and respiratory tract; corrosive by inhalation; inhalation may cause pulmonary oedema; ingestion may cause chemical pneumonitis; effects may be delayed; exposure may lead to death. Long-term exposure effects: prolonged or repeated contact may cause dermatitis. Threshold limit values: 5ppm (TWA); 10ppm (STEL) (ACGIH 1995-1996).
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 01-1347 Isobutylamine
Isobutylamine [in French]
Isobutilamina [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation and ingestion. Short-term exposure effects: corrosive for the skin, eyes and respiratory tract; corrosive by inhalation; inhalation may cause pulmonary oedema; effects may be delayed. No TLV has been established; MAK=5ppm; 15mg/m³.
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 00-45 Cary R., Dobson S., Delic J.
Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
1,2-Diaminoethane (ethylenediamine)
Ethylenediamine is an irritant to skin and eyes. It induces allergic skin reactions and has sensitizing properties. It is also a respiratory tract irritant causing respiratory tract hypersensitivity, bronchoconstriction and asthma. Summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1999. iv, 30p. 129 ref. Price: CHF 16.00 (CHF 11.20 in developing countries).
http://www.who.int/ipcs/publications/cicad/en/cicad15.pdf [in English]

CIS 00-169 Reed J., Shaw S.
Occupational allergic contact dermatitis in water-pipe renovators from diethylenetriamine in an epoxy resin system
Topics: diethylenetriamine; case study; eczema; epoxy resins; hand; repair work; sensitization dermatitis; skin allergies; skin tests; water supply.
Contact Dermatitis, Nov. 1999, Vol.41, No.5, p.297. 3 ref.

CIS 99-1250 Järvinen P., Engström K., Riihimäki V., Ruusuvaara P., Setälä K.
Effects of experimental exposure to triethylamine on vision and the eye
Four people were exposed to triethylamine (TEA) for four hours at three concentration levels. After exposure to 40.6 mg/m³ TEA there was a marked oedema in the corneal epithelium and subepithelial microcysts. However, corneal thickness increased only minimally because of the epithelial oedema. The lachrymal concentrations of TEA were, on average, 41 times higher than the serum TEA concentrations. The vision was blurred in all subjects and visual acuity and contrast sensitivity had decreased in three of the four subjects. After exposure to TEA at 6.5 mg/m³ two subjects experienced symptoms, and contrast sensitivity had decreased in three of the four subjects. TEA caused a marked oedema and microcysts in corneal epithelium but only minor increases in corneal thickness. The effects may be mediated by the lachrymal fluid owing to its high TEA concentration. Four hour exposure to a TEA concentration of 3.0 mg/m³ seemed to cause no effects, whereas exposure to 6.5 mg/m³ for the same period caused blurred vision and a decrease in contrast sensitivity. Topics: amblyopia; biological threshold limits; trimethylamine; chemical industry; corneal damage; exposure evaluation; eyes; lacrimating agents; visual acuity; visual function disorders.
Occupational and Environmental Medicine, Jan. 1999, Vol.56, No.1, p.1-5. Illus. 11 ref.

1998

CIS 99-547 Domański W.
2,2'-Iminobis(ethylamine)
2,2'-Iminobis(etyloamina) [in Polish]
Topics: diethylenetriamine; description of technique; determination in air; gas chromatography; sampling and analysis.
Podstawy i Metody Oceny Środowiska Pracy, 1998, Vol.19, p.96-99. 3 ref.

CIS 99-207 Kanerva L., Jolanki R., Estlander T.
Occupational epoxy dermatitis with patch test reactions to multiple hardeners including tetraethylenepentamine
Topics: amines; tetraethylenepentamine; case study; eczema; epoxy resins; hardeners; paint spraying; paints; sensitization dermatitis; skin tests.
Contact Dermatitis, May 1998, Vol.38, No.5, p.299-301. Illus. 17 ref.

CIS 99-174 Sommer S., Wilkinson S.M.
Contact dermatitis caused by phenoxybenzamine hydrochloride
Topics: phenoxybenzamine hydrochloride; case study; drugs; eczema; irritants; nursing personnel; sensitization dermatitis; skin allergies.
Contact Dermatitis, June 1998, Vol.38, No.6, p.352-353. 4 ref.

CIS 99-173 Corazza M., Mantovani L., Bertelli G., Virgili A.
A goldsmith with occupational allergic contact dermatitis due to ethylenediamine in a detergent
Topics: ethylenediamine; ethanolamine; case study; detergents; eczema; jewellery manufacture; sensitization dermatitis; skin allergies.
Contact Dermatitis, June 1998, Vol.38, No.6, p.350-351. Illus. 10 ref.

CIS 99-208 Verma D.K., Pagotto J.G., Shaw D.S., Destombe K., Nieboer E.
Assessment of triethylamine and diethylamine emission from military gas mask canisters
Topics: diethylamine; triethylamine; defence services; determination in air; exposure evaluation; gas removing respirators; leakage testing; threshold limit values.
Annals of Occupational Hygiene, July 1998, Vol.42, No.5, p.325-330. Illus. 13 ref.

CIS 98-1320 Tarvainen K., Jolanki R., Eckerman M.L.H., Estlander T.
Occupational allergic contact dermatitis from isophoronediamine (IPDA) in operative-clothing manufacture
Topics: isophorone diamine; case study; eczema; epoxy resins; sensitization dermatitis; skin allergies.
Contact Dermatitis, July 1998, Vol.39, No.1, p.46-47. 15 ref.

CIS 98-1165 Triethylamine
Trietilamina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: cardiovascular disorders; triethylamine; data sheet; determination in air; elimination of spills; explosion hazards; eye irritation; fire fighting; fire hazards; first aid; health hazards; hepatic damage; irritation; limitation of exposure; medical supervision; personal protective equipment; renal damage; respirators; skin absorption; USA; waste disposal.
Noticias de seguridad, Sep. 1998, Vol.60, No.9, 4p. Insert.

CIS 98-231
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Dimethyl aminopropylamine (DMAPA)
This report is a translation of a report finalized in German in October 1996. Topics: criteria document; dimethylaminopropylamine; ecotoxicology; eczema; Germany; legislation; literature survey; respiratory impairment; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1998. xv, 64p. Bibl.ref. Price: DEM 53.00.

1997

CIS 02-1543 Dimethylbenzylamine
Dimethylbenzylamin [in German]
Dimethylbenzylamine concentration in the urine of workers at the end of a shift has been shown to be significantly correlated with the exposure concentration. No skin or respiratory sensitization have been reported. Animal experiments show toxicity upon acute oral, dermal and inhalation exposure. The substance is a severe irritant to the skin and eyes of rabbits. No mutagenic or genotoxic effects have been reported. The results of a carcinogenic study on rabbits are not suitable for the evaluation of the carcinogenic potential of the substance.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 23p. 29 ref.

CIS 98-807
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Ethylenediamine
This report is a translation of a report finalized in German in December 1995. Topics: allergens; ethylenediamine; criteria document; ecotoxicology; Germany; hypersensitivity; irritants; legislation; literature survey; sensitization; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. xix, 138p. 272 ref.

CIS 97-1282 Brooke I., et al.
Health and Safety Executive
1,2-Diaminoethane [Ethylenediamine, (EDA)] - Risk assessment document
Conclusions of this risk assessment document: 1,2-diaminoethane (ethylenediamine) is a skin sensitizer in humans; repeated occupational exposure causes asthma; the substance is a skin irritant, and skin contact may cause irritant or allergic dermatitis.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1997. iv, 70p. 94 ref. Price: GBP 10.00.

1996

CIS 97-1284
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
1,2-Ethanediamine: Health based recommended exposure limit
In this report the Dutch Committee on Occupational Standards discusses the consequences of occupational exposure to 1,2-ethanediamine (ethylenediamine) and recommends an occupational exposure limit. Main conclusions: in humans, 1,2-ethanediamine is corrosive to the skin, and is a skin sensitizer and probably a respiratory sensitizer. Recommended occupational exposure limit (8h TWA): 18mg/m³ (7.2ppm). Summary in Dutch.
Gezondheidsraad, Postbus 90517, 2509 LM Den Haag, Netherlands, 1996. 70p. 105 ref.

CIS 97-759 Trimethylamine
Data sheet. May enter the body when breathed in. May burn the eyes, skin and respiratory tract. May cause pulmonary oedema. It is a highly flammable liquid or gas.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 96-2234
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
4,4'-Diamino-3,3'-dimethyldicyclohexylmethane
Conclusions of this criteria document, translation of a report finalized in Apr. 1994: exposure to 4,4'-diamino-3,3'-dimethyldicyclohexylmethane has caused sclerotic skin changes in humans; indications of liver damage have also been reported. Animal studies show that it has a severely irritating to corrosive effect on the skin and eyes.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xvi, 50p. 91 ref. Price: DEM 48.00.

CIS 96-482 Cyclohexylamine
Cyclohexylamine [in French]
Chemical safety information sheet. Acute toxicity: irritation of the eyes, skin and respiratory tract; pulmonary oedema; chemical burns; may have neurotoxic and cardiovascular effects. Chronic toxicity: irritation of the skin.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1996. 4p. 21 ref.

1995

CIS 99-606 Lundberg P.
Scientific basis for Swedish occupational standards XVI
Vetenskapligt Underlag för Hygieniska Gränsvärden 16 [in Swedish]
This volume consists of the consensus reports submitted by the Criteria Group at the Swedish National Institute for Working Life between July 1994 and June 1995. Topics: 1,1,1,2-tetrafluoroethane; 2-nitropropane; aluminium; butoxyethoxyethyl acetate; diethylaminoethanol; isopropoxyethanol; propyl acetate; diethylenetriamine; diethylene glycol butyl ether; dimethyl ether; pentaerythritol; diphenylamine; diethylene glycol isobutyl ether; ethylene glycol monoisopropyl ether acetate; trimethylolpropane; criteria document; determination of exposure limits; gallium and compounds; lactates; limitation of exposure; literature survey; Sweden; toxic effects; toxicology; translation.
Arbetslivsinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1995. 94p. Bibl.ref.

CIS 97-198 Reilly M.J., Rosenman K.D., Abrams J.H., Zhu Z., Tseng C., Hertzberg V., Rice C.
Ocular effects of exposure to triethylamine in the sand core cold box of a foundry
The acute and chronic ophthalmological effects of triethylamine exposure among foundry workers in the sand core cold box were assessed. A corneal examination, a visual acuity test and a questionnaire to assess vision symptoms in exposed workers were performed. Personal air measurements for triethylamine were also obtained. Despite low concentrations of triethylamine and no corneal oedema, exposed workers reported vision symptoms. Further research is needed to elucidate the mechanism for the reported vision symptoms, which occurred below the current United States standard. The current recommended ACGIH threshold of 4.1mg/m³ seems more appropriate.
Occupational and Environmental Medicine, 1995, Vol.52, p.337-343. 10 ref.

CIS 95-2182
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Triethylenetetramine
Conclusions of this criteria document, translation of a report finalized in June 1992: triethylenetetramine is a severe skin irritant and induces skin sensitization. Liver damage is a possible systemic effect. In appendix: copy of the report Toxicological Evaluation No.181 on triethylenetetramine by the Berufsgenossenschaft der chemischen Industrie (Heidelberg, 1991, 49 ref.).
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. xiv, 84p. approx. 120 ref. Price: DEM 48.00.

CIS 95-992 Ng T.P., Lee H.S., Malik M.A., Chee C.B.E., Cheong T.H., Wang Y.T.
Asthma in chemical workers exposed to aliphatic polyamines
Respiratory morbidity was assessed in 12 workers exposed to aliphatic polyamines in a chemical factory and in 60 unexposed workers in three other workplaces. Many amine workers reported symptoms of chronic cough, chronic phlegm, wheezing and exertional breathlessness. Exposed workers also had a greater diurnal variation in peak expiratory flow rates than did the unexposed workers. One case of amine-induced asthma was confirmed while three other workers showed asthmatic symptoms which bore a temporal relationship to work exposure. The study indicated a very high risk of asthma and chronic airways disease among workers exposed to aliphatic amines.
Occupational Medicine, Feb. 1995, Vol.45, No.1, p.45-48. Illus. 11 ref.

1994

CIS 97-959 Beije B., Lundberg P.
Criteria documents from the Nordic Expert Group 1994
Kriteriedokument från Nordiska Expertgruppen 1994 [in Swedish]
The Nordic Expert Group is a standing committee with the task of producing criteria documents on health effects of occupationally used chemicals. The documents are meant to be used by the regulatory authorities in the five Nordic countries as a scientific basis for the setting of national occupational exposure limits. This volume consists of translations into a Scandinavian language (Danish, Norwegian or Swedish) of the criteria documents which were published in English during 1994. The documents concern: 1,3-butadiene (CIS 97-954), cobalt and cobalt compounds (CIS 97-955), diethylamine, diethylenetriamine, dimethylamine, ethylenediamine, 2-ethylhexanoic acid, industrial enzymes (CIS 97-953), N-methyl-2-pyrrolidone (NMP)(CIS 97-956).
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1994. 263p. 753 ref.

CIS 95-1618 Dimethylamine
Dimetilamina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: irritation of the eyes, skin and respiratory tract; chemical burns; may cause pulmonary oedema, hepatic damage and visual function disorders.
Noticias de seguridad, Sept. 1994, Vol.56, No.9. 4p. Insert.

CIS 95-53 Ethylenediamine
Etilenediamina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; irritation of the eyes, skin and respiratory tract; sensitization (dermatitis, asthma); may affect the liver, kidneys and lungs.
Noticias de seguridad, Aug. 1994, Vol.56, No.8. 4p. Insert.

1993

CIS 95-420 Diethylenetriamine
International chemical safety card. Short-term exposure effects: skin absorption; delayed effects; corrosive effects on the eyes, skin and respiratory tract; corrosive on ingestion; chemical burns; pulmonary oedema; chemical pneumonitis. Long-term exposure effects: skin sensitization; asthma. Occupational exposure limits: TLV: 1ppm; 4.2mg/m³ (TWA) (skin) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 94-999
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Tributylamine (N,N-dibutylbutane-1-amine)
No data are available on the effects of tributylamine in humans. Animal experiments indicate that at low doses the substance causes a fall of blood pressure, slowing of the pulse and increase in heart volume; severe skin irritation and necroses have also been observed. No studies on carcinogenicity or reproductive toxicology are available.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1993. xii, 52p. 102 ref. Price: DEM 48.00.

CIS 94-473 Isophorone diamine
International chemical safety card. Short-term exposure effects: skin absorption; delayed effects; corrosive to the eyes, skin and respiratory tract; tear drawing; pulmonary oedema; chemical pneumonitis; skin burns. Long-term exposure effects: skin sensitization; may affect the lungs.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-304 Kanerva L., Estlander T., Jolanki R., Henriks-Eckerman M.L.
Occupational allergic contact dermatitis caused by diethylenetriamine in carbonless copy paper
Carbonless copy paper, or 'no carbon required' (NCR) paper, has often been implicated as the cause of skin, respiratory, or general symptoms, but allergy has been verified in only a few cases. A 43-year-old machinist whose work involved the manufacture of NCR paper developed occupational dermatitis on the hands. On patch testing, both the NCR paper and 1 of the chemicals used to produce the microcapsules of the NCR paper, namely diethylenetriamine (DETA), provoked an allergic reaction. Analysis of the paper showed that it contained enough DETA to induce allergic contact dermatitis. People who handle NCR paper and develop symptoms of contact dermatitis should be patch tested with DETA.
Contact Dermatitis, Sep. 1993, Vol.29, No.3, p.147-151. 31 ref.

CIS 94-38 Diisopropylamine
International chemical safety card. Short-term exposure effects: skin absorption; corrosive to the eyes and respiratory tract; pulmonary oedema. Long-term exposure effects: dermatitis. Occupational exposure limits: TLV: 5ppm; 21mg/m³ (skin) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-34 Diethylamine
International chemical safety card. Short term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; pulmonary oedema. Long term exposure effects: liquid defats the skin. Occupational exposure limits: TLV 10ppm; 30mg/m³ (as TWA) (ACGIH 1989-1990). PDK 30mg/m³ (USSR 1973).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1787 sec-Butylamine
International chemical safety card. Short term exposure effects: corrosive to the eyes, skin and respiratory tract; corrosive on ingestion; pulmonary oedema; visual function disorders. Long term exposure effects: dermatitis. Occupational exposure limits: TLV for n-butylamine: 5ppm, 15mg/m³ (as ceiling) (skin) (ACGIH 1990-1992). MAK: 5ppm, 15mg/m³, I,H (1990).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1449 n-Butylamine
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; pulmonary oedema; narcotic effects. Long-term exposure effects: liquid defats the skin. Occupational exposure limits: TLV: 5ppm; ceiling value (skin): 15mg/m³ (ACGIH 1989-1990); PDK: 10mg/m³ (USSR 1980).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

1992

CIS 01-1626 Isopropylamine
Isopropylamine [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 90-1808. Acute toxicity: strong irritation of the nose and throat and respiratory disorders; visual function disorders; chemical burns; severe eye lesions which may be irreversible (projections). Chronic toxicity: skin diseases. Exposure limits (France): TWA = 12mg/m³ (5ppm). EEC number and mandatory labelling codes: No.612-007-00-1; F, Xi, R12, R36/37/38, S16, S26, S29. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, June 2001. 4p. Illus. 21 ref.

CIS 93-1609 Aleva R.M., Aalbers R., Koëter G.H., De Monchy J.G.R.
Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine
An otherwise healthy 44 year-old man experienced a serious attack of bronchial obstruction after working with resins and hardeners that released fumes of a mixture of an aliphatic and a cycloaliphatic diamine hardener. Eight hours after deliberate challenge with the hardener a large increase of airway resistance was found. Seventy-two hours after challenge, eosinophils was seen. After cessation of contact with this hardener, no more acute episodes occurred, although maintenance treatment with a topical corticosteroid and a β₂-agonist remained necessary. A BAL performed one year later showed a normal cell distribution. The results suggest that these aliphatic and cycloaliphatic diamine hardeners may be occupational hazards. Eosinophil inflammation may play a causal role.
American Review of Respiratory Disease, May 1992, Vol.145, No.5, p.1217-1218. 16 ref.

CIS 93-1604 Lundqvist G.R., Yamagiwa M., Pedersen O.F., Nielsen G.D.
Inhalation of diethylamine - Acute nasal effects and subjective response
Adult volunteers were exposed to 25ppm (75mg/m³) diethylamine in a climate chamber for 15min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value short-term exposure limit. Changes in nasal volume and nasal resistance were measured by acoustic rhinometry and by rhinomanometry. Acute change in nasal volume, usually seen as acute nasal mucosa response to thermal stimuli, was not observed, nor was an acute change in nasal airway resistance. In a subsequent experiment, the aim was to measure acute sensory effects. Exposure to a concentration increasing from 0 to 12ppm took place for 60min, equal to an average concentration of 10ppm (30mg/m³). A moderate to strong olfactory response and distinct nasal and eye irritation were observed. In spite of considerable individual variation, the results were in agreement with sensory effect estimates obtained from animal studies.
American Industrial Hygiene Association Journal, Mar. 1992, Vol.53, No.3, p.181-185. Illus. 19 ref.

CIS 93-1113 Butylamine
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Effects of short-term exposure: skin absorption; irritation of the eyes, nose and upper respiratory tract; contact of the skin or eyes with liquid causes severe irritation, corrosive burns and possible blindness; severe exposure causes hypoxia, pulmonary oedema and convulsions.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1992. 7p. 16 ref.

CIS 93-375 Butylamine
Fire safety data sheet prepared by the Loss Prevention Association of India, Warden House, Sir P.M. Road, Bombay 400 001, India. Health hazards: skin absorption; irritation of skin, nose, throat, mucous membranes and eyes; pulmonary oedema.
Loss Prevention News, Jan.-Mar. 1992, Vol.14, No.1, p.21-22.

CIS 92-1112 Methylamine
Metilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Toxicity: irritation of skin, eyes and respiratory tract; chemical burns; dermatitis; conjunctivitis.
Noticias de seguridad, Apr. 1992, Vol.53, No.4, 4p. Insert.

1991

CIS 00-643 3-Dimethylaminopropylamine
3-Aminopropildimetilamina [in Spanish]
Spanish version of IPCS ICSC 1227. International Chemical Safety Card. Short-term exposure effects: corrosive for skin, eyes and respiratory tract; corrosive by ingestion. Long-term exposure effects: extended or repeated contact may lead to skin sensitization.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p. Illus.

CIS 99-751 Trimethylamine, anhydrous (liquefied)
Trimetilamina, anhidra (licuado) [in Spanish]
Spanish version of IPCS ICSC 3-0206. International Chemical Safety Card. Topics: trimethylamine; caustic substances; chemical hazards; data sheet; delayed effects; elimination of spills; environmental pollution; explosion hazards; fire fighting; fire hazards; first aid; frostbite; health hazards; IPCS; irritation; labelling; liquefied gases; physical hazards; pulmonary oedema; Spain; storage; threshold limit values; translation; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 98-1129 Ethylenediamine
Etilendiamina [in Spanish]
Spanish version of IPCS ICSC 0269 (CIS 92-1487). International Chemical Safety Card. Topics: asthma; ethylenediamine; caustic substances; chemical burns; chemical hazards; data sheet; delayed effects; dermatitis; elimination of spills; environmental pollution; explosion hazards; fire fighting; fire hazards; first aid; health hazards; IPCS; irritation; labelling; pulmonary oedema; respiratory impairment; sensitization; skin absorption; Spain; storage; threshold limit values; translation; visual function disorders; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

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