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  • Alcohols

1991

CIS 96-468 3-Clorofenol
Versión española de la futura ficha IPCS ICSC 0150. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: irritación de ojos, piel y vías respiratorias.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.
96-0468.pdf [en español]

CIS 95-1607 2,3,5,6-Tetraclorofenol
Versión española de IPCS ICSC 8-0573. Ficha internacional de seguridad química. Efectos de una exposición de corta duración: absorción cutánea; irritación de ojos, piel y vías respiratorias superiores. No se dispone de información sobres este isómero, pero una mezcla de tetraclorofenoles puede causar efectos tóxicos sobre el hígado y el sistema nervioso central.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 95-1229 Propano-1,2-diol
Versión española de IPCS ICSC 6-0321. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: irritación ocular.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 95-1228 Propan-1-ol
Versión española de IPCS ICSC 7-0553. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: absorción cutánea; síntomas diferidos; irritación de ojos, piel y vías respiratorias; efectos neurotóxicos (sistema nervioso central). Efectos de una exposición prolongada: dermatitis. Límites de exposición: valor umbral (TLV): 200 ppm, 492 mg/m3 (TWA); 250 ppm, 614 mg/m3 (STEL) (piel)
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 95-1225 Pentan-1-ol
Versión española de IPCS ICSC 7-0535. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: irritación de ojos, piel y vías respiratorias; puede causar lesiones en la córnea; efectos neurotóxicos (sistema nervioso central). Efectos de una larga exposición: dermatitis.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 95-1223 Propan-2-ol
Versión española de IPCS ICSC 7-0554. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: síntomas diferidos; irritación ocular, cutánea y de vías respiratorias; efectos neurotóxicos (sistema nervioso central). Efectos de una exposición de larga duración: dermatitis. Límites de exposición: valor umbral (TLV): 400 ppm, 983 mg/m3 (TWA); 500 ppm, 1.230 mg/m3 (STEL)
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 95-1212 Prop-2-in-1-ol
Versión española de IPCS ICSC 8-0673. Ficha internacional de seguridad de las sustancias químicas. Efectos de una exposición de corta duración: absorción cutánea; irritación de ojos, piel y vías respiratorias; quemaduras químicas; puede afectar el hígado, los riñones y la coagulación sanguínea. Límites de exposición: valor umbral (TLV): 1 ppm, 2,3 mg/m3 (piel) (ACGIH 1990-1991); PDK: 1 mg/m3
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, España, 1991. 2p.

CIS 94-1635 Kawai T., Yasugi T., Mizunuma K., Horiguchi S., Hirase Y., Uchida Y., Ikeda M.
Methanol in urine as a biological indicator of occupational exposure to methanol vapour
The exposure-excretion relationship and possible health effects of exposure to methanol vapour were studied in 33 exposed workers during the second half of two working weeks. There was a significant correlation between exposure to methanol vapour at concentrations of up to 5,500ppm and the levels of methanol measured in the shift-end urine samples. The calculation indicated that a mean level of 42mg methanol/L urine was excreted in the shift-end urine sample following 8h exposure to methanol at 200ppm (the current occupational exposure limit). Dimmed vision and nasal irritation were among the most frequent symptoms reported during the week.
International Archives of Occupational and Environmental Health, 1991, Vol.63, No.5, p.311-318. Illus. 38 ref.

CIS 94-1148 Butano-1,2-diol
Spanish version of IPCS ICSC 6-0395. International chemical safety card. Short-term exposure effects: eye irritation. Long-term exposure effects: may affect the kidneys.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 94-645 Imbriani M., Di Nucci A.
Effects on interaction between ethanol and solvents
Effetti della interazione tra etanolo e solventi [en italiano]
Collection of ten research and review papers on various aspects of the interaction between ethanol and solvents. Papers cover the topic in relation to: pharmacokinetic behaviour of organic solvents (Sato A.); toxicological data in animals and humans (Mutti A.); toxicological and metabolic interaction among solvents (Perbellini L., Brugnone F.); interactions in humans (Riihimäki V., Elovaara E.); solvent interactions and biological monitoring (Tichi M., Mraz J.); metabolism of toluene in man I-II (Imbriani M., Ghittori S., Maestri L.); the glutathione system (Di Nucci A., Coccini T.); neurobehavioural effects (Gilioli R. et al); liver toxicity - definition of the risk and diagnostic implications (Franco G.).
Fondazione Clinica del Lavoro, IRCCS, Via Severino Boezio, 24-26, 27100 Pavia, Italy, 1991. 143p. Illus. Bibl.ref.

CIS 93-382 Ethylene glycol
Fire safety data sheet prepared by the Loss Prevention Association of India, Warden House, Sir P.M. Road, Bombay 400 001, India. Health hazards: injury to kidneys, liver and brain; mild irritation of skin and eyes.
Loss Prevention News, Oct.-Dec. 1991, Vol.13, No.4, p.21-22.

CIS 93-565 Thind K.S., Karmali S., House R.A.
Occupational exposure of electrical utility linemen to pentachlorophenol
Exposure to pentachlorophenol (PCP) by electrical utility linemen was monitored over a six-month period. Urine samples were collected from two groups, plus one control group. Group A was required to use new gloves after each four-week work period; Group B changed gloves as per normal operating procedure. The results showed that the linemen experienced a seasonal exposure pattern with exposures peaking in July and August. This seasonal effect was also observed with glove contamination data. The glove contamination levels were significantly associated with urine PCP concentrations when both these variables were expressed as geometric means for the individuals in Group A. Over the study period, the difference in long-term exposures of Group A and Group B linemen was not statistically significant. The long-term individual exposures, calculated as the geometric mean of each individual's sequential sample readings, were all below the biological monitoring guideline value of 1000µgPCP/g creatinine.
American Industrial Hygiene Association Journal, Dec. 1991, Vol.52, No.12, p.547-552. Illus. 11 ref.

CIS 93-51 Nonyl phenol
International chemical safety card. Short term exposure effects: skin absorption; corrosive to the eyes, skin and respiratory tract; pulmonary oedema.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 93-47 Neopentyl glycol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1818 4-Methylcyclohexanol
International chemical safety card. Long term exposure effects: see ICSC No.294 (CIS 92-1816).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1817 3-Methylcyclohexanol
International chemical safety card. Long term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1816 2-Methylcyclohexanol
International chemical safety card. Short term exposure effects: skin absorption; irritant. Long term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1815 1-Methylcyclohexanol
International chemical safety card. Long term exposure effects: no available data; refer to ICSC No.292 methylcyclohexanol (mixed isomers) (see CIS 92-1814).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1814 Methylcyclohexanol (Mixed isomers)
International safety card. Short term exposure effects: skin absorption; irritant. Long term exposure effects: dermatitis; neurotoxic effects.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1802 2,5-Hexanediol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract. Long-term exposure effects: dermatitis; may affect nervous system resulting in polyneuropathy and changes in the electromyogramme.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1792 Ethylene glycol
International chemical safety card. Short term exposure effects: irritation of eyes, skin and respiratory tract; possible effects on kidneys and central nervous system resulting in brain damage. Long term exposure effects: risk of dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1462 Cyclohexanol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes, skin and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: liquid defats the skin.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1455 Chloroethanol
International chemical safety card. Short term exposure effects: skin absorption; delayed effects; irritation of eyes, skin and respiratory tract; pulmonary oedema; may cause kidney, heart or brain injury.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-753 Hydroquinone
International chemical safety card. Short term exposure effects: irritation of skin, eyes and respiratory tract. Long term exposure effects: dermatitis; sensitisation; may cause discoloration of the conjunctiva and cornea, loss of vision, skin depigmentation, hair and nail discoloration; may cause genetic damage in humans.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-748 Hexachlorophene
International chemical safety card. Short term exposure effects: skin absorption; neurotoxic effects (central nervous system); blindness; respiratory arrest; cardiovascular disturbances. Long term exposure effects: dermatitis; skin sensitisation; asthma; neurotoxic effects resulting in brain damage, blindness and death; may impair male fertility; may cause birth defects and retarded development of the new-born.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-571
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Nonylphenol
Conclusions of this critera document, translation of a German report published in Jan. 1988: no information is available on the adverse effects of nonylphenol in humans. It is known to cause severe local irritation to the skin, eyes and mucous membranes of experimental animals. Ecotoxicity data. Legislative requirements in Germany.
VCH Verlagsgesellschaft mbH, D-W-6940 Weinheim, Germany, 1991. 53p. 70 ref.

CIS 92-395 4-Chloro-meta-cresol
International chemical safety card. Short-term exposure effects: skin absorption; delayed effects; corrosive to the eyes, skin and respiratory tract; pulmonary oedema; larynx oedema; neurotoxic effects (central nervous system); hepatic and renal damage. Long-term exposure effects: dermatitis; effects on the lungs; neurotoxic effects (central nervous system); hepatic and renal damage.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-224 Saracci R., Kogevinas M., Bertazzi P., Bueno de Mesquita B.H., Coggon D., Green L.M., Kauppinen T., L'Abbé K.A., Littorin M., Lynge E., Mathews J.D., Neuberger M., Osman J., Pearce N., Winkelmann R.
Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols
This paper reports a historical cohort study of mortality in an international register of 18,910 chlorophenoxy herbicide production workers or sprayers from 10 countries. Exposure was reconstructed through questionnaires, factory or spraying records and job histories. A non-significant increase, based on 4 observed deaths, was noted for soft-tissue sarcoma. Increased risks were found for some uncommon neoplasms, but results are difficult to interpret because of the small numbers. The excess of soft-tissue sarcomas among sprayers is compatible with a causal role of chlorophenoxy herbicides but the excess does not seem to be specifically associated with those herbicides probably contaminated by the toxic dioxin TCDD.
Lancet, 26 Oct. 1991, Vol.338, No.8774, p.1027-1032. 35 ref.

CIS 92-50 Ciclohexanol
Chemical safety sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. It is an adaptation into Spanish of the corresponding data sheet from the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards" (DHHS (NIOSH) Publication No.89-104).
Noticias de seguridad, July 1991, Vol.53, No.7, 4p. Insert.

CIS 92-46 tert-Butanol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes and respiratory tract; neurotoxic effects. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-45 Isobutyl alcohol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes and respiratory tract; neurotoxic effects. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-43 2-Butanol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes and respiratory tract; neurotoxic effects. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg, International Programme on Chemical Safety (IPCS); World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-42 1-Butanol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes and respiratory tract; neurotoxic effects. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-27 Allyl alcohol
International chemical safety card. Short-term exposure effects: skin absorption; irritation of the skin, eyes and respiratory tract; hepatic and renal damage.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

1990

CIS 94-806 Methanol
Methanol [en alemán]
Chemical safety information sheet. Risk phrases and preventive measures (European Union); fire and explosion hazards; fire fighting; storage; first aid and medical supervision; waste disposal and elimination of spills; labelling; occupational exposure limits (MAK): 260mg/m3 (1989).
Allgemeine Unfallversicherungsanstalt, Abteilung für Unfallverhütung und Berufskrankheitenbekämpfung, Adalbert-Stifter-Strasse 65, 1200 Wien, Austria, 1990. 3p.

CIS 92-1630 Barrat G., Frisch C., Choudat D., Conso F.
Cutaneous, ocular, neurologic and cardiac disorders following occupational exposure to trimethylhydroquinone
Manifestations cutanées, oculaires et atteinte du système nerveux central au cours d'une exposition professionnelle à la triméthylhydroquinone [en francés]
Case study of a worker exposed to trimethylhydroquinone during the synthesis of Vitamin E.
Archives des maladies professionnelles, 1990, Vol.51, No.5, p.319-321. 12 ref.

CIS 92-1618 Weber M., Martin A., Bollaert P.E., Bauer P., Leroy F., Meley M., Mur J.M., Carry C., Lambert H.
Acute percutaneous intoxication caused by methylene chloride and methanol
Intoxication aiguë par chlorure de méthylène et méthanol par voie percutanée [en francés]
Case study of cutaneous and percutaneous intoxication caused by methylene chloride (dichloromethane) and methanol in a paint stripper worker who fell in a vat full of these chemicals. The worker lost consciousness for 15min, during which time he was exposed to fumes of the chemicals. The lesions secondary to the irritant effect of methylene chloride included skin burns, severe keratoconjunctivitis, tympanic perforation and anosmia. Only two similar case records of skin burn lesions caused by methylene chloride have been reported before.
Archives des maladies professionnelles, 1990, Vol.51, No.2, p.103-106. Illus. 8 ref.

CIS 92-1304 Foussereau J.
Allergens potentially responsible for occupational eczema
Allergènes divers pouvant être responsables d'eczémas en milieu de travail [en francés]
This data sheet provides condensed information on the following occupational allergens: aziridine (ethylenimine), 4-tert-butylpyrocatechol, chloroacetamide, 2-chloroacetophenone, o-chlorobenzylidene-malonitrile, methyl dichlorobenzenesulfonate, dicyclohexylcarbodiimide, dodicin, formaldehyde, triglydicyl isocyanurate, Kathon CG, 2-chloro-N-(hydroxymethyl)-acetamide, phenylindole, propanidid, propolis, phenol-formaldehyde polymers, Skane M-8, 2,4,5,6-tetrachloroisophthalonitrile, tetryl, methyl p-toluenesulfonate, trinitrotoluene.
Documents pour le médecin du travail, 3rd Quarter 1990, No.43, p.233-238. Illus. 51 ref.

CIS 91-1451 Phenol
International chemical safety card. Short term exposure effects: skin absorption; corrosive to the eyes, the skin and the respiratory tract; pulmonary oedema (delayed effects); central nervous system, liver and kidney disorders. Long term exposure effects: dermatitis; kidney and liver damage.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 91-1450 Pentachlorophenol
International chemical safety card. Short term exposure effects: skin absorption; delayed effects; irritation of skin and eyes; corrosive to the respiratory tract; pulmonary oedema; heart failure. Long term exposure effects: dermatitis; disorders of the central nervous system, lungs, liver and kidneys.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 91-1631
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for 2,4,6-trichlorophenol
No reliable human data exist relating to exposure to 2,4,6-trichlorophenol and adverse health effects. Animal studies show that long-term exposure results in changes in liver and spleen cells and decreased body weight. Long-term high-level exposure results in death in some animals and long-term oral exposure causes animal cancer. Glossary.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta, GA 30333, USA, Dec. 1990. xi, 119p. Illus. ca.350 ref.

CIS 91-1279 Seminar on nonylphenolethoxylates (NPE) and nonylphenol (NP)
Proceedings of a seminar on nonylphenolethoxylates (NPE) and nonylphenol (NP) held in Saltsjöbaden, Sweden, 6-8 February 1991. Papers cover: EPA's chemical testing program for NP; use pattern of NPEs and their application properties; health effects; toxicity of 4-nonylphenol to aquatic organisms and potential for bioaccumulation; aerobic and anaerobic biotransformation and photo-oxidation; behaviour of nonylphenol polyethoxylates and their metabolites in mechanical-biological sewage treatment; environmental occurrence and behaviour of alkylphenol polyethoxylates and their degradation products in rivers and groundwaters; behaviour in sludge treated soils and in landfills; environmental aspects of ethoxylates based on alkylphenol and primary alcohols; products to replace NP.
Swedish Environmental Protection Agency (SNV), Information Department, 171 85 Solna, Sweden, 1990. 265p. Illus. Bibl.ref.

CIS 91-1238
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards)
Health-based recommended occupational exposure limits for cyclohexanol
Contents of this report: chemical and physical data on cyclohexanol, environmental monitoring, biological monitoring; toxicokinetics and toxicodynamics. Evaluation of the risks to human health of exposure to cyclohexanol resulted in the conclusion that there are no indications of groups at extra risk. The Committee recommends a health-based occupational exposure limit for cyclohexanol of 1mg/m3 (0.25ppm) as an 8-hour TWA concentration. This limit should be considered to be tentative, until a NAEL as to male reproduction has been established.
Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 69, 2270 MA Voorburg, Netherlands, 1990. 40p. 63 ref.

CIS 91-768 Methanol
International chemical safety card. Danger symbols: highly flammable; toxic. Short-term exposure effects: delayed effects; skin absorption; corrodes the eyes, skin and respiratory tract; neurotoxic effects (central nervous system); blindness. Long-term exposure effects: dermatitis; neurotoxic effects; vision disorders. EC identification number and labelling codes: 603-001-00-X; F; T; R11-23/25; S2-7-16-24. United Nations number and hazard class: UN 1230 (3; 6.1; II).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 91-908 Flyvholm M.A., Menné T.
Sensitizing risk of butylated hydroxytoluene based on exposure and effect data
A national database on chemical products (the Danish Product Register (PROBAS)) was searched for products containing butylated hydroxytoluene (BHT). As of March 1990, 440 products containing BHT were registered. The BHT content was below 50ppm in 66% of these products. Paints/lacquers (1- and 2-component) and hardeners for 2-component paints, glues, fillers, etc. make up the main categories. No positive reactions were seen in 1336 consecutive eczema patients patch tested with BHT. As BHT is widely used, one can consider it as a safe antioxidant in the normally used concentrations. The possibilities, limitations, and demands of product registration as exposure estimates are discussed.
Contact Dermatitis, Nov. 1990, Vol.23, No.5, p.341-345. 14 ref.

CIS 91-907 O'Malley M.A., Carpenter A.V., Sweeney M.H., Fingerhut M.A., Marlow D.A., Halperin W.E., Mathias C.G.
Chloracne associated with employment in the production of pentachlorophenol
To evaluate the association between exposure to pentachlorophenol (PCP) and the occurrence of chloracne, the medical and personnel records for individuals employed in the manufacturing of PCP were studied. Forty-seven cases of chloracne were identified among 648 workers (7%) assigned to PCP production at a single plant between 1953 and 1978. No linear trend in the risk of chloracne was observed with the duration of employment. Workers with a documented episode of direct skin contact with PCP had a significantly increased risk of chloracne compared with workers who did not have such an episode. Results confirm that chloracne is associated with exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p-dioxins and dibenzofurans.
American Journal of Industrial Medicine, 1990, Vol.17, No.4, p.411-421. 23 ref.

CIS 91-384 Ethanol (anhydrous)
International chemical safety card. Danger symbols: highly flammable. Short term exposure effects: irritation of skin, eyes and respiratory tract; neurotoxic effects. Long term exposure effects: hepatic damage; neurotoxic effects (central nervous system). EC identification number and labelling codes: 603-002-00-5; F; R11; S7-16. United Nations number and hazard class: UN 1170 (3-102 & 144).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.

CIS 91-63 2-Propene-1-ol
2-Propène-1-ol [en francés]
Chemical safety information sheet. Exposure limits (France, 1986): maximum exposure value = 10mg/m3; TWA value = 5mg/m3. Toxicity: skin absorption; strong irritation of respiratory tract, skin and eyes; chemical burns. EC identification numbers and mandatory labelling codes: No. 603-015-00-6; F, T; R11-26-36/37/38; S16-39-45.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 5p. 25 ref.

CIS 91-56 Methanol
Méthanol [en francés]
Chemical safety information sheet. Short term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; drunkeness; blurred vision and blindness at high concentrations. Long term effects: same as above.
Canadian Centre for Occupational Health and Safety, 250 Main St. E., Hamilton, Ontario L8N 1H6, Canada, Oct. 1990. 1p. Illus.

CIS 91-53 Isopropyl alcohol
Alcool isopropylique [en francés]
Chemical safety information sheet. Short term exposure effects: mild irritation of throat and eyes. Long term exposure effects: drying and cracking of skin.
Canadian Centre for Occupational Health and Safety, 250 Main St. E., Hamilton, Ontario L8N 1H6, Canada, Oct. 1990. 1p. Illus.

CIS 91-47 Furfuryl alcohol
Alcool furfurylique [en francés]
Chemical safety information sheet. Exposure limits (France, 1987): TWA value = 40mg/m3. Short-term effects: skin absorption; irritation of eyes, upper respiratory tract and skin. Long-term effects: dermatitis. EC identification numbers and mandatory labelling codes: 603-018-00-2; Xn; R20/21/22.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 4p. 18 ref. Illus.

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