Occupational exposure limits - 3,466 entries found

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1999

CIS 01-1627 Brondeau M.T., Falcy M., Miraval S., Protois J.C., Reynier M., Schneider O.
2-Methoxyethyl acetate
Acétate de 2-méthoxyéthyle [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-837. Toxicity: there is little information on toxicity in humans; tendency to anaemia, granulopenia and oligospermia; malformations of the genital organs (hypospadias) in children born to women heavily exposed during pregnancy; increase in the number of spontaneous abortions. Chronic toxicity: carcinogen; skin and nasal septum ulcers; renal damage (ingestion). Exposure limits (France): TWA = 24mg/m³ (5ppm). EEC number and mandatory labelling codes: No.607-036-00-1; T, R60, R61, R10, R20/21/22, S53, S45, 203-772-9. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, June 2001. 4p. Illus. 15 ref.

CIS 01-1472 Threshold limit values for occupational exposure to chemicals in France
Valeurs limites d'exposition professionnelle aux agents chimiques en France [in French]
This article presents, in a single table, all the different substances, including carcinogenic substances, for which the French Ministry of Labour has published occupational exposure limit values (VLEPs), whether they are recommended (VLs) or mandatory (VRs). The table is preceded by some background information concerning workplace atmospheric monitoring (sampling and analysis, aerosols), permitted values (definitions and objectives, additivity convention, elements and compounds, VLs, carcinogens), mandatory values and values recommended by the CNAM national health insurance fund. European recommended limit values are appended.
Cahiers de notes documentaires - Hygiène et sécurité du travail, 1st Quarter 1999, No.174, p.59-77. Illus.

CIS 01-1350 Isopropylamine
Isopropylamine [in French]
Isopropilamina [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: corrosive for the skin, eyes and respiratory tract; corrosive by inhalation; inhalation may cause pulmonary oedema; ingestion may cause chemical pneumonitis; effects may be delayed; exposure may lead to death. Long-term exposure effects: prolonged or repeated contact may cause dermatitis. Threshold limit values: 5ppm (TWA); 10ppm (STEL) (ACGIH 1995-1996).
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 01-1339 Dibenzoyl peroxide
Peroxyde de dibenzoyle [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 88-738. Acute toxicity: irritation of eyes, nose and throat. Chronic toxicity: allergic dermatitis. Exposure limits (France): TWA = 5mg/m³. EC number and mandatory labelling codes: No.617-008-00-0; Xi, E, R2, R36, R43, S3/7, S14, S36/37/38, 202-327-6. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 15 ref.

CIS 01-1334 1,4,-Dioxane
1,4-Dioxane [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 89-1120. Acute toxicity: skin absorption; strong irritation of eyes and respiratory tract. Chronic toxicity: hepatic and renal damage; carcinogenic in experimental animals. Exposure limits (France): TWA = 35mg/m³ (10ppm); ceiling limit = 140mg/m³ (40ppm). EC number and mandatory labelling codes: No.603-024-00-5; Xn, F, R11, R19, R36/37, R40, S18, S35/37, 204-661-8. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 14 ref.

CIS 01-1318 Ammonium fluoride
Fluorure d'ammonium [in French]
Fluoruro de amonio [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: irritation of the skin, eyes and respiratory tract. Long-term exposure effects: effects on bones and teeth (fluorosis). Threshold limit value: 2.5mg/m³ A4 (as F) (ACGIH 1998).
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 01-1315 Fenchlorphos
Fenchlorphos [in French]
Fenclorfos [in Spanish]
International Chemical Safety Card. Synonym: ronnel. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: effects on the nervous system (convulsions); cholinesterase inhibition; effects may be delayed. Long-term exposure effects: animal tests show that this substance possibly causes malformations in newborns. Threshold limit value: 10mg/m³ A4 (ACGIH 1998).
On the Internet site http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/index.htm ; Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 01-660 2-Furaldehyde
2-Furaldéhyde [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-414. Acute toxicity: irritation of the eye and the mucous membranes of the respiratory tract; convulsions. Chronic toxicity: irritation of the eye and respiratory tract mucous membranes; headache; decrease olfaction and taste; eczema and allergic asthma. Exposure limit (France): ceiling value = 8mg/m³ (2ppm). EEC number and mandatory labelling codes: No.605-010-00-4; T, R21, R23/25, R36/37, R40, S26, S36/37/39, S45, 202-627-7. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 27 ref.

CIS 01-849 Huici Montagud A., Ferrer Panzano R.
Criteria for the establishment of occupational exposure limits in the European Union
Criterios de establecimiento de valores límite de exposición profesional en la Unión Europea [in Spanish]
This information note describes the procedure developed by the European Union for determining occupational exposure limit values for chemicals. It is based on documents prepared by a committee of scientific experts (SCOEL) which analyses the harmful effects resulting from an exposure to the chemical and decides on the appropriate type of exposure limit (LOAEL, TWA, STEL) on the basis of published studies. The basic criteria considered by the committee are reviewed. They include limits for an average 8-hour exposure, limits for short-term exposure, uncertainty factors, toxicity for the reproductive system, carcinogens and acceptable threshold limits, products causing sensitization of the respiratory tract, skin notation and biological threshold values. The structure of basic EU documentation is also included.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1999. 6p. 2 ref.

CIS 01-357
Dutch Expert Committee on Occupational Standards (DECOS)
Vinylbromide - Health-based calculated occupational cancer risk values
. Additional lifetime cancer risks for vinyl bromide amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.012mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 1.2mg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers; calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile existing occupational exposure limits; toxicity profile (acute toxicity, repeated-dose toxicity). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 34p. 16 ref.

CIS 01-356
Dutch Expert Committee on Occupational Standards (DECOS)
Procarbazine hydrochloride - Health-based calculated occupational cancer risk values
Procarbazine hydrochloride is an antineoplastic agent. Additional lifetime cancer risk for procarbazine hydrochloride amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.002mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 0.2mg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers; calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (leucopenia, thrombocytopenia, nausea, vomiting, myelosuppression). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 34p. 17 ref.

CIS 01-303 Exposure limits at the workplace 1999 [Switzerland]
Valeurs limites d'exposition aux postes de travail 1999 [Suisse] [in French]
Loose-leaf compendium listing average exposure limits (VME) and maximum exposure limits (VLE) for harmful substances, tolerable biological exposure values (VBT) and exposure limits for physical hazards (radiation and noise) according to Swiss legislation. A new chapter addresses health risk assessment for substances without published VMEs. Important modifications have been made to chapters concerning airborne substances, isocyanates, inert dusts and electromagnetic fields. The exposure limit values are for the most part taken from German publications. The list includes the VMEs and VLEs of approximately 1000 chemical substances, VBTs for 41 commonly-used substances and permissible levels for physical agents such as UV radiation, electromagnetic radiation and noise. Previous (1992) edition analysed: CIS 92-1070.
Suva, Division Médecine du travail, Case postale, 6002 Lucerne, Switzerland, 1999. 154p. Illus.

CIS 01-355 Brondeau M.T., Falcy M., Miraval S., Protois J.C., Reynier M., Schneider O.
2-Methoxyethyl acetate
Acétate de 2-méthoxyéthyle [in French]
Toxicological data sheet. 2-Methoxyethyl acetate is a toxic substance. Its effects on humans are not well known but in animals it induces mucosal irritation, depression of the central nervous system, renal tubule damage, malformation of the external genital organs and an increase in spontaneous abortions. In vitro it induces chromosome changes and sister chromatid exchanges. It is recommended not to expose pregnant women. Mean exposure limit value is 5ppm, or 24mg/m³. Replaces CIS 87-837.
Cahiers de notes documentaires - Hygiène et sécurité du travail, 2nd Quarter 1999, No.175, 4p. Insert. Illus. 15 ref.

CIS 01-341 Diethyl ether
Oxyde de diéthyle [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 88-1795. Acute toxicity: irritation of the respiratory tract; inhalation anaesthetic. Chronic toxicity: digestive disorders; headache; polypnoea; dryness of the skin. Exposure limits (France): TWA = 400ppm (1200mg/m³); ceiling value = 500ppm (1500mg/m³). EEC number and mandatory labelling codes: No.603-022-00-4; Xn, F+, R12, R19, R22, R66, R67, S9, S16, S29, S33, 200-467-2.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., 1999. 5p. Illus. 28 ref.

CIS 01-184 Petroleum waxes and related products
This dossier summarizes the health, safety and environmental data currently available on paraffin waxes, microcrystalline waxes, slack waxes and petrolatums which are used in wide range of industries, including the food industry. Petroleum waxes and related products are at most slightly irritant; slack wax is weakly carcinogenic. Advice is given on the storage and handling of waxes and related products, on emergency treatment in case of exposure and on disposal. These products are biodegradable.
CONCAWE, Madouplein, 1210 Brussels, Belgium, Dec. 1999. iv, 32p. 54 ref.

CIS 01-34 Brondeau M.T., Jargot D., Pillière F., Protois J.C., Reynier M., Schneider O., Serre P.
Acrolein
Acroléine [in French]
Acrolein is used in a number of industrial chemical reactions. In non-EU countries it is also used as a biocide in production lines and industrial water. Acute toxicity: irritation of the eyes, nose, skin and respiratory tract; dyspnoea; upper airways lesions. French exposure limit: 0.1ppm (0.25mg/m³) (VLE).
Cahiers de notes documentaires - Hygiène et sécurité du travail, 4th Quarter 1999, No.177, p.155-160. Illus. 23 ref.
http://www.inrs.fr/dossiers/fichtox/ft57.pdf [in French]

CIS 01-33 Brondeau M.T., Falcy M., Jargot D., Miraval S., Protois J.C., Reynier M., Schneider O.
Diethyl oxide
Oxyde de diéthyle [in French]
Diethyl ether (synomym: diethyl oxide) is an anaesthetic. Acute toxicity: irritation of the respiratory tract; narcosis; excitement or somnolence; vomiting; reduced pulse rate and body temperature; ingestion induces similar effects to state of intoxication similar to that when under the influence of alcohol. Chronic toxicity: gastro-intestinal disorders; headache; polypnoea. French exposure limits: 400ppm (1200mg/m³) (VME); 500ppm (1500mg/m³) (VLE).
Cahiers de notes documentaires - Hygiène et sécurité du travail, 4th Quarter 1999, No.177, p.149-153. Illus. 28 ref.
http://www.inrs.fr/dossiers/fichtox/ft10.pdf [in French]

CIS 01-146 Kiilunen M.
Biomonitoring action levels in Finland
In Finland, biomonitoring action levels (BAL) have been set since the 1970s. There are different ways of setting these BALs. The value for blood lead is based on legislation. Exposure limits have been set on the basis of the indicative values for carbon disulfide, ethylene, benzene, toluene and phenol. The number of BALs set by the Finnish Institute of Occupational Health (FIOH) has increased year by year, and there are now BAL values for more than 36 different chemicals or chemical groups. The Institute annually publishes a booklet with the latest information about the biomonitoring tests, sample collection and limit values. The booklet is also available in English as a web version (http://www.occuphealth.fi/tt/bio/guide346.htm).
International Archives of Occupational and Environmental Health, July 1999, Vol.72, No.4, p.261-267. 26 ref.

CIS 01-141 Morgan M.S., Schaller K.H.
An analysis of criteria for biological limit values developed in Germany and in the United States
The biological tolerance values established by the German Research Foundation and the biological exposure indices developed by the American Conference of Governmental Hygienists represent two extensive lists of occupational exposure guidelines for use in biological monitoring. Although there is substantial agreement between the two organizations on most points, there are several important differences in the approaches taken in the setting of guideline values. Analysis of these distinctions serves to focus attention on the current issues impeding international agreement over occupational exposure guidelines. Among these issues are (1) the specification of the biological monitoring guidelines as ceiling or average values, (2) whether carcinogenic substances should be treated differently from agents with other toxic outcomes, (3) the method of accounting for variability among individual workers, and (4) the extent to which these guidelines should be extended to include genetic markers, indicators of susceptibility, or indicators of early biological response.
International Archives of Occupational and Environmental Health, July 1999, Vol.72, No.4, p.195-204. 14 ref.

CIS 00-1685
Ministerio de trabajo y asuntos sociales
Occupational exposure limits for chemical agents in Spain, 1999
Límites de exposición profesional para agentes químicos en España 1999 [in Spanish]
Topics: chemical products; harmful substances; limitation of exposure; short-term exposure; Spain; threshold limit values; TLV list.
Instituto Nacional de Seguridad e Higiene en el Trabajo, c/Torrelaguna 73, 28027 Madrid, Spain, 1999. 59p. 8 ref.

CIS 00-1726 McCunney R.J., Masse F., Galanek M.
Occupational ingestion of P-32: The value of monitoring techniques to determine dose - A case report
The internal dose of a P-32-labelled compound that had inadvertently been ingested was estimated using the International Commission on Radiation Protection (ICPR)-30 model. This metabolic model assumes that 80% of the material ingested is absorbed through the gastrointestinal tract because P-32 is soluble. Twenty-four-hour urine sampling over a 6-week period, coupled with daily whole body counting over the same period, was performed. An assessment of the laboratory where the accident occurred indicated that approximately 600µCi of radioactive phosphorus was missing. The total effective dose equivalent was estimated at 4.8rem (48mSv). This report confirms the value of using the ICRP-30 model with urinary measurements and whole body counting to estimate the radioactive dose received as a result of ingestion of P-32.
Journal of Occupational and Environmental Medicine, Oct. 1999, Vol.41, No.10, p.878-883. Illus. 7 ref.

CIS 00-1703 Analysis of dangerous substances
Gefahrstoff-Analytik [in German]
CD-ROM with analytical techniques used for the enforcement of MAK and TRK values, emission controls and for the determination of gas concentrations in the chemical industry.
Ecomed Verlagsgesellschaft AG & Co. KG, Rudolf-Diesel-Str. 3, 86899 Landsberg, Germany, May 1999. CD-ROM for Windows 95, Windows 98, Windows NT or Windows 3.1 (recommended configuration: Pentium, min. 16 MB RAM, hard disk min. 18 MB, graphic card min. 800x600, 256 colours).

CIS 00-1228 Grand-Ducal Regulation of 28 February 1999 amending the Grand-Ducal Regulation of 10 July 1995 on the fixing of limit values for the protection of workers against the risks resulting from exposure to chemicals during work [Luxembourg]
Règlement grand-ducal du 28 février 1999 modifiant le Règlement grand-ducal du 10 juillet 1995 relatif à la fixation de valeurs limites concernant la protection des travailleurs contre les risques liés à une exposition à des agents chimiques pendant le travail [Luxembourg] [in French]
This Regulation amends the Grand-Ducal Regulation of 1995 (CIS 00-1227) by appending Annexe II of the Commission Directive 96/94/EC of 18 December 1996 establishing a second list of occupational exposure limit values (CIS 97-9).
Mémorial - Journal officiel du Grand-Duché de Luxembourg, 17 Mar. 1999, A-No.26, p.657-658.

CIS 00-1137 Prescribing, recording and reporting photon beam therapy (Supplement to ICRU Report 50)
This report is an update of an earlier report (ICRU 50, published in 1993) on the same subject, taking into account recent advances in irradiation techniques, three-dimensional imaging and treatment systems. Detailed theoretical and practical analysis of target volumes, treated volumes and absorbed doses are provided, leading to updated recommendations and guidance for reporting treatments of individuals and series of patients. Clinical case studies of breast cancer, prostate cancer and lung cancer are included.
International Commission on Radiation Units and Measurements (ICRU), 7910 Woodmont Avenue, Bethesda, MD 20814, USA, 1999. ix, 52p. Illus. 54 ref. Index.

CIS 00-1089
Dutch Expert Committee on Occupational Standards (DECOS)
2-Nitropropane - Health-based calculated occupational cancer risk values
Additional lifetime cancer risk for 2-nitropropane amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.036mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 3.6mg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (accidental exposure: liver damage; daily exposure: headache, nausea, anorexia). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 34p. 25 ref.

CIS 00-1088
Dutch Expert Committee on Occupational Standards (DECOS)
N-Nitrosodimethylamine (NDMA) - Health-based calculated occupational cancer risk values
Additional lifetime cancer risk for dimethylnitrosoamine amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.002µg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 0.2µg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (highly toxic, hepatotoxicity, centrilobular necrosis with haemorrage, followed by ascites and jaundice). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 33p. 19 ref.

CIS 00-1087
Dutch Expert Committee on Occupational Standards (DECOS)
Metronidazole - Health-based calculated occupational cancer risk values
Metronidazole is an active substance used in the treatment of trichomoniasis. Additional lifetime cancer risk for metronidazole amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.12µg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 12µg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; estimation of the potential risk of cancer under workplace exposure conditions on the basis of epidemiologic data; existing occupational exposure limits; toxicity profile. Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 35p. 29 ref.

CIS 00-1086
Dutch Expert Committee on Occupational Standards (DECOS)
2-Methylaziridine (propylene imine) - Health-based calculated occupational cancer risk values
Additional lifetime cancer risk for 2-methylaziridine amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.6µg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 60µg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 30p. 11 ref.

CIS 00-1085
Dutch Expert Committee on Occupational Standards (DECOS)
Diglycidyl resorcinol ether - Health-based calculated occupational cancer risk values
Due to a lack of sufficient data, it is not possible to estimate the additional lifetime cancer risk for resorcinol diglycidyl ether. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; existing occupational exposure limits; toxicity profile (severe skin irritation and sensitization). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 30p. 9 ref.

CIS 00-1084
Dutch Expert Committee on Occupational Standards (DECOS)
Diethylsulphate - Health-based calculated occupational cancer risk values
Due to a lack of sufficient data, it is not possible to estimate the additional lifetime cancer risk for diethyl sulfate. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; existing occupational exposure limits; toxicity profile (corrosive substance that can cause skin burns; it is harmful following inhalation, oral and dermal exposure). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 30p. 18 ref.

CIS 00-1083
Dutch Expert Committee on Occupational Standards (DECOS)
1,2-Dibromoethane - Health-based calculated occupational cancer risk values
1,2-Dibromoethane is used as a fumigant. Additional lifetime cancer risk for 1,2-dibromoethane amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.002mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 0.2mg/m³ Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (eyes, skin and respiratory tract irritation, nose metaplasia and hepatotoxic effects). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 21 ref.

CIS 00-1082
Dutch Expert Committee on Occupational Standards (DECOS)
Carbadox - Health-based calculated occupational cancer risk values
Additional lifetime cancer risk for carbadox (an antibiotic used in pigfeed) amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.003mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 0.3mg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile. Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 14 ref.

CIS 00-1080
Dutch Expert Committee on Occupational Standards (DECOS)
Azathioprine - Health-based calculated occupational cancer risk values
Azathioprine is an immunosupressant. Main tumours in human after treatment with azathioprine include non-Hodgkin's lymphoma, squamous cell cancers of the skin, hepatobiliary carcinomas and mesenchymal tumours. Additional lifetime cancer risk for azathioprine amounts to 4 x 10^-5 for 40 years of occupational exposure to 0.005mg/m³, and 4 x 10^-3 for 40 years of occupational exposure to 0.5mg/m³. Main topics covered: carcinogenicity studies and selection of the study suitable for risk estimation in occupational situations; carcinogenic activity in experimental animals, life-time low-dose exposure; health risk to humans; health risk to workers, calculation of the health-based calculated occupational cancer risk values; existing occupational exposure limits; toxicity profile (toxic effect: bone-marrow depression). Summary in Dutch.
Gezondheidsraad, Postbus 16052, 2500 BB Den Haag, Netherlands, 1999. 32p. 11 ref.

CIS 00-1100
Health and Safety Executive
Occupational exposure limits 1999
This annual guidance note replaces EH 40/98 (CIS 98-246). It lists maximum exposure limits, occupational exposure standards and biological monitoring guidance values for use with the Control of Substances Hazardous to Health Regulations 1999 (see CIS 00-620). Substances currently under review are also listed. Additional sections contain detailed discussions of how to control exposure (setting and applying occupational exposure limits; new limits, reviews and revisions; substances which constitute special cases - carcinogens, respiratory sensitizers, lead and asbestos, pesticides, exposure in mines); monitoring exposure and mixed exposures. A technical supplement describes changes to the previous edition and provides examples of exposure calculations.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1999. vi, 94p. Price: GBP 8.50.

CIS 00-813 Henn M.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
List of threshold limit values in air for substances with carcinogenic or mutagenic effects or toxicity to reproduction
Verzeichnis von Luftgrenzwerten und krebserzeugenden, erbgutverändernden oder fortpflanzungsgefährdenden Stoffen [in German]
This monograph provides a listing of harmful substances, their threshold limit values in air, and their classification with respect to carcinogenicity, mutagenicity and toxicity for reproduction. CAS, European EINECS and ELINCS registry numbers are also provided. This list contains all the substances of Appendix VI No.4 of the Council Directive 67/548/EEC (CIS 87-1162).
Wirtschaftsverlag NW, Verlag für neue Wissenschaft GmbH, Bürgermeister-Smidt-Str. 74-76, Postfach 10 11 10, 27568 Bremerhaven, Germany, 1999. 149p. 20 ref.

CIS 00-40 Osmium tetroxide
Tetróxido de osmio [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 0.002mg/m³; ACGIH recommends a TLV of 0.0002mg/m³. Health hazards: effets tardifs; irritation of the eyes and respiratory tract; skin burns; dermatitis; pulmonary oedema; may damage the eyes and the kidneys.
Noticias de seguridad, Dec. 1999, Vol.61, No.12, 4p. Insert.

CIS 00-39 Diphenylmethane diisocyanate (MDI)
Isocianato bisfenílico de metileno (MDI) [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 0.2mg/m³. Health hazards: delayed effects; irritation; skin and respiratory sensitization; allergic asthma; pulmonary oedema.
Noticias de seguridad, Dec. 1999, Vol.61, No.12, 4p. Insert.

CIS 00-38 Trifluoromonobromomethane
Trifluoromonobromometano [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 6100mg/m³. Health hazards: irritation of the skin; cardiac arrythmia; narcotic effects at high concentrations.
Noticias de seguridad, Nov. 1999, Vol.61, No.11, 3p. Insert.

CIS 00-37 1,2,3-Trichloropropane
1,2,3-Tricloropropano [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 300mg/m³. Health hazards: narcotic effects; irritation of the upper respiratory tract; liver damage.
Noticias de seguridad, Nov. 1999, Vol.61, No.11, 4p. Insert.

CIS 00-36 1,1,2,2-Tetrachloroethane
1,1,2,2-Tetracloroetano [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 35mg/m³; NIOSH recommends a reduction of the limit to 6.87mg/m³. Health hazards: skin absorption; hepatic and renal damage; neurotoxic effects (depression of the central nervous system); brain and lung oedema.
Noticias de seguridad, Oct. 1999, Vol.61, No.10, 4p. Insert.

CIS 00-35 Selenium hexafluoride
Hexafluoruro de selenio [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 0.4mg/m³. Health hazards: irritation by inhalation or by skin or eye contact. Induces strong irritation of the respiratory tract in animals.
Noticias de seguridad, Oct. 1999, Vol.61, No.10, 3p. Insert.

CIS 00-34 Titanium dioxide
Dióxido de titanio [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 15mg/m³. Health hazards: irritation of the respiratory tract; lung diseases.
Noticias de seguridad, Sep. 1999, Vol.61, No.9, 3p. Insert.

CIS 00-33 Azinphosmethyl
Azinfosmetilo [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 0.2mg/m³. Health hazards: skin absorption; delayed effects; inhibition of blood cholinesterase; eye irritation and pain; blurred vision; respiratory insufficiency; cardiac arrhythmia; neurotoxic effects (central nervous system).
Noticias de seguridad, Sep. 1999, Vol.61, No.9, 4p. Insert.

CIS 00-32 Ortho-toluidine
Orto-toluidina [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 22mg/m³. Health hazards: skin absorption; irritation of the eyes; methaemoglobinaemia; hypoxia; cyanosis; haematuria.
Noticias de seguridad, Aug. 1999, Vol.61, No.8, 4p. Insert.

CIS 00-31 TEPP
TEPP [in Spanish]
Chemical safety card on tetraethyl pyrophosphate published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 0.05mg/m³. Health hazards: skin absorption; delayed effects; inhibition of blood cholinesterase; eye irritation and pain; blurred vision; bronchoconstriction; dyspnoea; cyanosis; respiratory insufficiency; gastrointestinal effects; neurotoxic effects (central nervous system).
Noticias de seguridad, Aug. 1999, Vol.61, No.8, 4p. Insert.

CIS 99-1451 Methylcyclohexane
Metilciclohexano [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: bladder tumour; methylcyclohexane; data sheet; delayed effects; determination in air; dyspnoea; eczema; elimination of spills; fire fighting; fire hazards; first aid; health hazards; irritants; irritation; limitation of exposure; medical supervision; methaemoglobinaemia; narcotic effects; neurological effects; personal protective equipment; respirators; skin absorption; skin allergies; threshold limit values; unconsciousness; USA; vertigo; waste disposal.
Noticias de seguridad, Feb. 1999, Vol.61, No.2. 4p. Insert.

CIS 99-1449 Vanadium pentoxide fumes
Humo de pentóxido de vanadio [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: bronchitis; vanadium pentoxide; chronic bronchitis; data sheet; determination in air; eczema; first aid; health hazards; irritants; limitation of exposure; medical supervision; personal protective equipment; pneumotoxic effects; respirators; skin allergies; threshold limit values; USA; volatile substances.
Noticias de seguridad, Jan. 1999, Vol.61, No.1. 4p. Insert.

1998

CIS 02-1062 Falcy M., Hesbert A., Jargot D., Protois J.C., Reynier M., Schneider O., Serre P.
Lead and its inorganic compounds
Plomb et ses composés minéraux [in French]
Chemical safety information sheet. CD-ROM version of the document already analysed as CIS 99-1783. Acute toxicity: digestive disorders; haemolytic anaemia; cytologic hepatic damage; neurological effects (intracraneal hypertension and convulsive coma) which may leave sequelae. Chronic toxicity: haematological effects (anaemia); effects on the digestive tract (deposits of lead); neurological effects (convulsive coma, sensitive-motor neuropathy, amyotrophic lateral sclerosis); renal damage; high blood pressure; bone damage; effects on reproduction; carcinogenic effects (lung and stomach cancer). Exposure limits (France): 150µg/m³ (mean value over 40 hours expressed as lead). EC number and mandatory labelling codes: No.231-100-4 (lead), No.082-001-00-6 (lead monoxide); T, R61, R62, R20/22, R33, S53, S45, 215-267-0 (lead monoxide). The complete datasheet collection on CD-ROM has been analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. 8p. Illus. 38 ref.

CIS 01-1516
International Radiation Protection Association (IRPA)
Protection of workers from power frequency electric and magnetic fields - A practical guide
Arabic translation of the ILO publication analysed under CIS 94-704. It comprises a review of data on the effects of extremely low frequency (ELF) electric and magnetic fields on biological systems pertinent to the evaluation of health risks for workers. It provides information on the possible effects of exposure to 50/60Hz electric and magnetic fields on human health and gives guidance on the assessment of risks from occupational exposure. Areas in which uncertainties exist and further research is needed are also indicated. Biological effects of ELF electric and magnetic fields and national exposure standards are presented in appendices.
ILO Publications, International Labour Office, 1211 Genève 22, Switzerland, 1998. 189p. Illus. 112 ref.

CIS 01-1337 n-Butyl acetate
Acétate de n-butyle [in French]
Chemical safety information sheet. Acute toxicity: irritation of the respiratory and ocular mucus membranes, depression of the central nervous system possibly giving rise to effects similar to those of alcohol influence and to hallucinations. Chronic toxicity: irritation and dermatoses; keratitis; nausea; irritation of the respiratory and digestive tract; haematological and hepatic abnormailties. Exposure limits (France): TWA = 710mg/m³ (150ppm); ceiling limit = 940mg/m³ (200ppm). EC number and mandatory labelling codes: No.807-025-00-1; R10, 204-658-1. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. 4p. 18 ref.

CIS 01-1494 Huici Montagud A., Ferrer Panzano R.
Occupational exposure limits in the European Union and in Spain
Valores límite de exposición profesional en la Unión Europea y en España [in Spanish]
Council Directive 98/24/EC (see CIS 98-1094) which sets occupational exposure limits for a number of chemicals had to be transposed into the national legislations of European Union member states by 2001. Each member state was required to establish corresponding national exposure limit values based on, but not exceeding, the Community limit value. This information note lists the exposure limits set by the European Commission for approx. 50 substances and provides definitions for the terms used in the directive, including chemical agent, workplace, breathing zone, reference period, daily, short-term and 8-hour exposures, biological indicators and maximum working environment levels.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1998. 5p. 4 ref.

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