Leukaemia - 111 entries found

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1978

CIS 80-459 Mitelman F., Brandt L., Nilsson P.G.
Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings and bone marrow chromosomes in acute nonlymphocytic leukemia.
Chromosome banding patterns, cytological diagnosis and clinical findings were compared in 23 patients with acute non-lymphocytic leukaemia (ANLL) exposed to chemical solvents, insecticides, and petroleum products, and 33 with ANLL and no history of such exposure. Acute myeloid leukaemia was more common in the exposed group, and monocytic varieties of ANLL were common in the non-exposed group. 24.2% of the non-exposed and 82.6% of the exposed group had chromosome aberrations; 84.2% of the exposed group had at least one of monosomy 5 or 7 or trisomy 8 or 21, compared with only 2 aberrations in the non-exposed group. Other aberrations in the non-exposed group were not seen in the exposed subjects.
Blood, Dec. 1978, Vol.52, No.6, p.1229-1237. 28 ref.

CIS 78-1597 Najarian T., Colton T.
Mortality from leukaemia and cancer in shipyard nuclear workers
A review of death certificates of workers at a shipyard where nuclear submarines are repaired and refuelled is reported. Information on exposure to radiation was obtained for 592 workers (146 exposed, 446 non-exposed). Leukaemia deaths were 5.62 times higher, and overall cancer deaths 1.78 times higher, in the exposed than the non-exposed workers. These results exceed predictions based on previous data of radiation effects in man.
Lancet, 13 May 1978, Vol.1, No.8072, p.1018-1020. 4 ref.

1977

CIS 77-1991 Infante P.F., Rinsky R.A., Wagoner J.K., Young R.J.
Leukaemia in benzene workers.
Controlled mortality study in all (748) workers of 2 plants exposed to benzene during the production of a type of natural rubber cast film primarily used for food wrapping, in 1940-1949, followed up to 1975. Production methods are described. There was a 5-fold excess of leukaemia and a 10-fold excess of deaths from myeloid and monocytic leukaemias combined. These figures underestimate the true rates, on account of incomplete follow-up. Benzene levels were generally below recommended limits when measured. A letter by Tabershaw I.R. and Lamm S.H. taking a critical stand towards the article, and a reply by the authors, are published in Lancet, 22 Oct. 1977, No.8043, p.867-869.
Lancet, 9 July 1977, Vol.2, No.8028, p.76-78. 22 ref.

1976

CIS 78-189 Farulla A., Alimena G., Delfini A.M., Ogis M., Percoco V.D., Naro G.
In vitro chromosome radiosensitivity in preleukaemic syndromes
Radiosensibilità cromosomica "in vitro" nelle sindromi preleucemiche [in Italian]
Chromosome studies in 6 cases of preleukaemic syndrome showed particular radiosensitivity in forms of involutive myelopathy (medullary aplasia, sideroachrestic anaemia, chronic erythroblastopenia), while myeloproliferative forms (2 cases) showed a behaviour similar to that of controls.
Securitas, Mar.-Apr. 1976, Vol.61, No.3-4, p.118-124. Illus. 9 ref.

CIS 77-1623 Proceedings of NIOSH styrene-butadiene briefing.
The National Institute for Occupational Safety and Health held a briefing (Covington, Kentucky, 30 Apr. 1976) to explore with concerned persons from government, labour, management, and academic areas the implications of data on the possible linkage between exposure to styrene-butadiene and leukaemia deaths, the potential problems to be anticipated, and alternatives for action. Chemicals and working conditions in 2 Port Neches, Texas, styrene-butadiene plants were described. Reports of disease among workers included 8 leukaemia deaths in these 2 plants; a 6-fold excess of leukaemia and lymphoma deaths in an Akron, Ohio, plant; 1 death from leukaemia and 2 from Hodgkin's disease in a Louisville, Kentucky, plant; and 2 leukaemia deaths and 1 lymphoma death among 563 styrene workers in a plant in Pennsylvania. Speakers presented suggestions for epidemiologic studies, both industry-wide and in specific plants, and discussed sampling and analytical methods, engineering controls, work practices, and standards development as they relate to controlling exposures in styrene-butadiene plants.
HEW Publication No.(NIOSH)77-129, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, Dec. 1976. 169p. Illus. 64 ref.

CIS 77-159 Vigliani E.C., Forni A.
Benzene and leukemia.
From a review of the literature, the authors estimate that there must be at least 150 cases of acute leukaemia attributable to benzene, as many cases that were considered acute pancytopenia in the past, prior to the introduction of bone marrow biopsy, may in fact have been cases of acute leukaemia. Data relating to cases of benzene haemopathy in Italy and other countres are briefly discussed. The mechanism by which benzene induces leukaemia is still not clear. It is most probable that benzene is not active per se, but through its metabolites. There is at present no indication that the homologues of benzene are leukaemogenic.
Environmental Research, Feb. 1976, Vol.11, No.1, p.122-127. 19 ref.

CIS 76-1091 Pollini G., Biscaldi G.P., Carosi L.
Benzene-induced acute aleukaemic leucosis, with diffuse leukaemic infiltration of the parenchyma
Leucosi acuta aleucemica benzolica con diffusa infiltrazione parenchimale leucemica [in Italian]
Case report of a shoe-industry worker who has been employed in glueing soles for 2 years. The original condition diagnosed, benzene-induced progressive haemopathy, developed into leukaemia, which was recognisable only at autopsy. Clinical and pathological details of the case are given, and possible pathogenic mechanisms discussed.
Lavoro umano, Jan. 1976, Vol.28, No.1, p.10-16. Illus. 5 ref.

1975

CIS 75-1984 McMichael A.J., Spirtas R., Kupper L.L., Gamble J.F.
Solvent exposure and leukemia among rubber workers: An epidemiologic study.
After a literature survey on the epidemiology of these cancers, from which little evidence of chemical exposure as an aetiological factor emerges, a case-control analysis is described of an earlier mortality study (CIS 74-2047) in 6,678 rubber workers at a major U.S. rubber company. The report concentrates on 17 men who died of lymphatic leukaemia, each matched with 3 controls. There is a statistically significant association between solvent exposure (especially benzene) and lymphatic leukaemia, the over-all risk appearing to be 3 times (7 times in high-exposure jobs) greater than in non-exposed workers. The occupation with the greatest risk appeared to be tyre repairing.
Journal of Occupational Medicine, Apr. 1975, Vol.17, No.4, p.234-239. 14 ref.

1974

CIS 74-1635 Thorpe J.J.
Epidemiologic survey of leukaemia in persons potentially exposed to benzene.
8 European affiliates of Exxon Corporation participated in this survey undertaken to study the relationship of leukaemia to benzene exposure. The results are presented and discussed in detail. It was established that the occurrence of leukaemia in a population working in a variety of petroleum and petrochemical operations, some of whom were exposed to low levels of benzene over a 10-year period, is not abnormal when compared to the incidence in the general population in the countries concerned. There is need for improved methods of recording and storing biological observations, job histories, occupational exposures and demographic data.
Journal of Occupational Medicine, June 1974, Vol.16, No.6, p.375-382. Illus. 12 ref.

1973

CIS 74-1355 Pollini G., Biscaldi G.P.
Possible leukaemogenic effects of industrial chemical products
Sulla possibile azione leucemogena delle sostanze chimiche di uso industriale [in Italian]
Up to the present, only benzene, ionising radiation and perhaps hexachlorocyclohexane can be considered leukaemogenic with certainty. Substances which are toxic for the haemopoietic system are not necessarily leukaemogenic, nor are substances known to be carcinogenic (coal tar derivatives, aromatic amines, arsenic salts, etc.). 2 possible interpretations of benzene-induced leukaemia are suggested: real leukaemia due to the mutagenic potential of benzene, or severe cytopoietic insufficiency of the bone marrow, which does not have a cancerous character. The treatment should be different in the 2 cases.
Medicina del lavoro, Mar.-Apr. 1973, Vol.64, No.3-4, p.121-126. Illus. 22 ref.

1972

CIS 73-1083 Aksoy M.
Acute leukaemia due to chronic exposure to benzene
Description of 4 cases of acute leukaemia that developed in shoemakers using benzene-containing adhesives. In one of these workers, acute myeloblastic leukaemia occurred 3yrs after recovery from aplastic anaemia due to chronic benzene poisoning. In 2 of them acute myeloblastic leukaemia appeared without any preceding period of aplastic anaemia. In the fourth patient, thrombocythemia developed in the second year after an episode of aplastic anaemia due to chronic benzene poisoning; it lasted some months and was considered to be a preleukaemic stage. At this time the bone marrow did not show any signs of leukaemia, but later acute monocytic leukaemia appeared.
American Journal of Medicine, Feb. 1972, Vol.52, p.160-165. Illus. 30 ref.

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