Organosulfur compounds - 93 entries found

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1988

CIS 90-110 Easton D.F., Peto J., Doll R.
Cancers of the respiratory tract in mustard gas workers
In a study of a cohort of 2498 men and 1032 women employed in the manufacture of mustard gas in Cheshire (England) during the Second World War, 3354 (95%) individuals were successfully traced for mortality to the end of 1984. Highly significant excesses were observed as compared with national death rates for deaths from cancer of the larynx, pharynx and all other buccal cavity and upper respiratory sites combined. For lung cancer, a highly significant but more moderate excess was observed. Significant excesses were also observed for deaths from acute and chronic non-malignant respiratory disease. The risks for cancers of the pharynx and lung were significantly related to duration of employment. The results provide strong evidence that exposure to mustard gas can cause cancers of the upper respiratory tract and some evidence that it can cause lung cancer and non-malignant respiratory disease.
British Journal of Industrial Medicine, Oct. 1988, Vol.45, No.10, p.652-659. 14 ref.

CIS 89-1786 Ethyl mercaptan
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Exposure limits: OSHA PEL (ceiling value) = 25mg/m³; NIOSH REL (15min ceiling) = 1.3mg/m³; ACGIH TLV (8h-TWA) = 1mg/m³. Toxicity: irritation of mucous membranes.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226, USA, 1988. 6p. Bibl.

CIS 89-1459 n-Butyl mercaptan
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Exposure limits: OSHA PEL (8h-TWA) = 35mg/m³; NIOSH REL (15min ceiling) = 1.8mg/m³; ACGIH TLV (8h-TWA) = 1.5mg/m³. Odour threshold = 1.0 to 48ppb. Toxicity: irritation of the mucous membranes.
US Department of Health and Human Services, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1988. 6p. Bibl.

1987

CIS 89-758 Mustard gas
Bis(2-kloretyl)sulfid; 2,2'-diklordietylsulfid [in Swedish]
Chemical safety information sheet taken from the Kemiska Ämnen Register (CIS 89-214). Toxicity: carcinogen, irritates the eyes, skin and mucous membranes.
Arbetarskyddsnämnden, Box 3208, 103 64 Stockholm, Sweden, 1987. 3p.

CIS 88-818 Tetradifon health and safety guide
Chemical safety information sheet based on WHO Environmental Health Criteria 67: Tetradifon (CIS 86-1713). Acaricide. Toxicity: irritation of the eyes, skin and upper respiratory tract.
World Health Organization, Distribution and Sales, 1211 Genève 27, Switzerland, 1987. 40p. Illus. Price: CHF 5.00.

1986

CIS 86-1713
International Programme on Chemical Safety (IPCS)
Tetradifon
Aspects covered in this WHO Environmental Health Criteria Document: identity, physicochemical properties, analytical methods; environmental levels and human exposure; toxicology; recommendations for preventing exposure. No adverse health effects from exposure to Tetradifon (acaricide) have been reported in man.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1986. 47p. 89 ref. Price: SF.7.00.

1985

CIS 88-133 Sulfoxide, 3-chloropropyl octyl
Chemical safety information sheet. No established exposure limit. Toxicity: LD₅₀ (oral, rat) = 5660mg/kg; LD₅₀ (dermal, rabbit) = 8mg/kg; no data available on health hazards.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 88-117 Phenol, 2,2'-thiobis(4-chloro-6-methyl-
Chemical safety information sheet. Toxicity: LD₅₀ (oral, rat) = 1.3mg/kg; highly toxic by ingestion.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 87-1218 Ethanesulfonyl chloride, 2-chloro-
Chemical safety information sheet. Only toxicity data available: LC₅₀ (inhalation, mouse) = 0.25mg/L/4h. No established exposure limit.
In: EPA Chemical Profiles, United States Environmental Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 87-427 Perchloromethylmercaptan
Chemical safety information sheet. Exposure limits: OSHA=0.8mg/m³ (1985); ACGIH TLV (1980)=0.8mg/m³. Corrosive to most metals (reacts with iron or steel, evolving carbon tetrachloride). Very strong irritant to eyes skin and mucous membranes. Is absorbed through the skin. May cause death or permanent injury after short exposure to small quantities.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington DC 20460, USA, Dec. 1985. 4p.

CIS 87-422 Methyl disulfide
Chemical safety information sheet. Highly toxic by inhalation. Health hazards resemble those of sulfides and alkyldisulfides. Effects may be delayed. No established exposure limits. Vapour explosion hazard.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington, D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1888 Mustard gas
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1621 Thiophenol
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1327 Methyl mercaptan
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1325 Dimethyl sulfide
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 85-1935 Wulf H.C., Aasted A., Darre E., Niebuhr E.
Sister chromatid exchanges in fishermen exposed to leaking mustard gas shells
This letter to the editor reports on 11 cases of fishermen who were accidentally exposed to mustard gas leaking from gas shells dumped off the coast of Denmark after the Second World War. The shells, heavily corroded, are dug up by trawlers. In addition to skin and eye irritation, most cases showed significant mutagenic changes as revealed by the sister chromatid exchange test.
Lancet, 23 Mar. 1985, Vol.1, No.8430, p.690-691. 6 ref.

1984

CIS 85-1649 Maksimov G.G., Teregulova O.V., Pylev L.N., Gilev V.G., Gubajdullin R.M.
Investigation of the blastomogenic properties of dimethyl sulfoxide
Issledovanie blastomogennyh svojstv dimetilsulfoksida [in Russian]
Intragastric administration of dimethyl sulfoxide (DMSO) to rats and mice at 0.01LD₅₀ 3 times per week produced haemoblastosis in the rats and leukosis in the mice; frequencies of other neoplasms did not differ from controls. Neoplasms first appeared in both species after about a year. Tumours appeared at about the same time in experimental and control rats, but they appeared later in the experimental mice than in the controls. Subcutaneous administration of DMSO gave no significant difference in rates of tumour development from controls in either species. Development of standards for DMSO exposure should take account of this apparent carcinogenic effect.
Gigiena truda i professional'nye zabolevanija, May 1984, No.5, p.39-40. 11 ref.

CIS 85-848 Kangas J., Jäppinen P., Savolainen H.
Exposure to hydrogen sulfide, mercaptans and sulfur dioxide in the pulp industry
An occupational health survey of 10 paper mills in Finland revealed concentrations in air varying from 0 to 20ppm H₂S, 0 to 15ppm methyl mercaptan and dimethyl sulfide, 0 to 1.5ppm dimethyl disulfide and up to 20ppm SO₂. The exposed workers complained of headache and a decrease in concentration capacity. Their frequency of sick leave was greater than among a control group. Contaminant concentrations and health problems differed with the types of processes used.
American Industrial Hygiene Association Journal, Dec. 1984, Vol.45, No.12, p.787-790. 13 ref.

CIS 84-414 Girard-Wallon C., Aubrun J.C.
Organic sulfur derivatives
Dérivés organiques du soufre [in French]
This general review, divided into 6 sections on the basis of functional groups, covers thiols (mercaptans), thiahydrocarbons, sulfides, disulfides, episulfides, hydroxymercaptans and derivatives, sulfoxides, sulfones, sultones, sulfonates, sulfates, thioamides, thio amino acids, sulfamides, thiocarbamides, thiocarbamates, thiocyanates, thiazoles, thiazines, and thiohalogenated and thiophosphorylated compounds, indicating for each class its physical and chemical properties, industrial uses and toxicity. A final section covers preventive and protective measures: exposure limits where these are defined, determination of concentrations in the workplace, compensation in industry and agriculture, and diseases defined as occupational.
Encycolpédie médico-chirurgicale, 18, rue Seguier, 75006 Paris, France, 1983. Intoxications, 16058 U10, 10-1983, 16p. 35 ref.

1983

CIS 84-1896
Health and Safety Executive
Odorisation of bulk oxygen supplies in shipyards
This guidance note sets out standards for dimethyl sulfide (DMS) odorising plants for bulk oxygen supplies in shipyards and oil rig construction yards. Odorisation is used to reduce fire hazards and to reduce oxygen consumption due to oxygen spillage from bulk supplies of oxygen into confined spaces. DMS is a volatile, pungent-smelling, flammable and toxic organic liquid. For DMS to be detectable by smell, its concentration in the oxygen supply line should be above 5.6ppm, while for health reasons it should not exceed 12ppm. Detailed description of an odorising plant, of its control and operation are given. Preventive measures, protective equipment, spillages, first aid measures, monitoring and maintenance are described.
H.M. Stationery Office, 49 High Holborn, London WC1V 6HB, United Kingdom, Oct. 1983. 6p. Illus. Price: £1.00.

CIS 83-1937
(Institut national de recherche et de sécurité)
Methanethiol; ethanethiol; 1-butanethiol
Méthanethiol; éthanethiol; 1-butanethiol [in French]
Synonyms, uses, physical and chemical properties; storage; methods of detection and determination in air; fire hazards; pathology and toxicology: experimental toxicology, metabolism, toxicity to man (cutaneous and respiratory irritation; American (ACGIH) TLVs: 1mg/m³ for methanethiol and ethanethiol, 1.5mg/m³ for 1-butanethiol). French regulations on occupational health and safety and neighbourhood protection, and French and international regulations on transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 4th quarter 1983, No.113, p.597-600. 28 ref.

1982

CIS 89-438 2,4,6-Trinitrobenzenesulfonic acid
2,4,6-trinitrobentseenisulfonihappo [in Finnish]
Chemical safety information sheet. Explosive. Toxicity: irritates the skin and the eyes; effects can be cumulative; can cause eczema. Mandatory European labelling: T, R2, R28, R36, R38, S5, S3, S9, S24, S25.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, May 1982. 2p. Original on microfiche.

CIS 89-392 4-aminobenzenesulfonic acid
4-aminobentseenisulfonihappo [in Finnish]
Chemical safety information sheet. Toxicity: the dust and the solutions irritate the skin, the eyes and the mucous membranes; the dust can anaesthesise the nose and the mouth; long-term exposure to the dust can cause eczema, damage the eyes and cause inflammation of the respiratory tract. Mandatory European labelling: XN, R20, R21, R22, S25, S28.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, May 1982. 2p. Original on microfiche.

CIS 88-51 3-Aminobenzenesulfonic acid
3-Aminobentseenisulfonihappo [in Finnish]
3-aminobenzenesulfonic acid is harmful if inhaled, ingested or in contact with the skin. The dust irritates the skin, the eyes and the mucous membranes. Long term exposure to the dust can cause inflammation of the respiratory tract. Mandatory European labelling: XN, R20, R21, R22, S25, S28.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, May 1982. 2p. Original on microfiche.

CIS 83-511 Kilpikari I., Savolainen H.
Increased urinary excretion of thioether in new rubber workers
The thioether excretion was evaluated in 84 new rubber workers before starting work and after 1, 2-4 and 5 or more months of starting work. Urinary excretion of thioether decreased after 1 month's exposure and increased thereafter up to 5 months. Urinary thioether measurement in groups of new workers in the rubber industry is informative of exposure to alkylating agents only after several months from starting work.
British Journal of Industrial Medicine, Nov. 1982, Vol.39, No.4, p.401-403. 10 ref.

CIS 82-1111 Van Doorn R., Bos R.P., Brouns R.M.E., Henderson P.T.
Is the determination of thioethers in urine samples useful for the biological monitoring of genotoxic effects in the workplace environment?
Is de bepaling van thioethers in urinemonsters bruikbaar bij de biologische monitoring van genotoxische belasting door de arbeidsomgeving? [in Dutch]
Report on thio ether urinalysis among workers exposed to certain chemicals (e.g. incineration of chemical wastes and increase in urinary thio ether excretion on the day of exposure). Thio ether determination is useful in view of the electrophilic properties of chemicals and may serve as a warning signal.
Tijdschrift voor sociale geneeskunde, 20 Jan. 1982, Vol.60, No.2, p.30-34. Illus. 7 ref.

1981

CIS 82-1038 Knarr R.D., Rappaport S.M.
Impregnated filters for the collection of ethanethiol and butanethiol in air
Ethanethiol and butanethiol were collected on glass fibre filters impregnated with mercuric acetate. The entrapped thiols were regenerated from the mercuric mercaptide, formed during sampling, by treatment with acid. Samples were analysed by gas chromatography with a relative error of ± 4% and a relative standard deviation of < 2%. The method can be used for measuring long-term or short-term exposures in the range 0.1-1ppm.
American Industrial Hygiene Association Journal, Nov. 1981, Vol.42, No.11, p.839-841. 2 ref.

CIS 82-1061 Chovil A.
Laryngeal cancer: An explanation for the apparent occupational associations
The aetiology of laryngeal cancer is reviewed, and established causative factors are considered (smoking, alcohol, vocal abuse). Recent attempts to link laryngeal cancer with various types of occupational exposure (in particular asbestos but also nickel, mustard gas and isopropyl alcohol) are looked at. It is hypothesised that laryngeal cancer occurs as a result of exposure of the larynx to lipid-soluble carcinogenic agents - mainly from tobacco smoke but also, occasionally, from industrial agents such as mustard gas - that can penetrate the squamous epithelial covering. Alcohol and vocal abuse may have promoting effects. It is postulated that in many occupations involving asbestos exposure (e.g. construction and shipbuilding), workers are prone to abuse their voices.
Medical Hypotheses, 1981, Vol.7, No.7, p.951-956. 22 ref.

CIS 82-799 Van Doorn R., Leijdekkers C.M., Bos R.P., Brouns R.M.E., Henderson P.T.
Enhanced excretion of thioethers in urine of operators of chemical waste incinerators
Thioether concentrations were determined in 69 urine samples obtained from 10 workers in the despatch department, 34 prework and 33 end-of-work specimens from 3 chemical waste incinerator operators and 21 samples from an analyst, all working in the same chemical plant. Determinations were also made in 196 urine samples obtained from men, including smokers, not occupationally exposed to chemicals, to serve as controls. Enhanced excretion of thioethers was found in the urine samples taken from incinerator workers at the end of work. A regular pattern in the time course of urinary thioether excretion was shown by a non-smoking incinerator worker. End-of-work values were always higher than prework values. This phenomenon was not found in samples from the analyst. Incinerator workers inhale or otherwise absorb electrophilic compounds or their precursors, which are subsequently metabolised to, and excreted as, thioethers in urine.
British Journal of Industrial Medicine, May 1981, Vol.38, No.2, p.187-190. Illus. 20 ref.

CIS 82-808 Schwope A.D., Randel M.A., Broome M.G.
Dimethyl sulfoxide permeation through glove materials
The breakthrough time for dimethyl sulfoxide was measured through samples of 4 types of rubber used in commercially available protective gloves. Breakthrough times varied from 1.5-2h for natural rubber to >8h for neoprene latex.
American Industrial Hygiene Association Journal, Oct. 1981, Vol.42, No.10, p.722-725. Illus. 7 ref.

CIS 81-1361 Kilpikari I.
Correlation of urinary thioethers with chemical exposure in a rubber plant.
Exposure to potentially alkylating agents was measured by determining thioether concentrations in the urine at the end of the work week in 113 production workers and 11 office clerks. The highest excretion of thioethers was in female workers in the belt department, exposed through the palmar skin. Workers in the calender department and the raw material stores and chemical mixing sections also had high excretion. Urinary thioether determination appears to be a reliable and easy method of assessing exposure to certain rubber chemicals.
British Journal of Industrial Medicine, Feb. 1981, Vol.38, No.1, p.98-100. 5 ref.

1980

CIS 81-1938 Gluharev Ju.A., Uždavini Ė.P., Mamaeva A.A., Gilev V.G., Stepanova A.A.
Establishing a maximum allowable concentration for divinyl sulfide in the workplace air
K obosnovaniju predel'no dopustimoj koncentracii divinilsul'fida v vozduhe rabočej zony [in Russian]
Divinyl sulfide (DVS) is used as a plasticiser in elastomer vulcanisation. The commercial product under study contained 99.5% DVS and 0.5% dimethyl sulfide. DVS was determined in air spectrophotometrically using a wavelength of 241nm and heptane as the solvent. Data on DVS toxicity in the rat and mouse. Recommended threshold limit value: 0.2mg/m³.
Gigiena truda i professional'nye zabolevanija, July 1980, No.7, p.51-52. 3 ref.

CIS 81-912 Methyl mercaptan (cylinders).
Uses; hazards (highly flammable and toxic gas); precautions (storage; explosion venting; electrical apparatus for use in potentially explosive atmospheres, flameproof electric light fittings, with references to British standards); fire fighting; references to regulations; characteristics of CH₃SH.
Fire Prevention, Oct. 1980, No.138, p.47-48.

1979

CIS 80-447 Van Doorn R., Henderson P.T.
Urinary thio ether excretion as an indicator of exposure
Thioethers in urine als biologische parameter van expositie [in Dutch]
The possibility of detecting exposure to alkylating agents by determination of thio ethers as detoxication products in the urine is studied. Most carcinogenic and mutagenic agents fall into this category. Detection of thio ethers serves above all as warning signal. When their concentration increases, the probability of exposure to one or several alkylating agents is high. Determination of thio ethers (or of mercapturic acid) is described in the light of experiments reported in the literature. The possibility of detecting exposure to carbon disulfide and chloromethane is discussed.
Tijdschrift voor sociale geneeskunde, 24 Aug. 1979, Vol.57, No.21, p.657-663. Illus. 12 ref.

CIS 79-1990 Leskova G.E.
Protective effect of lipoic acid amide in experimental mercury poisoning
Zaščitnyj ėffekt amida lipoevoj kisloty pri ėksperimental'nom merkurializme [in Russian]
Several groups of rats were exposed to 0.8-1mg/m³ mercury vapour daily. 10mg/kg lipoic acid amide administered orally 10min before and immediately after exposure reduced the toxic effects of the mercury. Administration of 10mg/kg for 5 months had no effect on the animals' general condition. The protective effect of the amide is due to binding and elimination of mercury in the organism, and protection of the thiol groups of biologically active compounds.
Gigiena truda i professional'nye zabolevanija, June 1979, No.6, p.27-30. 8 ref.

1978

CIS 79-775 Criteria for a recommended standard - Occupational exposure to n-alkane monothiols, cyclohexanethiol, and benzenethiol.
Recommendations are made for the prevention of occupational disease due to monothiols. The ceiling concentrations determined for any 15min period are given in mg/m³ and ppm, respectively: benzenethiol (0.5; 0.1); 1-methanethiol (1.0, 0.5); 1-ethanethiol (1.3, 0.5); 1-propanethiol (1.6, 0.5); 1-butanethiol (1.8, 0.5); 1-pentanethiol (2.1, 0.5); 1-hexanethiol (2.4, 0.5); 1-heptanethiol (2.7, 0.5); 1-octanethiol (3.0, 0.5); 1-nonanethiol (3.3, 0.5); 1-decanethiol (3.6, 0.5); 1-undecanethiol (3.9, 0.5); 1-dodecanethiol (4.1, 0.5); 1-hexadecanethiol (5.3, 0.5); 1-octadecanethiol (5.9, 0.5); cyclohexanethiol (2.4, 0.5). Other recommendations relate to medical surveillance, labelling and posting, personal protective equipment (respirators), information of personnel, work practices, monitoring and recordkeeping. The criteria on which the recommendations are based are discussed at some length under the following heads: biological effects (literature review, odour thresholds, dose-response relations), environmental data and engineering controls, development of standard, research needs. Procedure for sampling and analysis for 1-butanethiol, which is being considered for use in determining n-alkane thiols and benzenethiol as well, first aid for eyes contaminated by benzenethiol and a material safety data sheet are given in appendices.
DHEW (NIOSH) Publication No.78-213, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, Sep. 1978. 129p. 143 ref.

CIS 78-1967 Morel C., Cavigneaux A., Protois J.C.
Fiche toxicologique n°137, Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14.
Dimethyl sulfoxide
Diméthylsulfoxyde. [in French]
Uses, physical and chemical properties, methods of detection and determination in air, fire and explosion hazards, pathology and toxicology. French occupational safety and health regulations in force; French and international regulations concerning transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 3rd quarter 1978, No.92, Note No.1137-92-78, p.465-468. 16 ref.

1977

CIS 78-1369 Radionova R.P., Ivanov N.G., Rozova T.A., Zuev A.N.
Comparative study of the toxicity and organic effects of some intermediates in lipoic acid synthesis
Sravnitel'naja harakteristika toksičnosti, opasnosti i haraktera vrednogo dejstvija na organizm nekotoryh poluproduktov sinteza lipoevoj kisloty [in Russian]
Synthesis of lipoic acid has become very important in vitamin production. This article examines the harmful and toxic properties of many of the raw materials used and intermediates encountered in this process: monoethyl adipate (MA); the acid chloride of this ester (AC); ethyl 6-oxo-8-chlorocaprylate (chloro ketone); ethyl 6,8-dichlorocaprylate (EDC); and ethyl 6-hydroxy-8-chlorocaprylate (EHC). Acute and chronic toxicity of these substances was investigated in animal experiments (intra-gastric administration; inhalation; application to the skin and conjunctiva), and the following TLVs were recommended in the light of the results of these experiments: MA: 3mg/m³; EDC and EHC: 5mg/m³; chloro ketone: 1mg/m³; AC: 2mg/m³.
Gigiena truda i professional'nye zabolevanija, Oct. 1977, No.10, p.39-42. 4 ref.

1976

CIS 77-1098 Weiss A., Weiss B.
Glioblastoma and neurofibroma after mustard gas exposure
Glioblastom und Neurofibrom nach Lost-Einwirkung [in German]
This report supports the results of experimental research that neurogenic tumours can be produced by alkylating substances. 34 years after occupational exposure to mustard gas in an army research station for synthetic poisons, a 64-year-old worker died of glioblastoma; a neurofibroma had been detected in the lung and removed by operation 2 years earlier. The conditions of exposure, case history, clinical observations and autopsy findings are described. A significant increase in malignant tumours and leukaemia was noted in a group of 300 former mustard gas workers under observation for more than 25 years. The central nervous symptoms of mustard gas exposure and animal experiments with nitrosoamines are described. After a long latency period, nitrosoamines induced several malignant neoplasms of the nervous system simultaneously. Table of tumour localisation in 40 former nitrogen mustard workers who died from malignant neoplasms.
Münchener medizinische Wochenschrift, 2 July 1976, Vol.118, No.27, p.875-878. 30 ref.

1975

CIS 76-444 Beutner W.
Safety measures to be taken in the construction and operation of natural gas odorising plant
Mesures de sécurité à prendre pour la construction et l'exploitation des installations d'odorisation du gaz naturel. [in French]
Translation of: Sicherheitsmassnahmen bei Errichtung und Betrieb von Erdgas-Odorierungsanlagen. Heft 17, Moderne Unfallverhütung, Essen, Germany (Fed.Rep.), 1973, p.71-74. 5 ref. Tetrahydrothiophene and ethyl mercaptan are readily flammable organic odorisers which present solvent properties. They have an irritant action on the skin, they are toxic, and they contain up to 0.1% benzene by volume. Main characteristics of these products relating to safety; general safety measures; fire and explosion protection; toxicity and protective measures. Natural gas with the addition of an odorising agent is dangerous on account of its asphyxiant effects, and not on account of the presence of such products. The hazards associated with the handling of the latter should not however be underrated.
Traduction INRS 44 B-75, Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1975. 12p. 5 ref.

1974

CIS 75-172 Vil'janov V.M.
Method permitting individual determination of carbon disulfide, mercaptans and dimethyl sulfide in air
Metod razdel'nogo opredelenija serovodoroda, merkaptanov i dimetildisul'fida v vozduhe [in Russian]
Description of colorimetric methods for the separate determination of carbon disulfide, mercaptans and dimethyl sulfide in the same atmosphere. These methods require an air sample of 1-2l. The error is 5-20%, depending on the concentrations in the samples at hand. Examples of concentrations detected in a cellulose and paper factory.
Gigiena i sanitarija, Apr. 1974, No.4, p.63-65. 2 ref.

1973

CIS 74-1967 Beutner W.
Safety measures in the construction and operation of natural-gas stenching plants
Sicherheitsmassnahmen bei Errichtung und Betrieb von Erdgas-Odorierungsanlagen [in German]
Tetrahydrothiophene and ethanethiol are highly flammable organic stenching compounds with solvent properties. They are irritant to the skin, toxic and contain up to 0.1% benzene in volume. Main characteristics of these substances from the health and safety point of view; general safety measures; explosion and fire safety; toxicity and protective measures. Natural gas to which stenching agents have been added is hazardous because of its asphyxiating effects, and not because of the presence of these agents. It is important, however, not to underestimate the hazards attached to the handling of these substances.
Heft 17, Moderne Unfallverhütung, Vulkan-Verlag, Haus der Technik, 43 Essen, Germany (Fed.Rep.), 1973, p.71-74. 5 ref.

1972

CIS 74-157 Zamfir G., Răileanu L., Avădănii R., Dragomirescu A.
Biochemical changes due to sublethal doses of tetradifon
Modificări biochimice ale unor doze subletale de Tetradifon [in Romanian]
Study of the influence exerted on certain biochemical indicators by a new organic chlorinated acaricide, tetradifon (4-chlorophenyl 2,4,5-trichlorophenyl sulfone), administered in sublethal doses to rats (20 mg per 100 g body weight) and fish (2 ml per l of water). The experimental animals did not show any clinical changes, but biochemical changes were observed (increase in the values of certain enzymes due to the permeability of the cellular membrane and subcellular units; diminution of 2 energy-generating processes; dissociation of the P/O ratio; diminution of glycolitic capacity). The authors interpret these changes as a consequence of cellular structural and functional impairment.
Igiena, Nov. 1972, Vol.21, No.11, p.665-669. 18 ref.

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