Halogenated hydrocarbons - 1,937 entries found

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1997

CIS 97-1939 Rivero-Rodriguez L., et al.
Exposure assessment for workers applying DDT to control malaria in Veracruz, Mexico
Chronic occupational exposure was studied in a group of 331 workers employed in spraying houses with DDT to control malaria vectors in the state of Veracruz, Mexico. Exposure was directly estimated for a subgroup of 40 workers by measuring DDT metabolites in adipose tissue samples and indirectly estimated for 331 workers using a questionnaire to determine their occupational history. High levels of DDT were observed in adipose tissue, highlighting the need for exposure prevention programs. The use of indirect measures of DDT exposure in epidemiologic studies of health effects is discussed.
Environmental Health Perspectives, Jan. 1997, Vol.105, No.1, p.98-101. 27 ref.

CIS 97-1635
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
1,2-Dichloroethane
Conclusions of this criteria document, translation of a report finalized in December 1994: acute intoxication by 1,2-dichloroethane following inhalation or oral intake is characterized by a prenarcotic stage, followed by depression of the central nervous system, gastroenteric symptoms, cardiovascular disturbances, and respiratory impairment; fatal outcomes are a result of therapy-resistant cardiovascular shock; main systemic effects include damage to the liver, kidneys, lungs, brain and heart.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. xxvi, 304p. 555 ref. Price: DEM 120.00.

CIS 97-1633
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
1,2,3-Trichloropropane
Conclusions of this criteria document, translation of a report finalized in December 1993: there are no published studies of the acute or chronic effects of 1,2,3-trichloropropane in man; inhalation tests show that a concentration of 613mg/m³ causes irritation of the eyes and throat, but not of the nose; in animal studies, the substance causes irritation of the skin and mucous membranes, damage to the liver and kidneys, and mutagenic and carcinogenic effects.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. xv, 97p. 212 ref. Price: DEM 88.00.

CIS 97-1280 Evans P., et al.
Health and Safety Executive
α-Chlorotoluene - Risk assessment document
Conclusions of this risk assessment document: no data are available on the effects of α-chlorotoluene (benzyl chloride) in humans; animal studies indicate that it is irritating to the skin, eyes and respiratory system; while the substance has genotoxic potential in vitro, results of in vivo tests are not conclusive; there is evidence that the substance is carcinogenic in mice.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1997. iv, 44p. 48 ref. Price: GBP 10.00.

CIS 97-1279 Smith A., et al.
Health and Safety Executive
3-Chloropropene - Risk assessment document
Conclusions of this risk assessment document: 3-chloropropene (allyl chloride) vapour causes irritation of the eyes and respiratory tact; there is evidence supported by animal tests that chronic exposure can result in damage to the peripheral nervous system in humans; repeated exposure may also cause liver and kidney dysfunction; the substance is genotoxic in vitro; animal studies and in vitro tests suggest that 3-chloropropene has the potential to act as a tumour initiator.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1997. iv, 60p. 69 ref. Price: GBP 10.00.

CIS 97-1278 Ryan E., et al.
Health and Safety Executive
Bromoethane - Risk assessment document
Conclusions of this risk assessment document: little information is available on the health hazards of bromoethane (ethyl bromide); there is some evidence that the vapour may cause eye irritation; at relatively high exposures, it may cause depression of the central nervous system; the substance is mutagenic to bacteria; while carcinogenic effects have been observed in mice, there are doubts about the significance of the findings for human health.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1997. iv, 43p. 35 ref. Price: GBP 10.00.

CIS 97-1264
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Benzal chloride. Benzotrichloride. Benzoyl chloride
These reports are translations of reports finalized in December 1991. Main conclusions: benzal chloride (benzylidene chloride) causes local irritation in humans and is mutagenic; benzotrichloride causes irritation of the skin, eyes and respiratory tract in humans; the substance is mutagenic and carcinogenic in experimental animals; benzoyl chloride is a local irritant, there are no indications that it is mutagenic; tumours of the respiratory tract have been observed in workers exposed to mixtures of all three chemicals.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. 100p. Bibl.ref. Price: DEM 80.00.

CIS 97-894 Maeng S.H., Yu I.J.
Mutagenicity of 2-bromopropane
2-bromopropane, a substitute for freon, is suspected to be responsible for an outbreak of reproductive dysfunctions among workers in an electronics factory. Bacterial mutation assays, chromosome aberration analysis in vitro and micronucleus tests in vivo were carried out to clarify the mutagenicity of 2-bromopropane. Results from reverse mutation assays using Salmonella typhimurium were positive and showed a dose-response relationship. The chromosome aberration tests and the micronucleus tests showed negative results.
Industrial Health, Jan. 1997, Vol.35, No.1, p.87-95. Illus. 30 ref.

1996

CIS 01-352 Luotamo M., Riihimäki V.
DECOS and NEG basis for an occupational standard - Tetrachloroethane
Of the two isomers, 1,1,1,2- and 1,1,2,2-tetrachloroethane, the latter is most widely used in industry. Exposure to 1,1,2,2-tetrachloroethane leads to toxic effects. Target organs are the liver, gastrointestinal tract and the nervous system. Tetrachloroethanes are carcinogenic and genotoxic in animals but there is insufficient data on carcinogenic effects in humans. The critical effect is considered to be carcinogenicity for exposed workers.
Arbetslivsinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1996. vi, 46p. 122 ref.

CIS 98-1406
International Programme on Chemical Safety (IPCS)
Methylene chloride (second edition)
Summaries in French and Spanish. Topics: carboxyhaemoglobin level; dichloromethane; central nervous system; chemical burns; criteria document; haematological effects; hepatic damage; IPCS; irritants; literature survey; neurotoxic effects; pulmonary oedema; renal damage; toxic effects; toxicology.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 242p. Illus. Approx. 500 ref. Price: CHF 35.00 (CHF 24.50 in developing countries).

CIS 98-1329 Lee F.I., Smith P.M., Bennett B., Williams D.M.J.
Occupationally related angiosarcoma of the liver in the United Kingdom 1972-1994
Topics: vinyl chloride; case study; chemical industry; latency; length of exposure; liver cancer; United Kingdom.
Gut, 1996, Vol.39, p.312-318. Illus. 31 ref.

CIS 98-829
International Programme on Chemical Safety (IPCS)
Chlorinated paraffins
Topics: carcinogenic effects; chlorinated paraffin waxes; chlorinated paraffin oils; criteria document; ILO; IPCS; literature survey; toxic effects; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 181p. 163 ref. Price: CHF 40.00 (CHF 28.00 in developing countries).

CIS 98-693 Hermouet C., Garnier R., Efthymiou M.L., Fournier P.E.
Methyl iodide poisoning: Report of two cases
Topics: iodomethane; case study; neurological effects; poisoning.
American Journal of Industrial Medicine, Dec. 1996, Vol.30, No.6, p.759-764. 26 ref.

CIS 98-801
International Programme on Chemical Safety (IPCS)
1,2-Dibromomethane
Environmental health criteria for dibromomethane (WHO), 1996. Topics: antifertility effects; carcinogens; dibromoethane; criteria document; dibromomethane; hepatic damage; ILO; IPCS; irritants; literature survey; poisoning; renal damage; skin absorption; toxic effects; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 148p. 305 ref. Price: CHF 23.00 (CHF 16.10 in developing countries).

CIS 97-1817 1,1,2-Trichloro-1,2,2-trifluoroethane
1,1,2-Tricloro-1,2,2-trifluoroetano [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: narcotic effects; irritation of the eyes, skin and upper respiratory tract; liquid defats the skin; may cause dermatitis.
Noticias de seguridad, June 1996, Vol.58, No.6. 4p. Insert.

CIS 97-1946 Wesseling C., et al.
Cancer in banana plantation workers in Costa Rica
In this retrospective cohort study workers of Costa Rica banana companies were followed up in the cancer registry between 1981 and 1992: 29,565 men and 4892 women for 407,468 person-years. There was heavy exposure to pesticides, such as dibromochloropropane. 368 cancer cases were identified. Among men, an increased standardized incidence ratio was observed for melanoma and penile cancer; among women, for cervical cancer and leukaemia. Risk estimates for lung cancer were elevated among male workers with the longest period of employment.
International Journal of Epidemiology, Dec. 1996, Vol.25, No.6, p.1125-1131. 23 ref.

CIS 97-1593 Deschamps F.J., Turpin J.C.
Methyl bromide intoxication during grain store fumigation
Over 300 cases of methyl bromide poisoning are reported in the literature. This case report demonstrates the marked toxicity of methyl bromide with the potential to cause long-term neurological damage. Two fumigation workers (equipped with rapidly saturable respiratory cartridges) entered a building where the concentration of methyl bromide was 17g/m³, almost 1000 times the recommended limit (20mg/m³). They rapidly became unwell, complaining of nausea and shortness of breath, followed by generalized convulsions in the case of one of them; five months later this man was still bedridden. A relationship between methyl bromide exposure and neurological damage was shown by the bromide levels in the blood of the most seriously injured worker and in the activated charcoal cartridge of his respirator.
Occupational Medicine, 1996, Vol.46, No.1, p.3-4. 6 ref.

CIS 97-1244 Rosas Vazquez E., et al.
Chloracne in the 1990s
Clinical features of nine patients affected by chloracne and exposed chronically to chlorobenzenes in the same factory were studied. All the patients were male and their skin lesions were characterized mainly by comedones and cysts. They also had chronic conjunctivitis, polyneuropathy and liver damage and seven of them had hypertriglyceridaemia. In the water used in the workplace there were high concentrations of substances that are known to cause chloracne. In workers exposed to such compounds, systemic complications should also be investigated in addition to those of cutaneous manifestation of chloracne.
International Journal of Dermatology, Sep. 1996, Vol.35, No.9, p.643-645. Illus. 11 ref.

CIS 97-771 Benzal chloride
Data sheet. Synonym: benzylidene chloride. May enter the body when breathed in and through the skin. May irritate the eyes, skin and respiratory tract. May cause dizziness, lightheadedness and fainting.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-766 1,1,2-Trichloroethane
Data sheet. May enter the body when breathed in and through the skin. May irritate the eyes, skin and respiratory tract. May cause dizziness, lightheadedness and fainting. May damage the liver and kidneys.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-761 Tetrachloroethylene
Data sheet. May enter the body when breathed in and through the skin. It is a carcinogen and should be handled with extreme caution. It may damage the developing foetus. May irritate the eyes, skin and respiratory tract. May cause dizziness, lightheadedness and fainting. May cause pulmonary oedema, damage the liver and kidneys and affect the nervous system.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-758 Trifluoromethane
Data sheet. May enter the body when breathed in. It is a mutagen and should be handled with extreme caution. May irritate the skin and respiratory tract. May cause dermatitis, dizziness, lightheadedness, fainting and irregular heartbeat.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-751 Polychlorinated biphenyls
Data sheet. Synonym (trade mark): Aroclors. May enter the body when breathed in and through the skin. These substances are carcinogens and should be handled with extreme caution. They may damage the reproductive system, irritate the eyes, skin and respiratory tract, may cause chloracne, and damage the nervous system and the liver.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-406 Vinylidene chloride
Data sheet. May enter the body when breathed in and through the skin. It is a carcinogen and should be handled with extreme caution. May irritate and burn the skin, eyes and respiratory tract. May damage the liver and kidneys. It is highly flammable.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-403 1,1,2,2-Tetrachloroethane
Data sheet. May enter the body when breathed in and through the skin. It is a mutagen and should be handled with extreme caution. Irritates the eyes, skin and respiratory tract. May damage the liver, kidneys and blood forming organs. May affect the central nervous system.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-402 1,1,2,2-Tetrachloro-1,2-difluoroethane
Data sheet. May enter the body when breathed in. Irritates the eyes, skin and respiratory tract. May reduce the number of white blood cells and damage the liver. May cause dizziness, lightheadedness and fainting. May affect the heart.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-401 1,1,1,2-Tetrachloro-2,2-difluoroethane
Data sheet. May enter the body when breathed in. Irritates the eyes, skin and respiratory tract. May reduce the number of white blood cells and damage the liver. May cause dizziness and lightheadedness.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-386 Ethyl chloride
Data sheet. May enter the body when breathed in and through the skin. Irritates the skin, eyes and respiratory tract. May burn the eyes and cause frostbite on the skin. May damage the liver and kidneys. It is a highly flammable gas that is also available as a liquid under pressure.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-566 Tanaka S., Taneka M., Kimura K., Nozaki K., Seki Y.
Breakthrough time of a respirator cartridge for carbon tetrachloride vapor flow of workers' respiratory patterns
Breakthrough times of a commercially-available respirator cartridge packed with a small amount of activated carbon were determined with three different flow patterns: workers' respiratory patterns, conventional steady-state flows, and three standard patterns consisting of square, sine and sawtooth waves. A mechanical breathing simulator was used to reproduce the three standard wave patterns as well as the workers' respiratory patterns, which had been recorded from three workers wearing a gas mask equipped with a respirator cartridge. The breakthrough test was carried out with 300ppm carbon tetrachloride vapour at average flow rates of the respiratory and standard patterns equivalent to the steady-state flow rates. The breakthrough times for the simulated workers' respiratory patterns were shorter than those for a steady-state flow at the equivalent flow rate, and to be as short as those for sine and sawtooth wave patterns. The shorter breakthrough times for the workers' respiratory patterns could be attributed to a faster maximum inspiratory flow rate than that in the case of steady-state flow. This suggests that the transit time of carbon tetrachloride molecules through the thin activated carbon layer of the respirator cartridge may be too short to permit attainment of adsorption equilibrium.
Industrial Health, 22 Apr. 1996, No.34, p.227-236. Illus. 17 ref.

CIS 97-581 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) CAS No.306-83-2
Conclusions of this criteria document: there are no reports of adverse health effects attributable to exposure to 1,1-dichloro-2,2,2-trifluoroethane. Animal studies indicate that it has a low acute toxicity; neurotoxic effects are seen at very high concentrations.
European Centre for Ecotoxicology and Toxicology of Chemicals, Avenue E. Van Nieuwenhuyse 4, Bte. 6, 1160 Bruxelles, Belgium, Feb. 1996. vi, 55p. 94 ref.

CIS 97-236 Hallier E.
Occupational medicine studies of the problems caused by fumigation with methyl bromide
Arbeitsmedizinische Untersuchungen zur Problematik der Durchführung von Begasungen mit Methylbromid [in German]
Methyl bromide is used in the food industry, agriculture and forestry as a pesticide, herbicide and disinfectant. Exposure levels during the fumigation of buildings and soil in greenhouses with methyl bromide were measured. In addition, the effects of methyl bromide on human tissue were studied in in vitro experiments. Blood samples from three cases with acute methyl bromide poisoning in France were analyzed. Based on the results, a new method for medical supervision was developed. This method relies on the analysis of protein adducts in blood samples.
Verlag Dr. Markus Hänsel-Hohenhausen, 63324 Egelsbach, Germany, 1996. 146p. Illus. 138 ref. Price: DEM 70.00.

CIS 97-218
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for toxaphene: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: lung diseases; neurotoxic effects; liver damage; renal damage; adrenal gland disorders; immunotoxic effects; embryotoxic effects; possible carcinogenic effects. (Update of CIS 91-1627).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1996. 215p. Illus. Bibl.ref.
http://www.atsdr.cdc.gov/toxprofiles/tp94.pdf [in English]

CIS 97-217
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for 1,1,2,2-tetrachloroethane: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: liver damage; gastric disorders; possible carcinogenic effects.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1996. 150p. Illus. Bibl.ref.
http://www.atsdr.cdc.gov/toxprofiles/tp93.pdf [in English]

CIS 97-213
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for hexachlorobenzene: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: immunotoxic effects; embryotoxic effects; porphyria cutanea tarda (skin lesions, arthritis, liver toxicity, neurological effects, gastric disorders); liver damage; thyroid disorders; neurotoxic effects; bone diseases; renal damage; haematotoxic effects; endocrine disorders; carcinogenic effects. (Update of CIS 91-1268).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1996. 268p. Illus. Bibl.ref.

CIS 97-212
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for endrin and endrin aldehyde: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: neurotoxic effects (central nervous system); brain and spinal cord damage; convulsions; liver damage; embryotoxic effects. (Update of CIS 91-1249).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1996. 191p. Illus. Bibl.ref.
http://www.atsdr.cdc.gov/toxprofiles/tp89.html [in English]

CIS 97-211
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for 1,2-dichloroethene: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: liver damage; lung diseases; heart diseases; haematotoxic effects; blood-cell anomalies (decreased number of red blood cells). (Update of CIS 91-1248).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Aug. 1996. 159p. Illus. Bibl.ref.
http://www.atsdr.cdc.gov/toxprofiles/tp87.pdf [in English]

CIS 97-183 Puerschel W.C., Odia S.G., Rakoski J., Ring J.
Trichloroethylene and concomitant contact dermatitis in an art painter
A brief case report is presented of an art painter who developed chronic dermatitis and eczematous skin lesions following daily contact with trichloroethylene (TCE) over a period of four years. The lesions cleared when the painter stopped working with TCE but eczema developed on both hands when holding TCE-painted pictures.
Contact Dermatitis, June 1996, Vol.34, No.6, p.430-431. Illus. 8 ref.

CIS 96-1760 Soden K.J., Marras G., Amsel J.
Carboxyhemoglobin levels in methylene chloride-exposed employees
Methylene chloride is a volatile liquid used in a wide variety of industrial applications. The present OSHA permissible occupational exposure (500ppm, 8h TWA) is proposed to be reduced to 25ppm. This is due to the concern about potentially adverse cardiac effects related to high levels of carboxyhaemoglobin (COHb) consequent to the exposure. Exposure assessments of non-smoking employees of a plant exposed to methylene chloride in the production process was performed, comparing the levels of COHb found with those of smokers. Exposure values were similar in both groups, with individually measured methylene chloride exposures averaging up to 99ppm. COHb levels ranged between 1.7-4% in non-smokers and between 4.95-6.35% in smokers. A dose-response effect was seen only in the non-smoking group. It was concluded that the observed COHb levels, resulting from exposures to methylene chloride at or below the current permissible limit (ACGIH) of 50ppm (8h TWA) are at a sufficiently low level and unlikely to produce an adverse cardiac effect in humans.
Journal of Occupational and Environmental Medicine, Apr. 1996, Vol.38, No.4, p.367-371. 12 ref.

CIS 96-1776 Gibbs G.W., Amsel J., Soden K.
A cohort mortality study of cellulose triacetate-fiber workers exposed to methylene chloride
The purpose of this study of 3,211 cellulose-fibre production workers exposed to methylene chloride was to evaluate earlier findings of excess biliary tract and liver cancer in a similarly exposed cohort. In the current study, mortality from biliary tract and liver cancer was not increased, and there was no excess mortality from pancreatic cancer. Results are in agreement with several other studies of workers exposed to methylene chloride which demonstrate no excess cancer mortality. At present, the combined epidemiological and bioassay data do not support the conclusion that methylene chloride is either a possible or probable human carcinogen.
Journal of Occupational and Environmental Medicine, July 1996, Vol.38, No.7, p.693-697. 14 ref.

CIS 96-1797
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
1,1,1-Trichloroethane
Conclusions of this criteria document, translation of a report finalized in August 1994: acute inhalation of 1,1,1-trichloroethane causes suppression of the central nervous system in humans, with narcotic effects at high concentrations. There are several reports of accidental inhalative intoxication. Occupational exposure has been reported to cause sleep apnoea, neurotic complaints and symptoms which could indicate an organic solvent encephalopathy. Repeated skin contact can lead to dermatitis through degreasing.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xxiv, 447p. 824 ref. Price: DEM 130.00.

CIS 96-1796
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
1,2-Dichloropropane
Conclusions of this criteria document, translation of a report finalized in October 1994: ingestion of 1,2-dichloropropane (propylene dichloride) by humans causes functional hepatic and renal disorders, haemolytic anaemia, metabolic acidosis, heart muscle weakness and shock; ingestion of large amounts can be fatal. Dermal contact can cause allergic contact dermatitis. Based on animal studies, the substance is classified as having carcinogenic potential.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xviii, 151p. 335 ref. Price: DEM 88.00.

CIS 96-1791
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Di(2-ethylhexyl)phthalate, chloromethane, o-nitroanisole, p-nitroanisole, m-/p-chloronitrobenzene, dinitrotoluene, diphenylamine, dibutylphthalate, chlorotoluene, N-ethylaniline, dioxane
This report contains supplementary data to 11 earlier BUA Reports: di(2-ethylhexyl)phthalate (BUA Report No. 4), chloromethane (BUA 7, see CIS 96-906), o-nitroanisole (1-methoxy-2-nitrobenzene) (BUA 9, CIS 94-636), p-nitroanisole (BUA 10, CIS 94-997), m-/p-chloronitrobenzene (BUA 11), dinitrotoluene (BUA 12), diphenylamine (BUA 15, CIS 95-572), dibutyl phthalate (BUA 22, CIS 94-998), chlorotoluene (BUA 38), N-ethylaniline (BUA 51) and dioxane (BUA 80). The supplements are translations of reports finalized between December 1992 and June 1993.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. 221p. Bibl.ref. Price: DEM 96.00.

CIS 96-1394 Saint-Vulbas T., Gout D.
Disposal of pyralene - Combining environment and safety
Elimination du pyralène - Marier environnement et sécurité [in French]
Description of the measures taken by a factory where transformers are dismantled, to protect workers and the environment from the chlorinated biphenyls in the "pyralenes" that serve as insulating and heat-transfer fluids. The variety of transformers to be processed prevents automation of the operations. In addition to the wearing of personal protective equipment, safety is provided by: emptying of the transformers by pumping rather than drainage; cutting up of metallic parts for recycling by the use of a hydraulic shear rather than a saw (which generates dust and heat); decontamination of parts in autoclaves.
Travail et sécurité, Jan. 1996, No.544, p.24-29. Illus.

CIS 96-613 Fontana L., Gautherie M., Albuisson E., Fleury-Duhamel N., Meyer S., Catilina P.
Chronothermobiologic study of Raynaud's phenomenon secondary to a past exposure to vinyl chloride
Etude chronothermobiologique de phénomènes de Raynaud secondaires à une exposition ancienne au chlorure de vinyle monomère [in French]
The evolution of Raynaud's phenomenon (RP) after the end of exposure to vinyl chloride monomer (VCM) is not well understood. Sixty-two patients were studied: 44 retired patients who had been exposed to VCM (time since last exposure, at least 8 years) and 18 non-exposed controls. Twelve of the retired patients reported RP affecting the fingers. In order to identify the objective causes of these complaints, a computerized chronothermodynamic examination using the standardized cold test on the 10 fingers was used. Results of exposed patients are compared with those of controls and are analyzed according to their complaints and past exposure to VCM. The authors observed: 1. In summer, a greater incidence of vasoconstriction due to cold in exposed patients with RP than in exposed patients without RP and controls. 2. No seasonal variation of cold test results in patients with RP. 3. No identification of the role of exposure levels on chronothermodynamic results. Conclusion: RP secondary to VCM exposure may persist more than 8 years after the end of exposure. Disorders are usually moderate, but present all year round.
Archives des maladies professionnelles et de médecine du travail, Feb. 1996, Vol.57, No.1, p.9-18. Illus. 27 ref.

CIS 96-943 Davies C., Cain J.R., Evans S.
Health and Safety Executive
Iodomethane - Criteria document for an occupational exposure limit
Very little data is available on the effects of iodomethane in humans. Reported health effects following repeated exposure include headache and nausea with neurological and psychological abnormalities. There is no information on mutagenicity, carcinogenicity or reproductive toxicity of iodomethane in humans. Proposed maximum exposure limit: 2ppm (8-hour TWA). Notation: skin.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1996. v, 19p. 37 ref. Price: GBP 10.00.

CIS 96-485 Octachloronaphthalene
Octacloronaftaleno [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; skin disorders: chloracne, dermatitis; hepatotoxic effect (jaundice).
Noticias de seguridad, Mar. 1996, Vol.58, No.3. 4p. Insert.

CIS 96-483 Pentachloronaphthalene
Pentacloronaftaleno [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; skin disorders: chloracne, dermatitis; hepatotoxic effect.
Noticias de seguridad, Apr. 1996, Vol.58, No.4. 4p. Insert.

CIS 96-781 Estill C.F., Spencer A.B.
Case study: Control of methylene chloride exposures during furniture stripping
High exposures to dichloromethane (methylene chloride) (600 to 1150ppm) at a furniture stripping operation prompted the design and installation of a modified ventilation system. Three configurations within the modified system were evaluated. Personal exposures to methylene chloride were reduced to 34ppm for a slot hood configuration, 30ppm for a downdraft hood, and 28ppm for a combination slot and downdraft hood. Although exposures are above the proposed OSHA permissible exposure level of 25ppm, results show a substantial improvement over the original ventilation system.
American Industrial Hygiene Association Journal, Jan. 1996, Vol.57, No.1, p.43-49. Illus. 18 ref.

CIS 96-903
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Supplementary reports II - m-Dichlorobenzene; Bromomethane; 1,3,5-Trichlorobenzene; N,N-Diethylaniline; Styrene; Biphenyl; o/m-Chloroaniline; Nitrobenzene
This document comprises translations of supplementary reports, finalized between June 1993 and April 1994, relating to eight substances evaluated in earlier BUA reports. The new data relate mainly to the results of animal studies carried out following recommendations in the original reports. No human effects are reported.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xxiv, 157p. Bibl.ref.

CIS 96-289
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Tetrachloroethylene
Conclusions of this criteria document, translation of a report finalized in August 1993: acute intoxication by inhalation of tetrachloroethylene causes irritation of the mucosa, respiratory tract and eyes and depression of the central nervous system. Chronic exposure also causes effects on the central nervous system and there is some evidence of liver damage. Epidemiological data from studies of dry cleaning workers are presented. There is insufficient evidence for the carcinogenic potential or antifertility effects of tetrachloroethylene in humans.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xxiii, 351p. Bibl.ref. Price: 120.00.

CIS 96-286
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Chlorinated paraffins
Conclusions of this criteria document, translation of a report finalized in June 1992: no epidemiological studies are available on the effects of chlorinated paraffins in humans. No cases of poisoning or contact allergies are known following occupational exposure; skin tests on human volunteers produced no symptoms of irritation or sensitization. Animal studies indicate that the acute toxicity of these compounds is low. In studies of chronic toxicity, the frequency and severity of toxic effects decreases with increasing chain length of the paraffins; target organs in mice and rats are the liver, kidneys and thyroid gland. Carcinogenic effects and reproductive toxicity have been observed in animals.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xxvi, 210p. Bibl.ref. Price: DEM 96.00.

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