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Aliphatic amines - 169 entries found

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  • Aliphatic amines

1991

CIS 98-1129 Ethylenediamine
Etilendiamina [in Spanish]
Spanish version of IPCS ICSC 0269 (CIS 92-1487). International Chemical Safety Card. Topics: asthma; ethylenediamine; caustic substances; chemical burns; chemical hazards; data sheet; delayed effects; dermatitis; elimination of spills; environmental pollution; explosion hazards; fire fighting; fire hazards; first aid; health hazards; IPCS; irritation; labelling; pulmonary oedema; respiratory impairment; sensitization; skin absorption; Spain; storage; threshold limit values; translation; visual function disorders; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 98-1128 Ethylamine (liquefied)
Etilamina (licuado) [in Spanish]
Spanish version of IPCS ICSC 0153 (CIS 92-741). International Chemical Safety Card. Topics: ethylamine; chemical hazards; data sheet; elimination of spills; environmental pollution; explosion hazards; fire fighting; fire hazards; first aid; health hazards; IPCS; irritation; labelling; lung diseases; renal damage; respiratory impairment; skin absorption; Spain; storage; threshold limit values; tissue damage; translation; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 98-1113 Dimethylamine, anhydride (liquefied)
Dimetilamina, anhidra (licuado) [in Spanish]
Spanish version of IPCS ICSC 0260 (CIS 92-1479). International Chemical Safety Card. Topics: dimethylamine; caustic substances; chemical burns; chemical hazards; data sheet; delayed effects; dermatitis; elimination of spills; environmental pollution; explosion hazards; fire fighting; fire hazards; first aid; frostbite; gastric disorders; health hazards; IPCS; irritation; labelling; pulmonary oedema; respiratory impairment; skin absorption; Spain; storage; threshold limit values; translation; visual function disorders; waste disposal.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 96-2002 Dipentylamine
Dipentilamina [in Spanish]
Spanish version of future IPCS ICSC 0537. International chemical safety card. Short-term exposure effects: skin absorption; irritation of the eyes, skin and respiratory tract. Data are insufficiently available on the health hazards of this substance.
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 96-465 Diisopropylamine
Diisopropilamina [in Spanish]
Spanish version of IPCS ICSC 6-0449. International chemical safety card. Short-term exposure effects: skin absorption; corrosive effect on the eyes, skin and respiratory tract; pulmonary oedema (may be delayed). Long-term exposure effects: dermatitis. Occupational exposure limit: TLV: 5ppm, 21mg/m3 (skin) (ACGIH 1990-1991).
Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p.

CIS 93-903 Lundh T., Ståhlbom B., Åkesson B.
Dimethylamine in mould core manufacturing: Exposure, metabolism and biological monitoring
Exposure to dimethylethylamine (DMEA) and metabolism of the substance were studied in 12 mould core makers in four foundries that use the Ashland cold box technique. The mean time weighted average (TWA) full work shift DMEA exposure concentration was 3.7mg/m3. Inhaled DMEA was excreted into urine as the original amine and as its metabolite dimethylethylamine-N-oxide (DMEAO). This metabolite made up a median of 87 (range 18-93)% of the sum of DMEA and DMEAO concentrations excreted into the urine. Occupational exposure did not significantly increase the urinary excretion of dimethylamine or methylethylamine. The data indicate half lives after the end of exposure for DMEA in urine of 1.5h and DMEAO of 3h. Postshift summed concentration of DMEA and DMEAO in plasma and urine is a good indicator of the TWA concentration in air during the workday, and might thus be used for biological monitoring. An air concentration of 10mg/m3 corresponds to a urinary excretion of the summed amount of DMEA and DMEAO of 135 mmol/mol creatinine.
British Journal of Industrial Medicine, Mar. 2791, Vol.48, No.3, p.203-207. 27 ref. Illus.

CIS 93-379 Diethylamine
Fire safety data sheet prepared by the Loss Prevention Association of India, Warden House, Sir P.M. Road, Bombay 400 001, India. Health hazards: irritation of eyes, mucous membranes, nose, throat and skin; vesiculation and necrosis of the skin; pulmonary oedema; corneal oedema.
Loss Prevention News, Oct.-Dec. 1991, Vol.13, No.4, p.19-20.

CIS 92-1487 Ethylene diamine
International chemical safety card. Short-term exposure effects: skin absorption; delayed effects; corrosive to the eyes, skin and respiratory tract; pulmonary oedema; hepatic and renal damage. Long-term exposure effects: dermatitis; skin sensitisation; asthmatic reactions.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1479 Dimethylamine
International chemical safety card. Short-term exposure effects: corrosive to the eyes, skin and respiratory tract; pulmonary oedema. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1464 Cyclohexylamine
International chemical safety card. Short-term exposure effects: skin absorption; corrosive to the eyes, skin and respiratory tract; pulmonary oedema; neurotoxic effects (central nervous system). Long-term exposure effects: skin sensitisation.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1653 Åkesson B.
Nordic Expert Group for Documentation of Occupational Exposure Limits - 96. Dimethylethylamine
Nordiska Expertgruppen för Gränsvärdesdokumentation - 96. Dimetyletylamin [in Swedish]
The literature on dimethylethylamine was reviewed and evaluated. The compound irritates the mucous membranes of the eye and produces corneal oedema. Subjective symptoms are foggy vision and a halo effect. Symptoms appear at levels as low as 10mg/m3. Effects reported at much lower levels of occupational exposure are probably due to short high exposure peaks. An exposure limit should be based on the effect of dimethylethylamine on the eyes.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1991. 15p. 28 ref.

CIS 92-1126 Trimethylamine
International chemical safety card. Short term exposure effects: delayed effects; corrosive to the eyes, skin and respiratory tract; pulmonary oedema; frostbite.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1123 Triethylamine
International chemical safety card. Short term exposure effects: skin absorption; irritation of eyes and respiratory tract; corrosive to the skin; pulmonary oedema; neurotoxic effects (central nervous system); effects on eyes. Long term exposure effects: asthma; effects on lung, kidney, liver and heart.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-1256 Ståhlbom B., Lundh T., Florén I., Åkesson B.
Visual disturbances in man as a result of experimental and occupational exposure to dimethylethylamine
Experimental exposure of four volunteers to 40-50mg/m3 of dimethylethylamine (DMEA) for eight hours caused irritation of the mucous membrane of their eyes, subjective visual disturbances (haze) and slight oedema of the corneal epithelium. The thickness of the cornea showed a slight but consistent increase in all four subjects at these exposures and in two subjects exposed to 10mg/m3. Concentrations of 80 and 160mg/m3 for 15 minutes caused eye irritation but no visual disturbances or corneal oedema. Occupational exposure for eight hours to about 25mg/m3 of DMEA (with peaks above 100mg/m3) was also associated with eye irritation, haze, and corneal oedema. The divergence between our findings and other reports in which visual disturbances occurred at low concentrations during occupational exposure may be due to peak concentrations.
British Journal of Industrial Medicine, Jan. 1991, Vol.48, No.1, p.26-29. Illus. 16 ref.

CIS 92-765 Methylamine
International chemical safety card. Short-term exposure effects: skin absorption; corrosive to the eyes, skin and respiratory tract; pulmonary oedema. Long-term exposure effects: dermatitis.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-741 Ethylamine
International chemical safety card. Short term exposure effects: delayed effects; irritation of skin, eyes and respiratory tract; pulmonary oedema; exposure above occupational exposure limit may result in death.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1991. 2p.

CIS 92-233 Buser S., Nicole C., Droz P.O.
Exposure to tertiary amines in iron foundries
Exposition aux amines tertiaires dans les fonderies [in French]
Tertiary amines, mainly N,N-dimethylethylamine (DMEA), are widely used in iron foundries for the manufacture of cores by the cold box or Ashland process. DMEA is known for its irritating effects and its effect on vision. Exposure standards in Switzerland, Germany and the USA do not seem to offer sufficient protection for workers. Instead of the present 25ppm limit, based on an 8-h average, 5ppm would be more justified after a review of the available toxicological information. The objective of the present study was to characterise the present situation regarding DMEA in some foundries, and to investigate if a 5ppm average concentration was technically feasible. Personal exposures to DMEA by 24 operators working on 15 machines in 3 foundries were measured. Based on the available toxicological information for DMEA and on the exposure levels found in the present study, the following recommendations can be made: decrease the TWA limit from 25 to 5ppm; establish a STEL limit of 25ppm for a 30 minutes period; use ventilation hoods with at least 0.5m/s face velocity. Finally, special care should be given to the maintenance of the core making machines and the moulds to avoid excessive and uncontrollable leaks.
Travail et santé, Winter 1991, Vol.7, No.4, p.S.33-S.37. Illus. 14 ref.

CIS 91-1523 Lewinsohn H.C., Ott M.G.
A review of medical surveillance records of employees exposed to ethyleneamines
A review of medical surveillance records was undertaken for 197 workers who had been assigned to an ethyleneamine (EA) production unit for one or more months between 1947 and 1983. Dispensary visit reports were examined relative to EA and other chemical exposures, medical records were reviewed for allergy and asthma histories, spirometry data were evaluated, and the mortality experience of these employees was studied relative to exposure status. The findings were compared with those for a group of employees who did not work in plant areas where contact with EA was likely. Among 75 persons reporting EA exposure, 7 definite and 8 suspect cases of respiratory sensitisation were identified. Similarly, there were 23 definite and 17 suspect cases of skin sensitisation. Pulmonary function did not differ between study and referent groups and was unrelated to both EA assignment duration and skin or respiratory sensitisation. There were no indications of increased mortality in the study group. These might have been careful selection of employees for assignment to this unit by plant physicians, who were aware of the potential sensitising properties of EA.
Journal of Occupational Medicine, Feb. 1991, Vol.33, No.2, p.148-154. 9 ref.

CIS 91-376 Diethylenetriamine
Diéthylènetriamine [in French]
Chemical safety information sheet. Exposure limits (France, 1986): TWA exposure limit = 4mg/m3. Short term effects: very corrosive substance; severe irritation of eyes, skin and respiratory tract; chemical burns; irreversible eye injuries. Long term effects: eczematous dermatitis; respiratory and cutaneous allergies. EC identification numbers and mandatory labelling codes: No. 612-058-00-X; C; R21/22-34-43; S26-36/37/39.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1991. 4p. Illus. 20 ref.

1990

CIS 01-1610 N,N-Dimethylisopropylamine
N,N-Diméthylisopropylamine [in French]
Chemical safety information sheet. Synonym: N,N'-dimethyl-2-propanamine. Toxicity: the only toxicological data available are from animal experiments; irritant effect on skin, eyes and respiratory mucous membranes; skin absorption. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, 2000. 3p. 9 ref.

CIS 91-1255
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards)
Health-based recommended occupational exposure limits for dimethylamine
The health hazards of exposure to dimethylamine are evaluated. Attention is given to: production, uses and occurrences; environmental and biological monitoring; occupational exposure limits in various countries; toxicokinetics; toxic effects (acute toxicity, carcinogenicity, mutageniticy, and epidemiology). From studies in animals it is concluded that 18mg/m3 is an adverse-effect level, causing minimal local (not systematic) effects in rats and mice. To take this into account a safety factor of 10 is applied which results in a recommended occupational exposure limit of 1.8mg/m3 (1ppm) TWA 8h for DMA. Summary in Dutch.
Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 69, 2270 MA Voorburg, Netherlands, 1990. 37p. 71 ref.

CIS 91-942
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards)
Health-based recommended occupational exposure limits for ethylamine
The risks to human health from exposure to ethylamine are evaluated. Attention is given to: production, uses and occurrence; environmental and biological monitoring; occupational exposure limits in variuos countries; toxicokinetics; toxic effects (acute toxicity, carcinogenicity, mutagenicity, and epidemiology). The main effects described in the literature are irritation of the eyes, skin and lung. Because no long-term study is available, the recommendation is based on a short-term toxicity study. A concentration of 90mg/m3, which is the lowest concentration tested, gives rise to adverse health effects. Experimentally, no no-adverse-effect-level has been determined. In order to take this lack of information into account, an arbitrary safety factor of 10 is introduced; therefore: for ethylamine an occupational exposure limit of 9mg/m3 TWA 8h is recommended.
Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid, Postbus 69, 2270 MA Voorburg, Netherlands, 1990. 22p. 62 ref.

CIS 91-44 N,N-Dimethylethylamine
N,N-Diméthyléthylamine [in French]
Chemical safety information sheet. Synonym: ethyldimethylamine. Exposure limits (France, 1984): maximum exposure value = 75mg/m3; 8h TWA Value = 15mg/m3. Short-term effects: severe irritation of ocular and respiratory tract mucous membranes; vision disorders; skin irritation; chemical burns. Long-term effects: eczemateous dermatitis; asthma. EC identification numbers and mandatory labelling codes: 612-076-00-8; F, C; R12-20/22-34; S3-16-26-36.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 4p. 14 ref.

CIS 91-245 Nordlinder R., Järvholm B.
Criteria document for exposure limits - Cyclohexylamine, diisopropylamine and isopropylamine
Kriteriedokument för gränsvärden - Cyklohexylamin, diisopropylamin och isopropylamin [in Swedish]
Literature survey on cyclohexylamine, diisopropylamine and isopropylamine, to be used as background information for discussions of occupational exposure limits. Data on toxic effects of the 3 amines are sparse. The critical effect for the 2 propylamines on industrial exposure is irritation of mucous membranes and temporary dimness of vision. The critical effect of cyclohexylamine is an irritant effect on the upper respiratory tract, eye and skin. There are conflicting data about sensitising effects. Cyclohexylamine can cause a rise in blood pressure in both animals and man. High doses (more than 100mg/kg/day) to rat and dog cause testicular changes.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1990. 31p. 41 ref.

CIS 90-1826 Triethylamine
Triéthylamine [in French]
Chemical safety information sheet. Exposure limits (France, 1982): maximum exposure limit = 40mg/m3. Toxicity: skin absorption; very strong irritation of mucous membranes, skin, eyes and respiratory tract; chemical burns; allergic dermatitis; asthma. EC identification numbers and mandatory labelling codes: No. 612-004-00-5; F, Xi; R11, R36/37; S16, S26, S29.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 5p. 30 ref.

CIS 90-1808 Isopropylamine
Isopropylamine [in French]
Chemical safety information sheet. Exposure limits (France, 1987): maximum exposure limit = 12mg/m3. Toxicity: skin absorption; irritation of mucous membranes, skin, eyes and respiratory tract; chemical burns; dermatitis; asthma. EC identification numbers and mandatory labelling codes: No. 612-007-00-1; F, Xi; R12, R36/37/38; S16, S26, S29.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 4p. 21 ref.

CIS 90-1806 Ethylamine
Ethylamine [in French]
Chemical safety information sheet. Exposure limits (France, 1987): maximum exposure limit = 27mg/m3; 8h TWA exposure limit = 18mg/m3. Toxicity: skin absorption; very strong irritation of mucous membranes, skin, eyes and respiratory tract; chemical burns; dermatitis; asthma. EC identification number and mandatory labelling codes: No.612-002-00-4; F, Xi; R13, R36/37; S16, S26, S29.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 4p. 27 ref.

CIS 90-1805 N,N-Dimethylisopropylamine
N,N-Diméthylisopropylamine [in French]
Chemical safety information sheet. Toxicity: no data available on humans. Animal studies show that the compound is a very strong irritant.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 3p. 9 ref.

CIS 90-1803 Diethylamine
Diéthylamine [in French]
Chemical safety information sheet. Exposure limits (France, 1982): maximum exposure limit = 30mg/m3. Toxicity: skin absorption; irritation of mucous membranes, skin, eyes and respiratory tract; chemical burns; allergic dermatitis; asthma. EC identification number and mandatory labelling codes: No.612-003-00-X; F, Xi; R11, R36/37; S16, S26, S29.
Institut national de recherche et de sécurité, 30, rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1990. 4p. 27 ref.

CIS 90-1472 Isopropylamine
Isopropylamine [in French]
Chemical safety information sheet. Toxicity: delayed effects; skin absorption; irritates eyes, skin and respiratory tract; pulmonary oedema; chemical burns; skin sensitisation.
Canadian Centre for Occupational Health and Safety, 250 Main St. East, Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

CIS 90-1461 Dibutylamine
Dibutylamine [in French]
Chemical safety information sheet. Toxicity: delayed effects; skin absorption; irritation of skin, eyes and respiratory tract; pulmonary oedema; eye and skin burns; skin sensitisation.
Canadian Centre for Occupational Health and Safety, 250 Main St. East, Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

CIS 90-1459 Cyclohexylamine
Cyclohexylamine [in French]
Chemical safety information sheet. Toxicity: delayed effects; irritation of skin, eyes and respiratory tract; pulmonary oedema; eye and skin burns; skin sensitisation.
Canadian Centre for Occupational Health and Safety, 250 Main St. East, Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

CIS 90-1448 Butylamine
Butylamine [in French]
Chemical safety information sheet. Toxicity: severe irritation of skin, eyes and respiratory tract; chemical burns; pulmonary oedema; sensitisation of skin and respiratory tract; allergic asthma; dermatitis.
Canadian Centre for Occupational Health and Safety, 250 Main St. East, Hamilton, Ontario L8N 1H6, Canada, 1990. 1p. Illus.

CIS 90-1133 Isopropylamine
Isopropilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 12mg/m3. Toxicity: skin absorption; strong irritation of skin, eyes and respiratory tract; corneal oedema; chemical burns; dermatitis.
Noticias de seguridad, June 1990, Vol.52, No.6, 4p. Insert.

CIS 90-738 Diethylamine
Dietilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 75mg/m3. Toxicity: skin absorption; irritates skin, eyes and respiratory tract; chemical burns; eye injuries.
Noticias de seguridad, Apr. 1990, Vol.52, No.4, 4p. Insert.

1989

CIS 91-1120
National Board of Labour Protection (Finland)
Isopropylamine
Translation into English of the chemical safety information sheet described in CIS 88-1115. Synonym: 2-aminopropane. Extremely flammable liquid. Exposure limit = 12mg/m3. Irritates the skin, the eyes and the respiratory tract. Harmful if ingested. Inhalation of high concentrations can have a narcotic effect. Long-term exposure can cause eczema. Mandatory European labelling: F, Xi, R12, R36, R37, R38, S16, S26, S29.
International Occupational Safety and Health Information Centre (CIS), International Labour Office, 1211 Genève 22, Switzerland, 1989. 2p.

CIS 91-1099
National Board of Labour Protection (Finland)
Benzylamine
Translation into English of the chemical safety information sheet described in CIS 88-67. Benzylamine is an irritating, corrosive liquid. The vapour irritates the eyes and the mucous membranes of the respiratory tract. The solution irritates and corrodes the skin. Long-term exposure can cause eczema. Mandatory European labelling: C, R34, S26.
International Occupational Safety and Health Information Centre (CIS), International Labour Office, 1211 Genève 22, Switzerland, 1989. 2p.

CIS 91-737
National Board of Labour Protection (Finland)
Allylamine
Translation into English of the chemical safety information sheet described in CIS 87-779. Allylamine is an extremely flammable, toxic liquid (LD50 = 106mg/kg). The vapour irritates severely the eyes and the mucous membranes in the nose and throat, causes coughing, in high concentrations unconsciousness, at long-term exposure inflammation of the conjunctiva and allergic eczema. The liquid corrodes tissues. Forms exploding mixtures with air. Mandatory European labelling: F, T, R11, R23, R24, R25, S9, S16, S24, S25, S44.
International Occupational Safety and Health Information Centre (CIS), International Labour Office, 1211 Genève 22, Switzerland, 1989. 2p.

CIS 91-931 Hansén L.
The use of isotachophoresis and high performance liquid chromatography for the determination of some tertiary amines in workroom air
Analytical isotachophoretic systems for 10 tertiary aliphatic amines were developed. Complete methods for the determination of dimethylethylamine (DMEA), dimethylethanolamine (DMEAA), triethylamine (TEA) and N-methylmorpholine (NMO) were developed, including generation of static standard gaseous mixtures, sampling, analysis and final field tests in authentic industrial environments. Isotachophoresis complemented with HPLC proved to be reliable analytical methods for the determination of several tertiary amines of occupational interest. The analytical methods were simple and easy to perform, as direct injection of absorption solutions from the sampling vessels could be made without any preceding sample treatment.
Arbetsmiljöinstitutet, Publikationsservice, 171 84 Solna, Sweden, 1989. 40p. Illus. 50 ref.

CIS 90-1573 Ormerod A.D., Wakeel R.A., Mann T.A.N., Main R.A., Aldrige R.D.
Polyamine sensitization in offshore workers handling drilling muds
Oil-based mud, a complex mixture containing amines in emulsifiers, is used in offshore drilling operations. It is a skin irritant that occasionally gives rise to allergic contact sensitivity. In patch testing patients with allergy to drilling mud we have identified polyamine (diethylenetriamine and triethylenetetramine) sensitivity in 5 patients. All 5 patients were also allergic to emulsifiers. These emulsifiers are cross-linked fatty acid amido-amines, in which unreacted amine groups are thought to cross-sensitise with these constituent polyamines. Cross-reactivity between ethylenediamine, diethyleneamine and triethylenetetramine was found in 9 subjects.
Contact Dermatitis, Nov. 1989, Vol.21, No.5, p.326-329. 3 ref.

CIS 89-1467 Ethylamine
Etilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 8h-TWA = 19mg/m3. Toxicity: skin absorption; irritation of mucous membranes, respiratory tract, skin and eyes; chemical burns; hepatic damage.
Noticias de seguridad, Aug. 1989, Vol.5l, No.8, 4p. Insert.

CIS 89-742 Butylamine
Butilamina [in Spanish]
Chemical safety information sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Exposure limit (OSHA): 8h-TWA = 15mg/m3. Toxicity: irritates eyes, skin and respiratory tract; chemical burns (eyes and skin).
Noticias de seguridad, Apr. 1989, Vol.51, No.4, 4p. insert.

1988

CIS 91-363
Environmental Protection Agency (EPA)
EPA Final Rule - Oleylamine; Final test standards and reporting requirements [USA]
This final test rule is issued under the Toxic Substances Control Act (see CIS 89-23) specifying the test standards and reporting requirements to be used by manufacturers and processors of oleylamine (synonym: 9-octadecenylamine or ODA). Extensive commentary.
Federal Register, 1 Dec. 1988, Vol.53, No.231, p.48542-48547.

CIS 91-130 Wolf C., Pospischil M., Petzi D.H., Petrak R.
Bronchial hyperreactivity in foundry workers
Bronchiale Hyperreaktivität bei Arbeitern einer Graugiesserei [in German]
Lung function tests before and after bronchial provocation were performed on 47 workers of a core shop in a light-metal foundry with 3 years of exposure. Visual disturbances (blue haze) due to exposure to dimethylisopropylamine were reported by 36 workers. Bronchial ractivity was elevated in 20 workers as compared with non-exposed controls.
Zentralblatt für Arbeitsmedizin, Arbeitsschutz, Prophylaxe und Ergonomie, 1988, Vol.38, No.9, p.279-285. Illus. 13 ref.

CIS 90-1827 Trimethylamine
Trójmetyloamina [in Polish]
Chemical safety information sheet. Exposure limit (Poland) = 5mg/m3.
Centralny Instytut Ochrony Pracy, 1 Ul. Tamka, 00-349 Warszawa 30, Poland, 1988. 2p.

CIS 90-479 Hogan D.J., Hill M., Lane P.R.
Results of routine patch testing of 542 patients in Saskatoon, Canada
542 patients (330 women, 212 men) with suspected allergic contact dermatitis were patch tested to standard series allergens between January 1983 and June 1987. Positive reactions were most frequently seen with nickel (17.4%), ethylenediamine (8.7%), formaldehyde (7.4%), colophony (7.0%), potassium dichromate (6.1%) and neomycin (5.7%). Patients with dermatitis involving the legs were those significantly more likely to be allergic to ethylenediamine (p=0.01) and benzocaine (p=0.04) than those with dermatitis not involving the legs. Neomycin allergy was not associated with dermatitis involving the legs. Patients allergic to ethylenediamine were significantly more likely to be allergic to neomycin than patients not allergic to ethylenediamine (p=0.002).
Contact Dermatitis, Aug. 1988, Vol.19, No.2, p.120-124. 17 ref.

CIS 89-1285 Åesson B., Skerfving S., Mattiasson L.
Experimental study on the metabolism of triethylamine in man
Five healthy volunteers were exposed by inhalation to triethylamine (TEA; 4 or 8h at about 10, 20, 35, and 50mg/m3), a compound widely used as a curing agent in polyurethane systems. Analysis of plasma and urine showed that an average of 24% of the TEA was biotransformed into triethylamine-N-oxide (TEAO) but with a wide interindividual variation (15-36%). The TEA and TEAO were quantitatively eliminated in the urine. The plasma and urinary concentrations of TEA and TEAO decreased rapidly after the end of exposure (averge half time of TEA was 3.2h). There was excellent association between air levels of TEA and the urinary concentrations in samples obtained within 2h of the end of exposure. Thus the urinary level of TEA taken in this period is useful as a biological monitoring of exposure. An air concentration of 10mg/m3 corresponds to an average urinary concentration of about 40mmol/mol creatinine (at sedentary work).
British Journal of Industrial Medicine, Apr. 1988, Vol.45, No.4, p.262-268. Illus. 14 ref.

CIS 89-1297 Albrecht W.N., Stephenson R.L.
Health hazards of tertiary amine catalysts
Tertiary amine catalysts are widely employed in foundry and polyurethane foam manufacture operations. These highly reactive amines have been associated with disturbances in vision and systemic health effects. Prominent among the reported effects on vision are mydriasis (dilated pupils), cycloplegia (loss of accommodation), and corneal oedema, which may result in hazy (looking through smoke) or blurry (out of focus) vision and halo perception. Systemic symptoms, possibly due to a release of endogenous histamine, are consistent with pharmacological actions of amines and are also described. These symptoms, as well as the disturbances in vision, are transient. Nevertheless, employees who work with or around machinery, or drive vehicles, may be at an increased risk of accident and injury when experiencing these symptoms.
Scandinavian Journal of Work, Environment and Health, Aug. 1988, Vol.14, No.4, p.209-219. 45 ref.

CIS 89-854 Mańkowska W.
Determination of ethylenediamine concentrations in air by gas chromatography
Oznaczanie stężenia etylenodwuaminy w powietrzu metodą chromatografii gazowej [in Polish]
Ethylenediamine concentrations in air are determined by gas chromatography using flame-ionisation detection in the presence of accompanying compounds. Air samples are taken by adsorption on activated carbon and desorption with ethyl alcohol. A column filled with 8% Carbowax 20M and 5% sodium hydroxide on Chromosorb W-AW-DMCS at a constant temperature of 90°C was used for the determination. The method is appropriate for determining ethylenediamine concentrations of 0.5-10mg/m3, which corresponds to 0.25-5 times the Polish exposure limit.
Prace Centralnego instytutu ochrony pracy, 1988, Vol.38, No.136, p.15-24. 13 ref.

1987

CIS 89-1287 Bajnova A., Hristeva V., Madžunov N., Daneva Z.
Dermal effect of ethylenediamine in petrochemical production
Dermalno văzdejstvie na etilendiamina v neftohimično proizvodstvo [in Bulgarian]
Of 47 workers engaged in ethylenediamine production 39% reported subjective complaints of the skin. Allergic dermatitis (26%) prevailed over irritant (6.5%), and often led to a change of employment. Epicutaneous tests with ethylenediamine and diethylene triamine gave respectively 32 and 20% positives, with high latency. Ethylenediamine dermal absorption at concentrations in the working area around the MAC (2mg/m3) was shown by the methaemoglobinaemia found in 15 operators. The elevated methaemoglobin in blood could be used as an indirect test for workers exposed to ethylenediamine and other aliphatic amines.
Problemi na higienata, Aug. 1987, Vol.12, p.109-114. 11 ref.

CIS 89-739 Allylamine
Allylamin; 2-propen-1-amin [in Swedish]
Chemical safety information sheet taken from the Kemiska Ämnen Register (CIS 89-214). Exposure limit: TLV = 5mg/m3. Toxicity: irritates the respiratory system; high exposure can cause convulsions, coma and finally death.
Arbetarskyddsnämnden, Box 3208, 10364 Stockholm, Sweden, 1987. 3p.

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