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Alcohols - 685 entries found

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  • Alcohols

1997

CIS 97-1578 Moen B.E., Øvrebø S.
Assessment of exposure to polycyclic aromatic hydrocarbons during fire fighting by measurement of urinary 1-hydroxypyrene
Urine samples were obtained from 9 students and 4 teachers at a firefighter training school before and 6 to 7 hours after extinguishing burning diesel fuel. The samples were analyzed by high-performance liquid chromatography for 1-hydroxypyrene. A small but significant increase in 1-hydroxypyrene levels was found after fire fighting. Fire fighting may cause exposure to polycyclic aromatic hydrocarbons, some of which are classified as carcinogenic.
Journal of Occupational and Environmental Medicine, June 1997, Vol.39, No.6, p.515-519. Illus. 29 ref.

CIS 97-1097 Cyclohexanol
Data sheet. May enter the body when breathed in and through the skin. May irritate and burn the eyes, skin and respiratory tract. May cause dizziness, nausea and fainting. May affect the liver and kidneys.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1997. 6p.

CIS 97-1273
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
4-Chloro-3-methylphenol (p-Chloro-m-cresol)
This report is a translation of a report finalized in December 1993. Main conclusions: cases of acute poisoning have been reported following oral uptake of 4-chloro-3-methylphenol (chlorocresol) in humans; animal studies indicate that the substance is absorbed through the gastrointestinal tract, lung and skin, and is corrosive to the eyes; chlorocresol is non-sensitizing in humans; laboratory studies give no indication of a mutagenic effect.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. xx, 151p. Bibl.ref. Price: DEM 87.00.

1996

CIS 00-1391 Teschke K., Marion S.A., Ostry A., Hertzmann C., Herschler R., Dimich-Ward H., Kelly S.
Reliability of retrospective chlorophenol exposure estimates over five decades
Historical chlorophenate exposures were estimated by teams of sawmill workers. The mill histories were divided into eras when jobs and exposures were relatively stable. Raters with at least 5 years of work experience in an era were asked to estimate the frequency and duration of exposure for each job in the mill. Reliability measures for these estimates were calculated for each of the mills and time period combinations, using the individual intraclass correlation coefficient (ICCind) to assess agreement between raters and the group intraclass correlation coefficient (ICCgroup). ICCind were low, but ICCgroup were considerably higher, indicating that the number of raters used in this study was sufficient to produce stable average estimates of exposure throughout the study period. These data confirm the intuitive expectation that reliability of exposure estimates decreases when reconstruction of conditions in the distant past is required, and therefore that the random component of exposure misclassification is a greater threat to validity in these earlier time periods.
American Journal of Industrial Medicine, Nov. 1996, Vol.30, No.5, p.616-622. Illus. 25 ref.

CIS 98-779 Dimich-Ward H., Hertzman C., Teschke K., Hershler R., Marion S.A., Ostry A., Kelly S.
Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry
Topics: antifertility effects; Canada; chlorophenols; cohort study; dioxins; exposure evaluation; parental exposure; sawmilling industry; teratogenic effects; wood preservatives.
Scandinavian Journal of Work, Environment and Health, Aug. 1996, Vol.22, No.4, p.267-273. 31 ref.

CIS 98-21
Environmental Protection Agency (EPA)
Testing consent order for phenol [USA]
This Order (entry into force 17.Jan. 1997) was made under the Control of Toxic Substances Act (CIS 89-23). Topics: chemical hazards; law; notification of dangerous substances; phenol; supply of information; toxic effects; toxicity evaluation; USA.
Federal Register, 17 Jan. 1997, Vol.62, No.12, p.2607-2611.

CIS 97-1829 sec-Butyl alcohol
Alcohol sec-butílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: irritation of the eyes and skin; liquid defats the skin; may cause dermatitis; exposure to high concentrations may have narcotic effects.
Noticias de seguridad, Dec. 1996, Vol.58, No.12. 4p. Insert.

CIS 97-1816 Propyl alcohol
Alcohol propílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Synonym: propanol. Health hazards: skin absorption; narcotic effects; irritation of upper respiratory tract; liquid defats the skin; may cause dermatitis.
Noticias de seguridad, May 1996, Vol.58, No.5. 4p. Insert.

CIS 97-1285
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
Phenol: Health based recommended occupational exposure limit
In this report the Dutch Committee on Occupational Standards discusses the consequences of occupational exposure to phenol and recommends an occupational exposure limit. Main conclusions: phenol and phenol solutions are caustic to human skin; the substance is absorbed through the skin; incidents of acute toxicity following dermal exposure in humans resulted in chemical burns and effects on the central nervous system; acute phenol poisoning may lead to respiratory failure and death. Recommended occupational exposure limit (8h TWA): 8mg/m3 (2ppm); a skin notation is advised. Summary in Dutch.
Gezondheidsraad, Postbus 90517, 2509 LM Den Haag, Netherlands, 1996. 86p. 194 ref.

CIS 97-1283
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
Bisphenol A and its diglycidylether: Health based recommended occupational exposure limits
In this report the Dutch Committee on Occupational Standards discusses the consequences of occupational exposure to bisphenol A and its diglycidyl ether and recommends occupational exposure limits. Main conclusions: in humans, bisphenol A causes mild irritation of the skin, eyes, nose and throat; the diglycidyl ether is a skin sensitizer. Recommended occupational exposure limits for both substances (8h TWA): 10 mg/m3 for substances in the form of inhalable dust, and 5mg/m3 for respirable dust. Skin contact with bisphenol A diglycidyl ether should be avoided. Summary in Dutch.
Gezondheidsraad, Postbus 90517, 2509 LM Den Haag, Netherlands, 1996. 110p. 108 ref.

CIS 97-1269
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Isodecanol
This report is a translation of a report finalized in December 1993. Main conclusions: no information is available on the effects of isodecanol (isodecyl alcohol) in humans; in animals the substance is slightly toxic and is a skin and eye irritant; there is no evidence of a mutagenic effect, and no information is available concerning sensitization, chronic toxicity or carcinogenicity.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1996. xiv, 43p. Bibl.ref. Price: DEM 48.00.

CIS 97-746 Methyl alcohol
Data sheet. Synonym: methanol. May enter the body when breathed in and through the skin. It is a teratogen and should be handled with extreme caution. May irritate the eyes, skin and respiratory tract. May cause blurred vision or blindness, neurotoxic effects and liver damage. It is a flammable liquid.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-739 Ethyl alcohol
Data sheet. Synonym: ethanol. May enter the body when breathed in and through the skin. May cause mutations and should be handled with extreme caution. May damage the foetus. Irritates the skin, eyes and respiratory tract. May cause neurotoxic effects and damage the liver. It is a flammable liquid.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-395 Pentachlorophenol
Data sheet. May enter the body when breathed in and through the skin. It is a carcinogen and a teratogen and should be handled with extreme caution. Irritates and burns the skin, eyes and respiratory tract. May damage the eyes, kidneys and liver. Exposure can cause poisoning with symptoms of headache, sweating, weakness, trouble in breathing, high fever and pain in the chest and abdomen. May cause an acne-like skin rash.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-390 Hydroquinone
Data sheet. May enter the body when breathed in. It is a mutagen and should be handled with extreme caution. May irritate, burn and cause staining and discolouration of the eyes. May permanently damage the vision. May irritate the skin and cause rash and changes in skin colour.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-388 Ethylene glycol
Data sheet. May enter the body when breathed in and through the skin. It is a teratogen and should be handled with extreme caution. Irritates the eyes and respiratory tract. May cause neurotoxic effects and damage the kidneys and the brain.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-567 Schecter A.J., Li L., Ke J., Fürst P., Fürst C., Päpke O.
Pesticide application and increased dioxin body burden in male and female agricultural workers in China
Following large-scale spraying of the pesticide sodium pentachlorophenol (Na-PCP) salt over agricultural and lake areas in China in the 1970s, dioxin levels were determined in sprayers or handlers of Na-PCP, and in persons living in sprayed and non-sprayed areas. Blood and breast-milk samples were collected and pooled for dioxin analysis, and samples of lake sediment were analyzed. Levels of polychlorinated dibenzodioxins and dibenzofurans (PCDD/F) in human tissue were found to be low in China compared with more industrialized countries. However, environmental and human tissue samples from sprayed areas had PCDD/F levels and international dioxin toxic equivalent (I-TEQ) levels several times higher than those from non-sprayed areas.
Journal of Occupational and Environmental Medicine, Sep. 1996, Vol.38, No.9, p.906-911. 10 ref.

CIS 97-207 Milton D.K., Walters M.D., Hammond K., Evans J.S.
Worker exposure to endotoxin, phenolic compounds and formaldehyde in a fiberglass insulation manufacturing plant
Worker exposures in a fibreglass wool insulation manufacturing plant were investigated using area and personal sampling. Both production and maintenance workers were exposed to endotoxin, phenolic compounds and formaldehyde. The greatest potential for exposure was restricted to specific areas of the plant. There was considerable within-area variation, and variability in personal exposures was high. Personal endotoxin exposures were frequently in excess of suggested thresholds for acute respiratory effects. The finding of highly variable exposure within individuals engaged in a continuous and routine manufacturing process has important implications for industrial hygiene practices and for occupational epidemiology.
American Industrial Hygiene Association Journal, Oct. 1996, Vol.57, No.10, p.889-896. 35 ref.

CIS 96-1836
International Programme on Chemical Safety (IPCS)
Hydroquinone - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 157 (see CIS 96-1806). Contents: identity and uses of hydroquinone; health hazards (poisoning, corrosion, allergic dermatitis, sensitization, eye irritation, corneal injury visual disturbances); guidance on hazard prevention and protection, first aid, explosion and fire hazards, storage and transport, spillage and disposal; current regulations and standards. Includes a summary of chemical safety information for workplace display.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 30p. Illus. 12 ref. Price: CHF 5.00 (CHF 3.50 in developing countries).

CIS 96-1835
International Programme on Chemical Safety (IPCS)
Cresols - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 168 (see CIS 96-1808). Contents: identity and uses of cresols; health hazards (irritation, corrosion); guidance on hazard prevention and protection, first aid, explosion and fire hazards, storage and transport, spillage and disposal; current regulations and standards. Includes a summary of chemical safety information for workplace display.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 22p. 6 ref. Price: CHF 5.00 (CHF 3.50 in developing countries).

CIS 96-489 tert-Butyl alcohol
Alcohol ter-butílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: irritation of the eyes, skin and respiratory tract; dermatitis; narcotic effect.
Noticias de seguridad, Jan. 1996, Vol.58, No.1. 4p. Insert.

1995

CIS 01-669 Dinonyl phenol (mixed isomers)
Dinonylphénol (mélange d'isomères) [in French]
Dinonilfenol (mezcla de isómeros) [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: the substance is corrosive to the eyes, the skin and the respiratory tract; corrosive on ingestion; inhalation of aerosol may cause lung oedema; effects may be delayed; medical observation is indicated. No TLV has been established.
Internet site: http://www.cdc.gov/niosh/ipcs/icstart.html, 1993-1995. Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain. 2p.

CIS 99-606 Lundberg P.
Scientific basis for Swedish occupational standards XVI
Vetenskapligt Underlag för Hygieniska Gränsvärden 16 [in Swedish]
This volume consists of the consensus reports submitted by the Criteria Group at the Swedish National Institute for Working Life between July 1994 and June 1995. Topics: 1,1,1,2-tetrafluoroethane; 2-nitropropane; aluminium; butoxyethoxyethyl acetate; diethylaminoethanol; isopropoxyethanol; propyl acetate; diethylenetriamine; diethylene glycol butyl ether; dimethyl ether; pentaerythritol; diphenylamine; diethylene glycol isobutyl ether; ethylene glycol monoisopropyl ether acetate; trimethylolpropane; criteria document; determination of exposure limits; gallium and compounds; lactates; limitation of exposure; literature survey; Sweden; toxic effects; toxicology; translation.
Arbetslivsinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1995. 94p. Bibl.ref.

CIS 97-584 Frentzel-Beyme R., Domizlaff I.
Epidemiologic study on solvent-induced diseases
Studie über die Epidemiologie lösemittelbedingter Erkrankungen [in German]
The present knowledge of the toxic and carcinogenic effects caused by exposure to solvents in the varnish industry from published case studies and epidemiologic studies is reviewed. The following solvents are covered: butyl alcohol, butyl acetate, carbon disulfide, chloromethane, dichloromethane, dimethylformamide, ethyl acetate, glycol ethers, methoxyethanol, cellosolve, hexane, isopropyl alcohol, methanol, 2-hexanone, butanone, styrene, toluene, 1,1,1-trichloroethane, trichloroethylene and xylene.
Umweltbundesamt, Postfach 33 00 22, 14191 Berlin, Germany, 1995. 235p. 436 ref.

CIS 96-1808
International Programme on Chemical Safety (IPCS)
Cresols
Conclusions of this criteria document: cresols are strongly irritant and corrosive. Occupational exposure usually results from dermal contact and can cause severe burns, anuria, coma and death. No information is available regarding the effects of chronic exposure to cresols. Primary targets of ingested cresols are the central nervous system, blood and kidneys. Summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1995. 144p. approx. 340 ref. Price: CHF 22.00 (CHF 15.40 in developing countries).

CIS 96-1267
National Occupational Health and Safety Commission (Worksafe Australia)
Guidelines for health surveillance
These guidelines are intended for appointed medical practitioners when planning and implementing a programme of health surveillance within enterprises. Such programmes should be instituted when a workplace assessment of health risks, conducted according to the National Model Regulations for the Control of Workplace Hazardous Substances (NOHSC 1005: (1994), see CIS 95-274), has determined that workplace exposure represents a significant risk to health. Contents of the 18 booklets: 1 - Introduction (basic aspects of health surveillance, extracts from the Model Regulations and the National Code of Practice (NOHSC: 2007 (1994), see CIS 95-274 as well), list of substances subject to control, criteria for determining whether a substance should be scheduled as requiring health surveillance). 2 - sample respiratory questionnaires to be administered to workers. 3-18: Specific substances (for each substance: information on health surveillance at time of employment, during exposure to a process where the substance is present and at termination of employment; data sheet with information on substance in question). The substances are: acrylonitrile, inorganic arsenic, asbestos, benzene, cadmium, inorganic cadmium, creosote, isocyanates, inorganic mercury, MOCA, organophosphate pesticides, pentachlorophenol, polycyclic aromatic hydrocarbons, crystalline silica, thallium, vinyl chloride.
Australian Government Publishing Service, GPO Box 84, Canberra ACT 2601, Australia, 1995-1996. 18 booklets in a ring binder. Bibl.ref.
http://www.ascc.gov.au/NR/rdonlyres/481CF3F5-8C4B-4BCC-AF65-3FDBA031D43B/0/HealthSurveillance.pdf [in English]

CIS 96-491 Allyl alcohol
Alcohol alilo [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; irritation of the eyes, skin and respiratory tract; chemical burns (eyes and skin); may affect the lungs: pulmonary oedema.
Noticias de seguridad, Dec. 1995, Vol.57, No.12. 4p. Insert.

CIS 96-305 Girre C., Hispard E., Tuszynski T.
Toxicity of ethanol
Toxicité de l'éthanol [in French]
Ethanol toxicity is seen at both the somatic and the psychological level. Contents: absorption, distribution and elimination of ethanol in the body; ethanol-xenobiotic interactions; effects of ethanol on the liver (pathology, physiopathology of hepatic changes due to alcohol, clinical aspects), digestive tract, central and peripheral nervous systems, cardiovascular system, endocrine glands, the foetus, the haematopoietic system, the metabolism, bones and muscles; ethanol and antioxidants.
Encyclopédie médico-chirurgicale, Toxicologie, Pathologie professionnelle, 3rd Quarter 1995, No.108. 8p. 42 ref.

CIS 96-260 Nowak A.K., Shilkin K.B., Jeffrey G.P., Care G.L.
Darkroom hepatitis after exposure to hydroquinone
A communication by Nowak et al, The Lancet, 6 May 1995, reports a case of toxic hepatitis in a hospital radiographer thought to be caused by exposure to hydroquinone fumes and dust from a radiographic developer. A reply by Care, The Lancet, 13 January 1996, describes how hydroquinone dust, vapour and aerosols may form near developers and thus present an inhalation risk.
Lancet, 6 May 1995 and 13 Jan. 1996, Vol.345, No.8958, p.1187. 5 ref. and Vol.347, No.8994, p.121. 3 ref.

CIS 96-60 Isoamyl alcohol
Alcohol isoamílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: irritation of the eyes and respiratory tract; respiratory diseases; dermatitis; diplopia.
Noticias de seguridad, July 1995, Vol.57, No.7. 4p. Insert.

CIS 95-1998 Hydroquinone
Hidroquinona [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: irritation of the eyes and skin; haematotoxic effects; methaemoglobinaemia; cyanosis; neurotoxic effects; eye injuries.
Noticias de seguridad, Feb. 1995, Vol.57, No.2. 5p. Insert.

CIS 95-2188
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
4-Chloro-2-methylphenol
Conclusions of this criteria document, translation of a report finalized in June 1993: no data are available on the effects of 4-chloro-2-methylphenol (4-chloro-o-cresol) in humans. Animal studies indicate a pronounced irritation of the skin and mucous membranes.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. xv, 74p. approx. 140 ref. Price: DEM 48.00.

CIS 95-2184
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Melamine. Diisopropanolamine. 1,6-Hexanediol. Tri/Dibutyl phosphate
Conclusions of these criteria documents, translation of reports finalized in June-Dec. 1992: no data are available on the acute or chronic effects of melamine in man; tests for irritating or sensitizing properties proved negative. Animal studies indicate that diisopropanolamine (1,1'-iminodi-2-propanol) is of low acute toxicity; tests on humans reveal that it does not induce allergic or photoallergic reactions. No data are available on the effects of 1,6-hexanediol in man; animal studies indicate a slight acute toxicity. Tributyl phosphate is strongly irritating to the skin and mucous membranes in man; exposure by inhalation leads to nausea and headache. The toxicological action of dibutyl phosphate is assumed to be comparable to that of tributyl phosphate.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. xxvii, 197p. Bibl.ref. Price: DEM 96.00.

CIS 95-1812 Simonsen L., Midtgård U., Lund S.P., Hass U.
Nordic Council of Ministers
Occupational neurotoxicity: Evaluation of neurotoxicity data for selected chemicals
Previously determined criteria for evaluating published data on the neurotoxicity of chemicals (see CIS 95-000) were applied to the literature on 79 common industrial chemicals. Data were too sparse to permit classification of 28. Of the rest, eight were classified as probably and 16 as possibly neurotoxic, and the following 27 as definitely neurotoxic: acrylamide, acrylonitrile, aluminium, arsenic, sodium azide, borax, boric acid, carbon monoxide, carbon disulfide, potassium cyanide, ethanol, ethylene oxide, hexachlorophene, manganese, mercury, methanol, methyl bromide, methyl butyl ketone (2-hexanone), methyl chloride, methyl methacrylate, n-hexane, nitrous oxide, styrene, thallium, toluene, trichloroethylene, triorthocresyl phosphate.
National Institute of Occupational Health, Lersø Parkallé 105, 2100 København Ø, Denmark, 1995. 119p. Bibl.ref.

1994

CIS 07-1412
International Programme on Chemical Safety (IPCS)
Phenol - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 161 (see CIS 98-1403). Contents: identity and uses of phenol; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; summary of chemical safety information for use in the workplace; current regulations and guidelines. Phenol is corrosive to the skin and may be absorbed by the skin; it causes eye irritation or corrosion; inhalation causes inflammation and oedema in the respiratory system and central nervous system depression. Repeated exposure may cause dermatitis and liver and kidney damage.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 31p. Illus. 9 ref.
http://www.inchem.org/documents/hsg/hsg/hsg88_e.htm [in English]

CIS 98-1403
International Programme on Chemical Safety (IPCS)
Phenol
Summaries in French and Spanish. Topics: caustic substances; criteria document; erythema; functional heart disorders; IPCS; irritants; literature survey; necrosis; odour threshold; phenol; renal damage; skin absorption; toxic effects; toxicology.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 151p. Illus. Approx. 420 ref. Price: CHF 23.00 (CHF 16.10 in developing countries).

CIS 98-1399
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
1-, 2- and t-butanol - Health based recommended occupational exposure limit
Topics: butanols; butyl alcohol; tert-butyl alcohol; sec-butyl alcohol; corneal damage; criteria document; eye irritation; irritants; limitation of exposure; Netherlands; threshold limit values; toxicology.
Gezondheidsraad, Postbus 90517, 2509 Den Haag, Netherlands, 1994. 91p. 90 ref.

CIS 98-1385 Toxicological profile for pentachlorophenol: Update
Topics: antifertility effects; bronchitis; carcinogenic effects; cardiovascular disorders; pentachlorophenol; criteria document; determination in biological matter; exposure evaluation; genetic effects; glossary; haematological effects; health hazards; hepatic damage; immunotoxic effects; irritation; legislation; limitation of exposure; literature survey; neurotoxic effects; renal damage; skin absorption; skin eruption; toxic effects; toxicity evaluation; toxicology; USA.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, May 1994. xvii, 200p. Illus. Bibl.ref.

CIS 97-939 Lundberg P.
Criteria Group for Occupational Standards
Scientific basis for Swedish occupational standards XV
Vetenskapligt underlag för hygieniska gränsvärden. 15 - Criteria Group for Occupational Standards XV [in Swedish]
Critical evaluation of those scientific data which are relevant as background for discussion of Swedish occupational exposure limits. This volume consists of the consensus reports submitted by the Criteria Group at the Swedish National Institute of Occupational Health between July 1993 and June 1994. They cover: ethylene glycol monopropylether (propoxyethanol) and its acetate (2-propoxyethanol acetate), hexachloroethane, some metal stearates, some stearates, hexylene glycol, barium and barium compounds, strontium and strontium compounds, dicyclopentadiene, N,N-dimethylacetamide, indium and inorganic indium compounds, o-chlorobenzylidene malononitrile and thioglycolic (mercaptoacetic) acid.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1994. 72p. (Eng.); 79p. (Swe.). 298 ref.

CIS 96-2207 Tardiff R., Sato A., Laparé S., Brodeur J.
Ethanol induced modification of m-xylene toxicokinetics in humans
This study was undertaken to determine whether previous subacute treatment with ethanol could modify the kinetics of m-xylene in humans. A group of six volunteers was exposed twice to either 100 or 400ppm of m-xylene during two hours. Ethanol was given orally in the early evening on each of two consecutive days before exposures (total ethanol intake of 137g). Overall, this study showed that the effect of enzyme induction on the metabolism of m-xylene, after ethanol ingestion, depends on the exposure concentration and is not likely to occur as long as the exposure concentrations remain under the current maximum allowable concentration (100ppm) in the workplace.
Occupational and Environmental Medicine, Mar. 1994, Vol.51, No.3, p.187-191. Illus. 26 ref.

CIS 96-1978 1,2-Dihydroxybenzene
Data sheet. Synonym: pyrocatechol. May enter the body by inhalation and through the skin. It is a mutagen. It should be handled with extreme caution. May cause skin and eye burns, headaches, nausea, muscle twitching and convulsions. Skin allergy with rash may occur. May cause methaemoglobinaemia and damage to the kidneys and liver.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1994. 6p.

CIS 96-1806
International Programme on Chemical Safety (IPCS)
Hydroquinone
Conclusions of this criteria document: there are reports of a possible relationship between occupational exposure to photographic developers containing hydroquinone and depigmentation of the skin. Patch testing with hydroquinone has resulted in irritation and contact allergy. Combined exposure to quinone vapour and hydroquinone dust causes eye irritation, sensitivity to light, corneal damage and visual disturbances. Cases of intoxication have been reported after oral ingestion. Summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 178p. approx. 340 ref. Price: CHF 27.00 (CHF 18.90 in developing countries).

CIS 96-896
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
1- and 2-Propanol: Health based recommended occupational exposure limit
In this report the Dutch Committee on Occupational Standards discusses the effects of exposure to 1-propanol and 2-propanol (isopropyl alcohol). Attention is given to: identity, physical and chemical properties, monitoring; sources of exposure; environmental levels and human exposure; guidelines and standards; toxicokinetics; effects in animals and man (acute toxicity, long-term toxicity/carcinogenicity, mutagenicity, reproduction toxicity, irritation and sensitization); previous evaluations by (inter)national bodies; evaluation of human health risk. The committee concludes that it cannot recommend a health-based occupational exposure limit for 1-propanol based on the available data. Based on an animal study in which no effects were observed at a concentration of 1925mg/m3 (770ppm) the committee recommends a health-based occupational exposure limit of 650mg/m3 (250ppm) for 2-propanol, to be averaged over an 8-hour working day (8h TWA). Summary in Dutch.
Gezondheidsraad, Postbus 90517, 2509 LM Den Haag, Netherlands, 1994. 117p. approx. 160 ref.

CIS 95-1742 Pendergrass S.M.
An alternative method for the analysis of phenol and o-, m-, and p-cresol by capillary GC/FID
A method for the sampling and simultaneous analysis of phenol, o-, m-, and p-cresol using XAD-7 as a sorbent for the collection of each analyte is described. Desorption was achieved with methanol followed by analysis of all samples using gas chromatography with flame ionization detection. Separation of all analytes was achieved on a Stabilwax-DA capillary column. The method provides a number of improvements over currently available methods.
American Industrial Hygiene Association Journal, Nov. 1994, Vol.55, No.11, p.1051-1054. 16 ref.

CIS 95-1318 Bieniek G.
The presence of 1-naphthol in the urine of industrial workers exposed to naphthalene
Occupational and Environmental Medicine, May 1994, Vol.51, No.5, p.357-359. Illus. 9 ref. ###

CIS 95-1404 Bieniek G.
Concentrations of phenol, o-cresol, and 2,5-xylenol in the urine of workers employed in the distillation of the phenolic fraction of tar
Occupational and Environmental Medicine, May 1994, Vol.51, No.5, p.354-356. Illus. 15 ref. ###

CIS 95-1012 Skogstad M., Levy F.
Occupational irritant contact dermatitis and fungal infection in construction workers
A study was made of six construction workers who developed chronic skin diseases on their hands over a period of 15 years. Four developed Trichophyton rubrum infection, and the other two an irritant contact dermatitis. All of them carried out jobs which caused traumatization of the skin due to the presence of ethylene glycol and mineral oils during operation of pneumatic hammers in winter. Construction workers may be at risk of developing an occupational skin disease involving fungal infection.
Contact Dermatitis, July 1994. Vol.31, No.1, p.28-30. 6 ref.

CIS 95-857 Propylene glycol
Propylèneglycol [in French]
Chemical safety information sheet. Acute toxicity: mild irritation of the skin. Chronic toxicity: metabolic disturbances; renal insufficiency; neurotoxic effects; irritation of the skin (dermatitis).
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1994. 4p. 20 ref.

CIS 95-1038
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
2,3-Dichlorophenol. 2,4,5-Trichlorophenol
No data are available on human exposure to 2,3-dichlorophenol (Report 110) and limited information is available from animal studies; it has a slight-to-moderate acute oral toxicity and is probably strongly irritating; no genotoxic effects have been observed. Trichlorophenol (Report 111) causes erythema and oedema at the site of application and chronic contact causes mild chemical burns; eye irritation and corneal damage have also been reported; animal studies indicate that the acute oral toxicity is slight and the substance is probably non-genotoxic.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1994. xi, 85p. Bibl.ref. Price: DEM 72.00.

CIS 95-1033
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Ethylene glycol
There are numerous reports of ethylene glycol poisoning in humans in which the kidneys proved to be the target organ; neurotoxic and cardiopulmonary effects have also been observed following poisoning. The substance has a strong irritative effect. Animal studies indicate that ethylene glycol has a low acute toxicity; general symptoms are depression of the central nervous system and kidney damage; no mutagenic or carcinogenic effects have been observed; embryotoxic and teratogenic effects have been demonstrated at very high doses.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1994. xvii, 139p. Bibl.ref. Price: DEM 88.00.

CIS 95-1060
Health and Safety Executive, Epidemiology and Medical Statistics Unit
Mortality study of workers employed at a factory manufacturing 2,4,5-trichlorophenol
A study was made of the mortality of 673 male workers employed at a factory manufacturing 2,4,5-trichlorophenol (2,4,5-TCP) between 1965 and 1976. The study population included workers employed at the time of a runaway reaction which resulted in the release of 2,4,5-TCP contaminated with 2,3,7,8-tetrachlorodibenzodioxin (TCDD). No overall excess of cancers was found. While there were indications of possible increased mortality from cancers of the stomach and lung, there was no clear evidence of causation. Tables show major causes of mortality for the total population and for workers employed before, during and after the time of the runaway reaction.
HSE Books, PO Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1994. 26p. 12 ref.

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