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Alcohols - 685 entries found

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1999

CIS 03-1072 3,5-Dichlorophenol
3,5-Dichlorophénol [in French]
3,5-Diclorofenol [in Spanish]
International Chemical Safety Card published in 1998. Exposure routes: inhalation, skin absorption and ingestion. Short term exposure effects: strong irritation of the skin, eyes and respiratory tract; chloracne. Insufficient data is available on long-term effects of the substance, therefore utmost care must be taken. Threshold limit value not established. Synonym: 1-hydroxy-3,5-dichlorobenzene.
Internet documents, 1998, 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc04/icsc0440.pdf [in English]
http://www.cdc.gov/niosh/ipcsnfrn/nfrn0440.html [in French]
hhttp://www.mtas.es/insht/ipcsnspn/nspn0440.htm [in Spanish]

CIS 03-1071 2,5-Dichlorophenol
2,5-Dichlorophénol [in French]
2,5-Diclorofenol [in Spanish]
International Chemical Safety Card published in 1998. Exposure routes: inhalation, skin absorption and ingestion. Short term exposure effects: strong irritation of the skin, eyes and respiratory tract; chloracne. Insufficient data are available on long-term effects of the substance, therefore utmost care must be taken. Threshold limit value not established. Synonym: 1-hydroxy-2,5-dichlorobenzene.
Internet documents, 1998, 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc04/icsc0439.pdf [in English]
http://www.cdc.gov/niosh/ipcsnfrn/nfrn0439.html [in French]
http://www.mtas.es/insht/ipcsnspn/nspn0439.htm [in Spanish]

CIS 03-1066 2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-nitropropane-1,3-diol [in French]
International Chemical Safety Card published in 1995 (Spanish version already abstracted under CIS 00-946). Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: irritation of the skin, eyes and respiratory tract. Long-term exposure effects: prolonged or repeated contact may induce skin sensitization. Threshold limit value not established. Synonym: β-bromo-β-nitrotrimethyleneglycol.
Internet documents, 1995, 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc04/icsc0415.pdf [in English]
http://www.cdc.gov/niosh/ipcsnfrn/nfrn0415.html [in French]

CIS 03-1053 m-Chlorophenol
m-Chlorophénol [in French]
International Chemical Safety Card (Spanish version already abstracted under CIS 96-468). Exposure routes: inhalation, skin absorption and ingestion. Short-term exposure effects: irritation of the skin, eyes and respiratory tract. Threshold limit value not established. Synonyms: 3-chlorophenol; 3-chloro-1-hydroxybenzene; 3-hydroxychlorobenzene.
Internet documents, 1999. 2p.
http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc01/icsc0150.pdf [in English]
http://www.cdc.gov/Niosh/ipcsnfrn/nfrn0150.html [in French]

CIS 01-489 Alvarez-Leite E.M., Coelho André Amorim L.
Comparing levels of o-cresol and hippuric acid in the urine of workers exposed to toluene
Comparação dos níveis de orto-cresol e ácido hipúrico na urina de trabalhadores expostos ao tolueno [in Portuguese]
Toluene is an aromatic solvent widely used in the manufacturing process of many products such as glue, thinners and paints. Its neurotoxicity is the main risk factor to workers' heath, therefore the use of control and evaluation measures of occupational exposure is essential. Toluene absorbed by workers is oxidized into aromatic compounds, including o-cresol, which has been suggested as a preferred biological indicator for exposure to toluene. The fact that o-cresol is not found in significant amounts in the urine of non-exposed individuals is a great advantage over hippuric acid as an indicator. This study focused on comparing the levels of o-cresol and hippuric acid in urine samples of individuals occupationally exposed to toluene in three industrial activities (shoe manufacturing, metalworking and printing) with those of an unexposed control group. Results indicate that further research is necessary to validate o-cresol as an biomarker for exposure to toluene.
Revista brasileira de saúde ocupacional, 1999, Vol.25, No.95/96, p.45-57. Illus. 33 ref.

CIS 00-1565
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for chlorophenols (Update)
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; references; glossary. Health hazards include: chloracne; porphyria; carcinogenic effects (soft tissue sarcoma, lung cancer, malignant lymphomas, non-Hodgkin's lymphomas, nose and nasopharyngeal cancer).
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, July 1999. xix, 222p. Illus. approx. 380 ref.

CIS 00-1396 Garabedian M.J., Hoppin J.A., Tolbert P.E., Herrick R.F., Brann E.A.
Occupational chlorophenol exposure and non-Hodgkin's lymphoma
Occupational exposure to chlorophenols is suspected to increase non-Hodgkin's lymphoma (NHL) risk. This association was examined using data from a population-based case-control study of men aged 32 to 60 years. Potential chlorophenol exposure was characterized by intensity estimates and confidence ratings based upon review of verbatim job histories. Cases with substantial chlorophenol exposure had a significantly greater number of years of chlorophenol exposure; however, in conditional logistic regression models, the odds ratio for more than 8 years of substantial exposure was 1.51. Overall, the findings do not provide strong support for an association with NHL risk. Chlorophenol exposure in this study is not based upon measured values and, therefore, may fail to characterize actual chlorophenol exposures accurately. These results are consistent with other findings, which suggest that chlorophenol exposure is not likely to be a strong risk factor for NHL.
Journal of Occupational and Environmental Medicine, Apr. 1999, Vol.41, No.4, p.267-272. Illus. 17 ref.

CIS 00-793 Pontén A., Bruze M.
Occupational allergic contact dermatitis from epoxy resins based on bisphenol F
Topics: allergens; aromatic diols; bisphenol F diglycidyl ether polymer; case study; dermatitis; diglycidyl ethers; eczema; epoxy resins; sensitization dermatitis; skin allergies; skin tests.
Contact Dermatitis, Oct. 1999, Vol.41, No.4, p.235. 3 ref.

CIS 00-454 Pendergrass S.M.
Determination of glycols in air: Development of sampling and analytical methodology and application to theatrical smokes
Glycol-based fluids are used in the production of theatrical smokes in theatres, concerts and other stage productions. The fluids are heated and dispersed in aerosol form to create the effect of a smoke, mist or fog. There have been reports of adverse health effects such as respiratory irritation, chest tightness, shortness of breath, asthma and skin rashes. In order to assess workplace exposures, an Occupational Safety and Health Administration versatile sampler tube was selected for the collection of various glycol aerosols. Limits of detection of the glycol analytes ranged from 7 to 16µg/sample. Desorption efficiencies for all glycol compounds were determined over the range of study and averaged greater than 90%. Storage stability results were acceptable after 28 days for all analytes except ethylene glycol, which was stable at ambient temperature for 14 days. Based on the results of this study, the new glycol method was published in the NIOSH Manual of Analytical Methods.
American Industrial Hygiene Association Journal, July-Aug. 1999, Vol.60, No.4, p.452-457. Illus. 23 ref.

CIS 00-188 Mäkinen M., Kalliokoski P., Kangas J.
Assessment of total exposure to phenol-formaldehyde resin glue in plywood manufacturing
Respiratory and dermal exposure to phenol-formaldehyde resin-glue components used in plywood manufacturing were assessed by monitoring formaldehyde and phenol in the workplace air. Formaldehyde was measured both in the breathing zones of the workers and at stationary sampling sites. Phenol was used as a marker agent for dermal exposure. Formaldehyde was noted to be the major compound causing respiratory exposure. When exposure assessment was done on the basis of air samples collected both at stationary sampling sites and in the breathing zonesof the workers, the agreement between the results obtained was good. The dermal sampling revealed that the workers were exposed to phenol, but the risk for toxic effects was slight due to the low concentrations of urinary phenol. It is concluded that is possible to use a stationary sampling method for the assessment of respiratory exposure in a plywood factory. The importance of taking dermal exposure into account is also outlined.
International Archives of Occupational and Environmental Health, Aug. 1999, Vol.72, No.5, p.309-314. Illus. 15 ref.

CIS 99-1764 Commission Directive 1999/51/EC of 26 May 1999 adapting to technical progress... Annex I to Council Directive 76/769/EEC... relating to restrictions on the marketing and use of certain dangerous substances and preparations (tin, PCP, cadmium) [European Communities]
Directive 1999/51/CE de la Commission du 26 mai 1999... adaptation... de l'annexe I de la Directive 76/769/CEE du Conseil... relative à... certaines substances et préparations dangereuses (étain, pentachlorophénol (PCP) et cadmium) [Communautés européennes] [in French]
For Council directive 76/769/EEC, see CIS 92-22. Topics: cadmium; tin; pentachlorophenol; directive; European Communities.
Journal officiel des Communautés européennes - Official Journal of the European Communities, 5 June 1999, Vol.42, No.L 142, p.22-25.

CIS 99-1268 Estlander T., Jolanki R., Henriks-Eckerman M.L., Kanerva L.
Occupational contact allergy to bisphenol A
Topics: bisphenol A; case study; eczema; individual susceptibility; protective gloves; sensitization dermatitis; skin allergies; skin tests.
Contact Dermatitis, Jan. 1999, Vol.40, No.1, p.52-53. 20 ref.

1998

CIS 01-1752 Angerer J., Ball M., Bollmacher H., Buck M., Krämer A., Woppowa L.
Second interlaboratory test on the determination of pentachlorophenol and lindane in indoor air organized by KRdL of VDI and DIN
Zweiter Ringversuch der KRdL im VDI und DIN für die Bestimmung von Pentachlorphenol und Lindan in Luft [in German]
The toxicity of the organochlorine compounds pentachlorophenol (PCP) and µg-hexachlorocyclohexane (lindane) requires indoor air measurements in order to evaluate possible exposure levels. In 1997, the German Commission on Air Pollution Prevention (KRdL) organized the second interlaboratory test for the determination of pentachlorophenol and lindane in indoor air. 45 laboratories participated in the test using either the VDI-test schedule or their own method. The results indicate an improvement in the analysis consistency compared to the first test conducted in 1995, which may be attributed to a better training of the participants or an increase in the use of the standard operating procedure developed by the VDI.
Gefahrstoffe Reinhaltung der Luft, Sep. 1998, Vol.58, No.9, p.333-336. 12 ref.

CIS 01-1359
International Programme on Chemical Safety (IPCS)
Screening information data set SIDS for high production volume chemicals - Volume 5, Part 1
Ecotoxicological and toxicological (acute toxicity, chronic toxicity, effects on reproduction, genetic effects) data for the risk assessment of o-cresol, 1,4-dicyanobutane (adiponitrile), 1-dodecanol and glutaraldehyde.
United Nations Environment Programme, Case postale 356, 1219 Châtelaine, Genève, Switzerland, Oct. 1998. viii, 311p. Bibl.ref.
http://www.chem.unep.ch/irptc/sids/insids.PDF [in English]

CIS 01-673 Disul-sodium
Disul-sodium [in French]
Disul-sodio [in Spanish]
International Chemical Safety Card. Exposure routes: inhalation and ingestion. Short-term exposure effects: irritation of the skin, eyes and respiratory tract; effects on the kidneys and the liver. TLV (TWA): 10mg/m3 A4 (ACGIH 1998); OSHA PEL (TWA): 15mg/m3 (total), 5mg/m3 (resp); NIOSH REL (TWA): 10mg/m3 (total), 5mg/m3 (resp); NIOSH IDLH: 500mg/m3.
Internet site: http://www.cdc.gov/niosh/ipcs/icstart.html, 1993-1998. Spanish version also from: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain. 2p.

CIS 00-1079 Volkheimer B., Alsen-Hinrichs C., Wassermann O.
Toxicological evaluation of a relationship between the exposure to pentachlorophenol-containing wood preservatives in day-care centres and health problems among nursery staff
Toxikologische Bewertung eines Zusammenhanges zwischen der Exposition gegenüber Pentachlorphenol-haltigen Holzschutzmitteln in Kindertagesstätten und der Ausbildung von Gesundheitsstörungen bei den dort beschäftigten Kindergärtnerinnen und Hilfskräften [in German]
Wood preservatives containing pentachlorophenol and gamma-hexachlorocyclohexane were widely applied in Germany in the 1970s inside buildings. The presence of the highly toxic polychlorinated dibenzodioxins and dibenzofurans as undesirable side products has been known since 1957. In the years 1985 to 1986 the first reports about nursery staff having been exposed to wood preservatives appeared in Germany. Measurements in nursery schools yielded high concentrations of 2,3,7,8-tetrachlorodibenzodioxin in indoor air. The relationship between exposure to wood preservatives and respiratory diseases, irritation of the skin, eyes and mucosa, tachycardia, headache, nausea and diseases of the blood-forming organs found in examinations of exposed nursery staff is discussed.
Institut für Toxikologie der Universität Kiel (ITUK), Brunswiker Str. 10, 24105 Kiel, Germany, 1998. 201p. Approx. 220 ref.

CIS 00-50
Agency for Toxic Substances and Disease Registry (ATSDR)
Toxicological profile for phenol: Update
Contents: public health statement; health effects; chemical and physical information; production, import, use and disposal; potential for human exposure; analytical methods; regulations and advisories; glossary. Health hazards include: irritation of the skin, eyes and respiratory tract; pneumotoxic effects, including hyperaemia, bronchopneumonia, bronchitis; cardiac arrythmia; haematological effects; hepatic effects; renal effects; neurological effects.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Dec. 1998. xix, 205p. Illus. approx. 500 ref.

CIS 99-1101 Propylene chlorohydrin
Topics: 2-chloropropanol; data sheet; elimination of spills; fire hazards; first aid; glossary; health hazards; irritation; limitation of exposure; New Jersey; personal protective equipment; storage; USA.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 99-1100 Propargyl alcohol
Topics: propargyl alcohol; data sheet; elimination of spills; explosion hazards; fire hazards; first aid; glossary; health hazards; hepatotoxic effects; irritants; limitation of exposure; medical examinations; nephrotoxic effects; neurotoxic effects; New Jersey; personal protective equipment; storage; threshold limit values; USA.
New Jersey Department of Health and Senior Services, Right to Know Program, PO Box 368, Trenton, NJ 08625-0368, USA, 1998. 6p.

CIS 99-953
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Phenol
Topics: animal experiments; phenol; criteria document; ecotoxicology; eye irritation; Germany; irritants; legislation; literature survey; neurotoxic effects; skin absorption; toxicology; translation.
S. Hirzel Verlag, P.O.Box 10 10 61, 70009 Stuttgart, Germany, 1998. xxvii, 414p. approx. 820 ref. Price: DEM 143.00.

CIS 99-951
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
p-Hydroxybenzoic acid. Hexabromocyclododecane. Propylene glycol
Topics: animal experiments; hexabromocyclododecane; propylene glycol; p-hydroxybenzoic acid; criteria document; ecotoxicology; Germany; legislation; literature survey; skin allergies; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O.Box 10 10 61, 70009 Stuttgart, Germany, 1998. 250p. Bibl.ref. Price: DEM 112.00.

CIS 99-602
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
1-Propanol
This report is a translation of a report finalized in April 1996. Main conclusions: propanol is absorbed via the skin, gastrointestinal and respiratory tracts; it has a slight acute toxicity; in man, lethal intoxication has been observed after oral intake of 100-350mL; lower oral doses cause dizziness, narcosis, nausea and reduced performance; allergic reactions have been observed in isolated cases. Topics: propanol; criteria document; ecotoxicology; Germany; legislation; literature survey; metabolic process; poisoning; skin absorption; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1998. xxi, 186p. Bibl.ref.

CIS 99-559 Hara K., Itani T.
Urinary 1-hydroxypyrene as a biological monitoring index for exposure to polycyclic aromatic hydrocarbons
takanhoukouzokutankasuisorui no seibutsugakuteki monitaringu shihyō toshiteno nyōchū 1-hidorokishipiren [in Japanese]
Summary in English. Literature review which suggests the need to extend the use of urinary 1-hydroxypyrene as a biological monitoring index for exposure to polycyclic aromatic hydrocarbons (PAHs) to other workplaces than coke ovens. Urinary 1-hydroxypyrene may be useful for assessing early effect markers more strictly. Assessment of individual susceptibility could be developed by observation of individual profiles of PAH metabolites in urine. Topics: 1-hydroxypyrene; aromatic hydrocarbons; determination in urine; evaluation of technique; polycyclic hydrocarbons; urinary metabolites.
Journal of Science of Labour - Rōdō Kagaku, Jan. 1998, Vol.74, No.1, p.1-16. Illus. 128 ref.

CIS 99-546 Politowicz M.
Hydroquinone
Hydrochinon [in Polish]
Topics: hydroquinone; description of technique; determination in air; sampling and analysis.
Podstawy i Metody Oceny Środowiska Pracy, 1998, Vol.19, p.91-95. 1 ref.

CIS 99-203 Brooke R., Beck M.H.
Contact allergy to 2,4,6-tris(dimethylaminomethyl)phenol
Topics: 2,4,6-tris(dimethylaminomethyl)phenol; case study; eczema; epoxy resins; hardeners; sensitization dermatitis; skin tests.
Contact Dermatitis, May 1998, Vol.38, No.5, p.284-285. Illus. 5 ref.

CIS 99-198 Batterman S.A., Franzblau A., D'Arcy J.B., Sargent N.E., Gross K.B., Schreck R.M.
Breath, urine, and blood measurements as biological exposure indices of short-term inhalation exposure to methanol
Topics: biological threshold limits; methanol; determination in blood; determination in exhaled air; determination in urine; evaluation of technique; exposure evaluation; exposure tests; inhalation; short-term exposure.
International Archives of Occupational and Environmental Health, July 1998, Vol.71, No.5, p.325-335. Illus. 29 ref.

CIS 98-1167 Ethylene chlorohydrin
Clorohidrina de etileno [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: brain tissue damage; 2-chloroethanol; data sheet; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; gastric disorders; health hazards; hepatic damage; irritation; limitation of exposure; medical supervision; personal protective equipment; pulmonary oedema; renal damage; respirators; skin absorption; unconsciousness; USA; visual function disorders; waste disposal.
Noticias de seguridad, Oct. 1998, Vol.60, No.10. 4p. Insert.

CIS 98-1333 Estlander T., Kostiainen M., Jolanki R., Kanerva L.
Active sensitization and occupational allergic contact dermatitis caused by para-tertiary-butylcatechol
Topics: 4-tert-butylpyrocatechol; allergens; p-tert-butylphenol; dermatitis; eczema; Finland; sensitization dermatitis; skin tests.
Contact Dermatitis, Feb. 1998, Vol.38, No.2, p.96-100. Illus. 20 ref.

1997

CIS 02-587 3-Methylbutanol-1
3-Methylbutanol-1 [in German]
Exposure to concentrations of 3-methylbutanol-1 in air exceeding 100ppm causes irritation of the eyes, nose and throat. Ingestion causes a decrease in attention span, and ingestion of 50 to 100mL of may lead to death within one or two days. Animal experiments show a low to moderate toxicity upon acute oral and inhalation exposure. 3-methylbutanol-1 is an irritant to the skin and the eyes of rabbits. Results of carcinogenicity studies do not enable the evaluation of its carcinogenic potential. No embryotoxic, foetotoxic or teratogenic effects have been reported.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 31p. 82 ref.

CIS 02-585 2-Methylpropanol-1
2-Methylpropanol-1 [in German]
2-Methylpropanol-1 vapours cause narcosis and irritation of the upper airways. Reversible eye damage may also occur. Ingestion induces a deterioration of the attention span. Animal experiments show a low toxicity upon acute oral and inhalation exposure. 2-methylpropanol-1 is an irritant to the skin and the eyes of rabbits. Results of carcinogenicity studies do not enable its carcinogenic potential to be evaluated. No embryotoxic, foetotoxic or teratogenic effects have been reported.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 43p. Illus. 117 ref.

CIS 02-545 Ethanol
Ethanol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 90-740. Acute toxicity: absorption by ingestion and inhalation (very limited through the skin); irritation of the eyes and respiratory tract; neurotoxic effects. Chronic toxicity: neuropsychic effects; liver damage, cirrhosis; cardiovascular effects; carcinogenic effects; effects on reproduction. Exposure limits (France): TWA = 1900mg/m3 (1000ppm); ceiling value = 9500mg/m3 (5000ppm). EEC number and mandatory labelling codes: No.603-003-00-5; F, R11, S7, S16, 200-578-6. The complete datasheet collection on CD-ROM has been analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 5p. Illus. 21 ref.

CIS 01-687 Ethylene glycol
Ethylène-glycol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 87-411. Acute toxicity: depressive effect on the central nervous system after several hours' delay; pulmonary oedema; hyperglycaemia. Chronic toxicity: irritation of the eye and of the respiratory tract mucous membranes; signs of central nervous system depression. Exposure limits: ceiling value = France: 125mg/m3 (50ppm); USA: 100mg/m3 (ACGIH 1996). EEC number and mandatory labelling codes: No.603-027-00-1; Xn, R22, 203-473-3. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 18 ref.

CIS 01-665 Cyclohexanol
Cyclohexanol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 90-1119. Acute toxicity: irritation of the eyes, nose and throat; headache; tremor; skin irritation. Chronic toxicity: disorders of the autonomous nervous system (vasomotor and neurovegetative disorders); repeated or prolonged skin contact may cause dermatitis. Exposure limits (France): TWA = 200mg/m3 (50ppm); ceiling value = 300mg/m3 (75ppm). EEC number and mandatory labelling codes: No.603-009-00-3; Xn, R420/22, R37/38, S24/25, 203-630-6. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, CD-ROM CD 613, May 2000. Rev.ed. 4p. Illus. 17 ref.

CIS 01-346 Phenol
Phénol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 88-1815. Acute toxicity: neurotoxic effects and respiratory impairment induced by skin absorption; skin diseases. Chronic toxicity: digestive disorders; erythema or eczema; liver and kidney damage. Exposure limits (France): TWA = 5ppm (19mg/m3). EEC number and mandatory labelling codes: No.604-001-00-2; T, R24/25, R34, S28, S45, 203-632-7.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM, 2000. 4p. Illus. 17 ref.

CIS 01-342 Pentachlorophenol and sodium salt
Pentachlorophénol et sel de sodium [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 88-1813. Acute toxicity: irritation of the skin, eyes, nose and respiratory tract; liver, heart, kidney and spleen damage. Chronic toxicity: chloracne; haematological changes. Exposure limits (France): TWA = 0.5mg/m3. EEC number and mandatory labelling codes: No.604-002-00-8 (pentachlorophenol), No.604-003-00-3 (sodium pentachlorophenolate); T+, N, R24/25, R26, R36/37/38, R40, R50/53, S22, S36/37, S45, S52, S60, S61, 201-778-6.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM, 2000. 5p. Illus. 36 ref.

CIS 01-32 Methanol
Méthanol [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 90-752. Acute toxicity: depression of the central nervous system; irritation of the gastric tract; metabolic acidosis; visual function disorders (mydriasis, amblyopia, possibly leading to blindness); irritation of the respiratory tract; effects may be delayed. Chronic toxicity: visual function disorders; migraine; dermatosis. Exposure limits (France, 1985): TWA = 260mg/m3 (200ppm); ceiling value = 1300mg/m3 (1000ppm). EC number and mandatory labelling codes: No.603-001-00-X; F, T, R11, R23/25, S7, S16, S24, 200-659-6.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM, 2000. 5p. Illus. 27 ref.

CIS 99-1620
Agency for Toxic Substances and Diseases Registry (ATSDR)
Toxicological profile for ethylene glycol and propylene glycol
Topics: ethylene glycol; propylene glycol; criteria document; exposure evaluation; functional heart disorders; functional respiratory disorders; glossary; health hazards; irritation; limitation of exposure; literature survey; nephrotoxic effects; neurological effects; skin absorption; toxic effects; toxicity evaluation; toxicology; USA.
U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, GA 30333, USA, Sep. 1997. xvii, 249p. Illus. approx. 500 ref.

CIS 99-1228 Conso F., Mignée C.
Monoalcohols other than ethyl alcohol
Monoalcools autres que l'alcool éthylique [in French]
Replaces CIS 85-1324. Topics: acute poisoning; butyl alcohol; methanol; isopropyl alcohol; chronic poisoning; encyclopaedia; medical supervision; medical treatment; metabolic process; poisoning; toxicology.
Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle, 4th Quarter 1997, No.117, 9p. Illus. 120 ref.

CIS 99-1226 Bieniek G.
Urinary naphthols as an indicator of exposure to naphthalene
Concentrations of naphthalene and naphthols in breathing-zone air during a workshift and naphthols in urine collected after the workshift were determined for 102 coke plant workers. 1-Naphthol, 2-naphthol and 1,4-naphthoquinone were identified in urine samples. The time-weighted average concentrations of naphthalene and naphthols in breathing-zone air showed that the exposure level was rather low. There was a significant correlation between naphthol concentrations in urine and breathing-zone air concentrations of naphthalene. Findings suggest that the summary concentration of naphthols in urine can be used as a biomarker for naphthalene exposure. Topics: 1,4-naphthoquinone; napthtol; coal tar; 1-naphthol; naphthalene; case-control study; coking plants; detection by flame ionization; determination in air; determination in urine; distillation; gas chromatography; mass spectrometry; naphthols; urinary excretion; urinary metabolites.
Scandinavian Journal of Work, Environment and Health, Oct. 1997, Vol.23, No.6, p.414-420. Illus. 28 ref.

CIS 99-875 Pillière F., Falcy M.
Reduction in the legal alcohol limit: What consequences for workers occupationally exposed to chemical products?
Diminution du taux légal d'alcoolémie: quelles incidences pour les salariés professionnellement exposés aux produits chimiques? [in French]
Topics: alcohols; ethyl acetate; ethanol; methanol; isopropyl alcohol; propanol; butyl alcohol; determination in blood; determination in exhaled air; drug testing; France; interferences; legislation; metabolic process.
Documents pour le médecin du travail, 1st Quarter 1997, No.69, p.3-12. 31 ref.

CIS 99-933 van Muiswinkel W.J., Kromhout H., Onos T., Kersemaekers W.
Monitoring and modelling of exposure to ethanol in hairdressing salons
Personal exposure to solvents was studied among hairdressers in 28 salons in two regions during two seasons in the Netherlands. Ethanol was used as a marker for solvent exposure. The average exposure to ethanol was well below the occupational exposure limit, but large differences in average concentrations were observed between salons. Exposure concentrations were significantly higher on Fridays than on other days of the week. Exposures were somewhat lower in spring than in summer and lower in urban than in semi-rural areas. A classification scheme based on two easily obtainable salon and task characteristics was developed. Topics: air temperature; ethanol; determination in air; epidemiologic study; exposure evaluation; hairdressing; job-exposure relation; mathematical models; personal sampling; seasonal variation; solvents.
Annals of Occupational Hygiene, Apr. 1997, Vol.41, No.2, p.235-247. 20 ref.

CIS 98-1327 Kogevinas M., Becher H., Benn T., Bertazzi P.A., Boffetta P., Bueno-de-Mesquita H.B., Coggon D., Colin D., Flesch-Janys D., Fingerhut M., Green L., Kauppinen T., Littorin M., Lynge E., Mathews J.D., Neuberger M., Pearce N., Saracci R.
Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated international cohort study
Topics: cancer; tetrachlorodibenzodioxin; chlorophenols; cohort study; dioxins; exposure evaluation; herbicides; IARC; length of exposure; lymphoma; mortality; neoplasms; pesticide production; pesticide spraying; sarcomas.
American Journal of Epidemiology, 15 June, 1997, Vol.145, No.12, p.1061-1075. Illus. 54 ref.

CIS 98-833
International Programme on Chemical Safety (IPCS)
Methanol
Topics: antidote treatment; methanol; criteria document; ILO; IPCS; literature survey; neurotoxic effects; poisoning; toxic effects; toxicology; UNEP; visual function disorders; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1997. 180p. 480 ref. Price: CHF 42.00 (CHF 29.40 in developing countries).

CIS 98-818
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Bisphenol A (2,2-bis-(4-hydroxyphenyl)propane)
This report is a translation of a report finalized in German in December 1995. Topics: bisphenol A; criteria document; ecotoxicology; Germany; irritants; legislation; literature survey; skin allergies; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1997. xvii, 117p. 223 ref.

CIS 98-43 Pentachlorophenol
Pentaclorofenol [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: acne; bronchitis; data sheet; dermatitis; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; irritation; limitation of exposure; medical supervision; metabolic disturbances; pentachlorophenol; personal protective equipment; respirators; skin absorption; USA; waste disposal.
Noticias de seguridad, Aug. 1997, Vol.59, No.8. 4p. Insert.

CIS 98-41 Methylcyclohexanol
Metilciclohexanol [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: data sheet; dermatitis; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; hepatic damage; irritation; limitation of exposure; medical supervision; methylcyclohexanol; narcotic effects; personal protective equipment; renal damage; respirators; skin absorption; USA; waste disposal.
Noticias de seguridad, June 1997, Vol.59, No.6. 4p. Insert.

CIS 98-37 Furfuryl alcohol
Alcohol furfurílico [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: data sheet; dermatitis; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; furfuryl alcohol; health hazards; irritation; limitation of exposure; medical supervision; neurotoxic effects; personal protective equipment; respirators; USA; waste disposal.
Noticias de seguridad, Apr. 1997, Vol.59, No.4. 5p. Insert.

CIS 98-204 Sabouraud S., Testud F., Rogerie M.J., Descotes J., Evreux J.C.
Occupational depigmentation from dinoterbe
Topics: case study; dinoterb; France; leukoderma; skin diseases.
Contact Dermatitis, Apr. 1997, Vol.36, No.4, p.227. Illus. 9 ref.

CIS 98-223
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
Pentaerythritol - Health-based recommended occupational exposure limit
Topics: criteria document; Netherlands; pentaerythritol; threshold limit values; toxicity evaluation; toxicology.
Gezondheidsraad, Postbus 5406, 2280 HK Rijswijk, Netherlands, 1997. 49p. 10 ref.

CIS 97-1988 Hertzman C., et al.
Mortality and cancer incidence among sawmill workers exposed to chlorophenate wood preservatives
A cohort study was conducted of 26,487 workers employed for at least one year between 1950 and 1985 in 11 chlorophenate-using and 3 non-using sawmills in Canada. Exposure was assessed by reconstructing industrial histories for each mill. Probabilistic record linkage to Canadian mortality and cancer registries found 4710 deaths between 1950 and 1990, and 1547 incident cases of cancer between 1969 and 1989. None of the cancers of interest had elevated mortality related to chlorophenate exposure. However non-Hodgkin's lymphoma incidence (n = 65) increased with increasing chlorophenate exposure hours. The results support the case for careful handling of chlorophenate at work.
American Journal of Public Health, Jan. 1997, Vol.87, No.1, p.71-79. 39 ref.

CIS 97-1578 Moen B.E., Øvrebø S.
Assessment of exposure to polycyclic aromatic hydrocarbons during fire fighting by measurement of urinary 1-hydroxypyrene
Urine samples were obtained from 9 students and 4 teachers at a firefighter training school before and 6 to 7 hours after extinguishing burning diesel fuel. The samples were analyzed by high-performance liquid chromatography for 1-hydroxypyrene. A small but significant increase in 1-hydroxypyrene levels was found after fire fighting. Fire fighting may cause exposure to polycyclic aromatic hydrocarbons, some of which are classified as carcinogenic.
Journal of Occupational and Environmental Medicine, June 1997, Vol.39, No.6, p.515-519. Illus. 29 ref.

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