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Alcohols - 685 entries found

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1982

CIS 83-439 Fielder R.J.
Pentachlorophenol
This data sheet contains: physical and chemical properties; metabolism; toxicity to animals and humans (acute; skin and eye irritancy; sub-acute; mutagenicity; carcinogenicity; reproductive effects); appendix on toxicity of chlorinated dioxin impurities in technical pentachlorophenol (hexachlorinated dioxin; heptachlorodibenzo-p-dioxin; octachlorodibenzo-p-dioxin); references.
H.M. Stationery Office, P.O. Box 569, London SE1 9NH, United Kingdom, Aug. 1982. 20p. Illus. 73 ref. Price: £2.50.

CIS 83-466 Alexandersson R., Hedenstierna G.
Pulmonary function after long-term exposure to trichlorophenol
Symptoms and pulmonary function were evaluated in 7 subjects exposed to trichlorophenol (used as a tracer gas in gas mask testing). Symptoms from upper airways and chest were more common among exposed than in control subjects (60% and 10%). Significantly reduced forced expiratory flow at 75% of vital capacity and increased closing volume were measured, while other spirometric variables and the transfer factor of the lung for CO were normal. Increased elastic recoil pressure of the lung and x-rays signs of lung tissue envolvement were noticed in 2 subjects. Blood and liver tests were normal. The findings suggest an irritating effect on the lung of trichlorophenol, and it cannot be excluded that long-term exposure may produce pulmonary fibrosis.
International Archives of Occupational and Environmental Health, Feb. 1982, Vol.49, No.3-4, p.275-280. Illus. 15 ref.

CIS 83-186 Haguenoer J.M., Bourrinet P., Frimat P.
Interrelations between alcoholism and exposure to industrial toxic substances
Les interrelations entre l'alcoolisme et l'exposition aux toxiques industriels [in French]
Critical review of the literature on the interactions between ethanol and various chemicals to which workers may be exposed. The article considers, in turn, pharmacodynamic interactions related to the gastrointestinal, cardiovascular and nervous systems, the liver and blood. Part 2 covers metabolic interactions in ethanol breakdown: toxic substances causing oxidation to acetaldehyde via various routes (alcohol dehydrogenase, catalase, etc.), oxidation to acetic acid. Reference is also made to interactions with metals (manganese, lead, mercury, cobalt, chromium) and carbon monoxide, and to interferences in forensic medicine.
Archives des maladies professionnelles, 1982, Vol.43, No.6, p.461-473. Illus. 107 ref.

CIS 83-112 Glycol chlorohydrin
Monochlorhydrine du glycol [in French]
Sections of this toxicology data sheet cover: synonyms; appearance and properties; uses; pathology (paths of entry, short-term exposure to low concentrations, long-term exposure to higher concentrations); industrial safety (personal protection, hygiene, TLVs), French regulations (medical supervision, labelling).
Cahiers de médecine interprofessionnelle, 2nd quarter 1982, Vol.22, Special Toxicology Issue (Supplement to No.86), p.5. 6 ref.

CIS 82-1933 Health hazard alert. Pentachlorophenol
This trade union data sheet summarises health data on pentachlorophenol (PCP) and on the major alternative wood preservatives, creosote and the arsenicals. Contents: chemistry, production, use and synonyms; dioxin contamination; cancers; birth deformities; liver effects; skin effects; current studies of health effects and hazards associated with timber treatment and telephone poles; regulations; alternatives (carcinogenic effects of creosote and the arsenicals); reproductive hazards of arsenicals; other alternative products; trade union action; timber preservers statement; recommendations.
ACTU-VTHC Occupational Health and Safety Unit, Trades Hall, Box 93, Carlton South, 3053 Vic., Australia, Mar. 1982. 16p. 14 ref.

CIS 82-1977 Guillon F., Raphael J.C., Girard-Wallon C., Goulon M.
Toxicity of ethylene glycol. Case study of fatal ingestion
Toxicité de l'éthylène glycol. A propos d'un cas d'ingestion mortelle [in French]
Clinical and anatomo-pathological case study of death due to ethylene glycol (EG) ingestion. Review of toxicological data, clinical and biological factors in EG poisoning, problems involved and importance of rapid diagnosis. Description of symptoms and disorders observed at different stages of EG metabolism.
Archives des maladies professionnelles, 1982, Vol.43, No.3, p.163-168. Illus. 39 ref.

CIS 82-2021 Coggon D., Acheson E.D.
Do phenoxy herbicides cause cancer in man?
Swedish and American studies showing evidence of links between occupational exposure to phenoxy herbicides, chlorophenols and dioxins, either as a result of their application or production, and the occurrence of soft tissue sarcomas, Hodgkin's disease and non-Hodgkin's lymphoma are discussed. Evidence for increased risks of sarcoma appears good but it is still unclear if the carcinogen is the herbicide or the dioxin contaminant. Association between exposure to these substances and lymphoma occurrence is weak, and more research is needed.
Lancet, 8 May 1982, Vol.1, No.8280, p.1057-1059. 31 ref.

CIS 82-1664 Plaa G.L., Hewitt W.R., du Souich P., Caillé G., Lock S.
Isopropanol and acetone potentiation of carbon tetrachloride-induced hepatotoxicity: Single versus repetitive pretreatments in rats
Rats were administered 2 minimally effective doses (MED) of 0.25ml/kg of acetone or isopropanol each day for 3 days prior to exposure to carbon tetrachloride (CCl4). These administrations caused greater potentiation of CCl4 hepatotoxicity than a single MED but not as much as 1 dose of 6 MED. Similar administration of 6 non-effective doses (NED) of 0.10ml/kg each did not potentiate CCl4 effects but a single dose equivalent to 6 NED did. After administration of 1.5ml/kg acetone by 4 different methods over 3 days, an excellent correlation was found between the degree of potentiation observed and the peak blood concentration attained but no correlation was found with the area under the concentration/time curve. A threshold for the effects of isopropanol and acetone exists in the rat.
Journal of Toxicology and Environmental Health, Feb. 1982, Vol.9, No.2, p.235-250. Illus. 19 ref.

CIS 82-1605 Morel C., Reynier M., Cavigneaux A., Protois J.C.
French National Research and Safety Institute (Institut national de recherche et de sécurité)
Benzyl alcohol
Alcool benzylique [in French]
Synonyms, uses, physical and chemical properties, methods of detection and determination in air, fire hazards (closed-cup flashpoint 96-101°C), pathology and toxicology. French OSH and environmental protection regulations; French and international regulations concerning transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 3rd quarter 1982, No.108, p.445-448. 15 ref.

CIS 82-1321 Morel C., Gendre M., Cavigneaux A., Protois J.C.
Hexylene glycol
Hexylène-glycol [in French]
Synonyms, uses, physical and chemical properties, methods of detection and determination in air, fire hazards (flash-point: 93°C, closed-cup method), pathology and toxicology (skin and eye irritant, narcotic effect at high concentrations, USA (ACGIH) TLV: 25ppm or 125mg/m3). Reference to French OSH regulations, and to French and international regulations on transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 2nd quarter 1982, No.107, p.313-316. 11 ref.

1981

CIS 87-1204 Benzyl alcohol
Bentsyylialkoholi [in Finnish]
Benzyl alcohol is is a toxic liquid (LD50 = 1230mg/kg). It irritates the skin, the mucous membranes and the respiratory tract. Can cause headache, vertigo, nausea, vomiting and diarrhoea. Mandatory European labelling: XN, R20, R22, S26.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, Sep. 1981. 2p. Original on microfiche.

CIS 87-778 Allyl alcohol
Allyylialkoholi [in Finnish]
Allyl alcohol is an extremely flammable, very toxic liquid (LD50 = 69mg/kg; TLV = 5mg/m3). The vapour irritates the eyes and the mucous membranes, is narcotic and can cause headache, nausea, cough, shortness of breath, long term exposure eczema and injuries to the cornea. The liquid irritates the skin. Mandatory European Labelling: F, T, R11, R26, R36, R37, R38, S16, S39, S45, S23, S38, S46.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, Sep. 1981. 2p. Original on microfiche.

CIS 86-431 Ethyl alcohol
Álcool etílico [in Portuguese]
Data sheet on ethyl alcohol, containing information on: chemical composition, properties, main hazards, emergency measures, first-aid measures, handling and storage, and treatment of residues. The TLV in Brazil is: 780ppm (1,480mg/m3).
Fundacentro, C.P. 11484, CEP 05499 São Paulo, SP, Brazil, 1981. 2p. Bibl.

CIS 83-1622 Gadalina I.D., Malyševa M.V.
Experimental data supporting the maximum acceptable concentration of furyl alcohol in workplace air
Ėksperimental'nye materialy k obosnovaniju predel'no dopustimoj koncentracii furilovogo spirta v vozduhe rabočej zony [in Russian]
17 toxicometric parameters were tabulated for furyl alcohol in experiments with rats and mice. The data support a maximum acceptable concentration of 0.5mg/m3. The alcohol should carry a warning that it penetrates the skin.
Gigiena truda i professional'nye zabolevanija, Sep. 1981, No.9, p.52-53. 6 ref.

CIS 83-1621 Bonitenko Ju.Ju., Bočarov N.V., Lišenko V.V.
Effect of ethyl alcohol on some indices of ethylene chlorohydrin toxicity
Vlijanie ėtilogo spirta na nekotorye pokazateli toksičnosti ėtilenhlorgidrina [in Russian]
Simultaneous administration of ethyl alcohol increased the LD50 of ethylene chlorohydrin (β-chloroethanol, a solvent for cellulose derivatives used in the paper and pharmaceutical industries) regardless of the route of administration (peroral or percutaneous). The necrotic lesions produced in the liver and kidney by ethylene chlorohydrin were also reduced in number and extent by ethanol. Blood concentrations of the chlorohydrin were raised by ethanol administration, which suggests that the protective effect is due to competitive inhibition of chlorohydrin metabolism to chloroacetaldehyde.
Gigiena truda i professional'nye zabolevanija, Sep. 1981, No.9, p.44-45. 9 ref.

CIS 83-1353 Ivanickaja L.I.
Gas-chromatographic determination of components of gasoline-methanol mixtures in air
Gazohromatografičeskoe opredelenie komponentov benzometanol'noj smesi v vozduhe [in Russian]
Components of gasoline-methanol mixtures in air are separated on a 3mm by 1m column of Inerton AW with 15% β,β'-hydroxydipropionitrile and detected with a flame-ionisation detector. The sample is collected by passing air through a column of BAU activated charcoal. Detection limits are: 0.8 mg/m3 for gasoline, 1.5 mg/m3 for methanol and 2.0 mg/m3 for isobutanol. The relative error of the method is 18%.
Gigiena i sanitarija, July 1981, No.7, p.45-46. Illus. 1 ref.

CIS 83-1406 Miri Vieira M.A., Álvares dos Santos J.P., Gondin Galbes F.
Work in contact with pentachlorophenol
Trabalho em contato com pentaclorofenol [in Portuguese]
Case study of 17 workers in a pentachlorophenol plant; detailed medical data on 10 are presented. The skin lesions and other symptoms were typical effects of pentachlorophenol. The masks, goggles and boots worn by the workers were apparently inadequate to prevent exposure; by providing places close to the body where pentachlorophenol could accumulate, they may even have aggravated the problem. Contrary to published information, the skin lesions did not disappear when the workers were removed from exposure. Disfigurement was severe enough in some cases to produce psychological effects. It is recommended that collective, rather than personal, protection be emphasised (containment of pentachlorophenol at all stages of processing and use), that medical surveillance be increased, that appropriate medical treatment (including restorative surgery) be applied, and that counselling services be made freely available.
Revista brasileira de saúde ocupacional, Oct.-Dec. 1981, Vol.9, No.36, p.31-35. Illus. 4 ref.

CIS 83-1392 Aristov V.N., Red'kin Ju.V., Bruskin Z.Z., Ogleznev G.A.
Experimental data on the mutagenic action of toluene, isopropanol and sulfur dioxide
Ėksperimental'nye dannye o mutagennom dejstvii toluola, izopropanola i sernistogo gaza [in Russian]
The nature and frequency of chromosomal and mitotic aberrations in the bone marrow of albino rats were determined in chronic inhalation experiments with toluene, isopropanol and sulfur dioxide in various concentrations and combinations. The statistical calculations involved in predicting no-effect concentrations of toluene and isopropanol are presented; a non-linear regression equation was used. The proposed method can be used to calculate no-effect concentrations of toxic substances for purposes of TLV determination or correction.
Gigiena truda i professional'nye zabolevanija, July 1981, No.7, p.33-36. 9 ref.

CIS 83-535 Sedov A.V., Surovcev N.A., Mazneva G.E., Ševkun O.N., Vissonov Ju.V., Byčkov S.V.
Combined effects of certain vital activity products during work in isolating personal protective equipment
O kombinirovannom dejstvii nekotoryh produktov žiznedejatel'nosti pri rabote čeloveka v izolirujuščih sredstvah individual'noj zaščity [in Russian]
The dead-space air inside isolating protective suits contains oxygen, carbon monoxide, methane, phenol and other substances in proportions which vary with the duration and type of work performed. To evaluate the combined toxic effect of various mixtures, 36 experiments were carried out with volunteers performing exercise tests in controlled atmospheres. Biological indices monitored included body temperature, heart rate, respiratory rate and minute volume, energy expenditure, serum cholinesterase activity, etc. Gaseous mixtures containing CO, methane and phenol in proportions of 15, 150 and 3mg% had independent effects similar to mixtures where these proportions were 30, 350 and 5mg/m3, respectively. These concentrations are considered to be maximum permissible ones under the conditions studied.
Gigiena i sanitarija, Apr. 1981, No.4, p.15-17. 8 ref.

CIS 82-1987 O'Sullivan J.J., Stevenson C.J.
Screening for occupational vitiligo in workers exposed to hydroquinone monomethyl ether and to paratertiary-amyl-phenol
Report of the follow-up of 2 cases of leucodermia (vitiligo) following exposure to hydroquinone monomethyl ether (HMME) described 8 years previously (CIS 72-1742, Darz Dedh Mhf Xkz Daht) and survey of 169 men exposed to HMME or paratertiary-amyl-phenol (PTAP) or both. In the follow-up, repigmentation of a significant degree was found in one man and of a limited degree in the other. Screening by means of the Wood's light technique (an ultra-violet light which is absorbed by normally pigmented skin and reflected by non-pigmented skin) of the 169 men surveyed in the same plant revealed no cases of leucoderma in the 148 men exposed to HMME or in the 129 men exposed to PTAP. Loss of light reflection on Wood's light examination was observed in 13 men due to scars or to other skin disorders.
British Journal of Industrial Medicine, Nov. 1981, Vol.38, No.4, p.381-383. Illus. 10 ref.

CIS 82-1696 Triebig G., Krekeler H., Golssler K., Valentin H.
Investigations on neurotoxicity of chemical substances at the wprkplace - II. Determination of the motor and sensory nerve conduction velocity in persons occupationally exposed to pentachlorophenol
Untersuchungen zur Neurotoxizität von Arbeitsstoffen - II. Messung der motorischen und sensorischen Nervenleitgeschwindigkeit bei beruflich Pentachlorophenol-belasteten Personen [in German]
Methods and results of examinations of 18 workers with a mean activity of 12 years in processing pentachlorophenol (PCP). The PCP levels in plasma ranged between 0.02 and 1.5ng/l (median 0.25ng/l) and in urine between 13 and 1.224µg/l (median 112γ/l) or between 11 and 2.111µg/l creatinine (median 111µg/g). The median values of the neurophysiological parameters showed a slight slowing trend, The decrease in sensory nerve conduction velocities was significant. A dose-effect relation between internal PCP load and nerve conduction velocities could not be demonstrated. The individual evaluation of the toxicological and neurophysiological results suggested that in some cases decreased nerve conduction velocity is caused by chronic exposure to PCP.
International Archives of Occupational and Environmental Health, 1981, Vol.48, No.4, p.357-367. 22 ref.

CIS 82-1695 Zober A., Schaller K.H., Gossler K., Krekeler H.J.
Pentachlorophenol and liver-function: A study on occupational exposed collectives
Pentachlorophenol und Leberfunktion: Eine Untersuchung an beruflich belasteten Kollektiven [in German]
Studies were carried out on 2 groups of workers exposed to pentachlorophenol (PCP) in the production and application of wood preserving products. The investigations involved measuring the external (in ambient air) and the internal (in urine and plasma) PCP concentrations as well as determining biochemical and immunological data for the evaluation of possible effects on the liver. The air concentrations of PCP were well below the MAK value of 500µg/m3. The plasma concentrations ranged from 0.02-2.4µg/ml; the renal excretion of PCP varied between 6 and 2.111µg/g creatinine. No correlation was found between the duration and degree of exposure to PCP and the PCP concentrations in the biological materials. In 6 persons the immunological investigations yielded remarkable findings. No dose-effect relation was proved for the rise in immunoglobulines, interpreted as the result of an increased mesenchymal activity. The biochemical investigations revealed elevated serum GLDH activities in both groups.
International Archives of Occupational and Environmental Health, 1981, Vol.48, No.4, p.347-356. 12 ref.

CIS 82-1694 Angerer J., Heinrich R., Laudehr H.
Occupational exposure to hexachlorocyclohexane - V. Gas chromatographic determination of monohydroxychlorobenzenes (chlorophenols) in urine
The hexachlorocyclohexane (HCH) isomers and particularly the γ-isomer (lindane), used as a pesticide, as well as the chlorobenzenes, used as pesticides and intermediates in chemical synthesis, are of great importance in occupational and environmental health. Increasing interest has focussed on pentachlorophenol, used in wood preservation, because of its potential risk to health. A sensitive and specific gas chromatographic method is described for the simultaneous determination of 10 chlorinated phenols that appear in the urine of persons exposed to HCH. The phenolic compounds in the urinary samples are hydrolysed in an acidic medium and esterified with acetic anhydride. This sample treatment permits routine application. The stationary phase has a high separating capability for the acetate esters of chlorophenols. The detection limits are 4.9 - 18.6µg/l.
International Archives of Occupational and Environmental Health, 1981, Vol.48, No.4, p.319-324. Illus. 11 ref.

CIS 82-1687 Šedivec V., Mráz M., Flek J.
Biological monitoring of persons exposed to methanol vapours
Study of absorption and excretion of methanol in man at low exposure levels aimed at establishing a procedure for biological monitoring and the determination of the influence of physical strain, daily repeated exposure and fluctuation of exposure levels. From the concentration in inhaled air, lung retention, minute lung ventilation and duration of exposure, the methanol dose retained in the organism of 5 volunteers was calculated. The dose correlated well with the methanol concentration (mmol/l or mg/l) in whole-shift urine; using other units the correlation was unsatisfactory. An exposure test is proposed which permits the estimation of the retained methanol dose on the basis of an analysis of whole-shift urine, even if the subjects perform physical work or in cases where the air also contains vapours of other organic solvents (ethanol, acetone).
International Archives of Occupational and Environmental Health, 1981, Vol.48, No.3, p.257-271. Illus. 22 ref.

CIS 82-1055 Wörmann H., Müller F.J.
Determination of phenol in air during hardening of phenol-formaldehyde polymer binders for moulding sand
Phenolbestimmung bei der Aushärtung von Giessereisandbindemitteln auf Phenolharzbasis [in German]
A laboratory method is described for comparative study of binders for moulding sand, to develop materials which present less health hazards and pollutants (a serious problem in foundries indequately equipped with exhaust ventilation). Principle of the method, equipment, chemicals used, pyrolysis, analysis, calibration. This standardised method gives reproducible results; uniform heating of the reaction tube is of great importance. The phenols given off are absorbed by caustic soda, coupled with p-nitroaniline and determined by colorimetry.
Giesserei, 1981, Vol.68, No.8, p.223-224. Illus.

CIS 82-800 Woiwode W., Drysch K.
Experimental exposure to toluene: further consideration of cresol formation in man
In 2 experiments 10 healthy men were exposed at rest to 200ppm toluene (T) in the air. Hippuric acid (HA), o-, m-, p-cresol and phenol in urine were detected by capillary gas chromatography at the beginning and at the end of exposure and at various times after the exposure ended. T in blood was determined at the same intervals. HA, o-, m-, p-cresol are metabolites of T and that detoxication lasts ≥24h.
British Journal of Industrial Medicine, May 1981, Vol.38, No.2, p.194-197. Illus. 17 ref.

CIS 82-789 Van Roosmalen P.B., Purham J., Drummond I.
An improved method for the determination of phenol in the urine of workers exposed to benzene or phenol
Interlaboratory comparison of phenol in urine analyses shows large variability, much larger than is normally associated with gas chromatographic analysis, which suggests that sample preparation problems are to blame. Description of a simple method of analysis which has been in use in the author's laboratory: 2-ethylphenol is added to the urine as an internal standard; the sample is distilled and the distillate directly analysed by gas chromatography on a column packed with Tenax-GC using flame-ionisation detectors. The detection limit is 0.1mg/l, and the coefficient of variation at 5.9mg/l is 4.1% (n=8).
International Archives of Occupational and Environmental Health, 1981, Vol.48, No.2, p.159-163. Illus. 8 ref.

CIS 82-780 Hardell L., Eriksson M.
Soft-tissue sarcomas, phenoxy herbicides, and chlorinated phenols
Several studies have shown an increased risk of soft-tissue sarcoma resulting from exposure to 2,4,5-T, TCDD, and other phenoxy herbicides and chlorophenols. The results obtained do not support the hypothesis of Cook that smokers acquiring chloracne as a result of exposure are at increased risk of soft-tissue sarcoma.
Lancet, Aug. 1981, Vol.II, No.8240, p.250. 7 ref.

CIS 82-700 Podolak G.E., McKenzie R.M., Rinehart D.S., Mazur J.F.
A rapid technique for collection and analysis of phenol vapors
Phenol is collected from an occupational environment on Tenax adsorbent contained in a glass tube and, after thermal desorption into a 20m infrared gas cell, the phenol is quantitatively determined at 1184cm-1. A 15min air sample, collected at 0.75l/min, was sufficient to measure phenol in the concentration range 0.7-10.4ppm. Analysis of 65 samples in this range resulted in a mean recovery of 99.3% with a standard deviation of 9.7%. Alipathic and aromatic hydrocarbons did not interfere with the method but cresols and xylenols caused some interference.
American Industrial Hygiene Association Journal, Oct. 1981, Vol.42, No.10, p.734-738. Illus. 9 ref.

CIS 82-481 Hardell L.
Relation of soft-tissue sarcoma, malignant lymphoma and colon cancer to phenoxy acids, chlorophenols and other agents
The posible relation between colon cancer and exposure to phenoxy acids or chlorophenols was evaluated using a case-control design study and validity of earlier studies on the association of soft-tissue sarcoma and malignant lymphoma and these same chemicals was also examined. Cases consisted of 157 men diangosed as having colon cancer. The 541 referents consisted of 206 used in the soft-tissue study and 335 from the malignant lymphoma study. The previously reported associations between exposure to phenoxy acids or chlorophenols and soft-tissue sarcoma and malignant lymphoma could not be explained by observational bias in the studies. No significant associations was found between the occurrence of colon cancer and these chemicals. Exposure to asbestos was excessive among the colon cancer patients as compared to the referents and this finding agreed with previous results.
Scandinavian Journal of Work, Environment and Health, June 1981, Vol.7, No.2, p.119-130. 26 ref.

CIS 82-194 Jensen O.
Contact allergy to propylene oxide and isopropyl alcohol in a skin disinfectant swab
2 hospital laboratory assistants developed contact dermatitis from a disposable swab for pre-injection use, containing 70% isopropyl alcohol (IPA) and 1% propylene oxide (PO). Patch testing showed that both patients had positive allergic reactions to PO, and 1 reacted to IPA. Testing of 25 control subjects gave negative results.
Contact Dermatitis, May 1981, Vol.7, No.3, p.148-150. 3 ref.

CIS 82-126
National Safety Council
Industrial ethyl alcohol
Physical properties; uses; hazards (volatile, flammable, irritant for skin and mucous membranes of eyes and throat; toxic vapours); TLV (250-1,000ppm; ACGIH TLV: 1,000ppm 8-h TWA); shipping and storage; personal protective equipment; ventilation; fire hazards; poisoning symptoms; first aid.
444 North Michigan Avenue, Chicago, Illinois 60611, USA, 1981. 3p. 2 ref.

CIS 81-1625 Morel C., Gendre M., Cavigneaux A., Protois J.C.
French National Research and Safety Institute (Institut national de recherche et de sécurité)
Furfuryl alcohol
Alcool furfurylique [in French]
Synonyms, uses, physical and chemical properties, methods of detection and determination in air, fire hazards (open-cup flash point: 75°C), pathology and toxicology (moderately irritant and allergic action, U.S. TLV 5ppm). French OSH regulations, French and international regulations concerning transport. Recommendations for technical and medical prevention.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 2nd quarter 1981, No.103, Note No.1327-103-81, p.325-328. 17 ref.

CIS 81-1624 Morel C., Gendre M., Cavigneaux A., Protois J.C.
French National Research and Safety Institute (Institut national de recherche et de sécurité)
Hydroquinone
Hydroquinone [in French]
Uses, physical and chemical properties, methods of detection and determination in air; fire hazards (not very flammable); pathology and toxicology (skin and eye contact, ingestion, U.S. TLV 2mg/m3). French OSH regulations; French and international regulations concerning transport. Recommendations for technical and medical prevention.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 2nd quarter 1981, No.103, Note No.1326-103-81, p.321-324. 15 ref.

CIS 81-1646 Perbellini L., De Grandis D., Semenzato F., Bongiovanni L.G.
Experimental studies on the neurotoxicity of cyclohexanol and cyclohexanone
Studio sperimentale sulla neurotossicità del cicloesanolo e del cicloesanone [in Italian]
One group of rats received injections of 200mg/kg of cyclohexanone twice daily, 5 days per week for a maximum of 6 weeks, another group received the same doses for 13 weeks. Electrophysiological and neuropathological tests during and after exposure revealed no evidence of damage to the peripheral nervous system. Chronic poisoning due to the main metabolites of cyclohexane, cyclohexanol and cyclohexanone does not seem to cause peripheral neuropathy in rats.
Medicina del lavoro, Mar.-Apr. 1981, Vol.72, No.2, p.102-106. Illus. 15 ref.

CIS 81-1353 Eriksson M., Hardell L., Berg N.O., Möller T., Axelson O.
Soft-tissue sarcomas and exposure to chemical substances: a case-referent study.
110 patients with soft-tissue sarcomas reported to the cancer registry in 5 Swedish countries and 220 controls were studied. The risk ratio for soft-tissue sarcomas after exposure to phenoxy acids or chlorophenols was 5.1; for phenoxy acids 6.8 (4.2 when free from impurities) and for chlorophenols 3.3. The risk for workers exposed to 2,4,5-T and other phenoxy acids was 17.
British Journal of Industrial Medicine, Feb. 1981, Vol.38, No.1, p.27-33. 30 ref.

CIS 81-739 Pentachlorophenol.
Pentachlorophenol is toxic to man by ingestion and skin absorption. Deaths have occurred as a result of skin exposure. In rats, pentachlorophenol is a foetotoxic agent. Dioxins are present as contaminants in pentachlorophenol. Precautionary measures proposed are: employee education, improved ventilation, automation, use of personal protective equipment, use of impervious protective clothing, observance of labelling information.
American Industrial Hygiene Association Journal, Jan. 1981, Vol.42, No.1, p.A-16/A-18.

1980

CIS 88-57 Amyl alcohol
Amyylialkoholi [in Finnish]
Amyl alcohol is a flammmable liquid (LD50 = 3030mg/kg). The liquid is absorbed through the skin. The liquid and the vapour strongly irritate the eyes, the respiratory tract and the skin. High concentrations of the vapour have a narcotic effect. Ingestion can cause methaemoglobinaemia. Long term exposure can cause hepatic, renal and blood vessel damage. Mandatory European labelling: XN, R10, R20, S24, S25.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, Aug. 1980. 2p. Original on microfiche.

CIS 82-453 Swarbrick P.
Vitiligo as an occupational disease
Vitiligo, a skin condition involving an absence of melanocytes and manifested by sharply demarcated areas of hypopigmentation, can be caused by occupational contact with alkyl phenols used in the adhesives, tanning, and plastics and rubber industries. Occupational vitiligo is recognised as a prescribed disease in the U.K. when it results from contact with specific phenols. Methods of protection, prevention, screening and treatment are described.
Occupational Health, Sep. 1980, Vol.32, No.9, p.442-448. Illus. 2 ref.

CIS 82-142 Dmitriev M.T., Rastjannikov E.G., Tarasova L.N.
Determination of methanol in air by gas chromatography
Gazohromatografičeskoe opredelenie metanola v vozduhe [in Russian]
Description of a method for determining methanol in the presence of gasoline vapours. The method is based on the oxidation of methyl alcohol in formaldehyde, the concentration being determined by reaction with chromotropic acid. Ethanol is used to extract the methanol in air samples which are collected at a rate of 0.2-0.4l/min for 30min. Desorption efficiency is 95-100% of methanol.
Gigiena i sanitarija, Nov. 1980, No.11, p.57-58. Illus. 9 ref.

CIS 81-1955 Comstock E.G.
Current literature on medical toxicology and a bibliography of pentachlorophenol
This bibliography, which results from a review of the clinical literature, reflects the current interests of practising medical toxicologists and presents the clinical problems of recent years.
Clinical Toxicology, 1980, Vol.16, No.4, p.531-539. 133 ref.

CIS 81-2001 Ferry D.G., Temple W.A., McQueen E.G.
Methanol monitoring - Comparison of urinary methanol concentration with formic acid excretion rate as a measure of occupational exposure
Methods of monitoring occupational exposure to methanol were investigated in volunteers with methanol ingestion. Urinary methanol concentrations accurately reflected those in the blood over a considerable range of concentrations. Urinary formic acid concentration (in µg/ml) was too variable but rate of urinary excretion of formic acid (in µg/min) did reflect methanol uptake. The ratio of urinary formic acid to creatinine concentrations is a practical monitoring method. However formic acid elimination rate is reduced by ingestion of alcoholic beverages. Urinary methanol concentration is favoured as a method of monitoring, and a concentration of 10µg/ml measured at the end of the work shift is suggested as the limit above which occupational exposure should be suspected and the appropriate action taken.
International Archives of Occupational and Environmental Health, Nov. 1980, Vol.47, No.2, p.155-163. 12 ref.

CIS 81-1939 Tarasov V.V., Liho V.G., Kamalov R.S.
Chromatographic determination of phenol, furfural and furfuryl alcohol in air
Hromatografičeskoe opredelenie fenola, furfurola i furilovogo spirta v vozduhe [in Russian]
Description of a method developed for determining the concentrations of these three substances when they are simultaneously present in air. Thin-layer chromatographic analysis takes only 20min. Sensitivity is 0.5µg for furfuryl alcohol and 1µg for phenol and furfural.
Gigiena truda i professional'nye zabolevanija, July 1980, No.7, p.52-53.

CIS 81-1303 Determination of epichlorhydrin and ethylene chlorhydrin in air
Bestämning av epiklorhydrin och etylenklorhydrin i luft [in Swedish]
Determination by gas chromatography. The air to be analysed is passed through activated carbon, and then pumped into the chromatograph after desorption by injection of dichloromethane (desorption can also be obtained with carbon disulfide).
Arbetarskyddsstyrelsen, Arbetsmedicinska avdelningen, 171 84 Solna, Sweden, 1980. 12p. 1 ref.

CIS 81-1117 Sedov A.V., Surovcev N.A., Mazneva G.E., Ševkun O.N.
Establishment of a TLV for phenol concentrations in the atmosphere of personal protective isolating equipment
O gigieničeskom normirovanii fenola v gazovoj srede izolirujuščih sredstv individual'noj zaščity [in Russian]
To determine this TLV a number of changes in functional indices were observed in volunteers exposed, during exercise tests, to concentrations of 3-9mg/m3 oxygen/phenol mixture. Considering odour threshold and effects on reproductive function, a TLV of 0.3mg/m3 was established for phenol in air inside breathing equipment.
Gigiena i sanitarija, May 1980 No.5, p.81-82. 5 ref.

CIS 81-951 Glanville J.O., Wightman J.P.
Wetting of powdered coals by alkanol-water solutions and other liquids.
A critical concentration of each alkanol is needed before any wetting occurs; this is lower for alcohols with longer carbon chains. A critical surface tension of 0.033J/m2 was estimated from the measured wetting concentrations. The heats of immersion of powdered coal in water-methanol mixtures vary smoothly with changing concentrations, reaching a maximum of 16J/g at 30mol% methanol. The heat of immersion of coal dust is released over periods of up to 9h.
Fuel, Aug. 1980, Vol.59, No.8, p.557-562. 42 ref.

CIS 81-770 Sato A., Nakajima T., Koyama Y.
Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
The activities of liver drug-metabolising enzymes for 16 aromatic or chlorinated hydrocarbons were measured in rats after daily intake of ethanol (30% of total energy intake) for 3 weeks. Ethanol only slightly increased the microsomal cytochrome P-450 content, but increased in vitro metabolism of most hydrocarbons 3-6 fold. A major part of this enhanced activity disappeared after withdrawal of ethanol, suggesting that recent intake of ethanol plays an important part in accelerating the metabolism of hydrocarbons. The enzyme activity enhanced by ethanol was related to changes occurring not in the soluble but in the microsomal fractions. A metabolism study with toluene showed its in vivo metabolism to be increased by chronic ethanol consumption in rats.
British Journal of Industrial Medicine, Nov. 1980, Vol.37, No.4, p.382-386. 23 ref.

CIS 81-757 Gebhart W., Luger T., Niebauer N.
Vitiligo due to p-tert-butylphenol
Vitiligo dû au p-tert-butylphénol. [in French]
Case studies of 14 men working in a plant producing synthetic resins and lacquer, where p-tert-bytylphenol was employed. Apart from the phenomema of depigmentation, the workers did not present any of the general symptoms usual in leukoderma (headache, fatigue, enlarged liver and spleen). Methods used for skin biopsy; results of microscopic study of skin affected by achromia. Review of possible pathogenic mechanisms.
Annales de dermatologie et de vénéréologie, 1980, Vol.107, No.8-9, p.809-814. Illus. 19 ref.

CIS 81-482 Schmidt P., Burck A., Bürger A., Gohlke R., Hinz G., Rothe R.
Toxicity of Ω-H-polyfluorinated carboxylic acids and alcohols with equal numbers of C atoms
Beitrag zur Toxicität Ω-H-polyfluorierter Carbonsäuren und einiger Alkohole gleicher C-Zahl [in German]
Studies in rats are reported with carboxylic acid and alcohols with the formula H(CF2CF2)n COOH and H(CF2CF2)n CH2OH in which n = 4 or 5. The acids produced prolonged hepatomegaly, lipid metabolism disorders and a reduction in microsomal enzyme activity in the liver. The LD50 values determined show the acids to have moderate toxicity. The alcohols have minimal acute toxicity on oral administration and have no irritant action.
Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete, Jan. 1980, Vol.26, No.1, p.9-13. 16 ref.

CIS 81-447 Morel C., Gendre M., Cavigneaux A., Protois J.C.
French National Research and Safety Institute (Institut national de recherche et de sécurité)
Allyl alcohol
Alcool allylique. [in French]
Uses, physical and chemical properties, methods of detection and determination in air, fire hazards (closed-cup flash point 21°C), pathology and toxicology (irritant, U.S. TLV 2ppm). French occupational safety and health regulations; French and international regulations concerning transport. Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 4th quarter 1980, No.101, Note No.1297-101-80, p.617-620. 21 ref.

CIS 81-323 Safety recommendations for loading and unloading tank trucks transporting alcohol
Recomendações de segurança para carga e descarga de caminhões-tanque utilizados no transporte de álcool [in Portuguese]
Points covered by these recommendations: accumulation of static electricity and its hazards; protective measures (prevention of sparks; bonding and bonding methods according to type of soil).
Cooperativa central dos productores de açucar e álcool, rua Boa Vista, 280, Caixa Postal 5691, 01014 São Paulo, Brasil, no date, 4p. Illus.

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