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Base de datos CISDOC

ID (ISN) del documento61657
Número CIS 94-316
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 1993
Número de serie
Autor(es) Golsdmith J.R., Goldsmith D.F.
Título Fibreglass or silica exposure and increased nephritis or ESRD (End-Stage Renal Disease)
Información bibliográfica June 1993, Vol.23, No.6, p.873-881. 27 ref.
Resumen A U.S. multi-plant cohort mortality study of workers producing manufactured mineral fibres is finding increasing mortality from nephritis and/or nephrosis. Other data were examined to see if similar effects can be identified. In a case-referent study among Michigan patients with end-stage renal disease (ESRD), men with exposures to silica have an elevated odds ratio for ESRD. In a California study based on 1979-81 data, some construction trades, farmers, and farm laborers showed excess mortality for renal disease. The highest mortality ratio was found in the category including insulation workers. California mortality data from 20 years earlier fail to show much excess renal disease in construction workers, but do for farmers. In Singapore, granite workers with a long-term exposure to silica have excess excretion of albumin and similar compounds, suggesting that silica exposure can lead to silica nephrotoxicity. Nephropathy has also been linked to non-occupational silica exposure. Although high blood concentrations of silica are found in persons with renal failure, the close association with elevated creatinine has been interpreted as evidence that the buildup of silica is due to renal failure, rather than vice-versa.
Descriptores (primarios) sílice; fibra de vidrio; lana mineral; exposición; nefritis; nefrosis; enfermedades del rinon
Descriptores (secundarios) revisión bibliográfica; efectos nefrotóxicos; insuficiencia renal
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaIsrael
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the kidney and the urinary system