|ID (ISN) del documento||61655|
|ISSN - Título de la serie
||0271-3586 - American Journal of Industrial Medicine
|Número de serie
||Sweeney M.H., Fingerhut M.A., Arezzo J.C., Hornung R.W., Connally L.B.
||Peripheral neuropathy after occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
||June 1993, Vol.23, No.6, p.845-858. 34 ref.
||In a cross-sectional study, prevalence of peripheral neuropathy was measured in 265 workers exposed 15 years earlier to chemicals contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in 244 unexposed. Cases of peripheral neuropathy were defined from examination, electrophysiologic and quantitative sensory tests, and symptoms. Exposure was assessed by measuring lipid-adjusted serum TCDD levels. The mean serum TCDD level for workers (220 parts per trillion (ppt)) was significantly higher than for referents (7ppt) (p<.0001). Thirty-two percent of both worker and referent groups met the case definition for peripheral neuropathy. In the logistic regression analyses, serum TCDD level was not related to peripheral neuropathy. These data suggest that despite continued high serum TCDD levels, peripheral neuropathy is not a long-term sequela of high exposure to TCDD-contaminated chemicals. However, the study cannot preclude the occurrence and subsequent resolution of acute effects caused by high exposure, as experienced in Seveso and by some workers exposed to high levels of TCDD-contaminated substances.
||efectos neurotóxicos; ácido triclorofenoxiacético; tetraclorodibenzodioxina; exposición; enfermedades del sistema nervioso periférico; tests de exposición; dioxinas
||estudio transversal; exámenes médicos; dosificación en la sangre
|Tipo de documento
||D - Artículos periódicos
|País / Estado o Provincia||Estados Unidos|
|Broad subject area(s)
|Navegación por categoria(s)
||Diseases of the nervous system