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Base de datos CISDOC

ID (ISN) del documento61655
Número CIS 94-315
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 1993
Número de serie
Autor(es) Sweeney M.H., Fingerhut M.A., Arezzo J.C., Hornung R.W., Connally L.B.
Título Peripheral neuropathy after occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Información bibliográfica June 1993, Vol.23, No.6, p.845-858. 34 ref.
Resumen In a cross-sectional study, prevalence of peripheral neuropathy was measured in 265 workers exposed 15 years earlier to chemicals contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in 244 unexposed. Cases of peripheral neuropathy were defined from examination, electrophysiologic and quantitative sensory tests, and symptoms. Exposure was assessed by measuring lipid-adjusted serum TCDD levels. The mean serum TCDD level for workers (220 parts per trillion (ppt)) was significantly higher than for referents (7ppt) (p<.0001). Thirty-two percent of both worker and referent groups met the case definition for peripheral neuropathy. In the logistic regression analyses, serum TCDD level was not related to peripheral neuropathy. These data suggest that despite continued high serum TCDD levels, peripheral neuropathy is not a long-term sequela of high exposure to TCDD-contaminated chemicals. However, the study cannot preclude the occurrence and subsequent resolution of acute effects caused by high exposure, as experienced in Seveso and by some workers exposed to high levels of TCDD-contaminated substances.
Descriptores (primarios) efectos neurotóxicos; ácido triclorofenoxiacético; tetraclorodibenzodioxina; exposición; enfermedades del sistema nervioso periférico; tests de exposición; dioxinas
Descriptores (secundarios) estudio transversal; exámenes médicos; dosificación en la sangre
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the nervous system
Heterocyclic compounds
Biological monitoring