ILO Home
Volver a la página de entrada
Site map | Contact us English | Français

Base de datos CISDOC

ID (ISN) del documento61334
Número CIS 93-1952
ISSN - Título de la serie 0867-8383 - Polish Journal of Occupational Medicine and Environmental Health
Año 1993
Número de serie
Autor(es) Korsak Z., Świercz R., Jędrychowski R.
Título Effects of acute combined exposure to n-butyl alcohol and m-xylene
Información bibliográfica 1993, Vol.6, No.1, p.35-41. Illus. 14 ref.
Resumen The effects of combined exposure to m-xylene and n-butyl alcohol on rotarod performance and motor activity in rats and respiratory rate in mice were investigated in the condition of an acute inhalation experiment. Both solvents and mixtures caused concentration-dependent disturbances of rotarod performance in rats. The medial effective concentration (EC50) for the effect amounted to 6530ppm, 1980ppm and 3080ppm for n-butyl alcohol, m-xylene and their mixture, respectively. Both solvents and their mixture changed the spontaneous motor activity in the rat. The tested solvents resulted in a concentration-dependent decrease in respiratory rate in mice. The concentration which decreased the respiratory rate to 50% (RD50) was 3010ppm, 1360ppm and 3140ppm for n-butyl alcohol, m-xylene and their mixture, respectively. In the animal tests the effect of the combined exposure to m-xylene and n-butyl alcohol was less than additive, suggesting that a similar phenomenon might occur in the conditions of combined occupational exposure to m-xylene and n-butyl alcohol.
Descriptores (primarios) efectos neurotóxicos; alcohol butílico; disolventes orgánicos; afectación respiratoria; exposición de corta duración; sinergismo; tests de exposición; m-xileno
Descriptores (secundarios) investigaciones en el animal; efectos tóxicos
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaPolonia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Alcohols
Aromatic hydrocarbons
Biological monitoring
Diseases of the respiratory system (except for pneumoconiosis & similar)
Diseases of the nervous system