| ID (ISN) del documento | 61169 |
| Número CIS |
93-1937 |
| ISSN - Título de la serie |
0096-1736 - Journal of Occupational Medicine |
| Año |
1993 |
| Número de serie |
|
| Autor(es) |
Sessink P.J.M., De Roos J.H.C., Pierik F.H., Anzion R.B.M., Bos R.P. |
| Título |
Occupational exposure of animal caretakers to cyclophosphamide |
| Información bibliográfica |
Jan. 1993, Vol.35, No.1, p.47-52. 15 ref. |
| Resumen |
The study examined environmental contamination with cyclophosphamide (CP) in an animal laboratory where mice were injected with this compound. Also studied was the contamination of gloves, sleeve protectors, and masks for personal protection. Analysis of air-circulation system filters revealed amounts of CP corresponding to <0.1-1.0µg/day. Wipe samples taken from different objects and surfaces were also analysed. The presence of CP was not only observed in the room where the mice were housed and treated but also in adjacent rooms (<0.02-44ng/cm2). The gloves used during CP injection were always contaminated (2-199µg/pair), although no penetration was established. The sleeve protectors were incidentally contaminated (<0.3-10µg) and no CP was found on the masks (<0.2µg). Eighty-seven urine samples from four animal caretakers were analysed for unmetabolised CP. CP was detected (0.7µg) in one sample. The results of this study show that animal caretakers are exposed to CP in their work. |
| Descriptores (primarios) |
ciclofosfamida; animales de experimentación; cuidado de animales; contaminación; valoración de la exposición |
| Descriptores (secundarios) |
guantes de protección; roedores; dosificación en la orina; toma de muestras del aire; contaminación del vestido |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | Países Bajos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Livestock rearing
Animal hazards
Exposure evaluation
Heterocyclic compounds
|
