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Base de datos CISDOC

ID (ISN) del documento61169
Número CIS 93-1937
ISSN - Título de la serie 0096-1736 - Journal of Occupational Medicine
Año 1993
Número de serie
Autor(es) Sessink P.J.M., De Roos J.H.C., Pierik F.H., Anzion R.B.M., Bos R.P.
Título Occupational exposure of animal caretakers to cyclophosphamide
Información bibliográfica Jan. 1993, Vol.35, No.1, p.47-52. 15 ref.
Resumen The study examined environmental contamination with cyclophosphamide (CP) in an animal laboratory where mice were injected with this compound. Also studied was the contamination of gloves, sleeve protectors, and masks for personal protection. Analysis of air-circulation system filters revealed amounts of CP corresponding to <0.1-1.0µg/day. Wipe samples taken from different objects and surfaces were also analysed. The presence of CP was not only observed in the room where the mice were housed and treated but also in adjacent rooms (<0.02-44ng/cm2). The gloves used during CP injection were always contaminated (2-199µg/pair), although no penetration was established. The sleeve protectors were incidentally contaminated (<0.3-10µg) and no CP was found on the masks (<0.2µg). Eighty-seven urine samples from four animal caretakers were analysed for unmetabolised CP. CP was detected (0.7µg) in one sample. The results of this study show that animal caretakers are exposed to CP in their work.
Descriptores (primarios) ciclofosfamida; animales de experimentación; cuidado de animales; contaminación; valoración de la exposición
Descriptores (secundarios) guantes de protección; roedores; dosificación en la orina; toma de muestras del aire; contaminación del vestido
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaPaíses Bajos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Exposure evaluation
Heterocyclic compounds
Livestock rearing
Animal hazards