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ID (ISN) del documento60743
Número CIS 93-1608
ISSN - Título de la serie 1040-8444 - Critical Reviews in Toxicology
Año 1992
Número de serie
Autor(es) Johnson E.S.
Título Human exposure to 2,3,7,8-TCDD and risk of cancer
Información bibliográfica 1992, Vol.21, No.6, p.451-463. 121 ref.
Resumen Most of the evidence for the carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in humans has centred around whether or not it causes malignant lymphomas (ML) and soft-tissue sarcomas (STS). A critical review of the literature indicates that the evidence does not support a causal role for TCDD in the aetiology of ML. For STS, the evidence does not specifically incriminate TCDD either, although there is room for doubt. Cancer of other sites, particularly of the respiratory system and thyroid, which were found to be statistically significantly in excess in both of the two largest studies of combined cohorts of occupationally exposed workers, were identified as candidate tumours for which a possible aetiological role of TCDD might need investigation in future studies.
Descriptores (primarios) tetraclorodibenzodioxina; linfoma; tumores; etiología; efectos cancerígenos; sarcomas
Descriptores (secundarios) revisión bibliográfica; encuesta epidemiológica; mortalidad
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Blood diseases
Heterocyclic compounds