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Base de datos CISDOC

ID (ISN) del documento60522
Número CIS 93-1264
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 1992
Número de serie
Autor(es) Nise G.
Título Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing
Información bibliográfica 1992, Vol.63, No.6, p.377-381. 25 ref.
Resumen In 62 male rotogravure printers, the time-weighted average (TWA) toluene exposure during one workweek ranged from 8 to 496mg/m3 (median 96). Post-shift urinary excretion of hippuric acid showed a poor correlation with the air toluene concentration. Level of o-cresol excretion ranged from 0.08 to 2.37mmol/mol creatinine and was associated with the exposure (rs=0.57, p<0.0001), although the variation was considerable. However, this metabolite was significantly influenced by smoking habits, both in the worker and in 21 unexposed controls. The excretion of these metabolites was followed during vacation, when the workers were unexposed. After 2-4 weeks of vacation, the concentration of o-cresol was significantly higher for the smokers than the non-smokers (0.14 vs 0.06mmol/mol creatinine). No smoking-associated difference was found for the urinary hippuric acid concentration. However, there was an association between alcohol consumption and hippuric acid excretion (p=0.003); no such difference was shown for o-cresol. These results demonstrate that hippuric acid and o-cresol excretion are unsuitable for biological monitoring of toluene exposure when the exposure level is below 200mg/m3.
Descriptores (primarios) imprenta; pruebas bioquímicas; valoración de la exposición; tolueno
Descriptores (secundarios) cloro-4 o-cresol; dosificación en la orina; metabolitos urinarios; ácido hipúrico
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaSuecia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Printing, photography and photocopying industry
Exposure evaluation
Aromatic hydrocarbons