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Base de datos CISDOC

ID (ISN) del documento60137
Número CIS 93-903
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1991
Número de serie
Autor(es) Lundh T., Ståhlbom B., Åkesson B.
Título Dimethylamine in mould core manufacturing: Exposure, metabolism and biological monitoring
Información bibliográfica Mar. 2791, Vol.48, No.3, p.203-207. 27 ref. Illus.
Resumen Exposure to dimethylethylamine (DMEA) and metabolism of the substance were studied in 12 mould core makers in four foundries that use the Ashland cold box technique. The mean time weighted average (TWA) full work shift DMEA exposure concentration was 3.7mg/m3. Inhaled DMEA was excreted into urine as the original amine and as its metabolite dimethylethylamine-N-oxide (DMEAO). This metabolite made up a median of 87 (range 18-93)% of the sum of DMEA and DMEAO concentrations excreted into the urine. Occupational exposure did not significantly increase the urinary excretion of dimethylamine or methylethylamine. The data indicate half lives after the end of exposure for DMEA in urine of 1.5h and DMEAO of 3h. Postshift summed concentration of DMEA and DMEAO in plasma and urine is a good indicator of the TWA concentration in air during the workday, and might thus be used for biological monitoring. An air concentration of 10mg/m3 corresponds to a urinary excretion of the summed amount of DMEA and DMEAO of 135 mmol/mol creatinine.
Descriptores (primarios) metabolización; etildimetilamina; fundiciones; confección de moldes y núcleos; tests de exposición; aminas alifáticas
Descriptores (secundarios) vida media; dosificación en la orina; dosificación en la sangre; valoración de la exposición
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaSuecia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Biological monitoring
Aliphatic amines
Foundries, metalcasting and forging operations