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Base de datos CISDOC

ID (ISN) del documento60064
Número CIS 93-913
ISSN - Título de la serie 0096-1736 - Journal of Occupational Medicine
Año 1992
Número de serie
Autor(es) Schecter A., Ryan J.J.
Título Persistent brominated and chlorinated dioxin blood levels in a chemist 35 years after dioxin exposure
Información bibliográfica July 1992, Vol.34, No.7, p.702-707. 38 ref.
Resumen In this case study a chemist, after synthesising 10g of 2,3,7,8-tetrabromodibenzodioxin (TBrDD), suffered from mild and transient chloracne of the neck and wrists. Later in the year (September 1956), after synthesising 16g of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), he suffered severe chloracne of the entire body, headaches, backache, and leg pain on exertion. His measured 2,3,7,8-TBrDD in 1991 was 625 parts per trillion (ppt) in whole blood lipid, 35 years after initial exposure and 18ppt TCDD, an elevated level in comparison with the mean 2,3,7,8-TCDD level of 5ppt in the US population. This is the first reported detection of a brominated dioxin in human tissue. The total halogenated dioxin body burden in September 1956 is estimated to have been between 13,005ppt and 146,726ppt. This uptake demonstrates an occupational hazard to chemists and chemical workers, and the usefulness of human tissue dioxin measurements to document absorption.
Descriptores (primarios) dibenzodioxinas cloradas; trabajos de laboratorio; tetraclorodibenzodioxina; exposición de larga duración; dioxinas; acné clórico; tetrabromodibenzodioxina
Descriptores (secundarios) dosificación en la sangre; estudio de caso
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaCanadá; Estados Unidos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Skin diseases
Heterocyclic compounds