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ID (ISN) del documento59322
Número CIS 93-239
ISSN - Título de la serie 0105-1873 - Contact Dermatitis
Año 1992
Número de serie
Autor(es) Damstra R.J., van Vloten W.A., van Ginkel C.J.W.
Título Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel®): A case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon® CG
Información bibliográfica Aug. 1992, Vol.27, No.2, p.105-109. Illus. 17 ref.
Resumen Occupational contact allergy to 1,2-benzisothiazolin-3-one (1,b-BIT, Proxel®) is analysed. This compound is widely used in industry as a preservative in water-based solutions such as pastes, paints and cutting oils. The optimal concentration for patch testing proved to be 0.4g/L (0.04%) in water. In 4 out of 17 patients (23%) at occupational risk (painters, paper-hangers), contact allergy to 1,2-BIT was found. Of 556 consecutive dermatological patients without clear occupational risk, 10 (1.8%) showed positive patch tests to 1,2-BIT; in 3 patients 1,2-BIT contact allergy was related to domestic paper-hanging. Although the chemical structure of 1,2-BIT shows some analogy with the preservative Kathon® CG true cross-sensitivity was found to be unlikely.
Descriptores (primarios) benceisotiazolina-1,2 ona-3; morbilidad; productos para la preservación; pintura; valoración de la exposición; eczema
Descriptores (secundarios) pinturas; tests cutáneos; líquidos de corte; alergias cutáneas
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaPaíses Bajos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Surface treatment
Exposure evaluation
Skin diseases
Heterocyclic compounds