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Base de datos CISDOC

ID (ISN) del documento57974
Número CIS 92-902
ISSN - Título de la serie Polish Journal of Industrial Medicine
Año 1990
Número de serie
Autor(es) Sorsa M., Pyy L.
Título Exposure assessment of workers in the production of cyclophosphamide
Información bibliográfica 1990, Vol.3, No.2, p.185-189. Illus. 7 ref.
Resumen Cyclophosphamide (CP) is an extremely well documented mutagen and carcinogen in both in vitro and in vivo test systems, as well as in humans. CP concentration in air was measured (66 air samples) in the production department where CP was manufactured. The highest potential exposure was found to occur during specific operations at the end of the process, when airborne concentrations of CP may rise up to several hundred µg/m3. Mutagenicity measurements of air samples at the beginning of the process revealed direct mutagenicity similar to the CP intermediates. The workers who were using supplied air masks, gloves and protective clothing, revealed no responses in urinary mutagenicity when after-work and after-holiday samples were compared. The cytogenetic parameters such as chromosomal aberrations and sister chromatid exchanges did not differ in frequency between the group of workers in the CP production unit and the control group.
Descriptores (primarios) ciclofosfamida; citostáticos; análisis de las aberraciones cromosómicas; dosificación en el aire; tests de exposición; valoración de la exposición
Descriptores (secundarios) mutágenos; substancias cancerígenas; estudio comparado; toma de muestras y análisis; substancias tóxicas
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaFinlandia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Heterocyclic compounds
Exposure evaluation
Biological monitoring