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Base de datos CISDOC

ID (ISN) del documento57254
Número CIS 92-219
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1990
Número de serie
Autor(es) Sherson D., Sabro P., Sigsgaard T., Johansen F., Autrup H.
Título Biological monitoring of foundry workers exposed to polycyclic aromatic hydrocarbons
Información bibliográfica July 1990, Vol.47, No.7, p.448-453. Illus. 37 ref.
Resumen This investigation describes benzo(a)pyrene (BP) serum protein adduct concentrations in 45 foundry workers and 45 matched non-occupationally exposed controls. High and low BP exposure groups were defined using breathing zone hygienic samples for both quartz and BP exposures. A newly developed enzyme linked immunosorbent assay detected benzo(a)pyrenediolepoxide-I binding to serum protein. Mean BP protein adduct concentrations (SD) for non-smoking and smoking foundry workers were significantly higher than mean values for non-smoking and smoking controls. Foundry workers with high exposures to either quartz or BP had slightly raised mean adduct concentrations compared with foundry workers with low exposure for quartz or BP. Highest mean adduct concentrations were found among a small group of workers with simultaneous high exposures to both quartz and BP suggesting an additive effect. These data support the presence of a possible aetiological connection between an increased risk of lung cancer and BP exposure among foundry workers, and of an additive effect between BP and quartz. Measurement of BP serum protein adduct concentrations appears to be a useful method by which groups exposed to BP may be biologically monitored.
Descriptores (primarios) hidrocarburos aromáticos; sílice; fundiciones; tests de exposición; hidrocarburos policíclicos
Descriptores (secundarios) cáncer de pulmón; benzo(a)pireno; pruebas bioquímicas; sinergismo; valoración de la exposición
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaDinamarca
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Biological monitoring
Polycyclic hydrocarbons
Aromatic hydrocarbons
Foundries, metalcasting and forging operations