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Base de datos CISDOC

ID (ISN) del documento56485
Número CIS 91-1277
ISBN(s) 90-5307-071-0
Año 1991
Número de serie Arbeidsinspectie RA 1/91
Autor(es)
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards)
Título Health-based recommended occupational exposure limits for tetrahydrofuran
Información bibliográfica Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 90804, 2509 LV Den Haag, Netherlands, 1991. 35p. 58 ref.
Resumen The present document is a joint production of the Dutch Expert Committee and the Nordic Group for Documentation of Occupational Exposure Limits. The risks to human health of exposure to tetrahydrofuran (THF) are evaluated. THF is often used as a solvent in adhesives for plastics and in lacquers. The most probably route of occupational exposure is by inhalation. Some results indicate that THF is metabolised by an induceable oxidative enzyme system. THF is an irritant to mucous membranes and skin. Effects on the liver and kidneys have been found in a few cases and in animal experiments. The studies of THF teratogenicity, mutagenicity and genotoxicity are negative. The critical effect of THF seems to be irritation of mucous membranes and skin. Analysis of the data available leads to a recommended occupational exposure limit of 300mg/m3 (=100ppm) TWA-8h (H notation). Summary in Dutch.
Descriptores (primarios) tetrahidrofurano; valores umbrales; efectos biológicos; Países Bajos; determinación de los límites de la exposición; Suecia
Descriptores (secundarios) revisión bibliográfica; documentación de base; valoración de la toxicidad; informe
Tipo de documento E - Libros, informes, actas
País / Estado o ProvinciaPaíses Bajos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Heterocyclic compounds
Occupational exposure limits