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Base de datos CISDOC

ID (ISN) del documento55965
Número CIS 91-897
ISSN - Título de la serie 0386-300X - Acta Medica Okayama
Año 1989
Número de serie
Autor(es) Jitsunari F., Asakawa F., Nakajima T., Shimada J., Ogata M.
Título Determination of 3,5,6-trichloro-2-pyridinol levels in the urine of termite control workers using chlorpyrifos
Información bibliográfica Oct. 1989, Vol.43, No.5, p.299-306. 15 ref.
Resumen Chlorpyrifos, an organophosphorus insecticide, has been used to control termites since regulatory measures against the use of chlordanes in Japan were taken in September 1989. An improved gas chromatographic (GC) method for the assay of 3,5,6-trichloro-2-pyridinol (TCP) in the urine was developed for the biological monitoring of exposure to chlorpyrifos. Urinary TCP was separated and determined precisely (coefficient of variation 4%) with high sensitivity (detection limit, 10ng/mL) and recovery (>90%) using a wide bore capillary column (WBC column). The accuracy and precision of the method are satisfactory. The time course of urinary excretion of TCP was followed in workers. Urinary TCP was low in the off-season and high in the busy season, and varied with the length of the working period. The TCP level showed a change reciprocal to the variations in the plasma cholinesterase activity. The urinary TCP level thus seems to reflect the extent of exposure to chlorpyrifos. The decrease in cholinesterase activity is probably due to exposure to chlorpyrifos.
Descriptores (primarios) clorpirifos; tricloro-3,5,6 piridinol-2; dosificación en la orina; tests de exposición; insecticidas
Descriptores (secundarios)
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaJapón
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Agricultural chemicals
Biological monitoring
Heterocyclic compounds
Esters and salts