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Base de datos CISDOC

ID (ISN) del documento55834
Número CIS 91-830
ISSN - Título de la serie 0301-0023 - Journal of the Society of Occupational Medicine
Año 1990
Número de serie
Autor(es) Brandt-Rauf P.W., Smith S., Perera F.P., Niman H.L., Yohannan W., Hemminki K., Santella R.M.
Título Serum oncogene proteins in foundry workers
Información bibliográfica Spring 1990, Vol.40, No.1, p.11-14. 22 ref.
Resumen Oncogene activation can be detected by immunoblotting for oncogene proteins in serum. This technique has been applied to screen a cohort of foundry workers with well-defined workplace exposures to polycyclic aromatic hydrocarbon carcinogens. Three of the 18 individuals screened were found to have abnormal expression of the proteins of the ras and fes oncogenes. These three individuals were known to have had medium to high workplace exposures to benzo(a)pyrene and to have correspondingly high levels of benzo(a)pyrene DNA adducts in their peripheral leukocytes. These results suggest the feasibility of using serum oncogene proteins along with DNA-carcinogen adducts as potential molecular epidemiological markers in exposed worker populations.
Descriptores (primarios) substancias cancerígenas; hidrocarburos aromáticos; modificaciones de las proteínas séricas; fundiciones; hidrocarburos policíclicos; efectos citológicos; benzo(a)pireno
Descriptores (secundarios) Finlandia; encuesta epidemiológica; tumores; descripción del procedimiento; dosificación en la sangre
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Foundries, metalcasting and forging operations
Blood diseases
Polycyclic hydrocarbons
Aromatic hydrocarbons