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Base de datos CISDOC

ID (ISN) del documento55725
Número CIS 91-538
ISSN - Título de la serie 0025-7818 - Medicina del lavoro
Año 1990
Número de serie
Autor(es) Clonfero E., Venier P., Granella M., Levis A.G.
Título Mutagenic and carcinogenic risks of leather azo dyes
Título original I coloranti azoici per cuoio: rischio mutageno e cancerogeno [en italiano]
Información bibliográfica May-June 1990, Vol.81, No.3, p.222-229. 32 ref.
Resumen The paper reviews the carcinogenicity and mutagenicity data on azo dyes used in the leather industry. Two water soluble benzidine-based dyes were classified as "probably carcinogenic in humans" by the International Agency for Research on Cancer (IARC). No other dyes have been evaluated by the IARC. Of the 48 azo dyes assayed in the Salmonella/microsome test, 20 gave positive results. Attention is drawn to the important role of the in vivo metabolism of azo compounds, which includes a preliminary reduction of the azo bonds and subsequent release of the aromatic amines of the dye. A useful assay (Prival test) for evaluating the mutagenic properties of azo dyes involves a reductive step that permits the release of any genotoxic agents present in the compounds. A list of leather azo dyes is furnished that are considered as potentially harmful due to the presence of a carcinogenic aromatic amine (benzidine, p-aminoazobenzene and derivatives) in their formulae.
Descriptores (primarios) substancias cancerígenas; fabricación de artículos de cuero; tintes; compuestos azoicos
Descriptores (secundarios) p-aminoazobenceno; tests de carcinogénesis; bencidina; aminas aromáticas
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaItalia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Footwear, leather and fur industry