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ID (ISN) del documento55724
Número CIS 91-537
ISSN - Título de la serie 0025-7818 - Medicina del lavoro
Año 1990
Número de serie
Autor(es) Clonfero E., Venier P., Granella M., Levis A.G.
Título Identification of genotoxic compounds used in the leather processing industry
Título original Identificazione di composti genotossici utilizzati nella lavorazione delle pelli [en italiano]
Información bibliográfica May-June 1990, Vol.81, No.3, p.212-221. 45 ref.
Resumen The release of mutagens from 7 carbon black-based leather dyes and from leather samples at various stages of finishing was determined. After vigorous treatment with toluene, 4 commercial dyes yielded mutagenic extracts on Salmonella typhimurium in the presence of microsomal enzymes. Only one of the responsible chemicals was a polycyclic aromatic hydrocarbon. The low bioavailability of mutagens contained in carbon black and their low mutagenic activity suggest that the risk associated with the use of these dyes is probably negligible. Ethanol extracts of finished leather were mutagenic in the absence of S9 mix. Analysis of extracts of leather samples at various stages of processing showed that mutagenic activity was detectable after the colouring process. The responsible compound was a nitroazo dye, C.I. Acid Brown 83. 18 commercial tannins containing mainly Cr(III) sulfates were assessed for genotoxicity. Most were contaminated with Cr(VI), a known mugaten and carcinogen, at levels sufficient to include sister chromatid exchanges in mammalian cells.
Descriptores (primarios) efectos mutágenos; mutágenos; fabricación de artículos de cuero; curtiduría; tintes
Descriptores (secundarios) hidrocarburos aromáticos; pardo ácido 83; tests de mutagénesis; negro de humo; hidrocarburos policíclicos; compuestos azoicos
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaItalia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Footwear, leather and fur industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects